| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S M Pickering-Brown, F Owen, A Isaacs, J Snowden, A Varma, D Neary, R Furlong, S E Daniel, N J Cairns, D M Man. Apolipoprotein E epsilon4 allele has no effect on age at onset or duration of disease in cases of frontotemporal dementia with pick- or microvacuolar-type histology. Experimental neurology. vol 163. issue 2. 2000-07-17. PMID:10833320. |
we conclude therefore that polymorphic variations in the apoe gene do not modulate either the occurrence or progression of these non-alzheimer forms of dementia. |
2000-07-17 |
2023-08-12 |
Not clear |
| S Moalem, M E Percy, D F Andrews, T P Kruck, S Wong, A J Dalton, P Mehta, B Fedor, A C Warre. Are hereditary hemochromatosis mutations involved in Alzheimer disease? American journal of medical genetics. vol 93. issue 1. 2000-07-10. PMID:10861683. |
because the apolipoprotein e (apoe) e4 allele is a risk factor for ad and possibly also for dementia of the ad type in ds, dna samples were also apoe genotyped. |
2000-07-10 |
2023-08-12 |
Not clear |
| N Hirono, M Yasuda, S Tanimukai, H Kitagaki, E Mor. Effect of the apolipoprotein E epsilon4 allele on white matter hyperintensities in dementia. Stroke. vol 31. issue 6. 2000-06-27. PMID:10835442. |
the clinical significance of the apoe epsilon4 allele in white matter changes in patients with dementia has been a subject of debate. |
2000-06-27 |
2023-08-12 |
human |
| N Hirono, M Yasuda, S Tanimukai, H Kitagaki, E Mor. Effect of the apolipoprotein E epsilon4 allele on white matter hyperintensities in dementia. Stroke. vol 31. issue 6. 2000-06-27. PMID:10835442. |
we studied the association between the apoe epsilon4 allele and white matter hyperintensities (wmhs) before and after control for (1) potential vascular risk factors and (2) the presence of lacunar infarcts in patients with dementia. |
2000-06-27 |
2023-08-12 |
human |
| L Traykov, A S Rigaud, L Caputo, R Couderc, J Coste, J L Michot, J de Rotrou, P Amouyel, F Forette, F Bolle. Apolipoprotein E phenotypes in demented and cognitively impaired patients with and without cerebrovascular disease. European journal of neurology. vol 6. issue 4. 2000-06-21. PMID:10362893. |
controversy exists regarding the apolipoprotein e (apoe) epsilon4 allele association with vascular dementia (vad), ranging from increased epsilon4 frequency, similar to that found for alzheimer's disease (ad), to no association between the epsilon4 allele and vad. |
2000-06-21 |
2023-08-12 |
Not clear |
| L Traykov, A S Rigaud, L Caputo, R Couderc, J Coste, J L Michot, J de Rotrou, P Amouyel, F Forette, F Bolle. Apolipoprotein E phenotypes in demented and cognitively impaired patients with and without cerebrovascular disease. European journal of neurology. vol 6. issue 4. 2000-06-21. PMID:10362893. |
to clarify further the relationship between apoe alleles polymorphism and cerebrovascular disease (cvd) in demented and cognitively impaired patients, we examined the apoe phenotypes in a sample of 280 patients: 155 with ad, 21 with vad, 32 with mixed dementia (md), 45 with mild cognitive impairment (mci) but without cvd, and 27 in which vascular disease was the most probable cause of cognitive decline [vascular mild cognitive impairment (vmci)]. |
2000-06-21 |
2023-08-12 |
Not clear |
| A S Khachaturian, J J Gallo, J C Breitne. Performance characteristics of a two-stage dementia screen in a population sample. Journal of clinical epidemiology. vol 53. issue 5. 2000-06-14. PMID:10812327. |
after adjustment for age, the efficiency of the both 3ms/iqcode and the dq was better for subjects with genotype epsilon4/epsilon4 at apoe, better among women, and better in those with two or more years duration of dementia. |
2000-06-14 |
2023-08-12 |
human |
| C Dufouil, C Tzourio, C Brayne, C Berr, P Amouyel, A Alpérovitc. Influence of apolipoprotein E genotype on the risk of cognitive deterioration in moderate drinkers and smokers. Epidemiology (Cambridge, Mass.). vol 11. issue 3. 2000-06-08. PMID:10784244. |
the apoe epsilon4 allele is an established risk factor for dementia and cognitive impairment. |
2000-06-08 |
2023-08-12 |
human |
| I Alafuzoff, S Helisalmi, A Mannermaa, H Soinine. Severity of cardiovascular disease, apolipoprotein E genotype, and brain pathology in aging and dementia. Annals of the New York Academy of Sciences. vol 903. 2000-06-02. PMID:10818513. |
on the other hand, the extent of vascular lesions currently used for the diagnosis of vascular dementia (vad) showed correlation with the cardiovascular index, whereas apoe epsilon 4 allele did not seem to influence the extent of vascular lesions. |
2000-06-02 |
2023-08-12 |
Not clear |
| F van Leuve. Single and multiple transgenic mice as models for Alzheimer's disease. Progress in neurobiology. vol 61. issue 3. 2000-05-31. PMID:10727777. |
mice overexpressing human presenilin 1, apoe 4 and protein tau to generate "multiple" transgenic mice, offer additional potential to define the pathological interactions of these genetic factors, known to be involved, directly or indirectly, in dementia of the alzheimer type. |
2000-05-31 |
2023-08-12 |
mouse |
| M Bonarek, P Barberger-Gateau, L Letenneur, V Deschamps, A Iron, B Dubroca, J F Dartigue. Relationships between cholesterol, apolipoprotein E polymorphism and dementia: a cross-sectional analysis from the PAQUID study. Neuroepidemiology. vol 19. issue 3. 2000-05-04. PMID:10705232. |
elevated high-density lipoprotein cholesterol was associated with a significantly decreased risk of dementia, independent of apoe status and other potential confounding variables, suggesting that cholesterol fractions could be involved in both alzheimer's disease and vascular dementia. |
2000-05-04 |
2023-08-12 |
human |
| V N Trieu, F M Ucku. Apolipoprotein E and apolipoprotein D expression in a murine model of singlet oxygen-induced cerebral stroke. Biochemical and biophysical research communications. vol 268. issue 3. 2000-03-22. PMID:10679292. |
the insights gained from this study should facilitate the elucidation of the role of apoe in neurological disorders such as dementia with stroke and alzheimer's disease. |
2000-03-22 |
2023-08-12 |
mouse |
| X A Alvarez, R Mouzo, V Pichel, P Pérez, M Laredo, L Fernández-Novoa, L Corzo, R Zas, M Alcaraz, J J Secades, R Lozano, R Cacabelo. Double-blind placebo-controlled study with citicoline in APOE genotyped Alzheimer's disease patients. Effects on cognitive performance, brain bioelectrical activity and cerebral perfusion. Methods and findings in experimental and clinical pharmacology. vol 21. issue 9. 2000-02-28. PMID:10669911. |
as compared to placebo, citicoline improved cognitive performance in alzheimer's disease patients with apoe e4 (adas: difference between groups = -3.2 +/- 1.8 scores, p < 0.05; adas-cog: difference between groups = -2.3 +/- 1.5, ns); and this improvement on cognition was more pronounced (adas, p < 0.01; adas-cog: difference between groups = -2.8 +/- 1.3, p < 0.06) in patients with mild dementia (gds < 5). |
2000-02-28 |
2023-08-12 |
Not clear |
| M Prince, S Lovestone, J Cervilla, S Joels, J Powell, C Russ, A Man. The association between APOE and dementia does not seem to be mediated by vascular factors. Neurology. vol 54. issue 2. 2000-02-18. PMID:10668701. |
the association between apoe and dementia does not seem to be mediated by vascular factors. |
2000-02-18 |
2023-08-12 |
Not clear |
| M Prince, S Lovestone, J Cervilla, S Joels, J Powell, C Russ, A Man. The association between APOE and dementia does not seem to be mediated by vascular factors. Neurology. vol 54. issue 2. 2000-02-18. PMID:10668701. |
the effect of apoe on dementia may be mediated through dyslipidemia and atherogenesis through its effect on cholesterol metabolism. |
2000-02-18 |
2023-08-12 |
Not clear |
| K Juva, A Verkkoniemi, P Viramo, T Polvikoski, K Kainulainen, K Kontula, R Sulkav. APOE epsilon4 does not predict mortality, cognitive decline, or dementia in the oldest old. Neurology. vol 54. issue 2. 2000-02-18. PMID:10668704. |
apoe epsilon4 does not predict mortality, cognitive decline, or dementia in the oldest old. |
2000-02-18 |
2023-08-12 |
Not clear |
| L Zhu, L Fratiglioni, Z Guo, H Basun, E H Corder, B Winblad, M Viitane. Incidence of dementia in relation to stroke and the apolipoprotein E epsilon4 allele in the very old. Findings from a population-based longitudinal study. Stroke. vol 31. issue 1. 2000-02-07. PMID:10625715. |
both stroke and the apolipoprotein e (apoe) epsilon4 allele increase the risk of dementia. |
2000-02-07 |
2023-08-12 |
Not clear |
| L Zhu, L Fratiglioni, Z Guo, H Basun, E H Corder, B Winblad, M Viitane. Incidence of dementia in relation to stroke and the apolipoprotein E epsilon4 allele in the very old. Findings from a population-based longitudinal study. Stroke. vol 31. issue 1. 2000-02-07. PMID:10625715. |
however, the interaction between stroke and apoe on dementia is still unclear. |
2000-02-07 |
2023-08-12 |
Not clear |
| J Thome, J C Gewirtz, N Sakai, V Zachariou, P Retz-Junginger, W Retz, R S Duman, M Rösle. Polymorphisms of the human apolipoprotein E promoter and bleomycin hydrolase gene: risk factors for Alzheimer's dementia? Neuroscience letters. vol 274. issue 1. 2000-02-04. PMID:10530514. |
in addition to the apolipoprotein e (apoe) tri-allele polymorphism, genetic variants of the apolipoprotein e promoter (-491a/t) and the bleomycin hydrolase (bh-pen) gene have also been proposed as genetic risk factors for alzheimer's dementia (ad). |
2000-02-04 |
2023-08-12 |
human |
| P de Knijff, C M van Duij. Role of APOE in dementia: A critical reappraisal. Haemostasis. vol 28. issue 3-4. 1999-12-22. PMID:10420066. |
role of apoe in dementia: a critical reappraisal. |
1999-12-22 |
2023-08-12 |
Not clear |