| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J M Johnston, J A Cauley, M Gangul. APOE 4 and hip fracture risk in a community-based study of older adults. Journal of the American Geriatrics Society. vol 47. issue 11. 1999-12-07. PMID:10573444. |
to investigate whether the apoe 4 allele was associated with increased risk of hip fracture in an older community-based sample and whether such an increased risk was independent of dementia and history of falling. |
1999-12-07 |
2023-08-12 |
Not clear |
| M Kanai, M Shizuka, K Urakami, E Matsubara, Y Harigaya, K Okamoto, M Shoj. Apolipoprotein E4 accelerates dementia and increases cerebrospinal fluid tau levels in Alzheimer's disease. Neuroscience letters. vol 267. issue 1. 1999-12-06. PMID:10400250. |
the apoe epsilon4 allele accelerates the progression of dementia and increases the levels of csf tau in ad patients. |
1999-12-06 |
2023-08-12 |
Not clear |
| A J Slooter, M Cruts, A Ott, M L Bots, J C Witteman, A Hofman, C Van Broeckhoven, M M Breteler, C M van Duij. The effect of APOE on dementia is not through atherosclerosis: the Rotterdam Study. Neurology. vol 53. issue 7. 1999-11-03. PMID:10534277. |
the effect of apoe on dementia is not through atherosclerosis: the rotterdam study. |
1999-11-03 |
2023-08-12 |
Not clear |
| A J Slooter, M Cruts, A Ott, M L Bots, J C Witteman, A Hofman, C Van Broeckhoven, M M Breteler, C M van Duij. The effect of APOE on dementia is not through atherosclerosis: the Rotterdam Study. Neurology. vol 53. issue 7. 1999-11-03. PMID:10534277. |
we studied, in a population-based setting (244 dementia cases; 1,002 nondemented controls), whether apoe is associated with dementia through atherosclerosis. |
1999-11-03 |
2023-08-12 |
Not clear |
| L M McConnell, G D Sanders, D K Owen. Evaluation of genetic tests: APOE genotyping for the diagnosis of Alzheimer disease. Genetic testing. vol 3. issue 1. 1999-10-21. PMID:10464577. |
however, although the medical community holds the near-unanimous opinion that apoe genotyping should not be used for prediction in asymptomatic individuals, controversy remains about whether it should be used for diagnosis in patients who show signs of dementia. |
1999-10-21 |
2023-08-12 |
Not clear |
| L F Lue, Y M Kuo, A E Roher, L Brachova, Y Shen, L Sue, T Beach, J H Kurth, R E Rydel, J Roger. Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease. The American journal of pathology. vol 155. issue 3. 1999-10-07. PMID:10487842. |
we have characterized amyloid beta peptide (abeta) concentration, abeta deposition, paired helical filament formation, cerebrovascular amyloid angiopathy, apolipoprotein e (apoe) allotype, and synaptophysin concentration in entorhinal cortex and superior frontal gyrus of normal elderly control (nd) patients, alzheimer's disease (ad) patients, and high pathology control (hpc) patients who meet pathological criteria for ad but show no synapse loss or overt antemortem symptoms of dementia. |
1999-10-07 |
2023-08-12 |
Not clear |
| J C Breitner, B W Wyse, J C Anthony, K A Welsh-Bohmer, D C Steffens, M C Norton, J T Tschanz, B L Plassman, M R Meyer, I Skoog, A Khachaturia. APOE-epsilon4 count predicts age when prevalence of AD increases, then declines: the Cache County Study. Neurology. vol 53. issue 2. 1999-09-21. PMID:10430421. |
to examine the prevalence of alzheimer's disease (ad) and other dementias in relation to age, education, sex, and genotype at apoe. |
1999-09-21 |
2023-08-12 |
Not clear |
| R Barber, A Gholkar, P Scheltens, C Ballard, I G McKeith, C M Morris, J T O'Brie. Apolipoprotein E epsilon4 allele, temporal lobe atrophy, and white matter lesions in late-life dementias. Archives of neurology. vol 56. issue 8. 1999-09-15. PMID:10448801. |
to examine the relationship between the apolipoprotein e (apoe) epsilon4 genotype, medial temporal lobe atrophy, and white matter hyperintensities on magnetic resonance imaging in late-life dementias. |
1999-09-15 |
2023-08-12 |
Not clear |
| A J Slooter, J J Houwing-Duistermaat, F van Harskamp, M Cruts, C Van Broeckhoven, M M Breteler, A Hofman, T Stijnen, C M van Duij. Apolipoprotein E genotype and progression of Alzheimer's disease: the Rotterdam Study. Journal of neurology. vol 246. issue 4. 1999-09-08. PMID:10367700. |
as change in cognitive function and severity of dementia are similar for ad patients with and without apoe*4, our study suggests that progression of ad is not related to the apoe*4 allele. |
1999-09-08 |
2023-08-12 |
Not clear |
| M F Weiner, G Vega, R C Risser, L S Honig, C M Cullum, D Crumpacker, R N Rosenber. Apolipoprotein E epsilon 4, other risk factors, and course of Alzheimer's disease. Biological psychiatry. vol 45. issue 5. 1999-08-10. PMID:10088051. |
we studied the relationship of apoe genotype in ad to educational attainment, history of heart disease or head injury, age of onset, gender, severity of illness, depression, psychotic symptoms, rate of dementia progression, and time from initial evaluation to nursing home placement. |
1999-08-10 |
2023-08-12 |
Not clear |
| B Regland, K Blennow, T Germgård, A C Koch-Schmidt, C G Gottfrie. The role of the polymorphic genes apolipoprotein E and methylene- tetrahydrofolate reductase in the development of dementia of the Alzheimer type. Dementia and geriatric cognitive disorders. vol 10. issue 4. 1999-08-05. PMID:10364640. |
the gene for apolipoprotein e (apoe) is polymorphic, and its variant apoe4 is a major risk factor for the development of alzheimer-type dementia (ad). |
1999-08-05 |
2023-08-12 |
Not clear |
| L O Wahlund, P Julin, L Lannfelt, J Lindqvist, L Svensso. Inheritance of the ApoE epsilon4 allele increases the rate of brain atrophy in dementia patients. Dementia and geriatric cognitive disorders. vol 10. issue 4. 1999-08-05. PMID:10364643. |
inheritance of the apoe epsilon4 allele increases the rate of brain atrophy in dementia patients. |
1999-08-05 |
2023-08-12 |
human |
| L O Wahlund, P Julin, L Lannfelt, J Lindqvist, L Svensso. Inheritance of the ApoE epsilon4 allele increases the rate of brain atrophy in dementia patients. Dementia and geriatric cognitive disorders. vol 10. issue 4. 1999-08-05. PMID:10364643. |
we investigated the influence of the apolipoprotein (apoe) epsilon4 allele on the rate of brain atrophy in patients with clinical dementia and in subjects at risk for dementia. |
1999-08-05 |
2023-08-12 |
human |
| N Hirono, E Mori, M Yasuda, T Imamura, T Shimomura, M Hashimoto, S Tanimukai, H Kazui, H Yamashit. Lack of effect of apolipoprotein E E4 allele on neuropsychiatric manifestations in Alzheimer's disease. The Journal of neuropsychiatry and clinical neurosciences. vol 11. issue 1. 1999-05-20. PMID:9990558. |
neither the severity nor the presence of any behavioral changes was associated with the number of apoe e4 alleles, even after controlling for the effects of age at onset, sex, education level, duration of illness, and severity of dementia. |
1999-05-20 |
2023-08-12 |
Not clear |
| H Houlden, P Rizzu, M Stevens, P de Knijff, C M van Duijn, J C van Swieten, P Heutink, J Perez-Tur, V Thomas, M Baker, H Morris, M Rossor, J C Jannsen, R C Petersen, P Dodd, F Dark, B Boeve, D Dickson, P Davies, S Pickering-Brown, D Mann, J Adamson, T Lynch, H Payami, J Hard. Apolipoprotein E genotype does not affect the age of onset of dementia in families with defined tau mutations. Neuroscience letters. vol 260. issue 3. 1999-05-17. PMID:10076900. |
we have assessed whether apolipoprotein e (apoe) genotype influences the age of onset of dementia in a series of families with frontal temporal dementia with defined mutations in the tau gene. |
1999-05-17 |
2023-08-12 |
Not clear |
| D Bartrés-Faz, I Clement. [Apolipoproteins and cognitive deterioration]. Actas luso-espanolas de neurologia, psiquiatria y ciencias afines. vol 26. issue 6. 1999-04-22. PMID:9972590. |
in some studies a relation between apoe's alleles and cerebral vascular disorders like ischemic, haemorrhagic, vascular (vd) and multi-infarct (md) dementias is also reported. |
1999-04-22 |
2023-08-12 |
human |
| M Kuriyam. [Lipoproteins in clinical laboratory medicine]. Rinsho byori. The Japanese journal of clinical pathology. vol 46. issue 12. 1999-03-22. PMID:9916507. |
the frequency of the apoe epsilon 4 allele was obviously high in ad patients compared with the controls, but it was not different between vascular dementia patients and the controls. |
1999-03-22 |
2023-08-12 |
Not clear |
| K Ikeda, H Akiyama, T Arai, T Oda, M Kato, E Iseki, K Kosaka, K Wakabayashi, H Takahash. Clinical aspects of 'senile dementia of the tangle type'-- a subset of dementia in the senium separable from late-onset Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 10. issue 1. 1999-03-03. PMID:9844032. |
this patient group was thought to be separable from those with alzheimer's disease based on the results of apoe allele analysis in addition to the substantial absence of amyloid beta deposits and has been designated as senile dementia of the tangle type (sdt). |
1999-03-03 |
2023-08-12 |
Not clear |
| C Murphy, A W Bacon, M W Bondi, D P Salmo. Apolipoprotein E status is associated with odor identification deficits in nondemented older persons. Annals of the New York Academy of Sciences. vol 855. 1999-02-24. PMID:9929680. |
persons who are either heterozygous or homozygous for the epsilon 4 allele of apolipoprotein e (apoe) have an increased risk of alzheimer's disease, although they show no dementia in the preclinical period. |
1999-02-24 |
2023-08-12 |
human |
| K Amar, S MacGowan, G Wilcock, T Lewis, M Scot. Are genetic factors important in the aetiology of leukoaraiosis? Results from a memory clinic population. International journal of geriatric psychiatry. vol 13. issue 9. 1998-12-07. PMID:9777422. |
to discover whether polymorphism in either the apolipoprotein e (apoe) or angiotensin-converting enzyme (ace) genes is associated with leukoaraiosis, white matter lesions visible on neuroimaging of the brain, which is commonly seen in dementia as well as some normal elderly subjects. |
1998-12-07 |
2023-08-12 |
human |