| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C A Alta. Neurotrophins and depression. Trends in pharmacological sciences. vol 20. issue 2. 1999-05-04. PMID:10101965. |
in this article, tony altar discusses how existing treatments of depression might work by increasing endogenous brain levels of bdnf or nt-3, which in turn could promote monoamine-containing neurone growth and function. |
1999-05-04 |
2023-08-12 |
rat |
| M Frerking, R C Malenka, R A Nicol. Brain-derived neurotrophic factor (BDNF) modulates inhibitory, but not excitatory, transmission in the CA1 region of the hippocampus. Journal of neurophysiology. vol 80. issue 6. 1999-02-10. PMID:9862938. |
we report here that bath application of bdnf causes a small but significant decrease in stimulus-evoked inhibitory postsynaptic currents (ipscs) on ca1 pyramidal cells, which is prevented by the tyrosine kinase inhibitor lavendustin a. bdnf causes a decrease in the 1/cv2 of the ipsc, and also reduces paired-pulse depression of the ipsc, suggesting a presynaptic site of action. |
1999-02-10 |
2023-08-12 |
Not clear |
| F Boris-Möller, F Kamme, T Wieloc. The effect of hypothermia on the expression of neurotrophin mRNA in the hippocampus following transient cerebral ischemia in the rat. Brain research. Molecular brain research. vol 63. issue 1. 1999-01-21. PMID:9838092. |
intraischemic hypothermia reduced the induction of ngf mrna, while the increase of bdnf mrna expression occurred earlier during recovery, and the post-ischemic nt3 mrna depression was not affected. |
1999-01-21 |
2023-08-12 |
rat |
| R S Duma. Novel therapeutic approaches beyond the serotonin receptor. Biological psychiatry. vol 44. issue 5. 1998-11-16. PMID:9755354. |
among the multiple target genes that could be regulated by creb and that could be involved in antidepressant actions and the pathophysiology of depression in brain-derived neurotrophic factor (bdnf). |
1998-11-16 |
2023-08-12 |
Not clear |
| A Balkowiec, D M Kat. Brain-derived neurotrophic factor is required for normal development of the central respiratory rhythm in mice. The Journal of physiology. vol 510 ( Pt 2). 1998-11-05. PMID:9706001. |
loss of one or both bdnf alleles resulted in an approximately 50% depression of central respiratory frequency compared with wild-type controls. |
1998-11-05 |
2023-08-12 |
mouse |
| A Balkowiec, D M Kat. Brain-derived neurotrophic factor is required for normal development of the central respiratory rhythm in mice. The Journal of physiology. vol 510 ( Pt 2). 1998-11-05. PMID:9706001. |
these derangements of central respiratory rhythm paralleled the ventilatory depression and irregular breathing characteristic of bdnf mutants in vivo, indicating that central deficits can largely account for the abnormalities in resting ventilation produced by genetic loss of bdnf. |
1998-11-05 |
2023-08-12 |
mouse |
| P D O'Leary, R A Hughe. Structure-activity relationships of conformationally constrained peptide analogues of loop 2 of brain-derived neurotrophic factor. Journal of neurochemistry. vol 70. issue 4. 1998-04-23. PMID:9523590. |
when tested in cultures of embryonic chick sensory neurons the peptides produced concentration-dependent inhibition of bdnf-mediated neuronal survival and caused both a rightward shift and depression of the maximum of the bdnf concentration-response curve. |
1998-04-23 |
2023-08-12 |
chicken |
| N Kawahara, S D Croll, S J Wiegand, I Klatz. Cortical spreading depression induces long-term alterations of BDNF levels in cortex and hippocampus distinct from lesion effects: implications for ischemic tolerance. Neuroscience research. vol 29. issue 1. 1998-01-09. PMID:9293491. |
cortical spreading depression induces long-term alterations of bdnf levels in cortex and hippocampus distinct from lesion effects: implications for ischemic tolerance. |
1998-01-09 |
2023-08-12 |
Not clear |
| R Stoop, M M Po. Synaptic modulation by neurotrophic factors: differential and synergistic effects of brain-derived neurotrophic factor and ciliary neurotrophic factor. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 16. issue 10. 1996-06-21. PMID:8627363. |
paired-pulse facilitation normally found at these synapses was reduced by bdnf but unaffected by cntf; cntf, but not bdnf, reduced the extent of synaptic depression during high-frequency tetanic stimulation. |
1996-06-21 |
2023-08-12 |
xenopus_laevis |
| T Timmusk, U Lendahl, H Funakoshi, E Arenas, H Persson, M Metsi. Identification of brain-derived neurotrophic factor promoter regions mediating tissue-specific, axotomy-, and neuronal activity-induced expression in transgenic mice. The Journal of cell biology. vol 128. issue 1-2. 1995-02-14. PMID:7822414. |
the genomic regions responsible for the in vivo upregulation of bdnf expression in the axotomized sciatic nerve and in the brain after kainic acid-induced seizures and kcl-induced spreading depression were mapped. |
1995-02-14 |
2023-08-12 |
mouse |
| Z Kokaia, G Gidö, T Ringstedt, J Bengzon, M Kokaia, B K Siesjö, H Persson, O Lindval. Rapid increase of BDNF mRNA levels in cortical neurons following spreading depression: regulation by glutamatergic mechanisms independent of seizure activity. Brain research. Molecular brain research. vol 19. issue 4. 1993-12-01. PMID:8231731. |
rapid increase of bdnf mrna levels in cortical neurons following spreading depression: regulation by glutamatergic mechanisms independent of seizure activity. |
1993-12-01 |
2023-08-12 |
rat |
| Z Kokaia, G Gidö, T Ringstedt, J Bengzon, M Kokaia, B K Siesjö, H Persson, O Lindval. Rapid increase of BDNF mRNA levels in cortical neurons following spreading depression: regulation by glutamatergic mechanisms independent of seizure activity. Brain research. Molecular brain research. vol 19. issue 4. 1993-12-01. PMID:8231731. |
levels of mrna for nerve growth factor (ngf), brain-derived neurotrophic factor (bdnf), neurotrophin-3 (nt-3) and the tyrosine kinase receptors trkb and trkc have been studied using in situ hybridization in the rat brain after topical application of kcl to the cortical surface (which induces spreading depression). |
1993-12-01 |
2023-08-12 |
rat |
| Z Kokaia, G Gidö, T Ringstedt, J Bengzon, M Kokaia, B K Siesjö, H Persson, O Lindval. Rapid increase of BDNF mRNA levels in cortical neurons following spreading depression: regulation by glutamatergic mechanisms independent of seizure activity. Brain research. Molecular brain research. vol 19. issue 4. 1993-12-01. PMID:8231731. |
repeated episodes of spreading depression during 2 h caused a rapid and marked increase of bdnf mrna levels in deep and, in particular, superficial cortical layers of the ipsilateral hemisphere (to 213 and 417% of control, respectively). |
1993-12-01 |
2023-08-12 |
rat |
| Z Kokaia, G Gidö, T Ringstedt, J Bengzon, M Kokaia, B K Siesjö, H Persson, O Lindval. Rapid increase of BDNF mRNA levels in cortical neurons following spreading depression: regulation by glutamatergic mechanisms independent of seizure activity. Brain research. Molecular brain research. vol 19. issue 4. 1993-12-01. PMID:8231731. |
maximal levels were reached within 2 h after the cessation of spreading depression and at 24 h bdnf mrna expression had returned to control values. |
1993-12-01 |
2023-08-12 |
rat |
| Z Kokaia, G Gidö, T Ringstedt, J Bengzon, M Kokaia, B K Siesjö, H Persson, O Lindval. Rapid increase of BDNF mRNA levels in cortical neurons following spreading depression: regulation by glutamatergic mechanisms independent of seizure activity. Brain research. Molecular brain research. vol 19. issue 4. 1993-12-01. PMID:8231731. |
also one single episode of spreading depression gave rise to a significant increase of cortical bdnf mrna levels (to 207% of control), which was attenuated (by 61%) after administration of the competitive nmda receptor antagonist cgs 19755. |
1993-12-01 |
2023-08-12 |
rat |