| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andrew C Robinson, Yvonne S Davidson, Federico Roncaroli, James Minshull, Phillip Tinkler, Michael A Horan, Antony Payton, Neil Pendleton, David M A Man. Influence of APOE genotype in primary age-related tauopathy. Acta neuropathologica communications. vol 8. issue 1. 2021-11-09. PMID:33287896. |
here, we investigate the relationships between part, ad and those pathologically normal for age, with an emphasis on apoe and cognition, using 152 selected participants from the university of manchester longitudinal study of cognition in normal healthy old age and the manchester arm of the brains for dementia research cohort. |
2021-11-09 |
2023-08-13 |
human |
| Mengyu Li, Jie V Zhao, Man Ki Kwok, C Mary Schoolin. Age and sex specific effects of APOE genotypes on ischemic heart disease and its risk factors in the UK Biobank. Scientific reports. vol 11. issue 1. 2021-11-08. PMID:33927215. |
apoe genotypes are associated with ischemic heart disease (ihd), several other cardiovascular diseases and dementia. |
2021-11-08 |
2023-08-13 |
human |
| Xiaoyue Li, Yelei Zhang, Xinyu Chen, Hongwei Yuan, Zhiqiang Wang, Guoqiang Wang, Kai Zhang, Huanzhong Li. Association of Gene Polymorphisms in APOE and BIN1 With Dementia of Alzheimer's Type Susceptibility in Chinese Han Population. Frontiers in psychiatry. vol 12. 2021-11-05. PMID:34733192. |
association of gene polymorphisms in apoe and bin1 with dementia of alzheimer's type susceptibility in chinese han population. |
2021-11-05 |
2023-08-13 |
Not clear |
| Na Zhang, Janice M Ranson, Zhi-Jie Zheng, Eilis Hannon, Zhenwei Zhou, Xuejun Kong, David J Llewellyn, Daniel A King, Jie Huan. Interaction between genetic predisposition, smoking, and dementia risk: a population-based cohort study. Scientific reports. vol 11. issue 1. 2021-11-02. PMID:34155245. |
we evaluated whether the association between cigarette smoking and dementia risk is modified by genetic predisposition including apolipoprotein e (apoe) genotype and polygenic risk (excluding the apoe region). |
2021-11-02 |
2023-08-13 |
human |
| Na Zhang, Janice M Ranson, Zhi-Jie Zheng, Eilis Hannon, Zhenwei Zhou, Xuejun Kong, David J Llewellyn, Daniel A King, Jie Huan. Interaction between genetic predisposition, smoking, and dementia risk: a population-based cohort study. Scientific reports. vol 11. issue 1. 2021-11-02. PMID:34155245. |
apoe genotype but not polygenic risk modified the effect of smoking on dementia risk. |
2021-11-02 |
2023-08-13 |
human |
| Jing Zhang, Lanyan Lin, Xiaoman Dai, Nai'an Xiao, Qinyong Ye, Xiaochun Che. ApoE4 increases susceptibility to stress-induced age-dependent depression-like behavior and cognitive impairment. Journal of psychiatric research. vol 143. 2021-11-02. PMID:34530340. |
the study provides rodent evidence that apoe ε4 may increase the risk of depression and dementia in the elderly population by impairing the gabaergic signaling pathway and enhancing the glun2b phosphorylation, which signifies that glun2b inhibitors in clinical settings may be effective for elderly depression patients with apoe4 carriers. |
2021-11-02 |
2023-08-13 |
mouse |
| Leonie N C Visser, Carolina Minguillon, Gonzalo Sánchez-Benavides, Marc Abramowicz, Daniele Altomare, Karine Fauria, Giovanni B Frisoni, Jean Georges, Federica Ribaldi, Philip Scheltens, Jetske van der Schaar, Marissa Zwan, Wiesje M van der Flier, José Luis Molinuev. Dementia risk communication. A user manual for Brain Health Services-part 3 of 6. Alzheimer's research & therapy. vol 13. issue 1. 2021-10-28. PMID:34635169. |
however, communicating about dementia risk is complex and challenging.in this paper, we provide an overview of (i) perspectives on communicating dementia risk from an ethical, clinical, and societal viewpoint; (ii) insights gained from memory clinical practice; (iii) available evidence on the impact of disclosing apoe and alzheimer's disease biomarker test results gathered from clinical trials and observational studies; (iv) the value of established registries in light of bhs; and (v) practical recommendations regarding effective strategies for communicating about dementia risk.in addition, we identify challenges, i.e., the current lack of evidence on what to tell on an individual level-the actual risk-and on how to optimally communicate about dementia risk, especially concerning worried yet cognitively unimpaired individuals. |
2021-10-28 |
2023-08-13 |
Not clear |
| Alexandra J Weigand, Kelsey R Thomas, Katherine J Bangen, Graham M L Eglit, Lisa Delano-Wood, Paul E Gilbert, Adam M Brickman, Mark W Bond. APOE interacts with tau PET to influence memory independently of amyloid PET in older adults without dementia. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17. issue 1. 2021-10-25. PMID:32886451. |
apoe interacts with tau pet to influence memory independently of amyloid pet in older adults without dementia. |
2021-10-25 |
2023-08-13 |
Not clear |
| Cecilia Camarda, Paola Torelli, Carmela Pipia, Gianluca Sottile, Giovanna Cilluffo, Rosolino Camard. APOE Genotypes and Brain Imaging Classes in Normal Cognition, Mild Cognitive Impairment, and Alzheimer's Disease: A Longitudinal Study. Current Alzheimer research. vol 17. issue 8. 2021-10-22. PMID:33167837. |
to evaluate in 419 stroke-free cognitively normal subjects (cn) aged 45-82 years covering during a long prospective study (11.54 ± 1.47 years) the preclinical to dementia spectrum: 1) the distribution of small vessel disease (v) and brain atrophy (a) aggregated as following: v-/a-, v-/a+, v+/a-, v+/a+; 2) the relationship of these imaging classes with individual apolipoprotein e (apoe) genotypes; 3) the risk of progression to alzheimer disease (ad) of the individual apoe genotypes. |
2021-10-22 |
2023-08-13 |
human |
| Binbing Y. Estimating age-specific incidence of dementia using prevalent cohort data. Journal of statistical computation and simulation. vol 81. issue 8. 2021-10-20. PMID:21860539. |
as application, the method is applied to the prevalent cases of dementia from the honolulu asia aging study to estimate dementia incidence rate and to assess the effect of hypertension, apoe 4 and education on dementia onset. |
2021-10-20 |
2023-08-12 |
human |
| Jessica Sarahi Alavez-Rubio, Nancy Martínez-Rodríguez, Jorge Escobedo-de-la-Peña, Osvaldo Garrido-Acosta, Teresa Juárez-Cedill. Relationship Between Genetic Variants of ACAT1 and APOE with the Susceptibility to Dementia (SADEM Study). Molecular neurobiology. vol 58. issue 3. 2021-10-13. PMID:33057949. |
relationship between genetic variants of acat1 and apoe with the susceptibility to dementia (sadem study). |
2021-10-13 |
2023-08-13 |
human |
| Jessica Sarahi Alavez-Rubio, Nancy Martínez-Rodríguez, Jorge Escobedo-de-la-Peña, Osvaldo Garrido-Acosta, Teresa Juárez-Cedill. Relationship Between Genetic Variants of ACAT1 and APOE with the Susceptibility to Dementia (SADEM Study). Molecular neurobiology. vol 58. issue 3. 2021-10-13. PMID:33057949. |
this study evaluates the relationship between acat1 and apoe genetic variants with susceptibility for the development of alzheimer's disease and other dementias. |
2021-10-13 |
2023-08-13 |
human |
| Jessica Sarahi Alavez-Rubio, Nancy Martínez-Rodríguez, Jorge Escobedo-de-la-Peña, Osvaldo Garrido-Acosta, Teresa Juárez-Cedill. Relationship Between Genetic Variants of ACAT1 and APOE with the Susceptibility to Dementia (SADEM Study). Molecular neurobiology. vol 58. issue 3. 2021-10-13. PMID:33057949. |
we examined four acat1 polymorphisms (rs2247071, rs2862616, rs3753526, rs1044925) and two in the apoe gene (rs7412, rs429358) in a group of 204 controls and 196 cases of dementia. |
2021-10-13 |
2023-08-13 |
human |
| Jessica Sarahi Alavez-Rubio, Nancy Martínez-Rodríguez, Jorge Escobedo-de-la-Peña, Osvaldo Garrido-Acosta, Teresa Juárez-Cedill. Relationship Between Genetic Variants of ACAT1 and APOE with the Susceptibility to Dementia (SADEM Study). Molecular neurobiology. vol 58. issue 3. 2021-10-13. PMID:33057949. |
the results support the hypothesis that the acat1 gene, together with the apoe gene, plays an important role in susceptibility to the development of dementia and shows genetic characteristics of the mexican population that can be used to identify the population at risk. |
2021-10-13 |
2023-08-13 |
human |
| Mark Lee, Timothy M Hughes, Kristen M George, Michael E Griswold, Sanaz Sedaghat, Jeannette Simino, Pamela L Lutse. Education and Cardiovascular Health as Effect Modifiers of APOE ε4 on Dementia: The Atherosclerosis Risk in Communities (ARIC) Study. The journals of gerontology. Series A, Biological sciences and medical sciences. 2021-10-06. PMID:34614170. |
education and cardiovascular health as effect modifiers of apoe ε4 on dementia: the atherosclerosis risk in communities (aric) study. |
2021-10-06 |
2023-08-13 |
Not clear |
| H Stocker, L Perna, K Weigl, T Möllers, B Schöttker, H Thomsen, B Holleczek, D Rujescu, H Brenne. Prediction of clinical diagnosis of Alzheimer's disease, vascular, mixed, and all-cause dementia by a polygenic risk score and APOE status in a community-based cohort prospectively followed over 17 years. Molecular psychiatry. 2021-10-02. PMID:32404947. |
prediction of clinical diagnosis of alzheimer's disease, vascular, mixed, and all-cause dementia by a polygenic risk score and apoe status in a community-based cohort prospectively followed over 17 years. |
2021-10-02 |
2023-08-13 |
human |
| H Stocker, L Perna, K Weigl, T Möllers, B Schöttker, H Thomsen, B Holleczek, D Rujescu, H Brenne. Prediction of clinical diagnosis of Alzheimer's disease, vascular, mixed, and all-cause dementia by a polygenic risk score and APOE status in a community-based cohort prospectively followed over 17 years. Molecular psychiatry. 2021-10-02. PMID:32404947. |
the aim of this study was to investigate the ability of an ad polygenic risk score (prs) and apoe status to predict clinical diagnosis of ad, vascular (vd), mixed (md), and all-cause dementia in a community-based cohort prospectively followed over 17 years and secondarily across age, sex, and education strata. |
2021-10-02 |
2023-08-13 |
human |
| H Stocker, L Perna, K Weigl, T Möllers, B Schöttker, H Thomsen, B Holleczek, D Rujescu, H Brenne. Prediction of clinical diagnosis of Alzheimer's disease, vascular, mixed, and all-cause dementia by a polygenic risk score and APOE status in a community-based cohort prospectively followed over 17 years. Molecular psychiatry. 2021-10-02. PMID:32404947. |
prediction ability of ad, vd, md, and all-cause dementia by the prs and apoe was assessed by multiple logistic regression and receiver operating characteristic curve analyses. |
2021-10-02 |
2023-08-13 |
human |
| H Stocker, L Perna, K Weigl, T Möllers, B Schöttker, H Thomsen, B Holleczek, D Rujescu, H Brenne. Prediction of clinical diagnosis of Alzheimer's disease, vascular, mixed, and all-cause dementia by a polygenic risk score and APOE status in a community-based cohort prospectively followed over 17 years. Molecular psychiatry. 2021-10-02. PMID:32404947. |
the prs enriched the ability of apoe to discern ad with stronger associations than to vd, md, or all-cause dementia in a prospective community-based cohort. |
2021-10-02 |
2023-08-13 |
human |
| H Stocker, L Perna, K Weigl, T Möllers, B Schöttker, H Thomsen, B Holleczek, D Rujescu, H Brenne. Correction: Prediction of clinical diagnosis of Alzheimer's disease, vascular, mixed, and all-cause dementia by a polygenic risk score and APOE status in a community-based cohort prospectively followed over 17 years. Molecular psychiatry. 2021-10-02. PMID:34599279. |
correction: prediction of clinical diagnosis of alzheimer's disease, vascular, mixed, and all-cause dementia by a polygenic risk score and apoe status in a community-based cohort prospectively followed over 17 years. |
2021-10-02 |
2023-08-13 |
Not clear |