| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiangyang Yu, Lili Jia, Kuoqi Yin, Jingshu Lv, Wenli Yu, Hongyin D. Src is Implicated in Hepatic Ischemia Reperfusion-Induced Hippocampus Injury and Long-Term Cognitive Impairment in Young Mice via NMDA Receptor Subunit 2A Activation. Neuroscience. vol 391. 2019-02-27. PMID:30213765. |
hepatic ischemia reperfusion (hir) has been found to induce hippocampus injury and cognitive dysfunction. |
2019-02-27 |
2023-08-13 |
mouse |
| Xiangyang Yu, Lili Jia, Kuoqi Yin, Jingshu Lv, Wenli Yu, Hongyin D. Src is Implicated in Hepatic Ischemia Reperfusion-Induced Hippocampus Injury and Long-Term Cognitive Impairment in Young Mice via NMDA Receptor Subunit 2A Activation. Neuroscience. vol 391. 2019-02-27. PMID:30213765. |
in summary, hir can lead to hippocampus injury and long-term cognitive dysfunction, and src-psd95-nr2a pathway plays an important role in the process. |
2019-02-27 |
2023-08-13 |
mouse |
| Li Juan Zheng, Yun Yan Su, Yun Fei Wang, U Joseph Schoepf, Akos Varga-Szemes, Jonathan Pannell, Xue Liang, Gang Zheng, Guang Ming Lu, Gui Fen Yang, Long Jiang Zhan. Different Hippocampus Functional Connectivity Patterns in Healthy Young Adults with Mutations of APP/Presenilin-1/2 and APOEε4. Molecular neurobiology. vol 55. issue 4. 2019-02-04. PMID:28502043. |
young healthy adults carrying apoe ε4 and app/presenilin-1/2 displayed different hippocampus functional connectivity patterns, which may underlie the discrepant mechanisms of gene-modulated cognitive dysfunction in alzheimer's disease. |
2019-02-04 |
2023-08-13 |
human |
| Lei An, Yuchen Sun, Wei Zhang, Xiaolong Huang, Rui Xue, Youzhi Zhang, Yousheng Wan. Walnut diets up-regulate the decreased hippocampal neurogenesis and age-related cognitive dysfunction in d-galactose induced aged rats. Food & function. vol 9. issue 9. 2019-01-22. PMID:30101966. |
walnut diets up-regulate the decreased hippocampal neurogenesis and age-related cognitive dysfunction in d-galactose induced aged rats. |
2019-01-22 |
2023-08-13 |
rat |
| Lei An, Yuchen Sun, Wei Zhang, Xiaolong Huang, Rui Xue, Youzhi Zhang, Yousheng Wan. Walnut diets up-regulate the decreased hippocampal neurogenesis and age-related cognitive dysfunction in d-galactose induced aged rats. Food & function. vol 9. issue 9. 2019-01-22. PMID:30101966. |
these findings confirmed that chronic walnut-rich diets could ameliorate cognitive dysfunction in d-gal model rats, and the up-regulation of neurogenesis, as well as the expression of pcreb and bdnf in hippocampus, may be one of the molecular and cellular mechanisms underlying these effects. |
2019-01-22 |
2023-08-13 |
rat |
| Xu Yang, Zheng Cao, Jian Zhang, Bing Shao, Miao Song, Yanfei Han, Yanfei L. Dendritic spine loss caused by AlCl Environmental pollution (Barking, Essex : 1987). vol 243. issue Pt B. 2019-01-11. PMID:30300874. |
hippocampal dendritic spine loss is a pathological characteristic of cognitive dysfunction. |
2019-01-11 |
2023-08-13 |
rat |
| Junli Jiang, Chunchun Tang, Juanjuan Ren, Chao Zhang, Liang Dong, Zhaoqiong Zh. Effect of multiple neonatal sevoflurane exposures on hippocampal apolipoprotein E levels and learning and memory abilities. Pediatrics and neonatology. vol 59. issue 2. 2019-01-07. PMID:28890046. |
in this study, we investigated whether early multiple exposures to sevoflurane induced cognitive dysfunction by altering the hippocampal expression of apoe later in development. |
2019-01-07 |
2023-08-13 |
Not clear |
| Ting Sun, Yu-Jiao Li, Qin-Qin Tian, Qi Wu, Dan Feng, Zhe Xue, Yan-Yan Guo, Le Yang, Kun Zhang, Ming-Gao Zhao, Yu-Mei W. Activation of liver X receptor β-enhancing neurogenesis ameliorates cognitive impairment induced by chronic cerebral hypoperfusion. Experimental neurology. vol 304. 2019-01-07. PMID:29447944. |
this study correlates a deficit of lxrβ in cognitive dysfunction in cch with impaired neurogenesis in hippocampus, and lxrs may serve as a potential therapeutic target for chronic cerebral ischemia. |
2019-01-07 |
2023-08-13 |
mouse |
| Zhitong Qiao, Yan Han, Xiaoxia Han, Han Xu, Will X Y Li, Dong Song, Theodore W Berger, Ray C C Cheun. ASIC Implementation of a Nonlinear Dynamical Model for Hippocampal Prosthesis. Neural computation. vol 30. issue 9. 2019-01-02. PMID:29949460. |
a hippocampal prosthesis is a very large scale integration (vlsi) biochip that needs to be implanted in the biological brain to solve a cognitive dysfunction. |
2019-01-02 |
2023-08-13 |
Not clear |
| Robert H Pietrzak, Simon M Laws, Yen Ying Lim, Sophie J Bender, Tenielle Porter, James Doecke, David Ames, Christopher Fowler, Colin L Masters, Lidija Milicic, Stephanie Rainey-Smith, Victor L Villemagne, Christopher C Rowe, Ralph N Martins, Paul Maruf. Plasma Cortisol, Brain Amyloid-β, and Cognitive Decline in Preclinical Alzheimer's Disease: A 6-Year Prospective Cohort Study. Biological psychiatry. Cognitive neuroscience and neuroimaging. vol 2. issue 1. 2018-12-19. PMID:29560886. |
hypothalamic-pituitary-adrenal axis dysregulation, which is typically assessed by measuring cortisol levels, is associated with cognitive dysfunction, hippocampal atrophy, and increased risk for mild cognitive impairment and alzheimer's disease (ad). |
2018-12-19 |
2023-08-13 |
Not clear |
| b' N Cabezas-Llobet, L Vidal-Sancho, M Masana, A Fournier, J Alberch, D Vaudry, X Xifr\\xc3\\xb. Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Enhances Hippocampal Synaptic Plasticity and Improves Memory Performance in Huntington\'s Disease. Molecular neurobiology. vol 55. issue 11. 2018-12-17. PMID:29526016.' |
first, we observed a hippocampal decline of all three pacap receptor expressions, i.e., pac1, vpac1, and vpac2, in two different hd mouse models, r6/1 and hdhq7/q111, from the onset of cognitive dysfunction. |
2018-12-17 |
2023-08-13 |
mouse |
| M G Gottschalk, P Mortas, M Haman, S Ozcan, B Biemans, S Bah. Fluoxetine, not donepezil, reverses anhedonia, cognitive dysfunctions and hippocampal proteome changes during repeated social defeat exposure. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 28. issue 1. 2018-12-11. PMID:29174946. |
fluoxetine, not donepezil, reverses anhedonia, cognitive dysfunctions and hippocampal proteome changes during repeated social defeat exposure. |
2018-12-11 |
2023-08-13 |
Not clear |
| Ming Cui, Huiwen Xiao, Yuan Li, Jiali Dong, Dan Luo, Hang Li, Guoxing Feng, Haichao Wang, Saijun Fa. Total abdominal irradiation exposure impairs cognitive function involving miR-34a-5p/BDNF axis. Biochimica et biophysica acta. Molecular basis of disease. vol 1863. issue 9. 2018-11-27. PMID:28668331. |
mechanically, microarray assay analysis revealed that tai elevated the expression level of mir-34a-5p in small intestine tissues and peripheral blood (pd), which targeted the 3'utr of brain-derived neurotrophic factor (bdnf) mrna in hippocampus to mediate cognitive dysfunction. |
2018-11-27 |
2023-08-13 |
mouse |
| Ze-Mei Zhu, Ji-Hua Yang, Si-Si Yang, Jian-Qin He, Kai-Fang Zhang, Shui-Dong Feng, Hong-Yan Lin. [The effects of dihydromyricetin on cognitive dysfunction in type 2 diabetes mice]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 33. issue 4. 2018-11-14. PMID:29926637. |
to observe the effects of dihydromyricetin(dhm) on cognitive dysfunction and expression of brain derived neurotrophic factor(bdnf) protein in hippocampus of type 2 diabetic mice(t2dm). |
2018-11-14 |
2023-08-13 |
mouse |
| Ping Dong, Jian Zhao, Ning Li, Lingling Lu, Liang Li, Xiyan Zhang, Bo Yang, Li Zhang, Dongliang L. Sevoflurane exaggerates cognitive decline in a rat model of chronic intermittent hypoxia by aggravating microglia-mediated neuroinflammation via downregulation of PPAR-γ in the hippocampus. Behavioural brain research. vol 347. 2018-11-13. PMID:29574103. |
the results suggest that microglia-mediated neuroinflammation in the hippocampus plays an important role in the pathogenesis of cih-associated cognitive dysfunction, and that a moderate duration of sevoflurane exaggerates cognitive decline under cih conditions by aggravating microglia-mediated neuroinflammation via downregulation of ppar-γ in the hippocampus. |
2018-11-13 |
2023-08-13 |
rat |
| Margalida Cifre, Andreu Palou, Paula Olive. Cognitive impairment in metabolically-obese, normal-weight rats: identification of early biomarkers in peripheral blood mononuclear cells. Molecular neurodegeneration. vol 13. issue 1. 2018-11-09. PMID:29566703. |
we aimed to evaluate whether monw-like animals present gene expression alterations in the hippocampus associated with an increased risk of cognitive impairment, and to identify early biomarkers of cognitive dysfunction in peripheral blood mononuclear cells (pbmc). |
2018-11-09 |
2023-08-13 |
rat |
| Chun Wang, Gaoyou Lü, Yan Li, Shidi Zhao, Li Huan. [Impairment of spatial learning and memory and changes of oxidative stress in hippocampus from Type 1 diabetic mice]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 43. issue 5. 2018-11-06. PMID:29886460. |
furthermore, the activity of inos and the content of mda were markedly increased, and the activity of sod was significantly decreased in hippocampus of diabetic encephalopathy mice (p<0.01).
conclusion: the established type 1 diabetic mice show symptoms of cognitive dysfunction, which might be related to the increase of oxidative stress in hippocampus. |
2018-11-06 |
2023-08-13 |
mouse |
| Yuanyuan Wang, Jie Tang, Lin Shen, Jiangyan Li, Cheng Zha, Rui Wang, Kun Hu, Jin Xi, Jianrong Chang, Changhao Xi. [Effects of dexamethasone on MRL/lpr mice with systemic lupus erythematosus complicated with cognitive dysfunction]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 42. issue 3. 2018-10-15. PMID:28364096. |
results: treatment with dexamethasone (1.5 mg/kg) alleviated the cognitive dysfunction and decreased the levels of il-6, il-1β and tnf-α in serum and hippocampus, and reduced the levels of p-pi3k, p-akt, p-iκba and p-nf-κb p65 in hippocampus in mrl/lpr mice.
conclusion: dexamethasone may play a protective role in the cognitive function by decreasing the levels of tnf-α and il-1β in the hippocampus of mrl/lpr lupus mice. |
2018-10-15 |
2023-08-13 |
mouse |
| Diana M Sama, Shaun W Carlson, Binoy Joseph, Stefanie Saenger, Friedrich Metzger, Kathryn E Saatma. Assessment of systemic administration of PEGylated IGF-1 in a mouse model of traumatic brain injury. Restorative neurology and neuroscience. vol 36. issue 4. 2018-10-15. PMID:29889090. |
traumatic brain injury can result in lasting cognitive dysfunction due to degeneration of mature hippocampal neurons as well as the loss of immature neurons within the dentate gyrus. |
2018-10-15 |
2023-08-13 |
mouse |
| Venkatanaidu Karri, Vikas Kumar, David Ramos, Eliandre Oliveira, Marta Schuhmache. Comparative In Vitro Toxicity Evaluation of Heavy Metals (Lead, Cadmium, Arsenic, and Methylmercury) on HT-22 Hippocampal Cell Line. Biological trace element research. vol 184. issue 1. 2018-10-09. PMID:28994012. |
many recent studies have supported the hippocampus as the major target for these four metals for inflicting cognitive dysfunction. |
2018-10-09 |
2023-08-13 |
human |