| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E M Reiman, R J Caselli, K Chen, G E Alexander, D Bandy, J Fros. Declining brain activity in cognitively normal apolipoprotein E epsilon 4 heterozygotes: A foundation for using positron emission tomography to efficiently test treatments to prevent Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 6. 2001-12-04. PMID:11248079. |
cross-sectional positron emission tomography (pet) studies find that cognitively normal carriers of the apolipoprotein e (apoe) epsilon4 allele, a common alzheimer's susceptibility gene, have abnormally low measurements of the cerebral metabolic rate for glucose (cmrgl) in the same regions as patients with alzheimer's dementia. |
2001-12-04 |
2023-08-12 |
human |
| A E Molero, G Pino-Ramírez, G E Maestr. Modulation by age and gender of risk for Alzheimer's disease and vascular dementia associated with the apolipoprotein E-epsilon4 allele in Latin Americans: findings from the Maracaibo Aging Study. Neuroscience letters. vol 307. issue 1. 2001-09-27. PMID:11516561. |
an ongoing longitudinal study in maracaibo, venezuela, examined the interaction between apolipoprotein e (apoe) genotypes and alzheimer's disease (ad) and vascular dementia (vd), evaluating age and gender as potential modifiers of risk. |
2001-09-27 |
2023-08-12 |
human |
| R Mayeux, S A Small, M Tang, B Tycko, Y Ster. Memory performance in healthy elderly without Alzheimer's disease: effects of time and apolipoprotein-E. Neurobiology of aging. vol 22. issue 4. 2001-08-30. PMID:11445269. |
the current study examined the effect of apoe on cognitive function over time in elderly without dementia. |
2001-08-30 |
2023-08-12 |
mouse |
| A Nunomura, G Perry, G Aliev, K Hirai, A Takeda, E K Balraj, P K Jones, H Ghanbari, T Wataya, S Shimohama, S Chiba, C S Atwood, R B Petersen, M A Smit. Oxidative damage is the earliest event in Alzheimer disease. Journal of neuropathology and experimental neurology. vol 60. issue 8. 2001-08-16. PMID:11487050. |
amyloid-beta (a beta) plaques and neurofibrillary tangles (nft), as well as duration of dementia and apolipoprotein e (apoe) genotype. |
2001-08-16 |
2023-08-12 |
Not clear |
| K Yamagata, K Urakami, K Ikeda, Y Ji, Y Adachi, H Arai, H Sasaki, K Sato, K Nakashim. High expression of apolipoprotein E mRNA in the brains with sporadic Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 12. issue 2. 2001-07-12. PMID:11173875. |
in order to study progressive dementia in alzheimer's disease (ad) patients, we analyzed the gene expression of apolipoprotein e (apoe). |
2001-07-12 |
2023-08-12 |
Not clear |
| Z Guo, L Fratiglioni, M Viitanen, L Lannfelt, H Basun, J Fastbom, B Winbla. Apolipoprotein E genotypes and the incidence of Alzheimer's disease among persons aged 75 years and older: variation by use of antihypertensive medication? American journal of epidemiology. vol 153. issue 3. 2001-06-28. PMID:11157409. |
compared with (*)epsilon3/(*)epsilon3, the apoe(*)epsilon4 allele increased the risk of developing dementia (relative risk (rr) = 1.5, 95% confidence interval (ci): 1.1, 2.1) and alzheimer's disease (rr = 1.7, 95% ci: 1.2, 2.5). |
2001-06-28 |
2023-08-12 |
human |
| Z Guo, L Fratiglioni, M Viitanen, L Lannfelt, H Basun, J Fastbom, B Winbla. Apolipoprotein E genotypes and the incidence of Alzheimer's disease among persons aged 75 years and older: variation by use of antihypertensive medication? American journal of epidemiology. vol 153. issue 3. 2001-06-28. PMID:11157409. |
subjects using antihypertensive medication at baseline (n = 432, 80% used diuretics) had a decreased risk of dementia (rr = 0.6, 95% ci: 0.5, 0.9) and alzheimer's disease (rr = 0.5, 95% ci: 0.3, 0.8) after adjustment for several variables, including apoe. |
2001-06-28 |
2023-08-12 |
human |
| Z Guo, L Fratiglioni, M Viitanen, L Lannfelt, H Basun, J Fastbom, B Winbla. Apolipoprotein E genotypes and the incidence of Alzheimer's disease among persons aged 75 years and older: variation by use of antihypertensive medication? American journal of epidemiology. vol 153. issue 3. 2001-06-28. PMID:11157409. |
the apoe(*)epsilon4 allele is an important predictor of dementia and alzheimer's disease incidence. |
2001-06-28 |
2023-08-12 |
human |
| J Yang, G Feng, J Zhang, Z Hui, G Breen, D St Clair, L H. Is ApoE gene a risk factor for vascular dementia in Han Chinese? International journal of molecular medicine. vol 7. issue 2. 2001-06-21. PMID:11172628. |
is apoe gene a risk factor for vascular dementia in han chinese? |
2001-06-21 |
2023-08-12 |
Not clear |
| J Yang, G Feng, J Zhang, Z Hui, G Breen, D St Clair, L H. Is ApoE gene a risk factor for vascular dementia in Han Chinese? International journal of molecular medicine. vol 7. issue 2. 2001-06-21. PMID:11172628. |
we have compared the apolipoprotein e (apoe) genotypes of han chinese with late-onset sporadic alzheimer's disease (load, n=191), and vascular dementia (vad, n=124) to controls (n=218) with a similar age distribution. |
2001-06-21 |
2023-08-12 |
Not clear |
| J Yang, G Feng, J Zhang, Z Hui, G Breen, D St Clair, L H. Is ApoE gene a risk factor for vascular dementia in Han Chinese? International journal of molecular medicine. vol 7. issue 2. 2001-06-21. PMID:11172628. |
apoe epsilon4 allele was also significantly associated with vascular dementia (or=1.75, p=0.026). |
2001-06-21 |
2023-08-12 |
Not clear |
| J Yang, G Feng, J Zhang, Z Hui, G Breen, D St Clair, L H. Is ApoE gene a risk factor for vascular dementia in Han Chinese? International journal of molecular medicine. vol 7. issue 2. 2001-06-21. PMID:11172628. |
our findings support previous reports of a positive association between apoe epsilon4 and both alzheimer's disease and vascular dementia in han chinese. |
2001-06-21 |
2023-08-12 |
Not clear |
| J Chey, J W Kim, H Y Ch. Effects of apolipoprotein E phenotypes on the neuropsychological functions of community-dwelling elderly individuals without dementia. Neuroscience letters. vol 289. issue 3. 2001-05-31. PMID:10961672. |
we examined the different effects of apoe polymorphism on the neuropsychological functions of 213 community-dwelling korean elderly individuals without dementia. |
2001-05-31 |
2023-08-12 |
human |
| K Czyzewski, M M Lalowski, A Pfeffer, M Barcikowsk. Lipid metabolism parameters in patients with Alzheimer's disease and their first degree relatives. Acta neurobiologiae experimentalis. vol 61. issue 1. 2001-05-21. PMID:11315318. |
recently, it was suggested that the presence of total cholesterol (tc), age and sex interaction in alzheimer's type dementia (ad) is linked with the apolipoprotein e (apoe) genotype. |
2001-05-21 |
2023-08-12 |
Not clear |
| V Senanarong, K Harnphadungkit, P Lertrit, C Mitrpant, S Udompunthurak, C Limwong, N Prayoonwiwat, N Poungvari. Experience of ApoE study in Thai elderly. Journal of the Medical Association of Thailand = Chotmaihet thangphaet. vol 84. issue 2. 2001-05-21. PMID:11336076. |
the association between apoe e4 and dementia is reported in alzheimer's disease and other dementia such as in multi-infarct dementia. |
2001-05-21 |
2023-08-12 |
Not clear |
| R Cacabelos, A Alvarez, L Fenández-Novoa, V R Lombard. A pharmacogenomic approach to Alzheimer's disease. Acta neurologica Scandinavica. Supplementum. vol 176. 2001-05-17. PMID:11261800. |
using a matrix genetic model, including apoe, ps1 and ps2 allelic variants, we have studied the distribution of 36 different genotypes in the ad population (n= 479) and the genotype-related cognitive response to a multifactorial therapy in ad patients with mild-to-moderate dementia. |
2001-05-17 |
2023-08-12 |
Not clear |
| M F Jefferson, S Burlinson, A Burns, D Mann, S Pickering-Brown, F Owen, C Sriwardhana, N Pendleton, M A Hora. Clinical features of dementia associated with apolipoprotein epsilon4: discrimination with a neural network genetic algorithm. International journal of geriatric psychiatry. vol 16. issue 1. 2001-04-12. PMID:11180489. |
it is unclear whether the apoe epsilon4 allele is associated with distinct clinical features in dementia. |
2001-04-12 |
2023-08-12 |
Not clear |
| R Frikke-Schmidt, B G Nordestgaard, D Thudium, M L Moes Grønholdt, A Tybjaerg-Hanse. APOE genotype predicts AD and other dementia but not ischemic cerebrovascular disease. Neurology. vol 56. issue 2. 2001-04-05. PMID:11160955. |
apoe genotype predicts ad and other dementia but not ischemic cerebrovascular disease. |
2001-04-05 |
2023-08-12 |
Not clear |
| R Frikke-Schmidt, B G Nordestgaard, D Thudium, M L Moes Grønholdt, A Tybjaerg-Hanse. APOE genotype predicts AD and other dementia but not ischemic cerebrovascular disease. Neurology. vol 56. issue 2. 2001-04-05. PMID:11160955. |
the hypothesis that apoe genotype, through its effect on lipoproteins, is a common risk factor for ischemic cerebrovascular disease (icvd), ad, and other dementia (od) was tested. |
2001-04-05 |
2023-08-12 |
Not clear |
| B Paradowski, M Szczepaniak, T Dobosz, M Sasiade. [Apolipoprotein E(ApoE)and tau protein in Alzheimer type dementia]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego. vol 9. issue 53. 2001-03-08. PMID:11204323. |
[apolipoprotein e(apoe)and tau protein in alzheimer type dementia]. |
2001-03-08 |
2023-08-12 |
Not clear |