| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shih-Jen Tsai, Chen-Jee Hong, Hsiu-Chih Liu, Tsung-Yun Liu, Li-En Hsu, Ching-Hua Li. Association analysis of brain-derived neurotrophic factor Val66Met polymorphisms with Alzheimer's disease and age of onset. Neuropsychobiology. vol 49. issue 1. 2004-03-08. PMID:14730194. |
further studies with genetic variations in bdnf relating either to ad-associated depression or to the ad treatment response are suggested. |
2004-03-08 |
2023-08-12 |
Not clear |
| Francesco Angelucci, Aleksander A Mathé, Luigi Alo. Neurotrophic factors and CNS disorders: findings in rodent models of depression and schizophrenia. Progress in brain research. vol 146. 2004-02-11. PMID:14699963. |
in a model of depression (flinders sensitive line/flinders resistant line; fsl/frl rats), increased ngf and bdnf concentrations were found in frontal cortex of female, and in occipital cortex of male 'depressed' fsl compared to frl control rats. |
2004-02-11 |
2023-08-12 |
rat |
| Chen-Jee Hong, Sheue-Jane Huo, Feng-Chang Yen, Chun-Liang Tung, Guo-Mei Pan, Shih-Jen Tsa. Association study of a brain-derived neurotrophic-factor genetic polymorphism and mood disorders, age of onset and suicidal behavior. Neuropsychobiology. vol 48. issue 4. 2004-02-09. PMID:14673216. |
the genotype and allele frequencies for the bdnf gene val66met polymorphism did not differ comparing depression groups (total, bipolar disorder or major depression) and control subjects. |
2004-02-09 |
2023-08-12 |
human |
| Björn Zörner, David P Wolfer, Dorothee Brandis, Oliver Kretz, Christiane Zacher, Rime Madani, Ilona Grunwald, Hans-Peter Lipp, Rüdiger Klein, Fritz A Henn, Peter Gas. Forebrain-specific trkB-receptor knockout mice: behaviorally more hyperactive than "depressive". Biological psychiatry. vol 54. issue 10. 2003-12-29. PMID:14625139. |
we investigated the hypothesis that mice with a forebrain-specific knockout of the trkb receptor, the main mediator of bdnf signaling, represent a genetic animal model for depression. |
2003-12-29 |
2023-08-12 |
mouse |
| Amelia Russo-Neustad. Brain-derived neurotrophic factor, behavior, and new directions for the treatment of mental disorders. Seminars in clinical neuropsychiatry. vol 8. issue 2. 2003-07-01. PMID:12728410. |
finally, our review focuses on the involvement of bdnf in treatments for clinical depression and other chronic neurodegenerative processes. |
2003-07-01 |
2023-08-12 |
Not clear |
| Srijan Sen, Randolph M Nesse, Scott F Stoltenberg, Sheng Li, Lillian Gleiberman, Aravinda Chakravarti, Alan B Weder, Margit Burmeiste. A BDNF coding variant is associated with the NEO personality inventory domain neuroticism, a risk factor for depression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 2. 2003-04-21. PMID:12589394. |
a bdnf coding variant is associated with the neo personality inventory domain neuroticism, a risk factor for depression. |
2003-04-21 |
2023-08-12 |
Not clear |
| Marzena Mackowiak, Michael J O'Neill, Caroline A Hicks, David Bleakman, Phil Skolnic. An AMPA receptor potentiator modulates hippocampal expression of BDNF: an in vivo study. Neuropharmacology. vol 43. issue 1. 2002-11-21. PMID:12213254. |
the regulation of bdnf expression by biarylpropylsulfonamids such as ly451646 may have important therapeutical implications for this class of molecule in the treatment of depression and other cns disorders. |
2002-11-21 |
2023-08-12 |
rat |
| Félicien Karege, Guillaume Perret, Guido Bondolfi, Michèle Schwald, Gilles Bertschy, Jean-Michel Aubr. Decreased serum brain-derived neurotrophic factor levels in major depressed patients. Psychiatry research. vol 109. issue 2. 2002-06-19. PMID:11927139. |
recent findings with animal models have suggested a possible role for brain-derived neurotrophic factor (bdnf) in depression. |
2002-06-19 |
2023-08-12 |
Not clear |
| Félicien Karege, Guillaume Perret, Guido Bondolfi, Michèle Schwald, Gilles Bertschy, Jean-Michel Aubr. Decreased serum brain-derived neurotrophic factor levels in major depressed patients. Psychiatry research. vol 109. issue 2. 2002-06-19. PMID:11927139. |
we have therefore hypothesized that depression could be characterized by low levels of serum bdnf. |
2002-06-19 |
2023-08-12 |
Not clear |
| Félicien Karege, Guillaume Perret, Guido Bondolfi, Michèle Schwald, Gilles Bertschy, Jean-Michel Aubr. Decreased serum brain-derived neurotrophic factor levels in major depressed patients. Psychiatry research. vol 109. issue 2. 2002-06-19. PMID:11927139. |
serum bdnf was assayed with the elisa method and the severity of depression was evaluated with montgomery-asberg-depression rating scale (madrs). |
2002-06-19 |
2023-08-12 |
Not clear |
| Félicien Karege, Guillaume Perret, Guido Bondolfi, Michèle Schwald, Gilles Bertschy, Jean-Michel Aubr. Decreased serum brain-derived neurotrophic factor levels in major depressed patients. Psychiatry research. vol 109. issue 2. 2002-06-19. PMID:11927139. |
analysis of covariance (madrs and gender as independent variable vs. bdnf as dependent variable) indicated that depression severity mainly accounted for the negative correlation. |
2002-06-19 |
2023-08-12 |
Not clear |
| Félicien Karege, Guillaume Perret, Guido Bondolfi, Michèle Schwald, Gilles Bertschy, Jean-Michel Aubr. Decreased serum brain-derived neurotrophic factor levels in major depressed patients. Psychiatry research. vol 109. issue 2. 2002-06-19. PMID:11927139. |
these results suggest that major depression is characterized by low serum bdnf levels and support the hypothesis of neurotrophic factor involvement in affective disorders. |
2002-06-19 |
2023-08-12 |
Not clear |
| V L Arvanian, L M Mendel. Acute modulation of synaptic transmission to motoneurons by BDNF in the neonatal rat spinal cord. The European journal of neuroscience. vol 14. issue 11. 2002-04-05. PMID:11860475. |
all motoneurons exhibited long-lasting (up to several hours) depression of the dr-activated monosynaptic ampa/kainate-receptor mediated epsp in response to bdnf but in about half of the motoneurons this was preceded by facilitation. |
2002-04-05 |
2023-08-12 |
rat |
| A Russo-Neustadt, T Ha, R Ramirez, J P Kessla. Physical activity-antidepressant treatment combination: impact on brain-derived neurotrophic factor and behavior in an animal model. Behavioural brain research. vol 120. issue 1. 2001-05-31. PMID:11173088. |
the induction of bdnf expression by activity/pharmacological treatment combinations could represent an important intervention for further study, to potentially improve depression treatment and management. |
2001-05-31 |
2023-08-12 |
rat |
| A D Medhurst, D C Harrison, S J Read, C A Campbell, M J Robbins, M N Pangalo. The use of TaqMan RT-PCR assays for semiquantitative analysis of gene expression in CNS tissues and disease models. Journal of neuroscience methods. vol 98. issue 1. 2000-08-15. PMID:10837866. |
brain-derived neurotrophic factor (bdnf) mrna was transiently upregulated 3.7-fold at 3 h, but not at 24 h or 3 days after induction of cortical spreading depression (csd) in rats. |
2000-08-15 |
2023-08-12 |
human |
| b' F Angelucci, L Aloe, P J Vasquez, A A Math\\xc3\\xa. Mapping the differences in the brain concentration of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in an animal model of depression. Neuroreport. vol 11. issue 6. 2000-07-17. PMID:10817624.' |
mapping the differences in the brain concentration of brain-derived neurotrophic factor (bdnf) and nerve growth factor (ngf) in an animal model of depression. |
2000-07-17 |
2023-08-12 |
human |
| b' F Angelucci, L Aloe, P J Vasquez, A A Math\\xc3\\xa. Mapping the differences in the brain concentration of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in an animal model of depression. Neuroreport. vol 11. issue 6. 2000-07-17. PMID:10817624.' |
cumulatively these observations suggest that bdnf and ngf may play a role in depression and, hypothetically, different brain regional concentrations of bdnf and ngf in male and female animals may be relevant to gender differences in vulnerability to depression. |
2000-07-17 |
2023-08-12 |
human |
| E Kumura, F Kimura, N Taniguchi, T Tsumot. Brain-derived neurotrophic factor blocks long-term depression in solitary neurones cultured from rat visual cortex. The Journal of physiology. vol 524 Pt 1. 2000-06-02. PMID:10747192. |
application of bdnf at 50 ng ml-1 blocked the depression of evoked epscs and the decrease in the frequency of spontaneous epscs. |
2000-06-02 |
2023-08-12 |
rat |
| F Asztely, M Kokaia, K Olofsdotter, U Ortegren, O Lindval. Afferent-specific modulation of short-term synaptic plasticity by neurotrophins in dentate gyrus. The European journal of neuroscience. vol 12. issue 2. 2000-05-25. PMID:10712646. |
using field recordings and whole-cell patch-clamp recordings in hippocampal slices, we found that paired-pulse (pp) depression at mpp-granule cell synapses was impaired in bdnf knock-out (+/-) mice, but pp facilitation at lpp synapses to the same cells was not impaired. |
2000-05-25 |
2023-08-12 |
mouse |
| F Asztely, M Kokaia, K Olofsdotter, U Ortegren, O Lindval. Afferent-specific modulation of short-term synaptic plasticity by neurotrophins in dentate gyrus. The European journal of neuroscience. vol 12. issue 2. 2000-05-25. PMID:10712646. |
in accordance, scavenging of endogenous bdnf with trkb-igg fusion protein also impaired pp depression at mpp-granule cell synapses, but not pp facilitation at lpp-granule cell synapses. |
2000-05-25 |
2023-08-12 |
mouse |