| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Philippe Fossati, Andrei Radtchenko, Patrice Boye. Neuroplasticity: from MRI to depressive symptoms. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 14 Suppl 5. 2005-01-19. PMID:15550349. |
this hypothesis seems to be confirmed by the decreased expression of neurotrophic factors (e.g., bdnf mrna) in animal models of depression. |
2005-01-19 |
2023-08-12 |
Not clear |
| Mark P Mattson, Stuart Maudsley, Bronwen Marti. BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders. Trends in neurosciences. vol 27. issue 10. 2004-11-30. PMID:15374669. |
impaired 5-ht and bdnf signaling is central to depression and anxiety disorders, but could also play important roles in the pathogenesis of several age-related disorders, including insulin resistance syndrome, alzheimer's disease and huntington's disease. |
2004-11-30 |
2023-08-12 |
Not clear |
| Hiroji Yanamoto, Jing-Hui Xue, Susumu Miyamoto, Izumi Nagata, Yoshikazu Nakano, Kenichi Murao, Haruhiko Kikuch. Spreading depression induces long-lasting brain protection against infarcted lesion development via BDNF gene-dependent mechanism. Brain research. vol 1019. issue 1-2. 2004-11-04. PMID:15306252. |
spreading depression induces long-lasting brain protection against infarcted lesion development via bdnf gene-dependent mechanism. |
2004-11-04 |
2023-08-12 |
mouse |
| Hiroji Yanamoto, Jing-Hui Xue, Susumu Miyamoto, Izumi Nagata, Yoshikazu Nakano, Kenichi Murao, Haruhiko Kikuch. Spreading depression induces long-lasting brain protection against infarcted lesion development via BDNF gene-dependent mechanism. Brain research. vol 1019. issue 1-2. 2004-11-04. PMID:15306252. |
in the result on infarcted lesion volumes following temporary focal ischemia, potent tolerance developed in the wild type (35% reduction) (p=0.007) but not in the heterozygous bdnf-deficient mice (<19% reduction) (p=0.155), indicating that bdnf expression level following spreading depression is contributing to infarct tolerance development. |
2004-11-04 |
2023-08-12 |
mouse |
| Shih-Jen Tsa. Down-regulation of the Trk-B signal pathway: the possible pathogenesis of major depression. Medical hypotheses. vol 62. issue 2. 2004-09-28. PMID:14962629. |
instead of a decrease in central bdnf, however, studies utilizing genetic depression animal models have found elevated levels of the factor. |
2004-09-28 |
2023-08-12 |
Not clear |
| Shih-Jen Tsa. Down-regulation of the Trk-B signal pathway: the possible pathogenesis of major depression. Medical hypotheses. vol 62. issue 2. 2004-09-28. PMID:14962629. |
in this report, it is suggested that trk-b pathway down-regulation may be the major pathogenesis for mdd, while stress, which may reduce central bdnf, acts as a precipitation factor to further dampen central bdnf activity and contribute to the development of depression. |
2004-09-28 |
2023-08-12 |
Not clear |
| A Ferrero, M Cereset. [Glutamatergic neurotransmission, depression and antidepressants]. Vertex (Buenos Aires, Argentina). vol 15. issue 56. 2004-09-28. PMID:15243652. |
the second one postulates that depression is closely correlated with neuronal atrophy due to a decrease in bdnf. |
2004-09-28 |
2023-08-12 |
Not clear |
| Shih-Jen Tsa. Is mania caused by overactivity of central brain-derived neurotrophic factor? Medical hypotheses. vol 62. issue 1. 2004-09-21. PMID:14728999. |
recent studies had demonstrated that bdnf may play a role in the antidepressant mechanism and the pathogenesis of major depression. |
2004-09-21 |
2023-08-12 |
Not clear |
| Bin Jiang, Akihiko Kitamura, Hiroki Yasuda, Kazuhiro Sohya, Atsushi Maruyama, Yuchio Yanagawa, Kunihiko Obata, Tadaharu Tsumot. Brain-derived neurotrophic factor acutely depresses excitatory synaptic transmission to GABAergic neurons in visual cortical slices. The European journal of neuroscience. vol 20. issue 3. 2004-09-21. PMID:15255981. |
paired-pulse ratios of the amplitude of epscs to paired stimulation at intervals of 10-100 ms were not significantly changed after bdnf application, suggesting that the site of depression may be postsynaptic. |
2004-09-21 |
2023-08-12 |
mouse |
| Bin Jiang, Akihiko Kitamura, Hiroki Yasuda, Kazuhiro Sohya, Atsushi Maruyama, Yuchio Yanagawa, Kunihiko Obata, Tadaharu Tsumot. Brain-derived neurotrophic factor acutely depresses excitatory synaptic transmission to GABAergic neurons in visual cortical slices. The European journal of neuroscience. vol 20. issue 3. 2004-09-21. PMID:15255981. |
the depressive action of bdnf was blocked by an intracellular injection of a ca(2+) chelator, suggesting that a rise in ca(2+) is involved in the acute depression of epscs. |
2004-09-21 |
2023-08-12 |
mouse |
| Kenji Hashimoto, Eiji Shimizu, Masaomi Iy. Critical role of brain-derived neurotrophic factor in mood disorders. Brain research. Brain research reviews. vol 45. issue 2. 2004-08-18. PMID:15145621. |
pre-clinical studies suggest that the expression of bdnf might be a downstream target of antidepressant treatments and mood stabilizers such as lithium and valproate, and that bdnf exerts antidepressant activity in animal models of depression. |
2004-08-18 |
2023-08-12 |
Not clear |
| Eiji Shimizu, Kenji Hashimoto, Masaomi Iy. [Major depressive disorders and BDNF (brain-derived neurotrophic factor)]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 24. issue 3. 2004-08-16. PMID:15291244. |
experimental studies suggest that bdnf expression is induced by chronic antidepressant treatments, and that bdnf itself have antidepressant activity in animal models of depression. |
2004-08-16 |
2023-08-12 |
Not clear |
| Eiji Shimizu, Kenji Hashimoto, Masaomi Iy. [Major depressive disorders and BDNF (brain-derived neurotrophic factor)]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 24. issue 3. 2004-08-16. PMID:15291244. |
our clinical study showed that serum levels of bdnf in drug naive patients with depression were significantly decreased as compared with normal controls. |
2004-08-16 |
2023-08-12 |
Not clear |
| Eiji Shimizu, Kenji Hashimoto, Masaomi Iy. [Major depressive disorders and BDNF (brain-derived neurotrophic factor)]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 24. issue 3. 2004-08-16. PMID:15291244. |
these findings suggest that low bdnf levels may play a pivotal role in the pathophysiology of major depression. |
2004-08-16 |
2023-08-12 |
Not clear |
| Eiji Shimizu, Kenji Hashimoto, Masaomi Iy. [Major depressive disorders and BDNF (brain-derived neurotrophic factor)]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 24. issue 3. 2004-08-16. PMID:15291244. |
it is unclear whether low bdnf levels are primary or secondary in patients with depression. |
2004-08-16 |
2023-08-12 |
Not clear |
| Eiji Shimizu, Kenji Hashimoto, Masaomi Iy. [Major depressive disorders and BDNF (brain-derived neurotrophic factor)]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 24. issue 3. 2004-08-16. PMID:15291244. |
one hypothesis would be that reduced bdnf might reflect a genetic vulnerability in patients with depression. |
2004-08-16 |
2023-08-12 |
Not clear |
| Eiji Shimizu, Kenji Hashimoto, Masaomi Iy. [Major depressive disorders and BDNF (brain-derived neurotrophic factor)]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 24. issue 3. 2004-08-16. PMID:15291244. |
in order to determine the precise mechanism underlying the relationship between reduced bdnf levels and the etiology of major depression under both genetic and environmental backgrounds, further detailed study will be necessary. |
2004-08-16 |
2023-08-12 |
Not clear |
| Mario Altieri, Francesca Marini, Roberto Arban, Giovanni Vitulli, Birger O Jansso. Expression analysis of brain-derived neurotrophic factor (BDNF) mRNA isoforms after chronic and acute antidepressant treatment. Brain research. vol 1000. issue 1-2. 2004-06-22. PMID:15053962. |
according to a proposed hypothetical model bdnf expression might play a central role in the pathogenesis of depression. |
2004-06-22 |
2023-08-12 |
rat |
| Ronald S Duma. Role of neurotrophic factors in the etiology and treatment of mood disorders. Neuromolecular medicine. vol 5. issue 1. 2004-06-07. PMID:15001809. |
basic research in rodents has demonstrated that exposure to stress decreases levels of brain-derived neurotrophic factor (bdnf) in brain regions associated with depression. |
2004-06-07 |
2023-08-12 |
Not clear |
| Sabine Chourbaji, Rainer Hellweg, Dorothee Brandis, Björn Zörner, Christiane Zacher, Undine E Lang, Fritz A Henn, Heide Hörtnagl, Peter Gas. Mice with reduced brain-derived neurotrophic factor expression show decreased choline acetyltransferase activity, but regular brain monoamine levels and unaltered emotional behavior. Brain research. Molecular brain research. vol 121. issue 1-2. 2004-04-19. PMID:14969734. |
the "neurotrophin hypothesis" of depression predicts that depressive disorders in humans coincide with a decreased activity and/or expression of brain-derived neurotrophic factor (bdnf) in the brain. |
2004-04-19 |
2023-08-12 |
mouse |