| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Haiyun Xu, Zhong Chen, Jue He, Samson Haimanot, Xiaokun Li, Lillian Dyck, Xin-Min L. Synergetic effects of quetiapine and venlafaxine in preventing the chronic restraint stress-induced decrease in cell proliferation and BDNF expression in rat hippocampus. Hippocampus. vol 16. issue 6. 2006-07-27. PMID:16652337. |
we hypothesized that the better therapeutic effects of combined treatment seen in schizophrenia and depression patients are related to the additive or synergistic effects of combined treatment on hippocampal neurogenesis and bdnf expression. |
2006-07-27 |
2023-08-12 |
rat |
| b' Astrid Bj\\xc3\\xb8rnebekk, Aleksander A Math\\xc3\\xa9, Stefan Bren\\xc3\\xa. The antidepressant effect of running is associated with increased hippocampal cell proliferation. The international journal of neuropsychopharmacology. vol 8. issue 3. 2006-07-19. PMID:15769301.' |
in order to identify possible biological underpinnings of depression and the antidepressant effect of running, we analysed cell proliferation, the level of the neurotrophic factor bdnf in hippocampus and dynorphin in striatum/accumbens in 'depressed' flinders sensitive line rats (fsl) and flinders resistant line (frl) rats with and without access to running-wheels. |
2006-07-19 |
2023-08-12 |
rat |
| Igor Branchi, Ivana D'Andrea, Jantine Sietzema, Marco Fiore, Veronica Di Fausto, Luigi Aloe, Enrico Allev. Early social enrichment augments adult hippocampal BDNF levels and survival of BrdU-positive cells while increasing anxiety- and "depression"-like behavior. Journal of neuroscience research. vol 83. issue 6. 2006-07-13. PMID:16477619. |
early social enrichment augments adult hippocampal bdnf levels and survival of brdu-positive cells while increasing anxiety- and "depression"-like behavior. |
2006-07-13 |
2023-08-12 |
mouse |
| Igor Branchi, Ivana D'Andrea, Jantine Sietzema, Marco Fiore, Veronica Di Fausto, Luigi Aloe, Enrico Allev. Early social enrichment augments adult hippocampal BDNF levels and survival of BrdU-positive cells while increasing anxiety- and "depression"-like behavior. Journal of neuroscience research. vol 83. issue 6. 2006-07-13. PMID:16477619. |
overall, these findings show that cn, an highly stimulating early social environment, increases adult neuronal plasticity, as suggested by high bdnf levels and augmented number of newly generated cells in the hippocampus, which is associated to an increased anxiety- and "depression"-like behavior. |
2006-07-13 |
2023-08-12 |
mouse |
| Allan V Kalueff, Damira F Avgustinovich, Natalia N Kudryavtseva, Dennis L Murph. BDNF in anxiety and depression. Science (New York, N.Y.). vol 312. issue 5780. 2006-07-03. PMID:16778038. |
bdnf in anxiety and depression. |
2006-07-03 |
2023-08-12 |
Not clear |
| Oliver von Bohlen und Halbach, Sonja Krause, Diego Medina, Carla Sciarretta, Liliana Minichiello, Klaus Unsicke. Regional- and age-dependent reduction in trkB receptor expression in the hippocampus is associated with altered spine morphologies. Biological psychiatry. vol 59. issue 9. 2006-06-28. PMID:16325153. |
decreased brain-derived neurotrophic factor (bdnf) levels seem to contribute to depression. |
2006-06-28 |
2023-08-12 |
mouse |
| Marek Lommatzsch, Katharina Hornych, Christiana Zingler, Peter Schuff-Werner, Jacqueline Höppner, J Christian Vircho. Maternal serum concentrations of BDNF and depression in the perinatal period. Psychoneuroendocrinology. vol 31. issue 3. 2006-06-08. PMID:16289360. |
maternal serum concentrations of bdnf and depression in the perinatal period. |
2006-06-08 |
2023-08-12 |
human |
| Marek Lommatzsch, Katharina Hornych, Christiana Zingler, Peter Schuff-Werner, Jacqueline Höppner, J Christian Vircho. Maternal serum concentrations of BDNF and depression in the perinatal period. Psychoneuroendocrinology. vol 31. issue 3. 2006-06-08. PMID:16289360. |
there is accumulating evidence that a deficiency in brain-derived neurotrophic factor (bdnf) plays a critical role in the pathophysiology of depression. |
2006-06-08 |
2023-08-12 |
human |
| Marek Lommatzsch, Katharina Hornych, Christiana Zingler, Peter Schuff-Werner, Jacqueline Höppner, J Christian Vircho. Maternal serum concentrations of BDNF and depression in the perinatal period. Psychoneuroendocrinology. vol 31. issue 3. 2006-06-08. PMID:16289360. |
this is in line with the postulate that low bdnf levels in serum are associated with depression. |
2006-06-08 |
2023-08-12 |
human |
| Marek Lommatzsch, Katharina Hornych, Christiana Zingler, Peter Schuff-Werner, Jacqueline Höppner, J Christian Vircho. Maternal serum concentrations of BDNF and depression in the perinatal period. Psychoneuroendocrinology. vol 31. issue 3. 2006-06-08. PMID:16289360. |
however, the regulation of maternal bdnf serum levels in the perinatal period, and its relationship to maternal depression is unknown. |
2006-06-08 |
2023-08-12 |
human |
| Marek Lommatzsch, Katharina Hornych, Christiana Zingler, Peter Schuff-Werner, Jacqueline Höppner, J Christian Vircho. Maternal serum concentrations of BDNF and depression in the perinatal period. Psychoneuroendocrinology. vol 31. issue 3. 2006-06-08. PMID:16289360. |
there was a trend to a decrease of bdnf and 5-ht levels in cases of maternal depression (as compared to cases without depression), but this was not significant. |
2006-06-08 |
2023-08-12 |
human |
| Marek Lommatzsch, Katharina Hornych, Christiana Zingler, Peter Schuff-Werner, Jacqueline Höppner, J Christian Vircho. Maternal serum concentrations of BDNF and depression in the perinatal period. Psychoneuroendocrinology. vol 31. issue 3. 2006-06-08. PMID:16289360. |
however, the individual serum concentration of bdnf alone did not predict maternal depression in our study. |
2006-06-08 |
2023-08-12 |
human |
| Nadia M Tsankova, Olivier Berton, William Renthal, Arvind Kumar, Rachel L Neve, Eric J Nestle. Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action. Nature neuroscience. vol 9. issue 4. 2006-06-08. PMID:16501568. |
to better understand the molecular mechanisms of depression and antidepressant action, we administered chronic social defeat stress followed by chronic imipramine (a tricyclic antidepressant) to mice and studied adaptations at the levels of gene expression and chromatin remodeling of five brain-derived neurotrophic factor (bdnf) splice variant mrnas (i-v) and their unique promoters in the hippocampus. |
2006-06-08 |
2023-08-12 |
mouse |
| Hiroshi Takeda, Minoru Tsuji, Tomoko Yamada, Jiro Masuya, Kaneaki Matsushita, Masashi Tahara, Makio Iimori, Teruhiko Matsumiy. Caffeic acid attenuates the decrease in cortical BDNF mRNA expression induced by exposure to forced swimming stress in mice. European journal of pharmacology. vol 534. issue 1-3. 2006-06-07. PMID:16497295. |
increased evidence suggests that brain-derived neurotrophic factor (bdnf), a member of the neurotrophin family that has high affinity for the tyrosine kinase receptor b (trkb), plays an important role in the pathophysiology and treatment of depression. |
2006-06-07 |
2023-08-12 |
mouse |
| Alain Gardie. [Mechanism of action of antidepressant drugs: importance of genetically modified mice in the pharmacological in vivo approach]. Therapie. vol 60. issue 5. 2006-03-28. PMID:16433012. |
these recent findings suggest that instead of being rejected, the monoaminergic hypothesis of depression should be improved, corrected and completed by studying the role of other neurotransmitter, neuromodulatory compounds (substance p, bdnf [brain-derived neurotrophic factor]). |
2006-03-28 |
2023-08-12 |
mouse |
| Pietro Baldelli, Jesus-Miguel Hernandez-Guijo, Valentina Carabelli, Emilio Carbon. Brain-derived neurotrophic factor enhances GABA release probability and nonuniform distribution of N- and P/Q-type channels on release sites of hippocampal inhibitory synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 13. 2006-03-23. PMID:15800191. |
nevertheless, bdnf preserved the fast recovery from depression associated with n-type channels. |
2006-03-23 |
2023-08-12 |
Not clear |
| Tamara B Franklin, Tara S Perrot-Sina. Sex and ovarian steroids modulate brain-derived neurotrophic factor (BDNF) protein levels in rat hippocampus under stressful and non-stressful conditions. Psychoneuroendocrinology. vol 31. issue 1. 2006-02-27. PMID:15996825. |
stress affects bdnf levels in various brain regions and thus, a heightened stress response in females could contribute to the development of depression. |
2006-02-27 |
2023-08-12 |
rat |
| Stephanie Ridder, Sabine Chourbaji, Rainer Hellweg, Alexandre Urani, Christiane Zacher, Wolfgang Schmid, Mathias Zink, Heide Hörtnagl, Herta Flor, Fritz A Henn, Günther Schütz, Peter Gas. Mice with genetically altered glucocorticoid receptor expression show altered sensitivity for stress-induced depressive reactions. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 26. 2006-02-14. PMID:15987954. |
as a first potential molecular correlate for such changes, we identified a downregulation of bdnf protein content in the hippocampus of gr+/- mice, which is in agreement with the so-called neurotrophin hypothesis of depression. |
2006-02-14 |
2023-08-12 |
mouse |
| Undine E Lang, Rainer Hellweg, Peter Kalus, Malek Bajbouj, Kirsten P Lenzen, Thomas Sander, Dieter Kunz, Jürgen Gallina. Association of a functional BDNF polymorphism and anxiety-related personality traits. Psychopharmacology. vol 180. issue 1. 2006-02-13. PMID:15918078. |
converging lines of evidence point to brain-derived neurotrophic factor (bdnf) as a factor in the pathophysiology of depression. |
2006-02-13 |
2023-08-12 |
human |
| Jakub F Filuś, Janusz Rybakowsk. [Neurotrophic factors and their role in the pathogenesis of affective disorders]. Psychiatria polska. vol 39. issue 5. 2006-01-12. PMID:16358589. |
preclinical and clinical studies of altered bdnf expression during chronic stress and increased bdnf activity during antidepressant treatment, confirm the role of bdnf in the pathogenesis of depression. |
2006-01-12 |
2023-08-12 |
Not clear |