| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaoqi Wang, Weijie Huang, Li Su, Yue Xing, Frank Jessen, Yu Sun, Ni Shu, Ying Ha. Neuroimaging advances regarding subjective cognitive decline in preclinical Alzheimer's disease. Molecular neurodegeneration. vol 15. issue 1. 2021-08-26. PMID:32962744. |
additionally, the interaction of scd with other risk factors for dementia due to ad, such as age and the apolipoprotein e (apoe) ɛ4 status, has also been described. |
2021-08-26 |
2023-08-13 |
Not clear |
| Michael Tran Duong, Ilya M Nasrallah, David A Wolk, Catherine C Y Chang, Ta-Yuan Chan. Cholesterol, Atherosclerosis, and APOE in Vascular Contributions to Cognitive Impairment and Dementia (VCID): Potential Mechanisms and Therapy. Frontiers in aging neuroscience. vol 13. 2021-08-14. PMID:33841127. |
cholesterol, atherosclerosis, and apoe in vascular contributions to cognitive impairment and dementia (vcid): potential mechanisms and therapy. |
2021-08-14 |
2023-08-13 |
Not clear |
| John L Robinson, Hayley Richardson, Sharon X Xie, EunRan Suh, Vivianna M Van Deerlin, Brian Alfaro, Nicholas Loh, Matias Porras-Paniagua, Jeffrey J Nirschl, David Wolk, Virginia M-Y Lee, Edward B Lee, John Q Trojanowsk. The development and convergence of co-pathologies in Alzheimer's disease. Brain : a journal of neurology. vol 144. issue 3. 2021-08-13. PMID:33449993. |
to investigate how plaques, tangles, age and apolipoprotein e ε4 (apoe ε4) interact with co-pathologies in alzheimer's disease, we analysed 522 participants ≥50 years of age with and without dementia from the center for neurodegenerative disease research (cndr) autopsy program and 1340 participants in the national alzheimer's coordinating center (nacc) database. |
2021-08-13 |
2023-08-13 |
human |
| Katherine J Bangen, Denis S Smirnov, Lisa Delano-Wood, Christina E Wierenga, Mark W Bondi, David P Salmon, Douglas Galask. Arterial stiffening acts synergistically with APOE genotype and AD biomarker status to influence memory in older adults without dementia. Alzheimer's research & therapy. vol 13. issue 1. 2021-08-13. PMID:34210365. |
arterial stiffening acts synergistically with apoe genotype and ad biomarker status to influence memory in older adults without dementia. |
2021-08-13 |
2023-08-13 |
Not clear |
| Alexandre Bejanin, Maria Florencia Iulita, Eduard Vilaplana, Maria Carmona-Iragui, Bessy Benejam, Laura Videla, Isabel Barroeta, Susana Fernandez, Miren Altuna, Jordi Pegueroles, Victor Montal, Silvia Valldeneu, Sandra Giménez, Sofía González-Ortiz, Laia Muñoz, Concepción Padilla, Mateus Rozalem Aranha, Teresa Estellés, Ignacio Illán-Gala, Olivia Belbin, Valle Camacho, Liam Reese Wilson, Tiina Annus, Ricardo S Osorio, Sebastián Videla, Sylvain Lehmann, Anthony J Holland, Henrik Zetterberg, Kaj Blennow, Daniel Alcolea, Jordi Clarimon, Shahid H Zaman, Rafael Blesa, Alberto Lleó, Juan Forte. Association of Apolipoprotein E ɛ4 Allele With Clinical and Multimodal Biomarker Changes of Alzheimer Disease in Adults With Down Syndrome. JAMA neurology. vol 78. issue 8. 2021-08-13. PMID:34228042. |
previous studies have suggested that the apoe ɛ4 allele plays a role in the risk and age at onset of dementia in ds; however, data on in vivo biomarkers remain scarce. |
2021-08-13 |
2023-08-13 |
Not clear |
| Jenna Najar, Sven J van der Lee, Erik Joas, Hanna Wetterberg, John Hardy, Rita Guerreiro, Jose Bras, Margda Waern, Silke Kern, Henrik Zetterberg, Kaj Blennow, Ingmar Skoog, Anna Zettergre. Polygenic risk scores for Alzheimer's disease are related to dementia risk in APOE ɛ4 negatives. Alzheimer's & dementia (Amsterdam, Netherlands). vol 13. issue 1. 2021-08-06. PMID:33532541. |
polygenic risk scores for alzheimer's disease are related to dementia risk in apoe ɛ4 negatives. |
2021-08-06 |
2023-08-13 |
Not clear |
| Xiaowei Ma, Jun Ma, Ruiyun Guo, Juan Du, Baofeng Feng, Xin Liu, Xiaofeng Du, Zhenhuan Ma, Huixian Cu. Blood-derived integration-free induced pluripotent stem cells (iPSCs) from one 53-years-old male donor with APOE-ε4/ε4 genotype. Stem cell research. vol 54. 2021-08-05. PMID:34218115. |
apolipoprotein e ε4 allele (apoe4) is a minor allele of the apoe gene associated with a higher risk for alzheimer's disease (ad) and vascular dementia (vd). |
2021-08-05 |
2023-08-13 |
Not clear |
| Megan C Bakeberg, Anastazja M Gorecki, Abigail L Pfaff, Madison E Hoes, Sulev Kõks, P Anthony Akkari, Frank L Mastaglia, Ryan S Anderto. TOMM40 '523' poly-T repeat length is a determinant of longitudinal cognitive decline in Parkinson's disease. NPJ Parkinson's disease. vol 7. issue 1. 2021-07-24. PMID:34234128. |
however, in apoe ε3/ε3 carriers, who accounted for ~60% of the whole cohort, carriage of shorter '523' alleles was associated with more severe cognitive decline in both sexes, while carriage of the longer alleles in females were associated with better preservation of global cognition and a number of cognitive sub-domains, and with a delay in progression to dementia. |
2021-07-24 |
2023-08-13 |
Not clear |
| Megan C Bakeberg, Anastazja M Gorecki, Abigail L Pfaff, Madison E Hoes, Sulev Kõks, P Anthony Akkari, Frank L Mastaglia, Ryan S Anderto. TOMM40 '523' poly-T repeat length is a determinant of longitudinal cognitive decline in Parkinson's disease. NPJ Parkinson's disease. vol 7. issue 1. 2021-07-24. PMID:34234128. |
the findings indicate that when taken in conjunction with the apoe genotype, tomm40 '523' allele length is a significant independent determinant and marker for the trajectory of cognitive decline and risk of dementia in pd. |
2021-07-24 |
2023-08-13 |
Not clear |
| Sevilay Tokgöz, Jurgen A H R Claasse. Exercise as Potential Therapeutic Target to Modulate Alzheimer's Disease Pathology in APOE ε4 Carriers: A Systematic Review. Cardiology and therapy. vol 10. issue 1. 2021-07-22. PMID:33403644. |
this review focuses on the effect of exercise on cognitive function, dementia risk, amyloid-β (aβ) metabolism, lipid metabolism, neuroinflammation, neurotrophic factors and vascularization in apoe ε4 carriers. |
2021-07-22 |
2023-08-13 |
Not clear |
| Knut Hestad, Knut Engedal, Peter Horndalsveen, Bjørn Heine Stran. Cognition in Patients With Memory Difficulties and Dementia Relative to APOE e4 Status. Frontiers in psychology. vol 12. 2021-07-02. PMID:34194377. |
cognition in patients with memory difficulties and dementia relative to apoe e4 status. |
2021-07-02 |
2023-08-13 |
Not clear |
| Moeen Riaz, Aamira Huq, Joanne Ryan, Suzanne G Orchard, Jane Tiller, Jessica Lockery, Robyn L Woods, Rory Wolfe, Alan E Renton, Alison M Goate, Robert Sebra, Eric Schadt, Amy Brodtmann, Raj C Shah, Elsdon Storey, Anne M Murray, John J McNeil, Paul Lacaz. Effect of APOE and a polygenic risk score on incident dementia and cognitive decline in a healthy older population. Aging cell. vol 20. issue 6. 2021-06-27. PMID:34041846. |
effect of apoe and a polygenic risk score on incident dementia and cognitive decline in a healthy older population. |
2021-06-27 |
2023-08-13 |
human |
| Moeen Riaz, Aamira Huq, Joanne Ryan, Suzanne G Orchard, Jane Tiller, Jessica Lockery, Robyn L Woods, Rory Wolfe, Alan E Renton, Alison M Goate, Robert Sebra, Eric Schadt, Amy Brodtmann, Raj C Shah, Elsdon Storey, Anne M Murray, John J McNeil, Paul Lacaz. Effect of APOE and a polygenic risk score on incident dementia and cognitive decline in a healthy older population. Aging cell. vol 20. issue 6. 2021-06-27. PMID:34041846. |
we studied cumulative incidence of dementia and cognitive decline, stratified by apoe genotypes and polygenic risk score (prs) tertiles, in 12,978 participants of the aspirin in reducing events in the elderly (aspree) trial. |
2021-06-27 |
2023-08-13 |
human |
| Moeen Riaz, Aamira Huq, Joanne Ryan, Suzanne G Orchard, Jane Tiller, Jessica Lockery, Robyn L Woods, Rory Wolfe, Alan E Renton, Alison M Goate, Robert Sebra, Eric Schadt, Amy Brodtmann, Raj C Shah, Elsdon Storey, Anne M Murray, John J McNeil, Paul Lacaz. Effect of APOE and a polygenic risk score on incident dementia and cognitive decline in a healthy older population. Aging cell. vol 20. issue 6. 2021-06-27. PMID:34041846. |
cumulative incidence for all-cause dementia and cognitive decline was calculated with mortality as a competing event, stratified by apoe genotypes and tertiles of a prs based on 23 common non-apoe variants. |
2021-06-27 |
2023-08-13 |
human |
| Moeen Riaz, Aamira Huq, Joanne Ryan, Suzanne G Orchard, Jane Tiller, Jessica Lockery, Robyn L Woods, Rory Wolfe, Alan E Renton, Alison M Goate, Robert Sebra, Eric Schadt, Amy Brodtmann, Raj C Shah, Elsdon Storey, Anne M Murray, John J McNeil, Paul Lacaz. Effect of APOE and a polygenic risk score on incident dementia and cognitive decline in a healthy older population. Aging cell. vol 20. issue 6. 2021-06-27. PMID:34041846. |
cumulative incidence of dementia to age 85 years was 7.4% in all participants, 12.6% in apoe ε3/ε4 and 26.6% in ε4/ε4. |
2021-06-27 |
2023-08-13 |
human |
| Moeen Riaz, Aamira Huq, Joanne Ryan, Suzanne G Orchard, Jane Tiller, Jessica Lockery, Robyn L Woods, Rory Wolfe, Alan E Renton, Alison M Goate, Robert Sebra, Eric Schadt, Amy Brodtmann, Raj C Shah, Elsdon Storey, Anne M Murray, John J McNeil, Paul Lacaz. Effect of APOE and a polygenic risk score on incident dementia and cognitive decline in a healthy older population. Aging cell. vol 20. issue 6. 2021-06-27. PMID:34041846. |
apoe ε4 heterozygosity/homozygosity was associated with a 2.5/6.3-fold increased dementia risk and 1.4/1.8-fold cognitive decline risk, versus ε3/ε3 (p < 0.001 for both). |
2021-06-27 |
2023-08-13 |
human |
| Moeen Riaz, Aamira Huq, Joanne Ryan, Suzanne G Orchard, Jane Tiller, Jessica Lockery, Robyn L Woods, Rory Wolfe, Alan E Renton, Alison M Goate, Robert Sebra, Eric Schadt, Amy Brodtmann, Raj C Shah, Elsdon Storey, Anne M Murray, John J McNeil, Paul Lacaz. Effect of APOE and a polygenic risk score on incident dementia and cognitive decline in a healthy older population. Aging cell. vol 20. issue 6. 2021-06-27. PMID:34041846. |
incidence of dementia among healthy older individuals is low across all genotypes; however, apoe ε4 and high prs increase relative risk. |
2021-06-27 |
2023-08-13 |
human |
| Elles Konijnenberg, Betty M Tijms, Johan Gobom, Valerija Dobricic, Isabelle Bos, Stephanie Vos, Magda Tsolaki, Frans Verhey, Julius Popp, Pablo Martinez-Lage, Rik Vandenberghe, Alberto Lleó, Lutz Frölich, Simon Lovestone, Johannes Streffer, Lars Bertram, Kaj Blennow, Charlotte E Teunissen, Robert Veerhuis, August B Smit, Philip Scheltens, Henrik Zetterberg, Pieter Jelle Visse. APOE ε4 genotype-dependent cerebrospinal fluid proteomic signatures in Alzheimer's disease. Alzheimer's research & therapy. vol 12. issue 1. 2021-06-24. PMID:32460813. |
the exact pathophysiology leading to dementia is still uncertain, but the apolipoprotein e (apoe) ε4 genotype plays a major role. |
2021-06-24 |
2023-08-13 |
Not clear |
| Amin Gharbi-Meliani, Aline Dugravot, Séverine Sabia, Melina Regy, Aurore Fayosse, Alexis Schnitzler, Mika Kivimäki, Archana Singh-Manoux, Julien Dumurgie. The association of APOE ε4 with cognitive function over the adult life course and incidence of dementia: 20 years follow-up of the Whitehall II study. Alzheimer's research & therapy. vol 13. issue 1. 2021-06-24. PMID:33397450. |
the association of apoe ε4 with cognitive function over the adult life course and incidence of dementia: 20 years follow-up of the whitehall ii study. |
2021-06-24 |
2023-08-13 |
Not clear |
| Nian Xiong, Martin R Schiller, Jingwen Li, Xiaowu Chen, Zhicheng Li. Severe COVID-19 in Alzheimer's disease: APOE4's fault again? Alzheimer's research & therapy. vol 13. issue 1. 2021-06-24. PMID:34118974. |
at a cellular level, the risk isoform apoe4 confers high infectivity by the underlying coronavirus sars-cov-2; at a genetic level, apoe4 is associated with severe covid-19; at a pathway level, networking connects apoe with covid-19 risk factors such as ace2, tmprss2, nrp1, and lztfl1; at a behavioral level, apoe4-associated dementia may increase the exposure to coronavirus infection which causes covid-19. |
2021-06-24 |
2023-08-13 |
Not clear |