| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Makoto Tamura, Timothy J Spellman, Andrew M Rosen, Joseph A Gogos, Joshua A Gordo. Hippocampal-prefrontal theta-gamma coupling during performance of a spatial working memory task. Nature communications. vol 8. issue 1. 2018-10-01. PMID:29259151. |
here we report that theta-slow gamma coupling between the hippocampus and medial prefrontal cortex (mpfc) is augmented in a genetic mouse model of cognitive dysfunction. |
2018-10-01 |
2023-08-13 |
mouse |
| Songyun Zhang, Lingling Yuan, Lihui Zhang, Caige Li, Jie L. Prophylactic Use of Troxerutin Can Delay the Development of Diabetic Cognitive Dysfunction and Improve the Expression of Nrf2 in the Hippocampus on STZ Diabetic Rats. Behavioural neurology. vol 2018. 2018-09-28. PMID:29849815. |
prophylactic use of troxerutin can delay the development of diabetic cognitive dysfunction and improve the expression of nrf2 in the hippocampus on stz diabetic rats. |
2018-09-28 |
2023-08-13 |
rat |
| B Cannerfelt, J Nystedt, A Jönsen, J Lätt, D van Westen, A Lilja, A Bengtsson, P Nilsson, J Mårtensson, P C Sundgre. White matter lesions and brain atrophy in systemic lupus erythematosus patients: correlation to cognitive dysfunction in a cohort of systemic lupus erythematosus patients using different definition models for neuropsychiatric systemic lupus erythematosus. Lupus. vol 27. issue 7. 2018-09-27. PMID:29523054. |
aim the aim of this study was to evaluate the extent of white matter lesions, atrophy of the hippocampus and corpus callosum, and their correlation with cognitive dysfunction (cd), in patients diagnosed with systemic lupus erythematosus (sle). |
2018-09-27 |
2023-08-13 |
Not clear |
| B Cannerfelt, J Nystedt, A Jönsen, J Lätt, D van Westen, A Lilja, A Bengtsson, P Nilsson, J Mårtensson, P C Sundgre. White matter lesions and brain atrophy in systemic lupus erythematosus patients: correlation to cognitive dysfunction in a cohort of systemic lupus erythematosus patients using different definition models for neuropsychiatric systemic lupus erythematosus. Lupus. vol 27. issue 7. 2018-09-27. PMID:29523054. |
number and volume of white matter lesions and atrophy of the hippocampus and corpus callosum were correlated to cognitive dysfunction. |
2018-09-27 |
2023-08-13 |
Not clear |
| Melissa L Perreault, Theresa Fan, Tomek J Banasikowski, Anthony A Grace, Susan R Georg. The atypical dopamine receptor agonist SKF 83959 enhances hippocampal and prefrontal cortical neuronal network activity in a rat model of cognitive dysfunction. The European journal of neuroscience. vol 46. issue 4. 2018-09-06. PMID:28677227. |
the atypical dopamine receptor agonist skf 83959 enhances hippocampal and prefrontal cortical neuronal network activity in a rat model of cognitive dysfunction. |
2018-09-06 |
2023-08-13 |
rat |
| Melissa L Perreault, Theresa Fan, Tomek J Banasikowski, Anthony A Grace, Susan R Georg. The atypical dopamine receptor agonist SKF 83959 enhances hippocampal and prefrontal cortical neuronal network activity in a rat model of cognitive dysfunction. The European journal of neuroscience. vol 46. issue 4. 2018-09-06. PMID:28677227. |
deficits in neuronal network synchrony in hippocampus and prefrontal cortex have been widely demonstrated in disorders of cognitive dysfunction, including schizophrenia and alzheimer's disease. |
2018-09-06 |
2023-08-13 |
rat |
| Yi Qiu, Ying Wang, Xiaodong Wang, Caixia Wang, Zhong-Yuan Xi. Role of the hippocampal 5-HT1A receptor-mediated cAMP/PKA signalling pathway in sevoflurane-induced cognitivedysfunction in aged rats. The Journal of international medical research. vol 46. issue 3. 2018-08-30. PMID:29332488. |
objective this study aimed to evaluate the role of the hippocampal 5-hydroxytryptamine-1a (5-ht1a)-mediated cyclic adenosine monophosphate/protein kinase a (camp/pka) signalling pathway in sevoflurane-induced cognitive dysfunction in aged rats. |
2018-08-30 |
2023-08-13 |
rat |
| Yi Qiu, Ying Wang, Xiaodong Wang, Caixia Wang, Zhong-Yuan Xi. Role of the hippocampal 5-HT1A receptor-mediated cAMP/PKA signalling pathway in sevoflurane-induced cognitivedysfunction in aged rats. The Journal of international medical research. vol 46. issue 3. 2018-08-30. PMID:29332488. |
conclusion sevoflurane-induced cognitive dysfunction in aged rats may be related to inhibited expression of the hippocampal 5-ht1a receptor-mediated camp/pka signalling pathway. |
2018-08-30 |
2023-08-13 |
rat |
| Yadong Zhai, Xiangbao Meng, Tianyuan Ye, Weijie Xie, Guibo Sun, Xiaobo Su. Inhibiting the NLRP3 Inflammasome Activation with MCC950 Ameliorates Diabetic Encephalopathy in db/db Mice. Molecules (Basel, Switzerland). vol 23. issue 3. 2018-08-27. PMID:29495433. |
treatment of db/db mice with nlrp3 inflammasome inhibitor mcc950 ameliorated anxiety- and depression-like behaviors as well as cognitive dysfunction, and reversed increased nlrp3, asc, and il-1βexpression levels and caspase-1 activity in hippocampus. |
2018-08-27 |
2023-08-13 |
mouse |
| Yi-Yun Tang, Ai-Ping Wang, Hai-Jun Wei, Man-Hong Li, Wei Zou, Xiang Li, Chun-Yan Wang, Ping Zhang, Xiao-Qing Tan. Role of silent information regulator 1 in the protective effect of hydrogen sulfide on homocysteine-induced cognitive dysfunction: Involving reduction of hippocampal ER stress. Behavioural brain research. vol 342. 2018-08-24. PMID:29307666. |
role of silent information regulator 1 in the protective effect of hydrogen sulfide on homocysteine-induced cognitive dysfunction: involving reduction of hippocampal er stress. |
2018-08-24 |
2023-08-13 |
Not clear |
| Patricia A Reis, Pedro C B Alexandre, Joana C D'Avila, Luciana D Siqueira, Barbara Antunes, Vanessa Estato, Eduardo V Tibiriça, Franck Verdonk, Tarek Sharshar, Fabrice Chrétien, Hugo C Castro-Faria-Neto, Fernando A Bozz. Statins prevent cognitive impairment after sepsis by reverting neuroinflammation, and microcirculatory/endothelial dysfunction. Brain, behavior, and immunity. vol 60. 2018-08-16. PMID:27833044. |
at another setting of experiments, after 15days, mice survivors from fecal supernatant peritoneal sepsis presented cognitive dysfunction for contextual hippocampal and aversive amygdala-dependent memories, which was prevented by atorvastatin/simvastatin treatment. |
2018-08-16 |
2023-08-13 |
mouse |
| Barrett D Allen, Munjal M Acharya, Celine Lu, Erich Giedzinski, Nicole N Chmielewski, David Quach, Mike Hefferan, Karl K Johe, Charles L Limol. Remediation of Radiation-Induced Cognitive Dysfunction through Oral Administration of the Neuroprotective Compound NSI-189. Radiation research. vol 189. issue 4. 2018-07-20. PMID:29351056. |
in previous work, multiple mechanisms have been identified that contribute to radiation-induced cognitive dysfunction, including the inhibition of neurogenesis caused by the depletion of radiosensitive populations of stem and progenitor cells in the hippocampus. |
2018-07-20 |
2023-08-13 |
rat |
| Claudia Schmaus. The roles of class I histone deacetylases (HDACs) in memory, learning, and executive cognitive functions: A review. Neuroscience and biobehavioral reviews. vol 83. 2018-07-18. PMID:29017914. |
it emphasizes the different roles of specific class i histone deacetylases (hdacs) in cognitive processes governed by the hippocampus and prefrontal cortex and discusses the potential therapeutic implications of targeting them to hold the progression of disease-related cognitive dysfunctions. |
2018-07-18 |
2023-08-13 |
Not clear |
| Michy P Kell. Cyclic nucleotide signaling changes associated with normal aging and age-related diseases of the brain. Cellular signalling. vol 42. 2018-07-18. PMID:29175000. |
among the most reproducible findings are 1) elevated circulating anp and bnp levels being associated with cognitive dysfunction or dementia independent of cardiovascular effects, 2) reduced basal and/or nmda-stimulated cgmp levels in brain with aging or alzheimer's disease (ad), 3) reduced adenylyl cyclase activity in hippocampus and specific cortical regions with aging or ad, 4) reduced expression/activity of pka in temporal cortex and hippocampus with ad, 5) reduced phosphorylation of creb in hippocampus with aging or ad, 6) reduced expression/activity of the pde4 family in brain with aging, 7) reduced expression of pde10a in the striatum with huntington's disease (hd) or parkinson's disease, and 8) beneficial effects of select pde inhibitors, particularly pde10 inhibitors in hd models and pde4 and pde5 inhibitors in aging and ad models. |
2018-07-18 |
2023-08-13 |
human |
| Fan Sun, Yanna Si, Hongguang Bao, Yajie Xu, XiaoXiao Pan, Lingqing Zeng, Ling Jin. Regulation of Sirtuin 3-Mediated Deacetylation of Cyclophilin D Attenuated Cognitive Dysfunction Induced by Sepsis-Associated Encephalopathy in Mice. Cellular and molecular neurobiology. vol 37. issue 8. 2018-07-13. PMID:28236057. |
the present study aimed to investigate cognitive dysfunction in the hippocampus induced by sepsis-associated encephalopathy (sae) via acetylation of cyclophilin d (cypd) and opening of mitochondrial permeability transition pore. |
2018-07-13 |
2023-08-13 |
mouse |
| Peipei Feng, Zhe Liu, Xin Wang, Wenjuan Wang, Gaimei Wang, Na L. [Effects of electroacupuncture on postoperative cognitive dysfunction and AngⅡ/AT1R in the hippocampus in aging rats induced by D-galactose]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. vol 37. issue 8. 2018-06-29. PMID:29231348. |
[effects of electroacupuncture on postoperative cognitive dysfunction and angⅡ/at1r in the hippocampus in aging rats induced by d-galactose]. |
2018-06-29 |
2023-08-13 |
rat |
| Peipei Feng, Zhe Liu, Xin Wang, Wenjuan Wang, Gaimei Wang, Na L. [Effects of electroacupuncture on postoperative cognitive dysfunction and AngⅡ/AT1R in the hippocampus in aging rats induced by D-galactose]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. vol 37. issue 8. 2018-06-29. PMID:29231348. |
to observe the effects of electroacupuncture (ea) on postoperative cognitive dysfunction (pocd) and angⅡ/at1r in the hippocampus in d-galactose-induced aging rats which received hepalobectomy, and to explore the possible mechanism of ea on pocd. |
2018-06-29 |
2023-08-13 |
rat |
| Qi Liu, Lizhou Chen, Fei Li, Ying Chen, Lanting Guo, Qiyong Gong, Xiaoqi Huan. [Voxel-Based Morphometry in Medicated-naive Boys with Attention-deficit/hyperactivity Disorder(ADHD)]. Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi. vol 33. issue 3. 2018-05-24. PMID:29709154. |
attention-deficit/hyperactivity disorder(adhd)is one of the most common neuro-developmental disorders occurring in childhood,characterized by symptoms of age-inappropriate inattention,hyperactivity/impulsivity,and the prevalence is higher in boys.although gray matter volume deficits have been frequently reported for adhd children via structural magnetic resonance imaging,few of them had specifically focused on male patients.the present study aimed to explore the alterations of gray matter volumes in medicated-naive boys with adhd via a relatively new voxel-based morphometry technique.according to the criteria of dsm-iv-tr,43medicated-naive adhd boys and 44age-matched healthy boys were recruited.the magnetic resonance image(mri)scan was performed via a 3t mri system with three-dimensional(3d)spoiled gradient recalled echo(spgr)sequence.voxel-based morphometry with diffeomorphic anatomical registration through exponentiated lie algebra in spm8 was used to preprocess the3dt1-weighted images.to identify gray matter volume differences between the adhd and the controls,voxelbased analysis of whole brain gray matter volumes between two groups were done via two sample t-test in spm8 with age as covariate,threshold at p<0.001.finally,compared to the controls,significantly reduced gray matter volumes were identified in the right orbitofrontal cortex(peak coordinates[-2,52,-25],t=4.01),and bilateral hippocampus(left:peak coordinates[14,0,-18],t=3.61;right:peak coordinates[-14,15,-28],t=3.64)of adhd boys.our results demonstrated obvious reduction of whole brain gray matter volumes in right orbitofrontal cortex and bilateral hippocampus in boys with adhd.this suggests that the abnormalities of prefrontal-hippocampus circuit may be the underlying cause of the cognitive dysfunction and abnormal behavioral inhibition in medicatednaive boys with adhd. |
2018-05-24 |
2023-08-13 |
Not clear |
| Huabin Gao, Zhaoli Han, Shan Huang, Ruojing Bai, Xintong Ge, Fanglian Chen, Ping Le. Intermittent hypoxia caused cognitive dysfunction relate to miRNAs dysregulation in hippocampus. Behavioural brain research. vol 335. 2018-05-22. PMID:28647595. |
intermittent hypoxia caused cognitive dysfunction relate to mirnas dysregulation in hippocampus. |
2018-05-22 |
2023-08-13 |
rat |
| Li-Na Sun, Xiao-Long Li, Fei Wang, Jun Zhang, Dan-Dan Wang, Li Yuan, Mei-Na Wu, Zhao-Jun Wang, Jin-Shun Q. High-intensity treadmill running impairs cognitive behavior and hippocampal synaptic plasticity of rats via activation of inflammatory response. Journal of neuroscience research. vol 95. issue 8. 2018-04-17. PMID:27918079. |
associated with the cognitive dysfunction, the induction and maintenance of hippocampal ltp were also impaired by the hie. |
2018-04-17 |
2023-08-13 |
rat |