| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J O Grove. Is it time to reassess the BDNF hypothesis of depression? Molecular psychiatry. vol 12. issue 12. 2008-03-05. PMID:17700574. |
the brain-derived neurotrophic factor (bdnf) hypothesis of depression postulates that a loss of bdnf is directly involved in the pathophysiology of depression, and that its restoration may underlie the therapeutic efficacy of antidepressant treatment. |
2008-03-05 |
2023-08-12 |
human |
| J O Grove. Is it time to reassess the BDNF hypothesis of depression? Molecular psychiatry. vol 12. issue 12. 2008-03-05. PMID:17700574. |
i will also review key studies, both human and animal, which have investigated the association of a bdnf single-nucleotide polymorphism (val66met) with depression pathogenesis, and detail the number of inconsistencies which also afflict this novel area of bdnf research. |
2008-03-05 |
2023-08-12 |
human |
| Vanja Duric, Kenneth E McCarso. Neurokinin-1 (NK-1) receptor and brain-derived neurotrophic factor (BDNF) gene expression is differentially modulated in the rat spinal dorsal horn and hippocampus during inflammatory pain. Molecular pain. vol 3. 2008-02-21. PMID:17974009. |
an opposite effect was observed in the hippocampus, where cfa down-regulated nk-1 receptor and bdnf gene expression, phenomena previously observed in immobilization models of stress and depression. |
2008-02-21 |
2023-08-12 |
rat |
| S Anttila, K Huuhka, M Huuhka, R Rontu, M Hurme, E Leinonen, T Lehtimäk. Interaction between 5-HT1A and BDNF genotypes increases the risk of treatment-resistant depression. Journal of neural transmission (Vienna, Austria : 1996). vol 114. issue 8. 2008-02-19. PMID:17401528. |
interaction between 5-ht1a and bdnf genotypes increases the risk of treatment-resistant depression. |
2008-02-19 |
2023-08-12 |
Not clear |
| S Anttila, K Huuhka, M Huuhka, R Rontu, M Hurme, E Leinonen, T Lehtimäk. Interaction between 5-HT1A and BDNF genotypes increases the risk of treatment-resistant depression. Journal of neural transmission (Vienna, Austria : 1996). vol 114. issue 8. 2008-02-19. PMID:17401528. |
we attempt to show that the interaction between 5-ht1a and bdnf polymorphism predicts the risk of treatment-resistant depression. |
2008-02-19 |
2023-08-12 |
Not clear |
| S Anttila, K Huuhka, M Huuhka, R Rontu, M Hurme, E Leinonen, T Lehtimäk. Interaction between 5-HT1A and BDNF genotypes increases the risk of treatment-resistant depression. Journal of neural transmission (Vienna, Austria : 1996). vol 114. issue 8. 2008-02-19. PMID:17401528. |
the combination of 5-ht1a gg and bdnf ga + aa genotypes is associated with an increased risk of depression. |
2008-02-19 |
2023-08-12 |
Not clear |
| Keri Martinowich, Husseini Manji, Bai L. New insights into BDNF function in depression and anxiety. Nature neuroscience. vol 10. issue 9. 2008-01-04. PMID:17726474. |
new insights into bdnf function in depression and anxiety. |
2008-01-04 |
2023-08-12 |
Not clear |
| Keri Martinowich, Husseini Manji, Bai L. New insights into BDNF function in depression and anxiety. Nature neuroscience. vol 10. issue 9. 2008-01-04. PMID:17726474. |
the 'neurotrophin hypothesis of depression' is based largely on correlations between stress or antidepressant treatment and down- or upregulation, respectively, of brain-derived neurotrophic factor (bdnf). |
2008-01-04 |
2023-08-12 |
Not clear |
| Keri Martinowich, Husseini Manji, Bai L. New insights into BDNF function in depression and anxiety. Nature neuroscience. vol 10. issue 9. 2008-01-04. PMID:17726474. |
thus, bdnf may be a target of antidepressants, but not the sole mediator of depression or anxiety. |
2008-01-04 |
2023-08-12 |
Not clear |
| Robert M Pos. Role of BDNF in bipolar and unipolar disorder: clinical and theoretical implications. Journal of psychiatric research. vol 41. issue 12. 2007-12-13. PMID:17239400. |
serum bdnf is low in proportion to the severity of mania and depression and increases with clinical improvement. |
2007-12-13 |
2023-08-12 |
human |
| Smita Thakker-Varia, Jennifer Jernstedt Krol, Jacob Nettleton, Parizad M Bilimoria, Debra A Bangasser, Tracey J Shors, Ira B Black, Janet Alde. The neuropeptide VGF produces antidepressant-like behavioral effects and enhances proliferation in the hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 45. 2007-12-06. PMID:17989282. |
brain-derived neurotrophic factor (bdnf) is upregulated in the hippocampus by antidepressant treatments, and bdnf produces antidepressant-like effects in behavioral models of depression. |
2007-12-06 |
2023-08-12 |
mouse |
| Gwyneth Zai, Emanuela Mundo, John Strauss, Gregory W H Wong, James L Kenned. Brain-derived neurotrophic factor (BDNF) gene not associated with antidepressant-induced mania. Bipolar disorders. vol 9. issue 5. 2007-11-07. PMID:17680923. |
moreover, increasing bdnf production might be one of the mechanisms involved in the alleviation of depression and aggravation of mania in antidepressant treatment. |
2007-11-07 |
2023-08-12 |
Not clear |
| Jae-Min Kim, Robert Stewart, Sung-Wan Kim, Su-Jin Yang, Il-Seon Shin, Young-Hoon Kim, Jin-Sang Yoo. Interactions between life stressors and susceptibility genes (5-HTTLPR and BDNF) on depression in Korean elders. Biological psychiatry. vol 62. issue 5. 2007-10-26. PMID:17482146. |
interactions between life stressors and susceptibility genes (5-httlpr and bdnf) on depression in korean elders. |
2007-10-26 |
2023-08-12 |
Not clear |
| Luciana Ribeiro, João V Busnello, Rita M Cantor, Fiona Whelan, Pamela Whittaker, Panos Deloukas, Ma-Li Wong, Julio Licini. The brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism and depression in Mexican-Americans. Neuroreport. vol 18. issue 12. 2007-09-27. PMID:17632285. |
the hypothesis that brain-derived neurotrophic factor (bdnf) is involved in the pathogenesis of major depression is supported by several research findings; however, genetic studies assessing the relationship between bdnf and psychiatric disorders have produced conflicting results. |
2007-09-27 |
2023-08-12 |
human |
| Luciana Ribeiro, João V Busnello, Rita M Cantor, Fiona Whelan, Pamela Whittaker, Panos Deloukas, Ma-Li Wong, Julio Licini. The brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism and depression in Mexican-Americans. Neuroreport. vol 18. issue 12. 2007-09-27. PMID:17632285. |
we examined the effect of a bdnf polymorphism on depression susceptibility in mexican-americans. |
2007-09-27 |
2023-08-12 |
human |
| Luciana Ribeiro, João V Busnello, Rita M Cantor, Fiona Whelan, Pamela Whittaker, Panos Deloukas, Ma-Li Wong, Julio Licini. The brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism and depression in Mexican-Americans. Neuroreport. vol 18. issue 12. 2007-09-27. PMID:17632285. |
our findings support the association of bdnf single nucleotide polymorphism rs6265 and depression, suggesting that this polymorphism may increase susceptibility to major depression in mexican-americans. |
2007-09-27 |
2023-08-12 |
human |
| K S Krabbe, A R Nielsen, R Krogh-Madsen, P Plomgaard, P Rasmussen, C Erikstrup, C P Fischer, B Lindegaard, A M W Petersen, S Taudorf, N H Secher, H Pilegaard, H Bruunsgaard, B K Pederse. Brain-derived neurotrophic factor (BDNF) and type 2 diabetes. Diabetologia. vol 50. issue 2. 2007-09-26. PMID:17151862. |
decreased levels of brain-derived neurotrophic factor (bdnf) have been implicated in the pathogenesis of alzheimer's disease and depression. |
2007-09-26 |
2023-08-12 |
human |
| Amrita Nair, Krishna C Vadodaria, Sunayana B Banerjee, Madhurima Benekareddy, Brian G Dias, Ronald S Duman, Vidita A Vaidy. Stressor-specific regulation of distinct brain-derived neurotrophic factor transcripts and cyclic AMP response element-binding protein expression in the postnatal and adult rat hippocampus. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 32. issue 7. 2007-08-31. PMID:17164818. |
stress regulation of brain-derived neurotrophic factor (bdnf) is implicated in the hippocampal damage observed in depression. |
2007-08-31 |
2023-08-12 |
rat |
| S A Heldt, L Stanek, J P Chhatwal, K J Ressle. Hippocampus-specific deletion of BDNF in adult mice impairs spatial memory and extinction of aversive memories. Molecular psychiatry. vol 12. issue 7. 2007-08-28. PMID:17264839. |
these data suggest that the cognitive deficits and impairment in extinction of aversive memory found in depression and anxiety disorders may be directly related to decreased hippocampal bdnf. |
2007-08-28 |
2023-08-12 |
mouse |
| Omer Aydemir, Artuner Deveci, Oryal E Taskin, Fatma Taneli, Aysen Esen-Danac. Serum brain-derived neurotrophic factor level in dysthymia: a comparative study with major depressive disorder. Progress in neuro-psychopharmacology & biological psychiatry. vol 31. issue 5. 2007-08-28. PMID:17433517. |
bdnf serum concentrations and ham-d score did not have any significant correlation in the dysthymia and major depression groups (r=-0.276, p=0.086). |
2007-08-28 |
2023-08-12 |
human |