| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D R S Souza, M R de Godoy, J Hotta, E H Tajara, A C Brandão, S Pinheiro Júnior, W A Tognola, J E dos Santo. Association of apolipoprotein E polymorphism in late-onset Alzheimer's disease and vascular dementia in Brazilians. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 36. issue 7. 2004-01-20. PMID:12845379. |
the distribution of alleles and genotypes of the apoe gene in late-onset alzheimer's disease (n = 68), other late-life dementias (n = 39), and in cognitively normal controls (n = 58) was determined, as also was the risk for alzheimer's disease associated with the epsilon4 allele. |
2004-01-20 |
2023-08-12 |
Not clear |
| Paola Lucarelli, Antonella Piciullo, Magda Verdecchia, Mariella Palmarino, Carla Arpino, Paolo Curatol. The role of -850 tumor necrosis factor-alpha and apolipoprotein E genetic polymorphism in patients with Down's syndrome-related dementia. Neuroscience letters. vol 352. issue 1. 2004-01-20. PMID:14615042. |
our findings suggest that the -850t allele, which is more common among patients at high risk of dementia such as those with ds, might eventually play a role in the development of dementia; no inference on the role of the allele apoe e4 in ds-related dementia may be derived from our results. |
2004-01-20 |
2023-08-12 |
human |
| Ramón Cacabelos, Lucía Fernández-Novoa, Valter Lombardi, Lola Corzo, Victor Pichel, Yasuhiko Kubot. Cerebrovascular risk factors in Alzheimer's disease: brain hemodynamics and pharmacogenomic implications. Neurological research. vol 25. issue 6. 2003-12-04. PMID:14503010. |
in addition, the genomic profiles of patients with dementia integrating ad-related genes (apoe, ps1, ps2, cfos) in a mini-tetragenic haplotype significantly differ from controls with an absolute genetic variation of about 50%-60%. |
2003-12-04 |
2023-08-12 |
Not clear |
| Erin D Bigler, Christopher M Lowry, Burton Kerr, David F Tate, Cory D Hessel, Heath D Earl, Michael J Miller, Sara A Rice, Kay H Smith, JoAnn T Tschanz, Kathleen Welsh-Bohmer, Brenda Plassman, Jeff Victorof. Role of white matter lesions, cerebral atrophy, and APOE on cognition in older persons with and without dementia: the Cache County, Utah, study of memory and aging. Neuropsychology. vol 17. issue 3. 2003-10-31. PMID:12959500. |
role of white matter lesions, cerebral atrophy, and apoe on cognition in older persons with and without dementia: the cache county, utah, study of memory and aging. |
2003-10-31 |
2023-08-12 |
human |
| Erin D Bigler, Christopher M Lowry, Burton Kerr, David F Tate, Cory D Hessel, Heath D Earl, Michael J Miller, Sara A Rice, Kay H Smith, JoAnn T Tschanz, Kathleen Welsh-Bohmer, Brenda Plassman, Jeff Victorof. Role of white matter lesions, cerebral atrophy, and APOE on cognition in older persons with and without dementia: the Cache County, Utah, study of memory and aging. Neuropsychology. vol 17. issue 3. 2003-10-31. PMID:12959500. |
neuropsychological, qualitative, and quantitative magnetic resonance imaging findings were examined in subjects with alzheimer's disease (ad), non-ad dementia or mixed neuropsychiatric disorder, subjects characterized as mild/ambiguous, and controls, all with known apolipoprotein e (apoe) genotype. |
2003-10-31 |
2023-08-12 |
human |
| L H Kulle. [Risk factors for dementia in the Cardiovascular Health Study cognition study]. Revista de neurologia. vol 37. issue 2. 2003-10-29. PMID:12938070. |
some studies have found that, older women, cerebrovascular risk factors (hypertension, ischemic heart disease, diabetes mellitus), and the presence of the apolipoprotein e (apoe) 4 allele to be associated with the development of dementia and ad. |
2003-10-29 |
2023-08-12 |
human |
| L H Kulle. [Risk factors for dementia in the Cardiovascular Health Study cognition study]. Revista de neurologia. vol 37. issue 2. 2003-10-29. PMID:12938070. |
the chs found that age, modified mini mental state examination scores, cerebral ventricular size, severity of white matter lesions, number of mri identified infarcts, and the presence of the apoe 4 allele were predictors of dementia. |
2003-10-29 |
2023-08-12 |
human |
| L H Kulle. [Risk factors for dementia in the Cardiovascular Health Study cognition study]. Revista de neurologia. vol 37. issue 2. 2003-10-29. PMID:12938070. |
scores of global cognitive measures, the presence of the apoe 4 allele, and mri of the brain were strong predictors of dementia and ad. |
2003-10-29 |
2023-08-12 |
human |
| Michael J Finton, John A Lucas, Julie D Rippeth, Daryl L Bohac, Glenn E Smith, Robert J Ivnik, Ronald C Petersen, Neill R Graff-Radfor. Cognitive asymmetries associated with apolipoprotein E genotype in patients with Alzheimer's disease. Journal of the International Neuropsychological Society : JINS. vol 9. issue 5. 2003-09-23. PMID:12901781. |
although age and dementia severity also contributed to these patterns, apoe genotype appears to have a significant unique contribution to cognitive performance in these individuals. |
2003-09-23 |
2023-08-12 |
human |
| Annette Skraep Nielsen, Rivka Ravid, Wouter Kamphorst, Ole Steen Jørgense. Apolipoprotein E epsilon 4 in an autopsy series of various dementing disorders. Journal of Alzheimer's disease : JAD. vol 5. issue 2. 2003-09-16. PMID:12719629. |
previous studies on apoe epsilon 4 in dementing disorders other than ad have been rather conflicting, in particular concerning frontotemporal dementia (ftd) and vascular dementia (vd). |
2003-09-16 |
2023-08-12 |
human |
| S Engelborghs, B Dermaut, J Goeman, J Saerens, P Mariën, B A Pickut, M Van den Broeck, S Serneels, M Cruts, C Van Broeckhoven, P P De Dey. Prospective Belgian study of neurodegenerative and vascular dementia: APOE genotype effects. Journal of neurology, neurosurgery, and psychiatry. vol 74. issue 8. 2003-09-09. PMID:12876259. |
prospective belgian study of neurodegenerative and vascular dementia: apoe genotype effects. |
2003-09-09 |
2023-08-12 |
Not clear |
| J M Serra-Grabulosa, P Salgado-Pineda, C Junqué, C Solé-Padullés, P Moral, A López-Alomar, T López, A López-Guillén, N Bargalló, J M Mercader, I C Clemente, D Bartrés-Fa. Apolipoproteins E and C1 and brain morphology in memory impaired elders. Neurogenetics. vol 4. issue 3. 2003-08-01. PMID:12736801. |
previous research has shown that polymorphisms of the apolipoproteins e ( apoe) and apoc1 represent genetic risk factors for dementia and for cognitive impairment in the elderly. |
2003-08-01 |
2023-08-12 |
human |
| Yoon-Ho Choi, Ji-Hae Kim, Doh Kwan Kim, Jong-Won Kim, Duk-Kyung Kim, Mee Sook Lee, Cheol Ho Kim, Sang Chul Par. Distributions of ACE and APOE polymorphisms and their relations with dementia status in Korean centenarians. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 58. issue 3. 2003-04-01. PMID:12634288. |
distributions of ace and apoe polymorphisms and their relations with dementia status in korean centenarians. |
2003-04-01 |
2023-08-12 |
human |
| Yoon-Ho Choi, Ji-Hae Kim, Doh Kwan Kim, Jong-Won Kim, Duk-Kyung Kim, Mee Sook Lee, Cheol Ho Kim, Sang Chul Par. Distributions of ACE and APOE polymorphisms and their relations with dementia status in Korean centenarians. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 58. issue 3. 2003-04-01. PMID:12634288. |
genetic polymorphisms of angiotensin-converting enzyme (ace) and apolipoprotein e (apoe) have been reported to be associated with human longevity and dementia in the elderly. |
2003-04-01 |
2023-08-12 |
human |
| Paola Castelli, Ana Luisa Sosa, Carlos Campillo, Humberto Nicolini, Carlos Cruz-Fuente. Apolipoprotein E genotypes in a group of elderly subjects of Spanish descent living in Mexico City. International psychogeriatrics. vol 14. issue 3. 2003-03-26. PMID:12475089. |
the association between the apoe gene and alzheimer's disease and other forms of dementia has been widely documented, but its relevance as a genetic risk factor in specific ethnic groups other than caucasians in the united states and europe is limited. |
2003-03-26 |
2023-08-12 |
human |
| Paola Castelli, Ana Luisa Sosa, Carlos Campillo, Humberto Nicolini, Carlos Cruz-Fuente. Apolipoprotein E genotypes in a group of elderly subjects of Spanish descent living in Mexico City. International psychogeriatrics. vol 14. issue 3. 2003-03-26. PMID:12475089. |
the higher frequency of the epsilon4 allele in the affected group (chi2 = 14.5; df = 4, p = .006) confirms an association between this apoe molecular variant and dementia in elderly spaniards. |
2003-03-26 |
2023-08-12 |
human |
| Mary N Haan, Dan M Mungas, Hector M Gonzalez, Teresa A Ortiz, Ananth Acharya, William J Jagus. Prevalence of dementia in older latinos: the influence of type 2 diabetes mellitus, stroke and genetic factors. Journal of the American Geriatrics Society. vol 51. issue 2. 2003-03-25. PMID:12558712. |
to estimate dementia prevalence in older mexican americans, determine the distribution of dementia by etiology, and evaluate the contribution of type 2 diabetes mellitus, stroke, and apolipoprotein e (apoe) genotype to dementia. |
2003-03-25 |
2023-08-12 |
Not clear |
| Asha Naidu, Qiang Xu, Rosanne Catalano, Barbara Cordel. Secretion of apolipoprotein E by brain glia requires protein prenylation and is suppressed by statins. Brain research. vol 958. issue 1. 2003-02-25. PMID:12468034. |
our finding that protein geranylgeranylation is required for apoe secretion in the brain parenchyma provides another contributing mechanism to explain the effective properties of statins against the development of dementia. |
2003-02-25 |
2023-08-12 |
Not clear |
| A Frank, E Díez-Tejedor, M J Bullido, F Valdivieso, P Barreir. APOE genotype in cerebrovascular disease and vascular dementia. Journal of the neurological sciences. vol 203-204. 2003-01-23. PMID:12417379. |
apoe genotype in cerebrovascular disease and vascular dementia. |
2003-01-23 |
2023-08-12 |
Not clear |
| A Frank, E Díez-Tejedor, M J Bullido, F Valdivieso, P Barreir. APOE genotype in cerebrovascular disease and vascular dementia. Journal of the neurological sciences. vol 203-204. 2003-01-23. PMID:12417379. |
the fact that the allele epsilon 4 of the apolipoprotein e (apoe) gene could act like a risk factor not only in late-onset familial and sporadic alzheimer's disease (ad) but also in cerebrovascular disease (cvd) and vascular dementia (vad) is still controversial. |
2003-01-23 |
2023-08-12 |
Not clear |