| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sarah T Pendlebury, Debbie Poole, Annette Burgess, Julia Duerden, Peter M Rothwel. APOE-ε4 Genotype and Dementia Before and After Transient Ischemic Attack and Stroke: Population-Based Cohort Study. Stroke. vol 51. issue 3. 2020-06-19. PMID:32070224. |
associations between pre- and post-event dementia and apoe genotype (ε4/ε4-homozygous and ε4/ε3-heterozygous versus ε3/ε3) were examined using logistic regression and cox regression models, respectively, adjusted for age, sex, education, cerebrovascular burden (stroke severity, prior stroke, white matter disease), diabetes mellitus, and dysphasia. |
2020-06-19 |
2023-08-13 |
Not clear |
| Vijay K Ramanan, Anna M Castillo, David S Knopman, Jonathan Graff-Radford, Val J Lowe, Ronald C Petersen, Clifford R Jack, Michelle M Mielke, Prashanthi Vemur. Association of Apolipoprotein E ɛ4, Educational Level, and Sex With Tau Deposition and Tau-Mediated Metabolic Dysfunction in Older Adults. JAMA network open. vol 2. issue 10. 2020-06-15. PMID:31642932. |
while amyloidosis is an early event in the alzheimer disease (ad) biomarker cascade, a complex interplay among the apolipoprotein e (apoe) ɛ4 allele, educational levels, and sex may be associated with an individual's resilience to dementia. |
2020-06-15 |
2023-08-13 |
Not clear |
| Maurizio Gallucci, Carola Dell'Acqua, Cristina Bergamelli, Chiara Fenoglio, Maria Serpente, Daniela Galimberti, Vittorio Fiore, Stefano Medea, Michele Gregianin, Maria Elena Di Battist. A Case with Early Onset Alzheimer's Disease, Frontotemporal Hypometabolism, ApoE Genotype ɛ4/ɛ4 and C9ORF72 Intermediate Expansion: A Treviso Dementia (TREDEM) Registry Case Report. Journal of Alzheimer's disease : JAD. vol 67. issue 3. 2020-05-29. PMID:30714955. |
a case with early onset alzheimer's disease, frontotemporal hypometabolism, apoe genotype ɛ4/ɛ4 and c9orf72 intermediate expansion: a treviso dementia (tredem) registry case report. |
2020-05-29 |
2023-08-13 |
Not clear |
| Jonathan Vogelgsang, Ruth Vukovich, Dirk Wedekind, Jens Wiltfan. Higher Level of Mismatch in APOEε4 Carriers for Amyloid-Beta Peptide Alzheimer's Disease Biomarkers in Cerebrospinal Fluid. ASN neuro. vol 11. 2020-05-13. PMID:31104469. |
we compared parallel measured csf biomarkers of two independent laboratories from 126 patients who underwent clinical dementia diagnostics regarding the apoe genotype. |
2020-05-13 |
2023-08-13 |
Not clear |
| Michal Prendecki, Jolanta Florczak-Wyspianska, Marta Kowalska, Jan Ilkowski, Teresa Grzelak, Katarzyna Bialas, Wojciech Kozubski, Jolanta Dorszewsk. APOE genetic variants and apoE, miR-107 and miR-650 levels in Alzheimer's disease. Folia neuropathologica. vol 57. issue 2. 2020-02-20. PMID:31556571. |
the aim of the study was to analyse the plasma concentration of apoe by elisa as well as the plasma levels of mir-107 and mir-650 by qpcr in relation to apoe genetic variants and clinical features including the age of onset and dementia severity in 64 ad patients and 132 controls. |
2020-02-20 |
2023-08-13 |
Not clear |
| Michal Prendecki, Jolanta Florczak-Wyspianska, Marta Kowalska, Jan Ilkowski, Teresa Grzelak, Katarzyna Bialas, Wojciech Kozubski, Jolanta Dorszewsk. APOE genetic variants and apoE, miR-107 and miR-650 levels in Alzheimer's disease. Folia neuropathologica. vol 57. issue 2. 2020-02-20. PMID:31556571. |
our data showed that a low apoe plasma concentration was a risk factor for developing ad (or = 5.18, p = 6.58e-06) and was particularly pronounced in severe dementia (p < 0.001) and correlated with cognitive functions (r = 0.295, p = 0.020), similarly as the level of mir-650 (r = 0.385, p = 0.033). |
2020-02-20 |
2023-08-13 |
Not clear |
| Nicolette Mary Heinsinger, Mariam Alexandra Gachechiladze, G William Rebec. Apolipoprotein E Genotype Affects Size of ApoE Complexes in Cerebrospinal Fluid. Journal of neuropathology and experimental neurology. vol 75. issue 10. 2020-02-05. PMID:27516118. |
compared to individuals with no dementia, those with the mildest stages of dementia had similar sized csf apoe complexes. |
2020-02-05 |
2023-08-13 |
human |
| Lynnette A Averill, Chadi G Abdallah, Daniel F Levey, Shizhong Han, Ilan Harpaz-Rotem, Henry R Kranzler, Steven M Southwick, John H Krystal, Joel Gelernter, Robert H Pietrza. Apolipoprotein E gene polymorphism, posttraumatic stress disorder, and cognitive function in older U.S. veterans: Results from the National Health and Resilience in Veterans Study. Depression and anxiety. vol 36. issue 9. 2020-02-03. PMID:31385647. |
although the ε4 allele of the apolipoprotein e (apoe) gene and posttraumatic stress disorder (ptsd) have been linked to cognitive dysfunction and dementia risk, it is unknown whether they interact to predict cognitive dysfunction. |
2020-02-03 |
2023-08-13 |
Not clear |
| Arvid Rongve, Aree Witoelar, Agustín Ruiz, Lavinia Athanasiu, Carla Abdelnour, Jordi Clarimon, Stefanie Heilmann-Heimbach, Isabel Hernández, Sonia Moreno-Grau, Itziar de Rojas, Estrella Morenas-Rodríguez, Tormod Fladby, Sigrid B Sando, Geir Bråthen, Frédéric Blanc, Olivier Bousiges, Afina W Lemstra, Inger van Steenoven, Elisabet Londos, Ina S Almdahl, Lene Pålhaugen, Jon A Eriksen, Srdjan Djurovic, Eystein Stordal, Ingvild Saltvedt, Ingun D Ulstein, Francesco Bettella, Rahul S Desikan, Ane-Victoria Idland, Mathias Toft, Lasse Pihlstrøm, Jon Snaedal, Lluís Tárraga, Mercè Boada, Alberto Lleó, Hreinn Stefánsson, Kári Stefánsson, Alfredo Ramírez, Dag Aarsland, Ole A Andreasse. Author Correction: GBA and APOE ε4 associate with sporadic dementia with Lewy bodies in European genome wide association study. Scientific reports. vol 9. issue 1. 2020-01-08. PMID:31619746. |
author correction: gba and apoe ε4 associate with sporadic dementia with lewy bodies in european genome wide association study. |
2020-01-08 |
2023-08-13 |
Not clear |
| Ville Rantalainen, Jari Lahti, Eero Kajantie, Pentti Tienari, Johan G Eriksson, Katri Raikkone. APOE ɛ4, rs405509, and rs440446 promoter and intron-1 polymorphisms and dementia risk in a cohort of elderly Finns-Helsinki Birth Cohort Study. Neurobiology of aging. vol 73. 2019-12-19. PMID:30293724. |
apoe ɛ4, rs405509, and rs440446 promoter and intron-1 polymorphisms and dementia risk in a cohort of elderly finns-helsinki birth cohort study. |
2019-12-19 |
2023-08-13 |
human |
| Ville Rantalainen, Jari Lahti, Eero Kajantie, Pentti Tienari, Johan G Eriksson, Katri Raikkone. APOE ɛ4, rs405509, and rs440446 promoter and intron-1 polymorphisms and dementia risk in a cohort of elderly Finns-Helsinki Birth Cohort Study. Neurobiology of aging. vol 73. 2019-12-19. PMID:30293724. |
we tested if the ε4 major isoform of the apoe gene and rs405509 and rs440446 promoter and intron-1 polymorphisms predicted risk of any dementia or alzheimer's disease with diagnoses derived from the hospital discharge and causes of death registers in 1453 participants of the helsinki birth cohort study. |
2019-12-19 |
2023-08-13 |
human |
| Ville Rantalainen, Jari Lahti, Eero Kajantie, Pentti Tienari, Johan G Eriksson, Katri Raikkone. APOE ɛ4, rs405509, and rs440446 promoter and intron-1 polymorphisms and dementia risk in a cohort of elderly Finns-Helsinki Birth Cohort Study. Neurobiology of aging. vol 73. 2019-12-19. PMID:30293724. |
apoe ε4 predicted higher risk of any dementia (hazard ratios >3.68; 95% confidence interval [ci] 1.76, 7.70) across all statistical models, and when adjusted for rs405509 and rs440446. |
2019-12-19 |
2023-08-13 |
human |
| Ville Rantalainen, Jari Lahti, Eero Kajantie, Pentti Tienari, Johan G Eriksson, Katri Raikkone. APOE ɛ4, rs405509, and rs440446 promoter and intron-1 polymorphisms and dementia risk in a cohort of elderly Finns-Helsinki Birth Cohort Study. Neurobiology of aging. vol 73. 2019-12-19. PMID:30293724. |
as rs405509 or rs440446 has been associated with nonpathological cognitive aging in this and other cohorts independent of the apoe major isoforms, these findings lend credence that apoe locus may be linked with dementia risk and nonpathological cognitive aging via separate mechanisms. |
2019-12-19 |
2023-08-13 |
human |
| Hee Jin Kim, Jong-Yun Park, Sang Won Seo, Young Hee Jung, Yeshin Kim, Hyemin Jang, Sung Tae Kim, Joon-Kyung Seong, Duk L N. Cortical atrophy pattern-based subtyping predicts prognosis of amnestic MCI: an individual-level analysis. Neurobiology of aging. vol 74. 2019-11-26. PMID:30415126. |
the pt subtype had higher prevalence of apoe ε4 carriers, amyloid pet positivity, and greater risk of dementia conversion than the min subtype. |
2019-11-26 |
2023-08-13 |
Not clear |
| Ruoyi Sun, Simin Yang, Bing Zheng, Jianping Liu, Xiaowei M. Apolipoprotein E Polymorphisms and Parkinson Disease With or Without Dementia: A Meta-Analysis Including 6453 Participants. Journal of geriatric psychiatry and neurology. vol 32. issue 1. 2019-11-26. PMID:30526202. |
a large number of case-control studies have investigated the association of apolipoprotein e ( apoe) polymorphisms with parkinson disease (pd) and parkinson disease dementia (pdd), with inconsistent results. |
2019-11-26 |
2023-08-13 |
human |
| Silvan Licher, Shahzad Ahmad, Hata Karamujić-Čomić, Trudy Voortman, Maarten J G Leening, M Arfan Ikram, M Kamran Ikra. Genetic predisposition, modifiable-risk-factor profile and long-term dementia risk in the general population. Nature medicine. vol 25. issue 9. 2019-11-12. PMID:31451782. |
the recognition of familial patterns of dementia has led to the discovery of genetic factors that have a role in the pathogenesis of dementia, including the apolipoprotein e (apoe) genotype and a large and still-growing number of genetic variants |
2019-11-12 |
2023-08-13 |
Not clear |
| M Clare O'Donoghue, Susannah E Murphy, Giovanna Zamboni, Anna C Nobre, Clare E Macka. APOE genotype and cognition in healthy individuals at risk of Alzheimer's disease: A review. Cortex; a journal devoted to the study of the nervous system and behavior. vol 104. 2019-10-17. PMID:29800787. |
in particular, it is challenging to separate whether cognitive deficits in apoe-ε4 carriers reflect the influence of prodromal dementia pathology ("prodromal hypothesis"), or a direct contribution of apoe genotype to individual differences ("phenotype hypothesis"). |
2019-10-17 |
2023-08-13 |
Not clear |
| M Clare O'Donoghue, Susannah E Murphy, Giovanna Zamboni, Anna C Nobre, Clare E Macka. APOE genotype and cognition in healthy individuals at risk of Alzheimer's disease: A review. Cortex; a journal devoted to the study of the nervous system and behavior. vol 104. 2019-10-17. PMID:29800787. |
these challenges have limited what can be learnt about the processes underlying cognitive ageing and dementia by studying the influence of apoe genotype on cognition. |
2019-10-17 |
2023-08-13 |
Not clear |
| Xuemei Ding, Magda Bucholc, Haiying Wang, David H Glass, Hui Wang, Dave H Clarke, Anthony John Bjourson, Le Roy C Dowey, Maurice O'Kane, Girijesh Prasad, Liam Maguire, KongFatt Wong-Li. A hybrid computational approach for efficient Alzheimer's disease classification based on heterogeneous data. Scientific reports. vol 8. issue 1. 2019-10-10. PMID:29950585. |
specifically, using clinical dementia rating as an index of ad severity, the most important indicators (mini-mental state examination, logical memory recall, grey matter and cerebrospinal volumes from mri and active voxels from pib-pet brain scans, apoe, and age) can be automatically identified from parallel data mining algorithms. |
2019-10-10 |
2023-08-13 |
Not clear |
| Christoforos Hadjichrysanthou, Kevin McRae-McKee, Stephanie Evans, Frank de Wolf, Roy M Anderso. Potential Factors Associated with Cognitive Improvement of Individuals Diagnosed with Mild Cognitive Impairment or Dementia in Longitudinal Studies. Journal of Alzheimer's disease : JAD. vol 66. issue 2. 2019-10-08. PMID:30320573. |
better cognitive function and in some cases the absence of apoe ɛ4 alleles are also significantly associated with transitions from types of dementia to less severe clinical states. |
2019-10-08 |
2023-08-13 |
Not clear |