| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lina Chen, Debbie A Lawlor, Sarah J Lewis, Wei Yuan, Mohammad R Abdollahi, Nicholas J Timpson, Ian N M Day, Shah Ebrahim, George Davey Smith, Yin Y Shugar. Genetic association study of BDNF in depression: finding from two cohort studies and a meta-analysis. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 147B. issue 6. 2008-12-04. PMID:18205169. |
further, we carried out a systematic review and meta-analysis of all association studies of these two bdnf polymorphisms and depression. |
2008-12-04 |
2023-08-12 |
human |
| Lina Chen, Debbie A Lawlor, Sarah J Lewis, Wei Yuan, Mohammad R Abdollahi, Nicholas J Timpson, Ian N M Day, Shah Ebrahim, George Davey Smith, Yin Y Shugar. Genetic association study of BDNF in depression: finding from two cohort studies and a meta-analysis. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 147B. issue 6. 2008-12-04. PMID:18205169. |
our findings suggest that bdnf genotype does not exert a major influence on the development of depression. |
2008-12-04 |
2023-08-12 |
human |
| Kevin K Caldwell, S Sheema, Rodrigo D Paz, Sabrina L Samudio-Ruiz, Mary H Laughlin, Nathan E Spence, Michael J Roehlk, Sara N Alcon, Andrea M Alla. Fetal alcohol spectrum disorder-associated depression: evidence for reductions in the levels of brain-derived neurotrophic factor in a mouse model. Pharmacology, biochemistry, and behavior. vol 90. issue 4. 2008-11-25. PMID:18558427. |
several recent studies have implicated reduced brain-derived neurotrophic factor (bdnf) levels in the hippocampal formation and frontal cortex as important contributors to the etiology of depression. |
2008-11-25 |
2023-08-12 |
mouse |
| Naomi R Wray, Michael R James, Herlina Y Handoko, Troy Dumenil, Penelope A Lind, Grant W Montgomery, Nicholas G Marti. Association study of candidate variants from brain-derived neurotrophic factor and dystrobrevin-binding protein 1 with neuroticism, anxiety, and depression. Psychiatric genetics. vol 18. issue 5. 2008-11-14. PMID:18797396. |
here, association between variants of bdnf and dtnbp1, and multiple anxiety and depression phenotypes is explored. |
2008-11-14 |
2023-08-12 |
Not clear |
| Tatsuya Okamoto, Reiji Yoshimura, Atsuko Ikenouchi-Sugita, Hikaru Hori, Wakako Umene-Nakano, Yoshiaki Inoue, Nobuhisa Ueda, Jun Nakamur. Efficacy of electroconvulsive therapy is associated with changing blood levels of homovanillic acid and brain-derived neurotrophic factor (BDNF) in refractory depressed patients: a pilot study. Progress in neuro-psychopharmacology & biological psychiatry. vol 32. issue 5. 2008-11-05. PMID:18403081. |
these results suggest that the mechanisms underlying ect's effect on refractory depression may be related to dopaminergic neurons and bdnf. |
2008-11-05 |
2023-08-12 |
Not clear |
| Rodrigo Grassi-Oliveira, Lilian Milnitsky Stein, Rodrigo Pestana Lopes, Antonio L Teixeira, Moisés Evandro Baue. Low plasma brain-derived neurotrophic factor and childhood physical neglect are associated with verbal memory impairment in major depression--a preliminary report. Biological psychiatry. vol 64. issue 4. 2008-11-03. PMID:18406398. |
the aim of this study was to investigate whether childhood physical neglect (cpn) and plasma bdnf levels would impact on memory performance in adult female subjects with recurrent major depression. |
2008-11-03 |
2023-08-12 |
human |
| Stephen Michael Taylo. Electroconvulsive therapy, brain-derived neurotrophic factor, and possible neurorestorative benefit of the clinical application of electroconvulsive therapy. The journal of ECT. vol 24. issue 2. 2008-10-21. PMID:18580563. |
hippocampal volumes are correlated with decreased expression of neurotrophic factors (most notably, brain-derived neurotrophic factor [bdnf]), and decreased expression of bdnf correlates with the presence of depression. |
2008-10-21 |
2023-08-12 |
Not clear |
| Stephen Michael Taylo. Electroconvulsive therapy, brain-derived neurotrophic factor, and possible neurorestorative benefit of the clinical application of electroconvulsive therapy. The journal of ECT. vol 24. issue 2. 2008-10-21. PMID:18580563. |
patients who undergo ect have also had measurable increases in bdnf, indicating that ect may be modulating intracellular processes in the patients with depression. |
2008-10-21 |
2023-08-12 |
Not clear |
| Christian Montag, Ulrike Basten, Christine Stelzel, Christian J Fiebach, Martin Reute. The BDNF Val66Met polymorphism and smoking. Neuroscience letters. vol 442. issue 1. 2008-10-14. PMID:18602452. |
although the brain derived neurotrophic factor (bdnf) has been mainly investigated in the context of depression and anxiety disorders, several studies also suggest an association between bdnf and smoking. |
2008-10-14 |
2023-08-12 |
human |
| Margaret I Davi. Ethanol-BDNF interactions: still more questions than answers. Pharmacology & therapeutics. vol 118. issue 1. 2008-09-16. PMID:18394710. |
anxiety and depression are precipitating factors for substance abuse and these disorders also involve region-specific changes in bdnf in both pathogenesis and response to pharmacotherapy. |
2008-09-16 |
2023-08-12 |
Not clear |
| Natalia Onishchenko, Nina Karpova, Farideh Sabri, Eero Castrén, Sandra Ceccatell. Long-lasting depression-like behavior and epigenetic changes of BDNF gene expression induced by perinatal exposure to methylmercury. Journal of neurochemistry. vol 106. issue 3. 2008-09-15. PMID:18485098. |
our study shows that developmental exposure to low levels of mehg predisposes mice to depression and induces epigenetic suppression of bdnf gene expression in the hippocampus. |
2008-09-15 |
2023-08-12 |
mouse |
| Rui Wang, Ying-Bo Li, Yu-Hua Li, Ying Xu, Hong-Li Wu, Xue-Jun L. Curcumin protects against glutamate excitotoxicity in rat cerebral cortical neurons by increasing brain-derived neurotrophic factor level and activating TrkB. Brain research. vol 1210. 2008-08-26. PMID:18420184. |
in the present study, we explored the effect of curcumin against glutamate excitotoxicity, mainly focusing on the neuroprotective effects of curcumin on the expression of brain-derived neurotrophic factor (bdnf), which is deeply involved in the etiology and treatment of depression. |
2008-08-26 |
2023-08-12 |
rat |
| Luisella Bocchio-Chiavetto, Carlo Miniussi, Roberta Zanardini, Anna Gazzoli, Stefano Bignotti, Claudia Specchia, Massimo Gennarell. 5-HTTLPR and BDNF Val66Met polymorphisms and response to rTMS treatment in drug resistant depression. Neuroscience letters. vol 437. issue 2. 2008-08-18. PMID:18450378. |
5-httlpr and bdnf val66met polymorphisms and response to rtms treatment in drug resistant depression. |
2008-08-18 |
2023-08-12 |
Not clear |
| Luisella Bocchio-Chiavetto, Carlo Miniussi, Roberta Zanardini, Anna Gazzoli, Stefano Bignotti, Claudia Specchia, Massimo Gennarell. 5-HTTLPR and BDNF Val66Met polymorphisms and response to rTMS treatment in drug resistant depression. Neuroscience letters. vol 437. issue 2. 2008-08-18. PMID:18450378. |
rtms treatment significantly improved depression symptomatology (p<0.0001) and the response was significantly greater in 5-httlpr ll homozygotes compared to s allele carriers (p=0.007) and in bdnf val/val homozygotes compared to met allele carriers (p=0.024). |
2008-08-18 |
2023-08-12 |
Not clear |
| L Pezawas, A Meyer-Lindenberg, A L Goldman, B A Verchinski, G Chen, B S Kolachana, M F Egan, V S Mattay, A R Hariri, D R Weinberge. Evidence of biologic epistasis between BDNF and SLC6A4 and implications for depression. Molecular psychiatry. vol 13. issue 7. 2008-08-13. PMID:18347599. |
evidence of biologic epistasis between bdnf and slc6a4 and implications for depression. |
2008-08-13 |
2023-08-12 |
mouse |
| L Pezawas, A Meyer-Lindenberg, A L Goldman, B A Verchinski, G Chen, B S Kolachana, M F Egan, V S Mattay, A R Hariri, D R Weinberge. Evidence of biologic epistasis between BDNF and SLC6A4 and implications for depression. Molecular psychiatry. vol 13. issue 7. 2008-08-13. PMID:18347599. |
5-httlpr and bdnf val66met, functional polymorphisms of the serotonin (5-ht) transporter (slc6a4) and brain-derived neurotrophic factor (bdnf) gene, impact on two distinct, but interacting signaling systems, which have been related to depression and to the modulation of neurogenesis and plasticity of circuitries of emotion processing. |
2008-08-13 |
2023-08-12 |
mouse |
| L Pezawas, A Meyer-Lindenberg, A L Goldman, B A Verchinski, G Chen, B S Kolachana, M F Egan, V S Mattay, A R Hariri, D R Weinberge. Evidence of biologic epistasis between BDNF and SLC6A4 and implications for depression. Molecular psychiatry. vol 13. issue 7. 2008-08-13. PMID:18347599. |
recent clinical studies suggest that the bdnf met allele, which shows abnormal intracellular trafficking and regulated secretion, has a protective effect regarding the development of depression and in mice of social defeat stress. |
2008-08-13 |
2023-08-12 |
mouse |
| L Pezawas, A Meyer-Lindenberg, A L Goldman, B A Verchinski, G Chen, B S Kolachana, M F Egan, V S Mattay, A R Hariri, D R Weinberge. Evidence of biologic epistasis between BDNF and SLC6A4 and implications for depression. Molecular psychiatry. vol 13. issue 7. 2008-08-13. PMID:18347599. |
these data provide in vivo evidence of biologic epistasis between slc6a4 and bdnf in the human brain by identifying a neural mechanism linking serotonergic and neurotrophic signaling on the neural systems level, and have implications for personalized treatment planning in depression. |
2008-08-13 |
2023-08-12 |
mouse |
| Darrick T Balu, Brian A Hoshaw, Jessica E Malberg, Sharon Rosenzweig-Lipson, Lee E Schechter, Irwin Luck. Differential regulation of central BDNF protein levels by antidepressant and non-antidepressant drug treatments. Brain research. vol 1211. 2008-08-08. PMID:18433734. |
the current experiments investigated the effects of acute and chronic treatment with different pharmacologic and somatic antidepressant treatments on protein levels of bdnf in several brain regions associated with depression in the rat. |
2008-08-08 |
2023-08-12 |
rat |
| Mary-Anne Enoch, Kenneth V White, Juwaria Waheed, David Goldma. Neurophysiological and genetic distinctions between pure and comorbid anxiety disorders. Depression and anxiety. vol 25. issue 5. 2008-08-07. PMID:17941097. |
two common functional polymorphisms in catechol-o-methyltransferase (comt val158met) and brain-derived neurotrophic factor (bdnf val66met) genes have been implicated in the neurobiology of anxiety and depression. |
2008-08-07 |
2023-08-12 |
human |