| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sergi Valero, Marta Marquié, Itziar De Rojas, Ana Espinosa, Sonia Moreno-Grau, Adelina Orellana, Laura Montrreal, Isabel Hernández, Ana Mauleón, Maitée Rosende-Roca, Montse Alegret, Alba Pérez-Cordón, Gemma Ortega, Natalia Roberto, Angela Sanabria, Carla Abdelnour, Silvia Gil, Juan Pablo Tartari, Liliana Vargas, Ester Esteban-De Antonio, Alba Benaque, Lluís Tárraga, Mercè Boada, Agustín Ruí. Interaction of neuropsychiatric symptoms with APOE ε4 and conversion to dementia in MCI patients in a Memory Clinic. Scientific reports. vol 10. issue 1. 2021-03-30. PMID:33208795. |
interaction of neuropsychiatric symptoms with apoe ε4 and conversion to dementia in mci patients in a memory clinic. |
2021-03-30 |
2023-08-13 |
Not clear |
| Sergi Valero, Marta Marquié, Itziar De Rojas, Ana Espinosa, Sonia Moreno-Grau, Adelina Orellana, Laura Montrreal, Isabel Hernández, Ana Mauleón, Maitée Rosende-Roca, Montse Alegret, Alba Pérez-Cordón, Gemma Ortega, Natalia Roberto, Angela Sanabria, Carla Abdelnour, Silvia Gil, Juan Pablo Tartari, Liliana Vargas, Ester Esteban-De Antonio, Alba Benaque, Lluís Tárraga, Mercè Boada, Agustín Ruí. Interaction of neuropsychiatric symptoms with APOE ε4 and conversion to dementia in MCI patients in a Memory Clinic. Scientific reports. vol 10. issue 1. 2021-03-30. PMID:33208795. |
to date, very few studies have been focused on the impact of the convergence of neuropsychiatric symptoms (nps) and apoe ε4 on the conversion to dementia in patients with mild cognitive impairment patients (mci), and none has been based in a clinical setting. |
2021-03-30 |
2023-08-13 |
Not clear |
| Sergi Valero, Marta Marquié, Itziar De Rojas, Ana Espinosa, Sonia Moreno-Grau, Adelina Orellana, Laura Montrreal, Isabel Hernández, Ana Mauleón, Maitée Rosende-Roca, Montse Alegret, Alba Pérez-Cordón, Gemma Ortega, Natalia Roberto, Angela Sanabria, Carla Abdelnour, Silvia Gil, Juan Pablo Tartari, Liliana Vargas, Ester Esteban-De Antonio, Alba Benaque, Lluís Tárraga, Mercè Boada, Agustín Ruí. Interaction of neuropsychiatric symptoms with APOE ε4 and conversion to dementia in MCI patients in a Memory Clinic. Scientific reports. vol 10. issue 1. 2021-03-30. PMID:33208795. |
the objective of the study is to determine the predictive value of additive and multiplicative interactions of nps and apoe ε4 status on the prediction of incident dementia among mci patients monitored in a memory clinic. |
2021-03-30 |
2023-08-13 |
Not clear |
| Sergi Valero, Marta Marquié, Itziar De Rojas, Ana Espinosa, Sonia Moreno-Grau, Adelina Orellana, Laura Montrreal, Isabel Hernández, Ana Mauleón, Maitée Rosende-Roca, Montse Alegret, Alba Pérez-Cordón, Gemma Ortega, Natalia Roberto, Angela Sanabria, Carla Abdelnour, Silvia Gil, Juan Pablo Tartari, Liliana Vargas, Ester Esteban-De Antonio, Alba Benaque, Lluís Tárraga, Mercè Boada, Agustín Ruí. Interaction of neuropsychiatric symptoms with APOE ε4 and conversion to dementia in MCI patients in a Memory Clinic. Scientific reports. vol 10. issue 1. 2021-03-30. PMID:33208795. |
synergistic interactions between nps and apoe ε4 are identified among mci patients when predicting incident dementia. |
2021-03-30 |
2023-08-13 |
Not clear |
| Yue Han, Aihong Zhou, Fangyu Li, Qi Wang, Lingzhi Xu, Jianping Ji. Apolipoprotein E ε4 allele is associated with vascular cognitive impairment no dementia in Chinese population. Journal of the neurological sciences. vol 409. 2021-03-19. PMID:31865187. |
the association between apolipoprotein e (apoe) ε4 allele and vascular cognitive impairment no dementia (vcind) is still controversial. |
2021-03-19 |
2023-08-13 |
Not clear |
| Sergi Valero, Marta Marquié, Itziar De Rojas, Ana Espinosa, Sonia Moreno-Grau, Adelina Orellana, Laura Montrreal, Isabel Hernández, Ana Mauleón, Maiteé Rosende-Roca, Montse Alegret, Alba Pérez-Cordón, Gemma Ortega, Natalia Roberto, Angela Sanabria, Carla Abdelnour, Silvia Gil, Juan Pablo Tartari, Liliana Vargas, Ester Esteban-De Antonio, Alba Benaque, Lluís Tárraga, Mercè Boada, Agustín Ruí. Author Correction: Interaction of neuropsychiatric symptoms with APOE ε4 and conversion to dementia in MCI patients in a Memory Clinic. Scientific reports. vol 11. issue 1. 2021-02-25. PMID:33619297. |
author correction: interaction of neuropsychiatric symptoms with apoe ε4 and conversion to dementia in mci patients in a memory clinic. |
2021-02-25 |
2023-08-13 |
Not clear |
| Sara G Aguilar-Navarro, Itzel I Gonzalez-Aparicio, José Alberto Avila-Funes, Teresa Juárez-Cedillo, Teresa Tusié-Luna, Alberto Jose Mimenza-Alvarad. Association between ApoE ε4 Carrier Status and Cardiovascular Risk Factors on Mild Cognitive Impairment among Mexican Older Adults. Brain sciences. vol 11. issue 1. 2021-02-18. PMID:33430178. |
cardiovascular risk factors (cvrf), such as hypertension, diabetes, or dyslipidemia, and the presence of the apolipoprotein e ε4 (apoe ε4) polymorphism have been associated with an increased risk of developing alzheimer's disease (ad) and other dementias but the relationship is inconsistent worldwide. |
2021-02-18 |
2023-08-13 |
Not clear |
| Permal Deo, Varinderpal S Dhillon, Ann Chua, Philip Thomas, Michael Fenec. APOE ε4 Carriers Have a Greater Propensity to Glycation and sRAGE Which Is Further Influenced by RAGE G82S Polymorphism. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 75. issue 10. 2021-02-16. PMID:31677348. |
our study indicates that apoe ε4 carriers have a greater propensity to glycation than noncarriers which may further increase their risk for diabetes and dementia. |
2021-02-16 |
2023-08-13 |
Not clear |
| Najada Stringa, Natasja M van Schoor, Yuri Milaneschi, M Arfan Ikram, Vieri Del Panta, Chantal M Koolhaas, Trudy Voortman, Stefania Bandinelli, Frank J Wolters, Martijn Huisma. Physical Activity as Moderator of the Association Between APOE and Cognitive Decline in Older Adults: Results from Three Longitudinal Cohort Studies. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 75. issue 10. 2021-02-16. PMID:32110803. |
previous studies have suggested that the association between apoe ɛ 4 and dementia is moderated by physical activity (pa), but the results remain inconclusive and longitudinal data on cognitive decline are missing. |
2021-02-16 |
2023-08-13 |
Not clear |
| Ana Kolicheski, Ronald L Walton, Alexandra I Soto-Beasley, Michael G Heckman, Ryan J Uitti, Francine Parfitt, Michelle R Graff-Radford, Zbigniew K Wszolek, Neill R Graff-Radford, Owen A Ros. CLEC3B p.S106G Mutant in a Caucasian Population of Successful Neurological Aging. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 75. issue 9. 2021-02-10. PMID:31570938. |
however, to date, only two genes have been consistently associated with longevity in humans: apoe and foxo3, with the apoe ɛ2 allele also protective against dementia. |
2021-02-10 |
2023-08-13 |
human |
| Mitsuru Shinohara, Yoshitaka Tashiro, Kaoru Suzuki, Akio Fukumori, Guojun Bu, Naoyuki Sat. Interaction between Alzheimer's & dementia (Amsterdam, Netherlands). vol 12. issue 1. 2021-02-06. PMID:32211501. |
interaction between although diabetes and apolipoprotein e (apoe) are both significant risk factors for dementia, including alzheimer's disease, it remains to be clarified how they are related to each other in contributing to the risk of dementia. |
2021-02-06 |
2023-08-13 |
Not clear |
| Corey W Bown, Dandan Liu, Katie E Osborn, Deepak K Gupta, Lisa A Mendes, Kimberly R Pechman, Timothy J Hohman, Thomas J Wang, Katherine A Gifford, Angela L Jefferso. Apolipoprotein E Genotype Modifies the Association Between Cardiac Output and Cognition in Older Adults. Journal of the American Heart Association. vol 8. issue 15. 2021-01-04. PMID:31364446. |
methods and results vanderbilt memory & aging project participants free of clinical stroke and dementia (n=306, 73±7 years, 42% female) underwent echocardiography to determine cardiac output (l/min), comprehensive neuropsychological assessment, and venous blood draw to determine apoe genotype and ε4 carrier status. |
2021-01-04 |
2023-08-13 |
human |
| Jaisalmer de Frutos-Lucas, Natalie Frost, Kirk I Erickson, Juan M Serrano, Fernando Maestu, Simon M Laws, Belinda M Brow. Does APOE genotype moderate the relationship between physical activity, brain health and dementia risk? A systematic review. Ageing research reviews. vol 64. 2020-12-30. PMID:32961338. |
does apoe genotype moderate the relationship between physical activity, brain health and dementia risk? |
2020-12-30 |
2023-08-13 |
Not clear |
| Jaisalmer de Frutos-Lucas, Natalie Frost, Kirk I Erickson, Juan M Serrano, Fernando Maestu, Simon M Laws, Belinda M Brow. Does APOE genotype moderate the relationship between physical activity, brain health and dementia risk? A systematic review. Ageing research reviews. vol 64. 2020-12-30. PMID:32961338. |
for decades, researchers have tried to understand the moderating effect of apoe ε4 carriage on the relationship between physical activity (pa), brain health and dementia risk. |
2020-12-30 |
2023-08-13 |
Not clear |
| Hanna Cho, Young-Eun Kim, Wonjeong Chae, Ko Woon Kim, Jong-Won Kim, Hee Jin Kim, Duk L Na, Chang-Seok Ki, Sang Won Se. Distribution and clinical impact of apolipoprotein E4 in subjective memory impairment and early mild cognitive impairment. Scientific reports. vol 10. issue 1. 2020-12-14. PMID:32770103. |
in our longitudinal data, apoe e4 carrier showed a steeper incline slope in a clinical dementia rating sum of boxes (cdr-sb) score than apoe e4 non-carrier in smi (b = 0.0066, p = 0.0104), e-amci (b = 0.0313, p < 0.0001), and l-amci (b = 0.0178, p = 0.0007). |
2020-12-14 |
2023-08-13 |
Not clear |
| Wen Huang, Man'e Chen, Yingqi Zhang, Ping Zhao, Guo'en Yao, Huadong Zho. Frequency distribution of apolipoprotein E genotypes in elderly population and relationship with senile dementia. Journal of neurosurgical sciences. vol 64. issue 1. 2020-12-07. PMID:25534515. |
the aim of this study was to determine the relationship between apolipoprotein e (apoe)-ε4 genotype and senile dementia (sd) by analyzing the apoe allelic frequency distributions among the elderly han chinese population. |
2020-12-07 |
2023-08-13 |
Not clear |
| Jing Zhao, Yuan Fu, Yu Yamazaki, Yingxue Ren, Mary D Davis, Chia-Chen Liu, Wenyan Lu, Xue Wang, Kai Chen, Yesesri Cherukuri, Lin Jia, Yuka A Martens, Lucy Job, Francis Shue, Thanh Thanh Nguyen, Steven G Younkin, Neill R Graff-Radford, Zbigniew K Wszolek, David A Brafman, Yan W Asmann, Nilüfer Ertekin-Taner, Takahisa Kanekiyo, Guojun B. APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer's disease patient iPSC-derived cerebral organoids. Nature communications. vol 11. issue 1. 2020-11-19. PMID:33139712. |
to address the underlying mechanism, we develop cerebral organoid models using induced pluripotent stem cells (ipscs) with apoe ε3/ε3 or ε4/ε4 genotype from individuals with either normal cognition or ad dementia. |
2020-11-19 |
2023-08-13 |
human |
| Kay Deckers, Mariagnese Barbera, Sebastian Köhler, Tiia Ngandu, Martin van Boxtel, Minna Rusanen, Tiina Laatikainen, Frans Verhey, Hilkka Soininen, Miia Kivipelto, Alina Solomo. Long-term dementia risk prediction by the LIBRA score: A 30-year follow-up of the CAIDE study. International journal of geriatric psychiatry. vol 35. issue 2. 2020-11-12. PMID:31736136. |
therefore, this study aimed to examine the predictive accuracy of the "lifestyle for brain health" (libra) score, a weighted compound score of 12 modifiable risk and protective factors, for dementia and mild cognitive impairment (mci) in midlife and late-life, and in individuals with high or low genetic risk based on presence of the apolipoprotein (apoe) ε4 allele. |
2020-11-12 |
2023-08-13 |
Not clear |
| Alica Rogojin, Diana J Gorbet, Kara M Hawkins, Lauren E Sergi. Cognitive-Motor Integration Performance Is Affected by Sex, APOE Status, and Family History of Dementia. Journal of Alzheimer's disease : JAD. vol 71. issue 2. 2020-11-04. PMID:31424400. |
cognitive-motor integration performance is affected by sex, apoe status, and family history of dementia. |
2020-11-04 |
2023-08-13 |
Not clear |
| Maria-Eleni Dounavi, Elijah Mak, Katie Wells, Karen Ritchie, Craig W Ritchie, Li Su, John T O' Brie. Volumetric alterations in the hippocampal subfields of subjects at increased risk of dementia. Neurobiology of aging. vol 91. 2020-10-30. PMID:32311609. |
the participants were stratified based on dementia fh, apoe genotype, and caide (cardiovascular risk factors, aging and dementia) risk score. |
2020-10-30 |
2023-08-13 |
human |