| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Laura Perna, Ute Mons, Hannah Stocker, Léon Beyer, Konrad Beyreuther, Kira Trares, Bernd Holleczek, Ben Schöttker, Robert Perneczky, Klaus Gerwert, Hermann Brenne. High cholesterol levels change the association of biomarkers of neurodegenerative diseases with dementia risk: Findings from a population-based cohort. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-01-13. PMID:36638231. |
this study assessed whether in a population with comorbidity of neurodegenerative and cerebrovascular disease (mixed pathology) the association of glial fibrillary acidic protein (gfap), neurofilament light chain (nfl), and phosphorylated tau181 (p-tau181) with dementia risk varied depending on levels of total cholesterol and apolipoprotein e (apoe) ε4 genotype. |
2023-01-13 |
2023-08-14 |
Not clear |
| Panpan He, Chun Zhou, Ziliang Ye, Mengyi Liu, Yuanyuan Zhang, Qimeng Wu, Yanjun Zhang, Sisi Yang, Gan Xiaoqin, Xianhui Qi. Walking pace, handgrip strength, age, APOE genotypes, and new-onset dementia: the UK Biobank prospective cohort study. Alzheimer's research & therapy. vol 15. issue 1. 2023-01-09. PMID:36624486. |
walking pace, handgrip strength, age, apoe genotypes, and new-onset dementia: the uk biobank prospective cohort study. |
2023-01-09 |
2023-08-14 |
Not clear |
| Panpan He, Chun Zhou, Ziliang Ye, Mengyi Liu, Yuanyuan Zhang, Qimeng Wu, Yanjun Zhang, Sisi Yang, Gan Xiaoqin, Xianhui Qi. Walking pace, handgrip strength, age, APOE genotypes, and new-onset dementia: the UK Biobank prospective cohort study. Alzheimer's research & therapy. vol 15. issue 1. 2023-01-09. PMID:36624486. |
the independent and additive associations of walking pace and grip strength on dementia risk and the potential modifying effects of age, apoe phenotypes, and other dementia risk factors on the walking pace and dementia relationships demand further clarification. |
2023-01-09 |
2023-08-14 |
Not clear |
| Panpan He, Chun Zhou, Ziliang Ye, Mengyi Liu, Yuanyuan Zhang, Qimeng Wu, Yanjun Zhang, Sisi Yang, Gan Xiaoqin, Xianhui Qi. Walking pace, handgrip strength, age, APOE genotypes, and new-onset dementia: the UK Biobank prospective cohort study. Alzheimer's research & therapy. vol 15. issue 1. 2023-01-09. PMID:36624486. |
we aimed to investigate the independent and additive relationships of walking pace and handgrip strength on the risk of new-onset dementia and examine the potentially modifying effects of age, apoe phenotypes, lifestyle factors, and family history of dementia in the relationships. |
2023-01-09 |
2023-08-14 |
Not clear |
| Jia-Yao Liu, Ling-Zhi Ma, Jun Wang, Xin-Jing Cui, Ze-Hu Sheng, Yan Fu, Meng Li, Ya-Nan Ou, Jin-Tai Yu, Lan Tan, Yan Lia. Age-Related Association Between APOE ɛ4 and Cognitive Progression in de novo Parkinson's Disease. Journal of Alzheimer's disease : JAD. 2022-12-24. PMID:36565124. |
apoe ɛ4 genotype was correlated with exacerbation of pathology and higher risk of dementia in parkinson's disease (pd). |
2022-12-24 |
2023-08-14 |
Not clear |
| Emma Nichols, Adam M Brickman, Kaitlin B Casaletto, Kristen Dams-O'Connor, Kristen M George, Raj G Kumar, Priya Palta, Jennifer S Rabin, Claudia L Satizabal, Julie Schneider, Judy Pa, Renaud La Joi. AD and non-AD mediators of the pathway between the APOE genotype and cognition. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022-12-14. PMID:36516004. |
the apolipoprotein e (apoe) genotype is a driver of cognitive decline and dementia. |
2022-12-14 |
2023-08-14 |
Not clear |
| Chloé Savignac, Sylvia Villeneuve, AmanPreet Badhwar, Karin Saltoun, Kimia Shafighi, Chris Zajner, Vaibhav Sharma, Sarah A Gagliano Taliun, Sali Farhan, Judes Poirier, Danilo Bzdo. APOE alleles are associated with sex-specific structural differences in brain regions affected in Alzheimer's disease and related dementia. PLoS biology. vol 20. issue 12. 2022-12-13. PMID:36512526. |
apoe alleles are associated with sex-specific structural differences in brain regions affected in alzheimer's disease and related dementia. |
2022-12-13 |
2023-08-14 |
human |
| Anllely Fernandez, Maria-Teresa Gomez, Ruben Vida. Lack of ApoE inhibits ADan amyloidosis in a mouse model of Familial Danish Dementia. The Journal of biological chemistry. 2022-11-27. PMID:36436561. |
lack of apoe inhibits adan amyloidosis in a mouse model of familial danish dementia. |
2022-11-27 |
2023-08-14 |
mouse |
| Ana C Valencia-Olvera, Juan Maldonado Weng, Amy Christensen, Mary Jo LaDu, Christian J Pik. Role of estrogen in women's Alzheimer's disease risk as modified by APOE. Journal of neuroendocrinology. 2022-11-24. PMID:36420620. |
in the brain, dementia risk is greater in apoe4 carriers, and the impacts of hormone therapy on cognitive decline and dementia risk vary according to both outcome measure and apoe genotype. |
2022-11-24 |
2023-08-14 |
Not clear |
| Raquel Real, Alejandro Martinez-Carrasco, Regina H Reynolds, Michael A Lawton, Manuela M X Tan, Maryam Shoai, Jean-Christophe Corvol, Mina Ryten, Catherine Bresner, Leon Hubbard, Alexis Brice, Suzanne Lesage, Johann Faouzi, Alexis Elbaz, Fanny Artaud, Nigel Williams, Michele T M Hu, Yoav Ben-Shlomo, Donald G Grosset, John Hardy, Huw R Morri. Association between the LRP1B and APOE loci in the development of Parkinson's disease dementia. Brain : a journal of neurology. 2022-11-09. PMID:36348503. |
association between the lrp1b and apoe loci in the development of parkinson's disease dementia. |
2022-11-09 |
2023-08-14 |
Not clear |
| Raquel Real, Alejandro Martinez-Carrasco, Regina H Reynolds, Michael A Lawton, Manuela M X Tan, Maryam Shoai, Jean-Christophe Corvol, Mina Ryten, Catherine Bresner, Leon Hubbard, Alexis Brice, Suzanne Lesage, Johann Faouzi, Alexis Elbaz, Fanny Artaud, Nigel Williams, Michele T M Hu, Yoav Ben-Shlomo, Donald G Grosset, John Hardy, Huw R Morri. Association between the LRP1B and APOE loci in the development of Parkinson's disease dementia. Brain : a journal of neurology. 2022-11-09. PMID:36348503. |
we have identified the apoe ε4 allele as a major risk factor for the conversion to parkinson's disease dementia [hazards ratio = 2.41 (1.94-3.00), p = 2.32 × 10-15], as well as a new locus within the apoe and app receptor lrp1b gene [hazards ratio = 3.23 (2.17-4.81), p = 7.07 × 10-09]. |
2022-11-09 |
2023-08-14 |
Not clear |
| Yanchun Chen, Yuan Zhang, Shu Li, Lihui Zhou, Huiping Li, Dun Li, Yaogang Wang, Hongxi Yan. Cardiometabolic diseases, polygenic risk score, APOE genotype, and risk of incident dementia: A population-based prospective cohort study. Archives of gerontology and geriatrics. vol 105. 2022-11-08. PMID:36347157. |
cardiometabolic diseases, polygenic risk score, apoe genotype, and risk of incident dementia: a population-based prospective cohort study. |
2022-11-08 |
2023-08-14 |
human |
| Yanchun Chen, Yuan Zhang, Shu Li, Lihui Zhou, Huiping Li, Dun Li, Yaogang Wang, Hongxi Yan. Cardiometabolic diseases, polygenic risk score, APOE genotype, and risk of incident dementia: A population-based prospective cohort study. Archives of gerontology and geriatrics. vol 105. 2022-11-08. PMID:36347157. |
genetic risk for dementia including apoe ε4 status and polygenic risk score (prs) categorized as low, intermediate, and high. |
2022-11-08 |
2023-08-14 |
human |
| Yanchun Chen, Yuan Zhang, Shu Li, Lihui Zhou, Huiping Li, Dun Li, Yaogang Wang, Hongxi Yan. Cardiometabolic diseases, polygenic risk score, APOE genotype, and risk of incident dementia: A population-based prospective cohort study. Archives of gerontology and geriatrics. vol 105. 2022-11-08. PMID:36347157. |
in joint effect analyses, compared to no cmds and apoe ε4 non-carriers, the hrs (95% cis) of dementia were 3.53 (3.31-3.76)/2.06 (1.89-2.23) in participants with only apoe ε4 carriers and cmds, and 5.06 (4.64-5.53) for those with apoe ε4 carriers plus cmds. |
2022-11-08 |
2023-08-14 |
human |
| Jody S Nicholson, Elizabeth M Hudak, Christine B Phillips, Marianne Chanti-Ketterl, Jennifer L O'Brien, Lesley A Ross, Jennifer J Lister, James R Burke, Guy Potter, Brenda L Plassman, Adam J Woods, Jeffrey Krischer, Jerri D Edward. The Preventing Alzheimer's with Cognitive Training (PACT) randomized clinical trial. Contemporary clinical trials. vol 123. 2022-11-07. PMID:36341846. |
the primary goal is to test the effectiveness of ufovt to reduce incidence of clinically defined mild cognitive impairment (mci) or dementia with a secondary objective to examine if effects are moderated by plasma β-amyloid level or apolipoprotein e e4 (apoe e4) allele status. |
2022-11-07 |
2023-08-14 |
Not clear |
| Kanika Mehta, Mohammadreza Mohebbi, Julie A Pasco, Lana J Williams, Ken Walder, Boon Lung Ng, Veer Bala Gupt. Genetic polymorphism in BIN1 rather than APOE is associated with poor recognition memory among men without dementia. Scientific reports. vol 12. issue 1. 2022-10-25. PMID:36280690. |
genetic polymorphism in bin1 rather than apoe is associated with poor recognition memory among men without dementia. |
2022-10-25 |
2023-08-14 |
Not clear |
| Zheng Zhu, Xiaoxi Ma, Jie Wu, Zhenxu Xiao, Wanqing Wu, Saineng Ding, Li Zheng, Xiaoniu Liang, Jianfeng Luo, Ding Ding, Qianhua Zha. Altered Gut Microbiota and Its Clinical Relevance in Mild Cognitive Impairment and Alzheimer's Disease: Shanghai Aging Study and Shanghai Memory Study. Nutrients. vol 14. issue 19. 2022-10-17. PMID:36235612. |
patients with ad or mci had increased bacterial taxa including erysipelatoclostridiaceae, erysipelotrichales, patescibacteria, saccharimonadales, and saccharimonadia, compared with nc group (p < 0.05), which were positively correlated with apoe 4 carrier status and clinical dementia rating (correlation coefficient: 0.11~0.31, p < 0.05), and negatively associated with memory (correlation coefficient: −0.19~−0.16, p < 0.01). |
2022-10-17 |
2023-08-16 |
human |
| Jinghuan Gan, Zhichao Chen, Shuai Liu, Zhihong Shi, Yiming Liu, Xiao-Dan Wang, Chunyan Liu, Yong J. The presence and co-incidence of geriatric syndromes in older patients with mild-moderate Lewy body dementia. BMC neurology. vol 22. issue 1. 2022-09-19. PMID:36123648. |
the purpose of this study is to investigate the distributions of apolipoprotein e (apoe) ε4 and geriatric symptoms, and explore their associaitons in dementia with lewy bodies (dlb) and parkinson's disease dementia (pdd). |
2022-09-19 |
2023-08-14 |
Not clear |
| Michel Satya Naslavsky, Claudia K Suemoto, Luciano Abreu Brito, Marília Oliveira Scliar, Renata Eloah Ferretti-Rebustini, Roberta Diehl Rodriguez, Renata E P Leite, Nathalia Matta Araujo, Victor Borda, Eduardo Tarazona-Santos, Wilson Jacob-Filho, Carlos Pasqualucci, Ricardo Nitrini, Kristine Yaffe, Mayana Zatz, Lea T Grinber. Global and local ancestry modulate APOE association with Alzheimer's neuropathology and cognitive outcomes in an admixed sample. Molecular psychiatry. 2022-09-07. PMID:36071110. |
paradoxically, clinical studies suggest an attenuation of apoe ε4 risk of dementia in african ancestry (afr), but a dearth of neuropathological data preclude the interpretation of the biological factors underlying these findings, including the association between apoe ε4 risk and alzheimer's disease (ad) pathology, the most frequent cause of dementia. |
2022-09-07 |
2023-08-14 |
Not clear |
| Peidong Zhang, Zhihao Li, Peiliang Chen, Ao Zhang, Yu Zeng, Xiru Zhang, Qingmei Huang, Dan Liu, Songtao Qi, Chen Ma. Regular proton pump inhibitor use and incident dementia: population-based cohort study. BMC medicine. vol 20. issue 1. 2022-08-31. PMID:36045363. |
to examine the association between regular use of proton pump inhibitors and the risk of incident dementia, including dementia subtypes, and whether the association differs between apoe genotypes. |
2022-08-31 |
2023-08-14 |
Not clear |