| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Kozicz, D Tilburg-Ouwens, G Faludi, M Palkovits, E Roubo. Gender-related urocortin 1 and brain-derived neurotrophic factor expression in the adult human midbrain of suicide victims with major depression. Neuroscience. vol 152. issue 4. 2008-08-07. PMID:18329817. |
we discuss the significance of these data for npew ucn1 and bdnf, and propose that altered expressions of ucn1 and bdnf in the npew contribute to the pathogenesis of major depression and/or suicidality in a gender-specific manner. |
2008-08-07 |
2023-08-12 |
mouse |
| Eero Castrén, Tomi Rantamäk. Neurotrophins in depression and antidepressant effects. Novartis Foundation symposium. vol 289. 2008-08-07. PMID:18497094. |
a polymorphism in the bdnf gene has been associated with depression and bipolar disorder. |
2008-08-07 |
2023-08-12 |
Not clear |
| Eero Castrén, Tomi Rantamäk. Neurotrophins in depression and antidepressant effects. Novartis Foundation symposium. vol 289. 2008-08-07. PMID:18497094. |
antidepressant treatments may, through enhanced bdnf signalling, improve the ability of critical brain circuits to respond optimally to environmental demands, a process that may be critical in the recovery from depression. |
2008-08-07 |
2023-08-12 |
Not clear |
| Viktorija Trajkovska, Maj Vinberg, Susana Aznar, Gitte M Knudsen, Lars V Kessin. Whole blood BDNF levels in healthy twins discordant for affective disorder: association to life events and neuroticism. Journal of affective disorders. vol 108. issue 1-2. 2008-06-05. PMID:17920693. |
depression has been associated with decreased blood bdnf concentrations; but it is unclear if low blood bdnf levels are a state or a trait marker of depression. |
2008-06-05 |
2023-08-12 |
Not clear |
| R Hellweg, A Ziegenhorn, I Heuser, M Deuschl. Serum concentrations of nerve growth factor and brain-derived neurotrophic factor in depressed patients before and after antidepressant treatment. Pharmacopsychiatry. vol 41. issue 2. 2008-05-13. PMID:18311687. |
recent research suggests that serum bdnf concentration is reduced in depression and that successful antidepressant treatment leads to an increase in serum bdnf concentration. |
2008-05-13 |
2023-08-12 |
Not clear |
| Armando Piccinni, Donatella Marazziti, Mario Catena, Luciano Domenici, Alessandro Del Debbio, Carolina Bianchi, Claudio Mannari, Claudia Martini, Eleonora Da Pozzo, Elisa Schiavi, Alessandra Mariotti, Isabella Roncaglia, Agnese Palla, Giorgio Consoli, Luca Giovannini, Gabriele Massimetti, Liliana Dell'Oss. Plasma and serum brain-derived neurotrophic factor (BDNF) in depressed patients during 1 year of antidepressant treatments. Journal of affective disorders. vol 105. issue 1-3. 2008-04-30. PMID:17553570. |
brain-derived neurotrophic factor (bdnf) has been hypothesized to be involved in the neurobiology of major depression. |
2008-04-30 |
2023-08-12 |
Not clear |
| Jae-Min Kim, Robert Stewart, Sung-Wan Kim, Su-Jin Yang, Il-Seon Shin, Young-Hoon Kim, Jin-Sang Yoo. BDNF genotype potentially modifying the association between incident stroke and depression. Neurobiology of aging. vol 29. issue 5. 2008-04-28. PMID:17222482. |
bdnf genotype potentially modifying the association between incident stroke and depression. |
2008-04-28 |
2023-08-12 |
Not clear |
| Jae-Min Kim, Robert Stewart, Sung-Wan Kim, Su-Jin Yang, Il-Seon Shin, Young-Hoon Kim, Jin-Sang Yoo. BDNF genotype potentially modifying the association between incident stroke and depression. Neurobiology of aging. vol 29. issue 5. 2008-04-28. PMID:17222482. |
to investigate the role of the brain-derived neurotrophic factor (bdnf) gene val66met polymorphism in the association between stroke and depression. |
2008-04-28 |
2023-08-12 |
Not clear |
| Artuner Deveci, Omer Aydemir, Oryal Taskin, Fatma Taneli, Aysen Esen-Danac. Serum BDNF levels in suicide attempters related to psychosocial stressors: a comparative study with depression. Neuropsychobiology. vol 56. issue 2-3. 2008-04-09. PMID:18037819. |
serum bdnf levels in suicide attempters related to psychosocial stressors: a comparative study with depression. |
2008-04-09 |
2023-08-12 |
human |
| Miao-Kun Sun, Daniel L Alko. Effects of 4-methylcatechol on spatial memory and depression. Neuroreport. vol 19. issue 3. 2008-04-09. PMID:18303581. |
bdnf enhancers may represent one of the new drug strategies in the fighting against depression associated with memory impairments. |
2008-04-09 |
2023-08-12 |
rat |
| Megumi Adachi, Michel Barrot, Anita E Autry, David Theobald, Lisa M Monteggi. Selective loss of brain-derived neurotrophic factor in the dentate gyrus attenuates antidepressant efficacy. Biological psychiatry. vol 63. issue 7. 2008-04-03. PMID:17981266. |
the neurotrophic hypothesis of depression suggests that loss of bdnf from the hippocampus contributes to an increased vulnerability for depression, whereas upregulation of bdnf in the hippocampus is suggested to mediate antidepressant efficacy. |
2008-04-03 |
2023-08-12 |
Not clear |
| Maria Nordheim Alme, Karin Wibrand, Grethe Dagestad, Clive R Bramha. Chronic fluoxetine treatment induces brain region-specific upregulation of genes associated with BDNF-induced long-term potentiation. Neural plasticity. vol 2007. 2008-04-03. PMID:18301726. |
several lines of evidence implicate bdnf in the pathogenesis of stress-induced depression and the delayed efficacy of antidepressant drugs. |
2008-04-03 |
2023-08-12 |
Not clear |
| Lori M Hilt, Lisa C Sander, Susan Nolen-Hoeksema, Arthur A Sime. The BDNF Val66Met polymorphism predicts rumination and depression differently in young adolescent girls and their mothers. Neuroscience letters. vol 429. issue 1. 2008-03-21. PMID:17959306. |
the bdnf val66met polymorphism predicts rumination and depression differently in young adolescent girls and their mothers. |
2008-03-21 |
2023-08-12 |
human |
| Lori M Hilt, Lisa C Sander, Susan Nolen-Hoeksema, Arthur A Sime. The BDNF Val66Met polymorphism predicts rumination and depression differently in young adolescent girls and their mothers. Neuroscience letters. vol 429. issue 1. 2008-03-21. PMID:17959306. |
a single nucleotide polymorphism (snp) in the brain-derived neurotrophic factor (bdnf) gene val66met has been associated with depression. |
2008-03-21 |
2023-08-12 |
human |
| Lori M Hilt, Lisa C Sander, Susan Nolen-Hoeksema, Arthur A Sime. The BDNF Val66Met polymorphism predicts rumination and depression differently in young adolescent girls and their mothers. Neuroscience letters. vol 429. issue 1. 2008-03-21. PMID:17959306. |
rumination may be an endophenotype in the pathway from the bdnf val66met polymorphism to depression. |
2008-03-21 |
2023-08-12 |
human |
| Clive R Bramha. Control of synaptic consolidation in the dentate gyrus: mechanisms, functions, and therapeutic implications. Progress in brain research. vol 163. 2008-03-14. PMID:17765733. |
dysregulation of bdnf synthesis and arc function, specifically within the dentate gyrus, is linked to behavioral symptoms and cognitive deficits in animal models of depression and alzheimer's disease. |
2008-03-14 |
2023-08-12 |
rat |
| Megan E Kozisek, David Middlemas, David B Bylun. Brain-derived neurotrophic factor and its receptor tropomyosin-related kinase B in the mechanism of action of antidepressant therapies. Pharmacology & therapeutics. vol 117. issue 1. 2008-03-11. PMID:17949819. |
the focus of this review is to critically examine and review the literature on the role of brain-derived neurotrophic factor (bdnf) and its primary receptor, tropomyosin-related kinase b (trkb), in the actions of pharmacologically diverse antidepressant treatments for depression. |
2008-03-11 |
2023-08-12 |
Not clear |
| Megan E Kozisek, David Middlemas, David B Bylun. Brain-derived neurotrophic factor and its receptor tropomyosin-related kinase B in the mechanism of action of antidepressant therapies. Pharmacology & therapeutics. vol 117. issue 1. 2008-03-11. PMID:17949819. |
this will include a review of the studies on the regulation of bdnf and trkb by different types of antidepressant drug treatments and animal in models of depression, as well as altered levels of bdnf and trkb in the blood and postmortem brain of patients with depression. |
2008-03-11 |
2023-08-12 |
Not clear |
| Megan E Kozisek, David Middlemas, David B Bylun. Brain-derived neurotrophic factor and its receptor tropomyosin-related kinase B in the mechanism of action of antidepressant therapies. Pharmacology & therapeutics. vol 117. issue 1. 2008-03-11. PMID:17949819. |
results from clinical and basic studies have demonstrated that stress and depression decrease bdnf expression and neurogenesis and antidepressant treatment reverses or blocks these effects, leading to the neurotrophic hypothesis of depression. |
2008-03-11 |
2023-08-12 |
Not clear |
| J O Grove. Is it time to reassess the BDNF hypothesis of depression? Molecular psychiatry. vol 12. issue 12. 2008-03-05. PMID:17700574. |
is it time to reassess the bdnf hypothesis of depression? |
2008-03-05 |
2023-08-12 |
human |