| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y Ihara, T Hayabara, K Sasaki, R Kawada, Y Nakashima, S Kurod. Relationship between oxidative stress and apoE phenotype in Alzheimer's disease. Acta neurologica Scandinavica. vol 102. issue 6. 2001-02-15. PMID:11125747. |
to investigate the relationship between oxidative stress and apoe phenotype in dementia of alzheimer type (dat). |
2001-02-15 |
2023-08-12 |
Not clear |
| N Durany, P Riederer, F F Cruz-Sánche. Apolipoprotein E genotype in Spanish schizophrenic patients. Psychiatric genetics. vol 10. issue 2. 2001-01-26. PMID:10994644. |
schizophrenia is in some cases associated with cognitive impairment similar to that of alzheimer patients; therefore, one may postulate that the apoe gene, whose role in the dementia of alzheimer's type has been clearly demonstrated, may also be involved in schizophrenia. |
2001-01-26 |
2023-08-12 |
Not clear |
| J M Johnston, V Nazar-Stewart, S F Kelsey, M I Kamboh, M Gangul. Relationships between cerebrovascular events, APOE polymorphism and Alzheimer's disease in a community sample. Neuroepidemiology. vol 19. issue 6. 2000-12-27. PMID:11060506. |
to investigate whether the apoe*4 allele modified the relationship between cerebrovascular events and alzheimer's disease (ad), we collected evidence of previous stroke or transient ischemic attack (tia) and determined apoe genotype among 102 subjects with ad and 375 nondemented subjects in a community-based study of dementia. |
2000-12-27 |
2023-08-12 |
human |
| C K Rosenberg, M A Pericak-Vance, A M Saunders, J R Gilbert, P C Gaskell, C M Hulett. Lewy body and Alzheimer pathology in a family with the amyloid-beta precursor protein APP717 gene mutation. Acta neuropathologica. vol 100. issue 2. 2000-12-22. PMID:10963361. |
a cousin without the app717 mutation who was apoe 3, 4, developed dementia at age 60 and died at age 75. |
2000-12-22 |
2023-08-12 |
Not clear |
| T Rodriguez Martin, A M Calella, S Silva, E Munna, P Modena, R Chiesa, S Terrevazzi, R M Ruggieri, R Palermo, F Piccoli, R Confalonieri, P Tiraboschi, C Fragiacomo, P Quadri, U Lucca, G Forlon. Apolipoprotein E and intronic polymorphism of presenilin 1 and alpha-1-antichymotrypsin in Alzheimer's disease and vascular dementia. Dementia and geriatric cognitive disorders. vol 11. issue 5. 2000-10-11. PMID:10940674. |
apolipoprotein e (apoe) genotypes, presenilin 1 (ps-1) and alpha(1)-antichymotrypsin (act) polymorphism and the association of the genotypes were examined in patients with alzheimer's disease (ad, n = 121) or vascular dementia (vd, n = 68) in comparison with elderly controls (n = 125). |
2000-10-11 |
2023-08-12 |
Not clear |
| J Shi, G Perry, M A Smith, R P Friedlan. Vascular abnormalities: the insidious pathogenesis of Alzheimer's disease. Neurobiology of aging. vol 21. issue 2. 2000-08-24. PMID:10867221. |
here, we review studies on the cerebral vasculature, cardiac vasculature, and apoe that lead us to contend that vascular abnormalities are likely an important mechanism underlying dementia. |
2000-08-24 |
2023-08-12 |
Not clear |
| B S Harhangi, M C de Rijk, C M van Duijn, C Van Broeckhoven, A Hofman, M M Bretele. APOE and the risk of PD with or without dementia in a population-based study. Neurology. vol 54. issue 6. 2000-08-18. PMID:10746597. |
apoe and the risk of pd with or without dementia in a population-based study. |
2000-08-18 |
2023-08-12 |
Not clear |
| B S Harhangi, M C de Rijk, C M van Duijn, C Van Broeckhoven, A Hofman, M M Bretele. APOE and the risk of PD with or without dementia in a population-based study. Neurology. vol 54. issue 6. 2000-08-18. PMID:10746597. |
to study the association between apoe genotype and pd with or without dementia. |
2000-08-18 |
2023-08-12 |
Not clear |
| S Y Bookheimer, M H Strojwas, M S Cohen, A M Saunders, M A Pericak-Vance, J C Mazziotta, G W Smal. Patterns of brain activation in people at risk for Alzheimer's disease. The New England journal of medicine. vol 343. issue 7. 2000-08-17. PMID:10944562. |
the epsilon4 allele of the apolipoprotein e gene (apoe) is the chief known genetic risk factor for alzheimer's disease, the most common cause of dementia late in life. |
2000-08-17 |
2023-08-12 |
Not clear |
| T Katsuya, N Sato, T Asai, M Fukuda, S Takiuchi, Y Fu, R Hanayama, A Moriguchi, H Rakugi, J Higaki, T Ogihar. Association of polymorphism in the promoter region of the apolipoprotein E gene with diastolic blood pressure in normotensive Japanese. Hypertension research : official journal of the Japanese Society of Hypertension. vol 23. issue 3. 2000-08-04. PMID:10821138. |
the epsilon4 allele of apolipoprotein e (apoe) is reported to be a genetic risk factor of atherosclerosis through hyperlipidemia and late-onset alzheimer's dementia. |
2000-08-04 |
2023-08-12 |
human |
| J W Knittweis, W A McMulle. The effect of apoE on dementia is not through atherosclerosis: the Rotterdam study. Neurology. vol 54. issue 12. 2000-07-31. PMID:10881278. |
the effect of apoe on dementia is not through atherosclerosis: the rotterdam study. |
2000-07-31 |
2023-08-12 |
Not clear |
| M Nishiyama, Y Kato, M Hashimoto, S Yukawa, K Omor. Apolipoprotein E, methylenetetrahydrofolate reductase (MTHFR) mutation and the risk of senile dementia--an epidemiological study using the polymerase chain reaction (PCR) method. Journal of epidemiology. vol 10. issue 3. 2000-07-19. PMID:10860300. |
although, it was not strongly related to the severity of senile dementia, a weak association between the apoe genotype and the severity of dementia was suggested. |
2000-07-19 |
2023-08-12 |
Not clear |
| M Nishiyama, Y Kato, M Hashimoto, S Yukawa, K Omor. Apolipoprotein E, methylenetetrahydrofolate reductase (MTHFR) mutation and the risk of senile dementia--an epidemiological study using the polymerase chain reaction (PCR) method. Journal of epidemiology. vol 10. issue 3. 2000-07-19. PMID:10860300. |
the results suggest that the apoe epsilon 4 genotype and the mthfr mutation are associated with the clinical phenotype and the clinical onset of senile dementia. |
2000-07-19 |
2023-08-12 |
Not clear |
| S M Pickering-Brown, F Owen, A Isaacs, J Snowden, A Varma, D Neary, R Furlong, S E Daniel, N J Cairns, D M Man. Apolipoprotein E epsilon4 allele has no effect on age at onset or duration of disease in cases of frontotemporal dementia with pick- or microvacuolar-type histology. Experimental neurology. vol 163. issue 2. 2000-07-17. PMID:10833320. |
here we have investigated the frequency of the epsilon4 allele of the apolipoprotein (apoe) gene in ftd and in other non-alzheimer forms of dementia related to ftd such as motor neurone disease dementia, semantic dementia, progressive aphasia, progressive supranuclear palsy, and corticobasal degeneration. |
2000-07-17 |
2023-08-12 |
Not clear |
| S M Pickering-Brown, F Owen, A Isaacs, J Snowden, A Varma, D Neary, R Furlong, S E Daniel, N J Cairns, D M Man. Apolipoprotein E epsilon4 allele has no effect on age at onset or duration of disease in cases of frontotemporal dementia with pick- or microvacuolar-type histology. Experimental neurology. vol 163. issue 2. 2000-07-17. PMID:10833320. |
we conclude therefore that polymorphic variations in the apoe gene do not modulate either the occurrence or progression of these non-alzheimer forms of dementia. |
2000-07-17 |
2023-08-12 |
Not clear |
| S Moalem, M E Percy, D F Andrews, T P Kruck, S Wong, A J Dalton, P Mehta, B Fedor, A C Warre. Are hereditary hemochromatosis mutations involved in Alzheimer disease? American journal of medical genetics. vol 93. issue 1. 2000-07-10. PMID:10861683. |
because the apolipoprotein e (apoe) e4 allele is a risk factor for ad and possibly also for dementia of the ad type in ds, dna samples were also apoe genotyped. |
2000-07-10 |
2023-08-12 |
Not clear |
| N Hirono, M Yasuda, S Tanimukai, H Kitagaki, E Mor. Effect of the apolipoprotein E epsilon4 allele on white matter hyperintensities in dementia. Stroke. vol 31. issue 6. 2000-06-27. PMID:10835442. |
the clinical significance of the apoe epsilon4 allele in white matter changes in patients with dementia has been a subject of debate. |
2000-06-27 |
2023-08-12 |
human |
| N Hirono, M Yasuda, S Tanimukai, H Kitagaki, E Mor. Effect of the apolipoprotein E epsilon4 allele on white matter hyperintensities in dementia. Stroke. vol 31. issue 6. 2000-06-27. PMID:10835442. |
we studied the association between the apoe epsilon4 allele and white matter hyperintensities (wmhs) before and after control for (1) potential vascular risk factors and (2) the presence of lacunar infarcts in patients with dementia. |
2000-06-27 |
2023-08-12 |
human |
| L Traykov, A S Rigaud, L Caputo, R Couderc, J Coste, J L Michot, J de Rotrou, P Amouyel, F Forette, F Bolle. Apolipoprotein E phenotypes in demented and cognitively impaired patients with and without cerebrovascular disease. European journal of neurology. vol 6. issue 4. 2000-06-21. PMID:10362893. |
controversy exists regarding the apolipoprotein e (apoe) epsilon4 allele association with vascular dementia (vad), ranging from increased epsilon4 frequency, similar to that found for alzheimer's disease (ad), to no association between the epsilon4 allele and vad. |
2000-06-21 |
2023-08-12 |
Not clear |
| L Traykov, A S Rigaud, L Caputo, R Couderc, J Coste, J L Michot, J de Rotrou, P Amouyel, F Forette, F Bolle. Apolipoprotein E phenotypes in demented and cognitively impaired patients with and without cerebrovascular disease. European journal of neurology. vol 6. issue 4. 2000-06-21. PMID:10362893. |
to clarify further the relationship between apoe alleles polymorphism and cerebrovascular disease (cvd) in demented and cognitively impaired patients, we examined the apoe phenotypes in a sample of 280 patients: 155 with ad, 21 with vad, 32 with mixed dementia (md), 45 with mild cognitive impairment (mci) but without cvd, and 27 in which vascular disease was the most probable cause of cognitive decline [vascular mild cognitive impairment (vmci)]. |
2000-06-21 |
2023-08-12 |
Not clear |