| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jean-Charles Lambert, Claudine Berr, Dominique Cottel, Philippe Amouyel, Nicole Helbecqu. APOE promoter polymorphisms and dementia in the elderly. Neuroscience letters. vol 365. issue 2. 2004-08-09. PMID:15245790. |
apoe promoter polymorphisms and dementia in the elderly. |
2004-08-09 |
2023-08-12 |
human |
| Jean-Charles Lambert, Claudine Berr, Dominique Cottel, Philippe Amouyel, Nicole Helbecqu. APOE promoter polymorphisms and dementia in the elderly. Neuroscience letters. vol 365. issue 2. 2004-08-09. PMID:15245790. |
previous observations suggest a contribution of two apoe promoter polymorphisms (-219 g/t and -491 a/t) in dementia. |
2004-08-09 |
2023-08-12 |
human |
| Jean-Charles Lambert, Claudine Berr, Dominique Cottel, Philippe Amouyel, Nicole Helbecqu. APOE promoter polymorphisms and dementia in the elderly. Neuroscience letters. vol 365. issue 2. 2004-08-09. PMID:15245790. |
haplotype estimations including the two promoter and the coding apoe polymorphisms indicated that the -491a/-219t/4 haplotype was at risk for the development of dementia (or = 3.5 (95% ci, 2.5-5.0), p < 0.0001), whereas the -491a/-219g/4 haplotype was not (or = 1.1 (95% ci, 0.6-2.1)). |
2004-08-09 |
2023-08-12 |
human |
| A J C Slooter, M Cruts, A Hofman, P J Koudstaal, D van der Kuip, M A J de Ridder, J C M Witteman, M M B Breteler, C Van Broeckhoven, C M van Duij. The impact of APOE on myocardial infarction, stroke, and dementia: the Rotterdam Study. Neurology. vol 62. issue 7. 2004-08-02. PMID:15079025. |
the impact of apoe on myocardial infarction, stroke, and dementia: the rotterdam study. |
2004-08-02 |
2023-08-12 |
Not clear |
| A J C Slooter, M Cruts, A Hofman, P J Koudstaal, D van der Kuip, M A J de Ridder, J C M Witteman, M M B Breteler, C Van Broeckhoven, C M van Duij. The impact of APOE on myocardial infarction, stroke, and dementia: the Rotterdam Study. Neurology. vol 62. issue 7. 2004-08-02. PMID:15079025. |
it is unclear how the apoe genotype contributes to the incidence of vascular diseases and dementia. |
2004-08-02 |
2023-08-12 |
Not clear |
| A J C Slooter, M Cruts, A Hofman, P J Koudstaal, D van der Kuip, M A J de Ridder, J C M Witteman, M M B Breteler, C Van Broeckhoven, C M van Duij. The impact of APOE on myocardial infarction, stroke, and dementia: the Rotterdam Study. Neurology. vol 62. issue 7. 2004-08-02. PMID:15079025. |
apoe is not strongly related to vascular diseases, but contributes substantially to dementia incidence. |
2004-08-02 |
2023-08-12 |
Not clear |
| Frank-Erik de Leeuw, Florence Richard, Jan Cees de Groot, Cornelia M van Duijn, Albert Hofman, Jan Van Gijn, Monique M B Bretele. Interaction between hypertension, apoE, and cerebral white matter lesions. Stroke. vol 35. issue 5. 2004-05-19. PMID:15060316. |
the epsilon4 allele of the apolipoprotein e gene (apoe) may be a candidate because this allele is associated with both the vascular risk factors and the consequences (cognitive impairment, dementia) of wmls. |
2004-05-19 |
2023-08-12 |
Not clear |
| M Boccardi, F Sabattoli, C Testa, A Beltramello, H Soininen, G B Frison. APOE and modulation of Alzheimer's and frontotemporal dementia. Neuroscience letters. vol 356. issue 3. 2004-05-10. PMID:15036621. |
the epsilon4 allele of the apoe might modulate the expression of degenerative dementias by enhancing the specific effects of neurodegenerative diseases on the brain. |
2004-05-10 |
2023-08-12 |
Not clear |
| Kalpana Luthra, Manjari Tripathi, Rahul Grover, Manjari Dwivedi, Amit Kumar, A B De. Apolipoprotein E gene polymorphism in Indian patients with Alzheimer's disease and vascular dementia. Dementia and geriatric cognitive disorders. vol 17. issue 3. 2004-05-03. PMID:14739533. |
however, the association of apoe polymorphism with vascular dementia (vad) is yet to be established in this population. |
2004-05-03 |
2023-08-12 |
Not clear |
| Deng Chen, Jun-Wu Zhang, Zhen-Xin Zhang, Hua-Lu Zhao, Xiao-Qing Li, Ya-Ning Wu, Qiu-Ming Q. [Apolipoprotein E gene polymorphisms and Alzheimer disease]. Yi chuan xue bao = Acta genetica Sinica. vol 30. issue 12. 2004-04-22. PMID:14986436. |
in addition, our results showed that the distributions of apoe alleles and genotypes were comparable among mild, moderate and severe dementia patients (p > 0.05), suggesting that apoe gene polymorphism was not likely to contribute to dementia severity of ad patients. |
2004-04-22 |
2023-08-12 |
human |
| Bogusław Paradowski, Tadeusz Dobosz, Maria Sasiadek, Małgorzata Szczepania. [Apolipoprotein E and tau protein in vascular dementia]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego. vol 15. issue 85. 2004-03-08. PMID:14593964. |
in 33 patients meeting the ninds-airen criteria of possible diagnosis of vascular dementia (vd) apoe genotype and tau protein level in cerebrospinal fluid were determined. |
2004-03-08 |
2023-08-12 |
Not clear |
| Bogusław Paradowski, Tadeusz Dobosz, Maria Sasiadek, Małgorzata Szczepania. [Apolipoprotein E and tau protein in vascular dementia]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego. vol 15. issue 85. 2004-03-08. PMID:14593964. |
the authors emphasize that apoe e4 and tau protein level determination is not very useful in the differential diagnosis of dementia. |
2004-03-08 |
2023-08-12 |
Not clear |
| Y Ji, Y Gong, W Gan, T Beach, D M Holtzman, T Wisniewsk. Apolipoprotein E isoform-specific regulation of dendritic spine morphology in apolipoprotein E transgenic mice and Alzheimer's disease patients. Neuroscience. vol 122. issue 2. 2004-03-01. PMID:14614898. |
these age dependent differences in the effects of apoe isoforms on neuronal integrity may relate to the increased risk of dementia in aged individuals with the apoe4 allele. |
2004-03-01 |
2023-08-12 |
mouse |
| Kathleen A Lane, Sujuan Gao, Siu L Hui, Jill R Murrell, Kathleen S Hall, Hugh C Hendri. Apolipoprotein E and mortality in African-Americans and Yoruba. Journal of Alzheimer's disease : JAD. vol 5. issue 5. 2004-02-24. PMID:14646029. |
we used data from the indianapolis-ibadan dementia study to examine this association between apoe and mortality in 354 african-americans from indianapolis and 968 yoruba from ibadan, nigeria. |
2004-02-24 |
2023-08-12 |
human |
| D R S Souza, M R de Godoy, J Hotta, E H Tajara, A C Brandão, S Pinheiro Júnior, W A Tognola, J E dos Santo. Association of apolipoprotein E polymorphism in late-onset Alzheimer's disease and vascular dementia in Brazilians. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 36. issue 7. 2004-01-20. PMID:12845379. |
the distribution of alleles and genotypes of the apoe gene in late-onset alzheimer's disease (n = 68), other late-life dementias (n = 39), and in cognitively normal controls (n = 58) was determined, as also was the risk for alzheimer's disease associated with the epsilon4 allele. |
2004-01-20 |
2023-08-12 |
Not clear |
| Paola Lucarelli, Antonella Piciullo, Magda Verdecchia, Mariella Palmarino, Carla Arpino, Paolo Curatol. The role of -850 tumor necrosis factor-alpha and apolipoprotein E genetic polymorphism in patients with Down's syndrome-related dementia. Neuroscience letters. vol 352. issue 1. 2004-01-20. PMID:14615042. |
our findings suggest that the -850t allele, which is more common among patients at high risk of dementia such as those with ds, might eventually play a role in the development of dementia; no inference on the role of the allele apoe e4 in ds-related dementia may be derived from our results. |
2004-01-20 |
2023-08-12 |
human |
| Ramón Cacabelos, Lucía Fernández-Novoa, Valter Lombardi, Lola Corzo, Victor Pichel, Yasuhiko Kubot. Cerebrovascular risk factors in Alzheimer's disease: brain hemodynamics and pharmacogenomic implications. Neurological research. vol 25. issue 6. 2003-12-04. PMID:14503010. |
in addition, the genomic profiles of patients with dementia integrating ad-related genes (apoe, ps1, ps2, cfos) in a mini-tetragenic haplotype significantly differ from controls with an absolute genetic variation of about 50%-60%. |
2003-12-04 |
2023-08-12 |
Not clear |
| Erin D Bigler, Christopher M Lowry, Burton Kerr, David F Tate, Cory D Hessel, Heath D Earl, Michael J Miller, Sara A Rice, Kay H Smith, JoAnn T Tschanz, Kathleen Welsh-Bohmer, Brenda Plassman, Jeff Victorof. Role of white matter lesions, cerebral atrophy, and APOE on cognition in older persons with and without dementia: the Cache County, Utah, study of memory and aging. Neuropsychology. vol 17. issue 3. 2003-10-31. PMID:12959500. |
role of white matter lesions, cerebral atrophy, and apoe on cognition in older persons with and without dementia: the cache county, utah, study of memory and aging. |
2003-10-31 |
2023-08-12 |
human |
| Erin D Bigler, Christopher M Lowry, Burton Kerr, David F Tate, Cory D Hessel, Heath D Earl, Michael J Miller, Sara A Rice, Kay H Smith, JoAnn T Tschanz, Kathleen Welsh-Bohmer, Brenda Plassman, Jeff Victorof. Role of white matter lesions, cerebral atrophy, and APOE on cognition in older persons with and without dementia: the Cache County, Utah, study of memory and aging. Neuropsychology. vol 17. issue 3. 2003-10-31. PMID:12959500. |
neuropsychological, qualitative, and quantitative magnetic resonance imaging findings were examined in subjects with alzheimer's disease (ad), non-ad dementia or mixed neuropsychiatric disorder, subjects characterized as mild/ambiguous, and controls, all with known apolipoprotein e (apoe) genotype. |
2003-10-31 |
2023-08-12 |
human |
| L H Kulle. [Risk factors for dementia in the Cardiovascular Health Study cognition study]. Revista de neurologia. vol 37. issue 2. 2003-10-29. PMID:12938070. |
some studies have found that, older women, cerebrovascular risk factors (hypertension, ischemic heart disease, diabetes mellitus), and the presence of the apolipoprotein e (apoe) 4 allele to be associated with the development of dementia and ad. |
2003-10-29 |
2023-08-12 |
human |