| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sevilay Tokgöz, Jurgen A H R Claasse. Exercise as Potential Therapeutic Target to Modulate Alzheimer's Disease Pathology in APOE ε4 Carriers: A Systematic Review. Cardiology and therapy. vol 10. issue 1. 2021-07-22. PMID:33403644. |
this review focuses on the effect of exercise on cognitive function, dementia risk, amyloid-β (aβ) metabolism, lipid metabolism, neuroinflammation, neurotrophic factors and vascularization in apoe ε4 carriers. |
2021-07-22 |
2023-08-13 |
Not clear |
| Knut Hestad, Knut Engedal, Peter Horndalsveen, Bjørn Heine Stran. Cognition in Patients With Memory Difficulties and Dementia Relative to APOE e4 Status. Frontiers in psychology. vol 12. 2021-07-02. PMID:34194377. |
cognition in patients with memory difficulties and dementia relative to apoe e4 status. |
2021-07-02 |
2023-08-13 |
Not clear |
| Moeen Riaz, Aamira Huq, Joanne Ryan, Suzanne G Orchard, Jane Tiller, Jessica Lockery, Robyn L Woods, Rory Wolfe, Alan E Renton, Alison M Goate, Robert Sebra, Eric Schadt, Amy Brodtmann, Raj C Shah, Elsdon Storey, Anne M Murray, John J McNeil, Paul Lacaz. Effect of APOE and a polygenic risk score on incident dementia and cognitive decline in a healthy older population. Aging cell. vol 20. issue 6. 2021-06-27. PMID:34041846. |
effect of apoe and a polygenic risk score on incident dementia and cognitive decline in a healthy older population. |
2021-06-27 |
2023-08-13 |
human |
| Moeen Riaz, Aamira Huq, Joanne Ryan, Suzanne G Orchard, Jane Tiller, Jessica Lockery, Robyn L Woods, Rory Wolfe, Alan E Renton, Alison M Goate, Robert Sebra, Eric Schadt, Amy Brodtmann, Raj C Shah, Elsdon Storey, Anne M Murray, John J McNeil, Paul Lacaz. Effect of APOE and a polygenic risk score on incident dementia and cognitive decline in a healthy older population. Aging cell. vol 20. issue 6. 2021-06-27. PMID:34041846. |
we studied cumulative incidence of dementia and cognitive decline, stratified by apoe genotypes and polygenic risk score (prs) tertiles, in 12,978 participants of the aspirin in reducing events in the elderly (aspree) trial. |
2021-06-27 |
2023-08-13 |
human |
| Moeen Riaz, Aamira Huq, Joanne Ryan, Suzanne G Orchard, Jane Tiller, Jessica Lockery, Robyn L Woods, Rory Wolfe, Alan E Renton, Alison M Goate, Robert Sebra, Eric Schadt, Amy Brodtmann, Raj C Shah, Elsdon Storey, Anne M Murray, John J McNeil, Paul Lacaz. Effect of APOE and a polygenic risk score on incident dementia and cognitive decline in a healthy older population. Aging cell. vol 20. issue 6. 2021-06-27. PMID:34041846. |
cumulative incidence for all-cause dementia and cognitive decline was calculated with mortality as a competing event, stratified by apoe genotypes and tertiles of a prs based on 23 common non-apoe variants. |
2021-06-27 |
2023-08-13 |
human |
| Moeen Riaz, Aamira Huq, Joanne Ryan, Suzanne G Orchard, Jane Tiller, Jessica Lockery, Robyn L Woods, Rory Wolfe, Alan E Renton, Alison M Goate, Robert Sebra, Eric Schadt, Amy Brodtmann, Raj C Shah, Elsdon Storey, Anne M Murray, John J McNeil, Paul Lacaz. Effect of APOE and a polygenic risk score on incident dementia and cognitive decline in a healthy older population. Aging cell. vol 20. issue 6. 2021-06-27. PMID:34041846. |
cumulative incidence of dementia to age 85 years was 7.4% in all participants, 12.6% in apoe ε3/ε4 and 26.6% in ε4/ε4. |
2021-06-27 |
2023-08-13 |
human |
| Moeen Riaz, Aamira Huq, Joanne Ryan, Suzanne G Orchard, Jane Tiller, Jessica Lockery, Robyn L Woods, Rory Wolfe, Alan E Renton, Alison M Goate, Robert Sebra, Eric Schadt, Amy Brodtmann, Raj C Shah, Elsdon Storey, Anne M Murray, John J McNeil, Paul Lacaz. Effect of APOE and a polygenic risk score on incident dementia and cognitive decline in a healthy older population. Aging cell. vol 20. issue 6. 2021-06-27. PMID:34041846. |
apoe ε4 heterozygosity/homozygosity was associated with a 2.5/6.3-fold increased dementia risk and 1.4/1.8-fold cognitive decline risk, versus ε3/ε3 (p < 0.001 for both). |
2021-06-27 |
2023-08-13 |
human |
| Moeen Riaz, Aamira Huq, Joanne Ryan, Suzanne G Orchard, Jane Tiller, Jessica Lockery, Robyn L Woods, Rory Wolfe, Alan E Renton, Alison M Goate, Robert Sebra, Eric Schadt, Amy Brodtmann, Raj C Shah, Elsdon Storey, Anne M Murray, John J McNeil, Paul Lacaz. Effect of APOE and a polygenic risk score on incident dementia and cognitive decline in a healthy older population. Aging cell. vol 20. issue 6. 2021-06-27. PMID:34041846. |
incidence of dementia among healthy older individuals is low across all genotypes; however, apoe ε4 and high prs increase relative risk. |
2021-06-27 |
2023-08-13 |
human |
| Elles Konijnenberg, Betty M Tijms, Johan Gobom, Valerija Dobricic, Isabelle Bos, Stephanie Vos, Magda Tsolaki, Frans Verhey, Julius Popp, Pablo Martinez-Lage, Rik Vandenberghe, Alberto Lleó, Lutz Frölich, Simon Lovestone, Johannes Streffer, Lars Bertram, Kaj Blennow, Charlotte E Teunissen, Robert Veerhuis, August B Smit, Philip Scheltens, Henrik Zetterberg, Pieter Jelle Visse. APOE ε4 genotype-dependent cerebrospinal fluid proteomic signatures in Alzheimer's disease. Alzheimer's research & therapy. vol 12. issue 1. 2021-06-24. PMID:32460813. |
the exact pathophysiology leading to dementia is still uncertain, but the apolipoprotein e (apoe) ε4 genotype plays a major role. |
2021-06-24 |
2023-08-13 |
Not clear |
| Amin Gharbi-Meliani, Aline Dugravot, Séverine Sabia, Melina Regy, Aurore Fayosse, Alexis Schnitzler, Mika Kivimäki, Archana Singh-Manoux, Julien Dumurgie. The association of APOE ε4 with cognitive function over the adult life course and incidence of dementia: 20 years follow-up of the Whitehall II study. Alzheimer's research & therapy. vol 13. issue 1. 2021-06-24. PMID:33397450. |
the association of apoe ε4 with cognitive function over the adult life course and incidence of dementia: 20 years follow-up of the whitehall ii study. |
2021-06-24 |
2023-08-13 |
Not clear |
| Nian Xiong, Martin R Schiller, Jingwen Li, Xiaowu Chen, Zhicheng Li. Severe COVID-19 in Alzheimer's disease: APOE4's fault again? Alzheimer's research & therapy. vol 13. issue 1. 2021-06-24. PMID:34118974. |
at a cellular level, the risk isoform apoe4 confers high infectivity by the underlying coronavirus sars-cov-2; at a genetic level, apoe4 is associated with severe covid-19; at a pathway level, networking connects apoe with covid-19 risk factors such as ace2, tmprss2, nrp1, and lztfl1; at a behavioral level, apoe4-associated dementia may increase the exposure to coronavirus infection which causes covid-19. |
2021-06-24 |
2023-08-13 |
Not clear |
| Manja Koch, Steven T DeKosky, Matthew Goodman, Jiehuan Sun, Jeremy D Furtado, Annette L Fitzpatrick, Rachel H Mackey, Tianxi Cai, Oscar L Lopez, Lewis H Kuller, Kenneth J Mukamal, Majken K Jense. High density lipoprotein and its apolipoprotein-defined subspecies and risk of dementia. Journal of lipid research. vol 61. issue 3. 2021-06-03. PMID:31892526. |
the level of total apoa1 was not significantly related to dementia risk, regardless of the coexistence of apoc3, apoj, or apoe. |
2021-06-03 |
2023-08-13 |
human |
| Aladdin Riad, Zsofia Lengyel-Zhand, Chenbo Zeng, Chi-Chang Weng, Virginia M-Y Lee, John Q Trojanowski, Robert H Mac. The Sigma-2 Receptor/TMEM97, PGRMC1, and LDL Receptor Complex Are Responsible for the Cellular Uptake of Aβ42 and Its Protein Aggregates. Molecular neurobiology. vol 57. issue 9. 2021-06-03. PMID:32572762. |
these receptors are expressed in the nervous system where they have implications in neurodegenerative diseases such as alzheimer's disease (ad), where apoe is involved in neuronal uptake and accumulation of aβ42, eventually cascading into neurodegeneration, synaptic dysfunction, and ultimately, dementia. |
2021-06-03 |
2023-08-13 |
Not clear |
| Amy C Ferguson, Rachana Tank, Laura M Lyall, Joey Ward, Carlos Celis-Morales, Rona Strawbridge, Frederick Ho, Christopher D Whelan, Jason Gill, Paul Welsh, Jana J Anderson, Patrick B Mark, Daniel F Mackay, Daniel J Smith, Jill P Pell, Jonathan Cavanagh, Naveed Sattar, Donald M Lyal. Alzheimer's Disease Susceptibility Gene Apolipoprotein E (APOE) and Blood Biomarkers in UK Biobank (N = 395,769). Journal of Alzheimer's disease : JAD. vol 76. issue 4. 2021-06-03. PMID:32651323. |
investigating the potential influence of apolipoprotein e (apoe), a major genetic risk factor, on common blood biomarkers could provide a greater understanding of the mechanisms of ad and dementia risk. |
2021-06-03 |
2023-08-13 |
Not clear |
| Chris D Meleti. Alkyl-Acylglycerols and the Important Clinical Ramifications of Raising Plasmalogens in Dementia and Alzheimer's Disease. Integrative medicine (Encinitas, Calif.). vol 19. issue 3. 2021-06-02. PMID:33132773. |
furthermore, it has been recently reported that high blood plasmalogen levels neutralize the increased risk of dementia in persons who carry the apoe epsilon 4 allele, the most significant genetic risk factor for ad. |
2021-06-02 |
2023-08-13 |
human |
| Michal Prendecki, Marta Kowalska, Ewa Toton, Wojciech Kozubsk. Genetic Editing and Pharmacogenetics in Current And Future Therapy Of Neurocognitive Disorders. Current Alzheimer research. vol 17. issue 3. 2021-05-24. PMID:32321403. |
the most promising results have been demonstrated for apoe e4, dementia risk variant, bche-k, reduced butyrylcholinesterase activity variant, and cyp2d6 um, ultrarapid hepatic metabolism. |
2021-05-24 |
2023-08-13 |
Not clear |
| Meliha Karsak, Konstantin Glebov, Marina Scheffold, Thomas Bajaj, Amit Kawalia, Ilker Karaca, Sebastian Rading, Johannes Kornhuber, Oliver Peters, Monica Diez-Fairen, Lutz Frölich, Michael Hüll, Jens Wiltfang, Martin Scherer, Steffi Riedel-Heller, Anja Schneider, Michael T Heneka, Klaus Fliessbach, Ahmed Sharaf, Holger Thiele, Martina Lennarz, Frank Jessen, Wolfgang Maier, Christian Kubisch, Zoya Ignatova, Peter Nürnberg, Pau Pastor, Jochen Walter, Alfredo Ramire. A rare heterozygous TREM2 coding variant identified in familial clustering of dementia affects an intrinsically disordered protein region and function of TREM2. Human mutation. vol 41. issue 1. 2021-05-19. PMID:31464095. |
in a whole-exome sequencing study of a family with probable ad-type dementia without pathogenic variants in known autosomal dominant dementia disease genes and negative for the apolipoprotein e (apoe) ε4 allele, we identified an extremely rare trem2 coding variant, that is, a glycine-to-tryptophan substitution at amino acid position 145 (nm_018965.3:c.433g>t/p.[gly145trp]). |
2021-05-19 |
2023-08-13 |
Not clear |
| Janik Goltermann, Jonathan Repple, Ronny Redlich, Katharina Dohm, Claas Flint, Dominik Grotegerd, Lena Waltemate, Hannah Lemke, Stella Mercedes Fingas, Susanne Meinert, Verena Enneking, Tim Hahn, Jochen Bauer, Simon Schmitt, Tina Meller, Frederike Stein, Katharina Brosch, Olaf Steinsträter, Andreas Jansen, Axel Krug, Igor Nenadić, Bernhard T Baune, Marcella Rietschel, Stephanie Witt, Andreas J Forstner, Markus Nöthen, Andreas Johnen, Judith Alferink, Tilo Kircher, Udo Dannlowski, Nils Ope. Apolipoprotein E homozygous ε4 allele status: Effects on cortical structure and white matter integrity in a young to mid-age sample. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 46. 2021-05-03. PMID:33648793. |
apolipoprotein e (apoe) genotype is the strongest single gene predictor of alzheimer's disease (ad) and has been frequently associated with ad-related brain structural alterations before the onset of dementia. |
2021-05-03 |
2023-08-13 |
human |
| Martin Medrano, Gelanys Castro-Tejada, Rafael Lantigua, Gretel Silvestre, Sergio Diaz, Patricia Mota, Franck Diaz-Garell. Vascular mild cognitive impairment and its relationship to hemoglobin A1c levels and apolipoprotein E genotypes in the Dominican Republic. Dementia & neuropsychologia. vol 15. issue 1. 2021-04-29. PMID:33907599. |
understanding the interplay of cardiometabolic risk factors and apolipoprotein e (apoe) may direct us to a more personalized medicine and preventative care in mci and dementia. |
2021-04-29 |
2023-08-13 |
human |
| Francisca S Rodriguez, Susanne Roehr, Alexander Pabst, Luca Kleineidam, Angela Fuchs, Birgitt Wiese, Dagmar Lühmann, Christian Brettschneider, Steffen Wolfsgruber, Michael Pentzek, Hendrik van den Bussche, Hans-Helmut König, Siegfried Weyerer, Jochen Werle, Horst Bickel, Dagmar Weeg, Wolfgang Maier, Martin Scherer, Michael Wagner, Steffi G Riedel-Helle. Effects of APOE e4-allele and mental work demands on cognitive decline in old age: Results from the German Study on Ageing, Cognition, and Dementia in Primary Care Patients (AgeCoDe). International journal of geriatric psychiatry. vol 36. issue 1. 2021-04-23. PMID:32819031. |
effects of apoe e4-allele and mental work demands on cognitive decline in old age: results from the german study on ageing, cognition, and dementia in primary care patients (agecode). |
2021-04-23 |
2023-08-13 |
human |