| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Connor M Wander, Tamy Harumy Moraes Tsujimoto, John F Ervin, Chanung Wang, Spencer M Maranto, Vanya Bhat, Julian D Dallmeier, Shih-Hsiu Jerry Wang, Feng-Chang Lin, William K Scott, David M Holtzman, Todd J Cohe. Corpora amylacea are associated with tau burden and cognitive status in Alzheimer's disease. Acta neuropathologica communications. vol 10. issue 1. 2022-08-08. PMID:35941704. |
using a cohort of postmortem ad brain samples, we examined ca in cognitively normal and dementia patients across braak stages with varying apoe status. |
2022-08-08 |
2023-08-14 |
mouse |
| Jie Guo, Anna Marseglia, Ying Shang, Abigail Dove, Giulia Grande, Laura Fratiglioni, Weili X. Association between late-life weight change and dementia: A population-based cohort study. The journals of gerontology. Series A, Biological sciences and medical sciences. 2022-08-03. PMID:35921193. |
we aimed to investigate the associations of body mass index (bmi) and weight changes with dementia and to explore the role of apoe ɛ4 in these associations. |
2022-08-03 |
2023-08-14 |
Not clear |
| Monika Kukuruzović, Vanja Bašić Kes, Maša Malenic. ASSOCIATION BETWEEN APOLIPOPROTEIN E POLYMORPHISMS AND EPILEPSY IN CHILDREN. Acta clinica Croatica. vol 60. issue 4. 2022-06-23. PMID:35734486. |
apolipoprotein e (apoe) plays an important role in lipid metabolism and is a proven risk factor for development of dementia and other neurodegenerative diseases. |
2022-06-23 |
2023-08-14 |
Not clear |
| Jing Wang, Tingting Sun, Ying Zhang, Xin Yu, Huali Wan. Distinct Effects of the Apolipoprotein E ε4 Genotype on Associations Between Delayed Recall Performance and Resting-State Electroencephalography Theta Power in Elderly People Without Dementia. Frontiers in aging neuroscience. vol 14. 2022-06-13. PMID:35693343. |
therefore, the present study primarily aimed to verify the role of resting theta rhythm in delayed recall deficits, and further explore the effects of the apoe genotype on the associations between the resting theta power and delayed recall performance in the elderly individuals without dementia. |
2022-06-13 |
2023-08-14 |
Not clear |
| Thitipon Yaowaluk, Vorapun Senanarong, Chanin Limwongse, Rasda Boonprasert, Duangkamon Bunditvorapoom, Supannee Kaewsutthi, Pornpimol Kijsanayoti. Association study identifies genetic determinants and non-genetic factors on steady-state plasma and therapeutic outcome of galantamine in mixed dementia. European journal of clinical pharmacology. 2022-05-28. PMID:35633386. |
this study aimed to evaluate the influence of genetic polymorphisms of drug-metabolizing enzyme genes, transporter gene, pathological gene (apoe), and non-genetic factors on therapeutic outcomes as well as steady-state plasma concentrations (cpss) of galantamine in thai patients with mixed dementia. |
2022-05-28 |
2023-08-13 |
Not clear |
| F M Sacks, J D Furtado, M K Jense. Protein-based HDL subspecies: Rationale and association with cardiovascular disease, diabetes, stroke, and dementia. Biochimica et biophysica acta. Molecular and cell biology of lipids. 2022-05-23. PMID:35605828. |
hdl that contains apoe and apoe itself are associated with lower risk of dementia. |
2022-05-23 |
2023-08-13 |
Not clear |
| Song-Yi Park, Veronica Wendy Setiawan, Lon R White, Anna H Wu, Iona Cheng, Christopher A Haiman, Lynne R Wilkens, Loїc Le Marchand, Unhee Li. Modifying effects of race and ethnicity and APOE on the association of physical activity with risk of Alzheimer's disease and related dementias. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022-04-27. PMID:35476309. |
modifying effects of race and ethnicity and apoe on the association of physical activity with risk of alzheimer's disease and related dementias. |
2022-04-27 |
2023-08-13 |
Not clear |
| Seung-Hyup Han, Dong-Hee Noh, Eun-Ju Jo, Kyung-Yoon Ka. Effects of Apolipoprotein E ɛ4 and Risk Factors on Domains of Cognition in Mild Cognitive Impairment and Dementia. Journal of Alzheimer's disease : JAD. 2022-04-25. PMID:35466935. |
the apolipoprotein e (apoe) gene is the most potent genetic risk factor for dementia. |
2022-04-25 |
2023-08-13 |
Not clear |
| Wanrui Wei, Kairong Wang, Jiyuan Shi, Zheng L. The Relationship Between Sleep Disturbance and Apolipoprotein E ε4 in Adults With Mild Cognitive Impairment and Alzheimer's Disease Dementia: An Integrative Review. Biological research for nursing. 2022-04-19. PMID:35439097. |
apolipoprotein e ε4 (apoe ε4) was shown to be a risk factor for mild cognitive impairment (mci) and alzheimer's disease (ad) dementia. |
2022-04-19 |
2023-08-13 |
Not clear |
| Thomas J Littlejohns, Jennifer A Collister, Xiaonan Liu, Lei Clifton, Neo M Tapela, David J Hunte. Hypertension, a dementia polygenic risk score, APOE genotype, and incident dementia. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022-04-19. PMID:35439339. |
hypertension, a dementia polygenic risk score, apoe genotype, and incident dementia. |
2022-04-19 |
2023-08-13 |
Not clear |
| Karri Kaivola, Zalak Shah, Ruth Chia, Sonja W Schol. Genetic evaluation of dementia with Lewy bodies implicates distinct disease subgroups. Brain : a journal of neurology. 2022-04-05. PMID:35381062. |
the apoe locus is strongly associated with risk for developing alzheimer's disease and dementia with lewy bodies. |
2022-04-05 |
2023-08-13 |
Not clear |
| Karri Kaivola, Zalak Shah, Ruth Chia, Sonja W Schol. Genetic evaluation of dementia with Lewy bodies implicates distinct disease subgroups. Brain : a journal of neurology. 2022-04-05. PMID:35381062. |
using an apoe-stratified genome-wide association study approach, we found that gba is associated with risk for dementia with lewy bodies in patients without apoe ε4 (p = 6.58 × 10-9, or = 3.41, 95% ci = 2.25-5.17), but not with dementia with lewy bodies with apoe ε4 (p = 0.034, or = 1.87, 95%, 95% ci = 1.05-3.37). |
2022-04-05 |
2023-08-13 |
Not clear |
| Karri Kaivola, Zalak Shah, Ruth Chia, Sonja W Schol. Genetic evaluation of dementia with Lewy bodies implicates distinct disease subgroups. Brain : a journal of neurology. 2022-04-05. PMID:35381062. |
our examination found that apoe ε4 was associated with dementia with lewy bodies + alzheimer's disease (p = 1.29 × 10-32, or = 4.25, 95% ci = 3.35-5.39) and dementia with lewy bodies + intermediate alzheimer's disease (p = 0.0011, or = 2.31, 95% ci = 1.40-3.83), but not with pure dementia with lewy bodies (p = 0.31, or = 0.75, 95% ci = 0.43-1.30). |
2022-04-05 |
2023-08-13 |
Not clear |
| Karri Kaivola, Zalak Shah, Ruth Chia, Sonja W Schol. Genetic evaluation of dementia with Lewy bodies implicates distinct disease subgroups. Brain : a journal of neurology. 2022-04-05. PMID:35381062. |
in conclusion, although deep clinical data were not available for these samples, our findings do not support the notion that apoe ε4 is an independent driver of α-synuclein pathology in pure dementia with lewy bodies, but rather implicate gba as the main risk gene for the pure dementia with lewy bodies subgroup. |
2022-04-05 |
2023-08-13 |
Not clear |
| Matthew D Cykowski, Anithachristy S Arumanayagam, Suzanne Z Powell, Andreana L Rivera, Erin L Abner, Gustavo C Roman, Joseph C Masdeu, Peter T Nelso. Patterns of amygdala region pathology in LATE-NC: subtypes that differ with regard to TDP-43 histopathology, genetic risk factors, and comorbid pathologies. Acta neuropathologica. 2022-04-02. PMID:35366087. |
the most common patterns were: pattern 1, with lamina ii tdp-43 + processes and preinclusion pathology in cortices of the amygdala region, and frequent late-nc stage 3 with hs; pattern 2, previously described as type-β, with neurofibrillary tangle-like tdp-43 neuronal cytoplasmic inclusions (ncis), high alzheimer's disease neuropathologic change (adnc), frequent apoe ε4, and usually late-nc stage 2; pattern 3, with round ncis and thick neurites in amygdala, younger age at death, and often comorbid lewy body disease; and pattern 4 (the most common pattern), with tortuous tdp-43 processes in subpial and wm regions, low adnc, rare hs, and lower dementia probability. |
2022-04-02 |
2023-08-13 |
human |
| Jonathan Blackman, Seth Love, Lindsey Sinclair, Richard Cain, Elizabeth Coulthar. APOE ε4, Alzheimer's disease neuropathology and sleep disturbance, in individuals with and without dementia. Alzheimer's research & therapy. vol 14. issue 1. 2022-03-31. PMID:35354468. |
apoe ε4, alzheimer's disease neuropathology and sleep disturbance, in individuals with and without dementia. |
2022-03-31 |
2023-08-13 |
Not clear |
| Clifford R Jack, Terry M Therneau, Emily S Lundt, Heather J Wiste, Michelle M Mielke, David S Knopman, Jonathan Graff-Radford, Val J Lowe, Prashanthi Vemuri, Christopher G Schwarz, Matthew L Senjem, Jeffrey L Gunter, Ronald C Peterse. Long-term associations between amyloid positron emission tomography, sex, apolipoprotein E and incident dementia and mortality among individuals without dementia: hazard ratios and absolute risk. Brain communications. vol 4. issue 2. 2022-03-21. PMID:35310829. |
the objective of this study was to examine long-term associations between amyloid pet, apoe ɛ4, sex, education and cardiovascular/metabolic conditions, and hazard and absolute risk of dementia and mortality in individuals without dementia at enrolment. |
2022-03-21 |
2023-08-13 |
human |
| Clifford R Jack, Terry M Therneau, Emily S Lundt, Heather J Wiste, Michelle M Mielke, David S Knopman, Jonathan Graff-Radford, Val J Lowe, Prashanthi Vemuri, Christopher G Schwarz, Matthew L Senjem, Jeffrey L Gunter, Ronald C Peterse. Long-term associations between amyloid positron emission tomography, sex, apolipoprotein E and incident dementia and mortality among individuals without dementia: hazard ratios and absolute risk. Brain communications. vol 4. issue 2. 2022-03-21. PMID:35310829. |
high versus normal amyloid (hazard ratio 2.11, 95% confidence interval 1.43-2.79), apoe ɛ4 (women: hazard ratio 2.24, 95% confidence interval 1.80-2.77; men: hazard ratio 1.37, 95% confidence interval 1.09-1.71), older age and two additional cardiovascular/metabolic conditions (hazard ratio 1.37, 95% confidence interval 1.22-1.53) were associated with the increased hazard of dementia (all |
2022-03-21 |
2023-08-13 |
human |
| Hao Ma, Tao Zhou, Xiang Li, Demetrius Maraganore, Yoriko Heianza, Lu Q. Early-life educational attainment, APOE ε4 alleles, and incident dementia risk in late life. GeroScience. 2022-03-20. PMID:35306636. |
early-life educational attainment, apoe ε4 alleles, and incident dementia risk in late life. |
2022-03-20 |
2023-08-13 |
human |
| Hao Ma, Tao Zhou, Xiang Li, Demetrius Maraganore, Yoriko Heianza, Lu Q. Early-life educational attainment, APOE ε4 alleles, and incident dementia risk in late life. GeroScience. 2022-03-20. PMID:35306636. |
after adjustment for covariates, we found that low education attainment was significantly associated with higher dementia risk in the apoe ε4 carriers, and such relation appeared to be stronger with the increasing number of ε4 alleles. |
2022-03-20 |
2023-08-13 |
human |