| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E Grünblatt, E Hupp, M Bambula, S Zehetmayer, S Jungwirth, K H Tragl, P Fischer, P Riedere. Association study of BDNF and CNTF polymorphism to depression in non-demented subjects of the "VITA" study. Journal of affective disorders. vol 96. issue 1-2. 2007-02-12. PMID:16797081. |
association study of bdnf and cntf polymorphism to depression in non-demented subjects of the "vita" study. |
2007-02-12 |
2023-08-12 |
human |
| Rainer Hellweg, Maha Zueger, Katharina Fink, Heide Hörtnagl, Peter Gas. Olfactory bulbectomy in mice leads to increased BDNF levels and decreased serotonin turnover in depression-related brain areas. Neurobiology of disease. vol 25. issue 1. 2007-01-23. PMID:16990008. |
with respect to the common bdnf hypothesis of depression--predicting decreased bdnf expression in depression-related brain areas--the novel and challenging conclusions concern the increased bdnf protein levels in target regions of the cholinergic basal forebrain system in bulbectomized mice. |
2007-01-23 |
2023-08-12 |
mouse |
| Jen-Ping Hwang, Shih-Jen Tsai, Chen-Jee Hong, Chen-Hong Yang, Jiing-Feng Lirng, Ya-Min Yan. The Val66Met polymorphism of the brain-derived neurotrophic-factor gene is associated with geriatric depression. Neurobiology of aging. vol 27. issue 12. 2007-01-03. PMID:16343697. |
brain-derived neurotrophic-factor (bdnf), the most abundant of the neurotrophins in the brain, has been implicated in both major depression and cognitive function. |
2007-01-03 |
2023-08-12 |
human |
| Jen-Ping Hwang, Shih-Jen Tsai, Chen-Jee Hong, Chen-Hong Yang, Jiing-Feng Lirng, Ya-Min Yan. The Val66Met polymorphism of the brain-derived neurotrophic-factor gene is associated with geriatric depression. Neurobiology of aging. vol 27. issue 12. 2007-01-03. PMID:16343697. |
the bdnf polymorphism did not affect age-of-onset, depression severity, cognitive function or suicidal attempt history. |
2007-01-03 |
2023-08-12 |
human |
| Jen-Ping Hwang, Shih-Jen Tsai, Chen-Jee Hong, Chen-Hong Yang, Jiing-Feng Lirng, Ya-Min Yan. The Val66Met polymorphism of the brain-derived neurotrophic-factor gene is associated with geriatric depression. Neurobiology of aging. vol 27. issue 12. 2007-01-03. PMID:16343697. |
the results suggest that the bdnf val66met polymorphism is a relevant risk factor for geriatric depression. |
2007-01-03 |
2023-08-12 |
human |
| Makoto Takahashi, Akiyoshi Kakita, Takashi Futamura, Yuichiro Watanabe, Makoto Mizuno, Kenji Sakimura, Eero Castren, Toshitaka Nabeshima, Toshiyuki Someya, Hiroyuki Naw. Sustained brain-derived neurotrophic factor up-regulation and sensorimotor gating abnormality induced by postnatal exposure to phencyclidine: comparison with adult treatment. Journal of neurochemistry. vol 99. issue 3. 2006-12-20. PMID:16903871. |
brain-derived neurotrophic factor (bdnf) is involved in synaptic development and plasticity, and alterations in bdnf expression or signaling are implicated in drug addiction and psychiatric diseases, such as depression and schizophrenia. |
2006-12-20 |
2023-08-12 |
rat |
| Jacob P R Jacobsen, Arne Mør. Chronic corticosterone decreases brain-derived neurotrophic factor (BDNF) mRNA and protein in the hippocampus, but not in the frontal cortex, of the rat. Brain research. vol 1110. issue 1. 2006-12-06. PMID:16876769. |
however, our findings do suggest that chronic corticosterone impairs hippocampal bdnf function, a finding with potential relevance for the hippocampal atrophy reported in major depression. |
2006-12-06 |
2023-08-12 |
rat |
| A A Khundakar, T S C Zetterströ. Biphasic change in BDNF gene expression following antidepressant drug treatment explained by differential transcript regulation. Brain research. vol 1106. issue 1. 2006-11-01. PMID:16842762. |
brain-derived neurotrophic factor (bdnf) has been suggested as a possible target for the treatment of depression. |
2006-11-01 |
2023-08-12 |
rat |
| Cigdem Aydemir, Esra Süer Yalcin, Sabahat Aksaray, Cebrail Kisa, Sema Gulen Yildirim, Tayfun Uzbay, Erol Gok. Brain-derived neurotrophic factor (BDNF) changes in the serum of depressed women. Progress in neuro-psychopharmacology & biological psychiatry. vol 30. issue 7. 2006-10-31. PMID:16647794. |
these findings suggest that bdnf level may be an important factor in the etiopathogenesis of depression and may have a role in the action mechanism of antidepressant drugs. |
2006-10-31 |
2023-08-12 |
human |
| Sjoukje D Kuipers, Clive R Bramha. Brain-derived neurotrophic factor mechanisms and function in adult synaptic plasticity: new insights and implications for therapy. Current opinion in drug discovery & development. vol 9. issue 5. 2006-10-19. PMID:17002218. |
brain-derived neurotrophic factor (bdnf) has emerged as a major regulator of synaptic plasticity and a key target in disorders such as major depression and alzheimner's disease. |
2006-10-19 |
2023-08-12 |
Not clear |
| A Nair, V A Vaidy. Cyclic AMP response element binding protein and brain-derived neurotrophic factor: molecules that modulate our mood? Journal of biosciences. vol 31. issue 3. 2006-10-19. PMID:17006024. |
the transcription factor cyclic amp response element binding protein (creb) and the neurotrophin brain-derived neurotrophic factor (bdnf) are targets of diverse classes of antidepressants and are known to be regulated in animal models and in patients suffering from depression. |
2006-10-19 |
2023-08-12 |
Not clear |
| A Nair, V A Vaidy. Cyclic AMP response element binding protein and brain-derived neurotrophic factor: molecules that modulate our mood? Journal of biosciences. vol 31. issue 3. 2006-10-19. PMID:17006024. |
the purpose of this review is to discuss the role of creb and bdnf in depression and as targets/mediators of antidepressant action. |
2006-10-19 |
2023-08-12 |
Not clear |
| Cornelius Schüle, Peter Zill, Thomas C Baghai, Daniela Eser, Peter Zwanzger, Nadine Wenig, Rainer Rupprecht, Brigitta Bond. Brain-derived neurotrophic factor Val66Met polymorphism and dexamethasone/CRH test results in depressed patients. Psychoneuroendocrinology. vol 31. issue 8. 2006-10-12. PMID:16890377. |
our results further contribute to the hypothesized association between hpa axis dysregulation and reduced neuroplasticity in depression and are consistent with the assumption that bdnf is a stress-responsive intercellular messenger modifying hpa axis activity. |
2006-10-12 |
2023-08-12 |
Not clear |
| Roberta Zanardini, Anna Gazzoli, Mariacarla Ventriglia, Jorge Perez, Stefano Bignotti, Paolo Maria Rossini, Massimo Gennarelli, Luisella Bocchio-Chiavett. Effect of repetitive transcranial magnetic stimulation on serum brain derived neurotrophic factor in drug resistant depressed patients. Journal of affective disorders. vol 91. issue 1. 2006-10-04. PMID:16448701. |
depression has been associated with low brain-derived neurotrophic factor (bdnf) serum levels, while antidepressant drugs appear to mend this alteration. |
2006-10-04 |
2023-08-12 |
Not clear |
| Hiroko Yano, Ipe Ninan, Hong Zhang, Teresa A Milner, Ottavio Arancio, Moses V Cha. BDNF-mediated neurotransmission relies upon a myosin VI motor complex. Nature neuroscience. vol 9. issue 8. 2006-09-27. PMID:16819522. |
brain-derived neurotrophic factor (bdnf) has been implicated in higher-order cognitive functions and in psychiatric disorders such as depression and schizophrenia. |
2006-09-27 |
2023-08-12 |
mouse |
| Eric J Nestler, William A Carlezo. The mesolimbic dopamine reward circuit in depression. Biological psychiatry. vol 59. issue 12. 2006-09-07. PMID:16566899. |
creb, dynorphin, bdnf, mch, or clock) within the vta-nac circuit of rodents produce unique behavioral phenotypes, some of which are directly relevant to depression. |
2006-09-07 |
2023-08-12 |
Not clear |
| Ronald S Duman, Lisa M Monteggi. A neurotrophic model for stress-related mood disorders. Biological psychiatry. vol 59. issue 12. 2006-09-07. PMID:16631126. |
although there are some limitations, the results of these studies are consistent with the hypothesis that decreased expression of bdnf and possibly other growth factors contributes to depression and that upregulation of bdnf plays a role in the actions of antidepressant treatment. |
2006-09-07 |
2023-08-12 |
human |
| Douglas F Levinso. The genetics of depression: a review. Biological psychiatry. vol 60. issue 2. 2006-08-28. PMID:16300747. |
newer hypotheses of depression neurobiology suggest closer study of genes related to neurotoxic and neuroprotective (neurotrophic) processes and to overactivation of the hypothalamic-pituitary axis, with mixed evidence regarding association of mdd with polymorphisms in one such gene (brain-derived neurotrophic factor [bdnf]). |
2006-08-28 |
2023-08-12 |
Not clear |
| Kenji Hashimot. [Depression and BDNF]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 127. issue 3. 2006-08-18. PMID:16651803. |
[depression and bdnf]. |
2006-08-18 |
2023-08-12 |
Not clear |
| Haiyun Xu, Zhong Chen, Jue He, Samson Haimanot, Xiaokun Li, Lillian Dyck, Xin-Min L. Synergetic effects of quetiapine and venlafaxine in preventing the chronic restraint stress-induced decrease in cell proliferation and BDNF expression in rat hippocampus. Hippocampus. vol 16. issue 6. 2006-07-27. PMID:16652337. |
animal studies demonstrate that some antipsychotics and antidepressants increase neurogenesis and bdnf expression in the hippocampus, which is reduced in volume in patients with depression or schizophrenia. |
2006-07-27 |
2023-08-12 |
rat |