| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bastiaan T Heijmans, P Eline Slagboom, Jacobijn Gussekloo, Simone Droog, A Margot Lagaay, Cornelis Kluft, Dick L Knook, Rudi G J Westendor. Association of APOE epsilon2/epsilon3/epsilon4 and promoter gene variants with dementia but not cardiovascular mortality in old age. American journal of medical genetics. vol 107. issue 3. 2002-02-12. PMID:11807900. |
the common apolipoprotein e (apoe) alleles epsilon2, epsilon3, and epsilon4 are associated with the risk of dementia and cardiovascular disease. |
2002-02-12 |
2023-08-12 |
human |
| Bastiaan T Heijmans, P Eline Slagboom, Jacobijn Gussekloo, Simone Droog, A Margot Lagaay, Cornelis Kluft, Dick L Knook, Rudi G J Westendor. Association of APOE epsilon2/epsilon3/epsilon4 and promoter gene variants with dementia but not cardiovascular mortality in old age. American journal of medical genetics. vol 107. issue 3. 2002-02-12. PMID:11807900. |
we investigated the contribution of these apoe gene variants to dementia and cardiovascular mortality in old age using a population-based cohort of 648 subjects aged 85 years and over (leiden 85-plus study). |
2002-02-12 |
2023-08-12 |
human |
| Bastiaan T Heijmans, P Eline Slagboom, Jacobijn Gussekloo, Simone Droog, A Margot Lagaay, Cornelis Kluft, Dick L Knook, Rudi G J Westendor. Association of APOE epsilon2/epsilon3/epsilon4 and promoter gene variants with dementia but not cardiovascular mortality in old age. American journal of medical genetics. vol 107. issue 3. 2002-02-12. PMID:11807900. |
genotypes containing an apoe epsilon4 allele were associated with a 4.1-fold (95% ci, 2.2-7.7) increased risk of dementia as compared to the epsilon3/epsilon3 genotype in old subjects. |
2002-02-12 |
2023-08-12 |
human |
| Bastiaan T Heijmans, P Eline Slagboom, Jacobijn Gussekloo, Simone Droog, A Margot Lagaay, Cornelis Kluft, Dick L Knook, Rudi G J Westendor. Association of APOE epsilon2/epsilon3/epsilon4 and promoter gene variants with dementia but not cardiovascular mortality in old age. American journal of medical genetics. vol 107. issue 3. 2002-02-12. PMID:11807900. |
in conclusion, both the apoe epsilon2/epsilon3/epsilon4 and the -219g/t variant were identified as risk factors for dementia but not cardiovascular mortality in old age. |
2002-02-12 |
2023-08-12 |
human |
| Bastiaan T Heijmans, P Eline Slagboom, Jacobijn Gussekloo, Simone Droog, A Margot Lagaay, Cornelis Kluft, Dick L Knook, Rudi G J Westendor. Association of APOE epsilon2/epsilon3/epsilon4 and promoter gene variants with dementia but not cardiovascular mortality in old age. American journal of medical genetics. vol 107. issue 3. 2002-02-12. PMID:11807900. |
our results support the hypothesis that both the isoform and the amount of apoe may influence the risk of dementia. |
2002-02-12 |
2023-08-12 |
human |
| Bastiaan T Heijmans, P Eline Slagboom, Jacobijn Gussekloo, Simone Droog, A Margot Lagaay, Cornelis Kluft, Dick L Knook, Rudi G J Westendor. Association of APOE epsilon2/epsilon3/epsilon4 and promoter gene variants with dementia but not cardiovascular mortality in old age. American journal of medical genetics. vol 107. issue 3. 2002-02-12. PMID:11807900. |
furthermore, they emphasize that variation at the apoe locus has a higher impact on the risk of dementia than on the risk of cardiovascular disease in old age. |
2002-02-12 |
2023-08-12 |
human |
| E M Reiman, R J Caselli, K Chen, G E Alexander, D Bandy, J Fros. Declining brain activity in cognitively normal apolipoprotein E epsilon 4 heterozygotes: A foundation for using positron emission tomography to efficiently test treatments to prevent Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 6. 2001-12-04. PMID:11248079. |
cross-sectional positron emission tomography (pet) studies find that cognitively normal carriers of the apolipoprotein e (apoe) epsilon4 allele, a common alzheimer's susceptibility gene, have abnormally low measurements of the cerebral metabolic rate for glucose (cmrgl) in the same regions as patients with alzheimer's dementia. |
2001-12-04 |
2023-08-12 |
human |
| A E Molero, G Pino-Ramírez, G E Maestr. Modulation by age and gender of risk for Alzheimer's disease and vascular dementia associated with the apolipoprotein E-epsilon4 allele in Latin Americans: findings from the Maracaibo Aging Study. Neuroscience letters. vol 307. issue 1. 2001-09-27. PMID:11516561. |
an ongoing longitudinal study in maracaibo, venezuela, examined the interaction between apolipoprotein e (apoe) genotypes and alzheimer's disease (ad) and vascular dementia (vd), evaluating age and gender as potential modifiers of risk. |
2001-09-27 |
2023-08-12 |
human |
| R Mayeux, S A Small, M Tang, B Tycko, Y Ster. Memory performance in healthy elderly without Alzheimer's disease: effects of time and apolipoprotein-E. Neurobiology of aging. vol 22. issue 4. 2001-08-30. PMID:11445269. |
the current study examined the effect of apoe on cognitive function over time in elderly without dementia. |
2001-08-30 |
2023-08-12 |
mouse |
| A Nunomura, G Perry, G Aliev, K Hirai, A Takeda, E K Balraj, P K Jones, H Ghanbari, T Wataya, S Shimohama, S Chiba, C S Atwood, R B Petersen, M A Smit. Oxidative damage is the earliest event in Alzheimer disease. Journal of neuropathology and experimental neurology. vol 60. issue 8. 2001-08-16. PMID:11487050. |
amyloid-beta (a beta) plaques and neurofibrillary tangles (nft), as well as duration of dementia and apolipoprotein e (apoe) genotype. |
2001-08-16 |
2023-08-12 |
Not clear |
| K Yamagata, K Urakami, K Ikeda, Y Ji, Y Adachi, H Arai, H Sasaki, K Sato, K Nakashim. High expression of apolipoprotein E mRNA in the brains with sporadic Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 12. issue 2. 2001-07-12. PMID:11173875. |
in order to study progressive dementia in alzheimer's disease (ad) patients, we analyzed the gene expression of apolipoprotein e (apoe). |
2001-07-12 |
2023-08-12 |
Not clear |
| Z Guo, L Fratiglioni, M Viitanen, L Lannfelt, H Basun, J Fastbom, B Winbla. Apolipoprotein E genotypes and the incidence of Alzheimer's disease among persons aged 75 years and older: variation by use of antihypertensive medication? American journal of epidemiology. vol 153. issue 3. 2001-06-28. PMID:11157409. |
compared with (*)epsilon3/(*)epsilon3, the apoe(*)epsilon4 allele increased the risk of developing dementia (relative risk (rr) = 1.5, 95% confidence interval (ci): 1.1, 2.1) and alzheimer's disease (rr = 1.7, 95% ci: 1.2, 2.5). |
2001-06-28 |
2023-08-12 |
human |
| Z Guo, L Fratiglioni, M Viitanen, L Lannfelt, H Basun, J Fastbom, B Winbla. Apolipoprotein E genotypes and the incidence of Alzheimer's disease among persons aged 75 years and older: variation by use of antihypertensive medication? American journal of epidemiology. vol 153. issue 3. 2001-06-28. PMID:11157409. |
subjects using antihypertensive medication at baseline (n = 432, 80% used diuretics) had a decreased risk of dementia (rr = 0.6, 95% ci: 0.5, 0.9) and alzheimer's disease (rr = 0.5, 95% ci: 0.3, 0.8) after adjustment for several variables, including apoe. |
2001-06-28 |
2023-08-12 |
human |
| Z Guo, L Fratiglioni, M Viitanen, L Lannfelt, H Basun, J Fastbom, B Winbla. Apolipoprotein E genotypes and the incidence of Alzheimer's disease among persons aged 75 years and older: variation by use of antihypertensive medication? American journal of epidemiology. vol 153. issue 3. 2001-06-28. PMID:11157409. |
the apoe(*)epsilon4 allele is an important predictor of dementia and alzheimer's disease incidence. |
2001-06-28 |
2023-08-12 |
human |
| J Yang, G Feng, J Zhang, Z Hui, G Breen, D St Clair, L H. Is ApoE gene a risk factor for vascular dementia in Han Chinese? International journal of molecular medicine. vol 7. issue 2. 2001-06-21. PMID:11172628. |
is apoe gene a risk factor for vascular dementia in han chinese? |
2001-06-21 |
2023-08-12 |
Not clear |
| J Yang, G Feng, J Zhang, Z Hui, G Breen, D St Clair, L H. Is ApoE gene a risk factor for vascular dementia in Han Chinese? International journal of molecular medicine. vol 7. issue 2. 2001-06-21. PMID:11172628. |
we have compared the apolipoprotein e (apoe) genotypes of han chinese with late-onset sporadic alzheimer's disease (load, n=191), and vascular dementia (vad, n=124) to controls (n=218) with a similar age distribution. |
2001-06-21 |
2023-08-12 |
Not clear |
| J Yang, G Feng, J Zhang, Z Hui, G Breen, D St Clair, L H. Is ApoE gene a risk factor for vascular dementia in Han Chinese? International journal of molecular medicine. vol 7. issue 2. 2001-06-21. PMID:11172628. |
apoe epsilon4 allele was also significantly associated with vascular dementia (or=1.75, p=0.026). |
2001-06-21 |
2023-08-12 |
Not clear |
| J Yang, G Feng, J Zhang, Z Hui, G Breen, D St Clair, L H. Is ApoE gene a risk factor for vascular dementia in Han Chinese? International journal of molecular medicine. vol 7. issue 2. 2001-06-21. PMID:11172628. |
our findings support previous reports of a positive association between apoe epsilon4 and both alzheimer's disease and vascular dementia in han chinese. |
2001-06-21 |
2023-08-12 |
Not clear |
| J Chey, J W Kim, H Y Ch. Effects of apolipoprotein E phenotypes on the neuropsychological functions of community-dwelling elderly individuals without dementia. Neuroscience letters. vol 289. issue 3. 2001-05-31. PMID:10961672. |
we examined the different effects of apoe polymorphism on the neuropsychological functions of 213 community-dwelling korean elderly individuals without dementia. |
2001-05-31 |
2023-08-12 |
human |
| K Czyzewski, M M Lalowski, A Pfeffer, M Barcikowsk. Lipid metabolism parameters in patients with Alzheimer's disease and their first degree relatives. Acta neurobiologiae experimentalis. vol 61. issue 1. 2001-05-21. PMID:11315318. |
recently, it was suggested that the presence of total cholesterol (tc), age and sex interaction in alzheimer's type dementia (ad) is linked with the apolipoprotein e (apoe) genotype. |
2001-05-21 |
2023-08-12 |
Not clear |