| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lan-Xue Zhao, Yan-Hui Ge, Jia-Bing Li, Cai-Hong Xiong, Ping-Yee Law, Jian-Rong Xu, Yu Qiu, Hong-Zhuan Che. M1 muscarinic receptors regulate the phosphorylation of AMPA receptor subunit GluA1 FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 33. issue 5. 2020-05-12. PMID:30794430. |
m1 muscarinic receptors regulate the phosphorylation of ampa receptor subunit glua1 m1 muscarinic acetylcholine receptors are highly expressed in key areas that control cognition, such as the cortex and hippocampus, representing one potential therapeutic target for cognitive dysfunctions of alzheimer's disease and schizophrenia. |
2020-05-12 |
2023-08-13 |
Not clear |
| Yuyuan Gao, Hongmei Tang, Kun Nie, Ruiming Zhu, Liang Gao, Shujun Feng, Limin Wang, Jiehao Zhao, Zhiheng Huang, Yuhu Zhang, Lijuan Wan. Hippocampal damage and white matter lesions contribute to cognitive impairment in MPTP-lesioned mice with chronic cerebral hypoperfusion. Behavioural brain research. vol 368. 2020-04-23. PMID:30959125. |
the aim of this study was to investigate the effect of chronic cerebral hypoperfusion (cch) on cognitive dysfunction, structural abnormalities of the hippocampus and white matter (wm), and levels of inflammatory cytokines in control and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-lesioned mouse models. |
2020-04-23 |
2023-08-13 |
mouse |
| Fanqing Meng, Ning Li, Dongliang Li, Bingfeng Song, Liang L. The presence of elevated circulating trimethylamine N-oxide exaggerates postoperative cognitive dysfunction in aged rats. Behavioural brain research. vol 368. 2020-04-23. PMID:30980850. |
one week after surgery, rats underwent laparotomy exhibited hippocampal-dependent cognitive dysfunction as evidenced by reduced contextual freezing time, which was associated with elevated plasma proinflammatory cytokine levels, increased microglia-mediated neuroinflammation and reactive oxygen species (ros) production in the hippocampus. |
2020-04-23 |
2023-08-13 |
rat |
| Fanqing Meng, Ning Li, Dongliang Li, Bingfeng Song, Liang L. The presence of elevated circulating trimethylamine N-oxide exaggerates postoperative cognitive dysfunction in aged rats. Behavioural brain research. vol 368. 2020-04-23. PMID:30980850. |
treatment with tmao, which elevated plasma tmao before and 1 week after surgery, further increased microglia-mediated neuroinflammation and ros production in the hippocampus, resulting in exaggerated cognitive dysfunction in laparotomy group but not in sham-operation group. |
2020-04-23 |
2023-08-13 |
rat |
| Liang Zhao, Chuanyang Zhang, Guilin Cao, Xueyi Dong, Dongliang Li, Lei Jian. Higher Circulating Trimethylamine N-oxide Sensitizes Sevoflurane-Induced Cognitive Dysfunction in Aged Rats Probably by Downregulating Hippocampal Methionine Sulfoxide Reductase A. Neurochemical research. vol 44. issue 11. 2020-04-06. PMID:31486012. |
higher circulating trimethylamine n-oxide sensitizes sevoflurane-induced cognitive dysfunction in aged rats probably by downregulating hippocampal methionine sulfoxide reductase a. |
2020-04-06 |
2023-08-13 |
rat |
| Sara Chavoshinezhad, Homa Mohseni Kouchesfahani, Abolhassan Ahmadiani, Leila Dargah. Interferon beta ameliorates cognitive dysfunction in a rat model of Alzheimer's disease: Modulation of hippocampal neurogenesis and apoptosis as underlying mechanism. Progress in neuro-psychopharmacology & biological psychiatry. vol 94. 2020-03-30. PMID:31152860. |
interferon beta ameliorates cognitive dysfunction in a rat model of alzheimer's disease: modulation of hippocampal neurogenesis and apoptosis as underlying mechanism. |
2020-03-30 |
2023-08-13 |
rat |
| Corinne G Jolivalt, Alexandra Marquez, David Quach, Michelle C Navarro Diaz, Carlos Anaya, Betelhem Kifle, Nabeel Muttalib, Gabriela Sanchez, Lucy Guernsey, Mike Hefferan, Darrel R Smith, Paul Fernyhough, Karl Johe, Nigel A Calcut. Amelioration of Both Central and Peripheral Neuropathy in Mouse Models of Type 1 and Type 2 Diabetes by the Neurogenic Molecule NSI-189. Diabetes. vol 68. issue 11. 2020-03-17. PMID:31492662. |
nsi-189 is a new chemical entity that when orally administered promotes neurogenesis in the adult hippocampus, increases hippocampal volume, enhances synaptic plasticity, and reduces cognitive dysfunction. |
2020-03-17 |
2023-08-13 |
mouse |
| Tao Sun, Zhi Liu, Mengying Liu, Ying Guo, Huan Sun, Jikai Zhao, Zhen Lan, Biyao Lian, Jiqiang Zhan. Hippocampus-specific Rictor knockdown inhibited 17β-estradiol induced neuronal plasticity and spatial memory improvement in ovariectomized mice. Behavioural brain research. vol 364. 2020-03-09. PMID:30753873. |
taken together, the current studies provided the first direct evidence for the important role of rictor in estrogenic action on the hippocampus, indicating that it may be a therapeutic target for the treatment of e2-related, hippocampus-dependent cognitive dysfunction. |
2020-03-09 |
2023-08-13 |
mouse |
| Jin-Hee Seo, Hye-Sang Park, Sang-Seo Park, Chang-Ju Kim, Dong-Hyun Kim, Tae-Woon Ki. Physical exercise ameliorates psychiatric disorders and cognitive dysfunctions by hippocampal mitochondrial function and neuroplasticity in post-traumatic stress disorder. Experimental neurology. vol 322. 2020-02-24. PMID:31446079. |
physical exercise ameliorates psychiatric disorders and cognitive dysfunctions by hippocampal mitochondrial function and neuroplasticity in post-traumatic stress disorder. |
2020-02-24 |
2023-08-13 |
Not clear |
| Hang Thi Nguyet Pham, Sinh Viet Phan, Hong Nguyen Tran, Xuyen Thi Phi, Xoan Thi Le, Khoi Minh Nguyen, Hironori Fujiwara, Masanori Yoneyama, Kiyokazu Ogita, Taro Yamaguchi, Kinzo Matsumot. Bacopa monnieri (L.) Ameliorates Cognitive Deficits Caused in a Trimethyltin-Induced Neurotoxicity Model Mice. Biological & pharmaceutical bulletin. vol 42. issue 8. 2020-01-14. PMID:31366873. |
extract (bme) ameliorated cognitive dysfunction in animal models of dementia by enhancing synaptic plasticity-related signaling in the hippocampus and protecting cholinergic neurons in the medial septum. |
2020-01-14 |
2023-08-13 |
mouse |
| Peng Yao, Yong Chen, Yiling Li, Yuzi Zhang, Hao Qi, Wenhao X. [Hippocampal neuronal ferroptosis involved in cognitive dysfunction in rats with sepsis-related encephalopathy through the Nrf2/GPX4 signaling pathway]. Zhonghua wei zhong bing ji jiu yi xue. vol 31. issue 11. 2020-01-10. PMID:31898571. |
[hippocampal neuronal ferroptosis involved in cognitive dysfunction in rats with sepsis-related encephalopathy through the nrf2/gpx4 signaling pathway]. |
2020-01-10 |
2023-08-13 |
rat |
| Peng Yao, Yong Chen, Yiling Li, Yuzi Zhang, Hao Qi, Wenhao X. [Hippocampal neuronal ferroptosis involved in cognitive dysfunction in rats with sepsis-related encephalopathy through the Nrf2/GPX4 signaling pathway]. Zhonghua wei zhong bing ji jiu yi xue. vol 31. issue 11. 2020-01-10. PMID:31898571. |
to evaluate the effects of ferroptosis in hippocampal neurons on cognitive dysfunction in rats with sepsis-associated encephalopathy (sae) and its potential molecular mechanisms. |
2020-01-10 |
2023-08-13 |
rat |
| Nianping Chen, Xiufang Chen, Jianping Xie, Chenglong Wu, Jiang Qia. Dexmedetomidine protects aged rats from postoperative cognitive dysfunction by alleviating hippocampal inflammation. Molecular medicine reports. vol 20. issue 3. 2020-01-09. PMID:31257507. |
dexmedetomidine protects aged rats from postoperative cognitive dysfunction by alleviating hippocampal inflammation. |
2020-01-09 |
2023-08-13 |
rat |
| Nianping Chen, Xiufang Chen, Jianping Xie, Chenglong Wu, Jiang Qia. Dexmedetomidine protects aged rats from postoperative cognitive dysfunction by alleviating hippocampal inflammation. Molecular medicine reports. vol 20. issue 3. 2020-01-09. PMID:31257507. |
the present study investigated the effect of dexmedetomidine on hippocampal inflammation and cognitive function in rats with postoperative cognitive dysfunction (pocd). |
2020-01-09 |
2023-08-13 |
rat |
| Hye-Sang Park, Sang-Seo Park, Chang-Ju Kim, Mal-Soon Shin, Tae-Woon Ki. Exercise Alleviates Cognitive Functions by Enhancing Hippocampal Insulin Signaling and Neuroplasticity in High-Fat Diet-Induced Obesity. Nutrients. vol 11. issue 7. 2020-01-09. PMID:31311133. |
overall, our findings indicate that physical exercise may act as a non-pharmacologic method that protects against cognitive dysfunction caused by obesity by improving hippocampal insulin signaling and neuroplasticity. |
2020-01-09 |
2023-08-13 |
mouse |
| Praveen K Kodumuri, Christofer Thomas, Raghu Jetti, Anil Kumar Pande. Fenugreek seed extract ameliorates cognitive deficits in streptozotocin-induced diabetic rats. Journal of basic and clinical physiology and pharmacology. vol 30. issue 4. 2020-01-06. PMID:31326961. |
conclusion in conclusion, administration of t. foenum-graecum seed extract ameliorates diabetes-linked cognitive dysfunction in rats by decreasing blood glucose levels, reducing lipid peroxidation and oxidative stress in the hippocampus, and preventing neuronal loss from the hippocampus. |
2020-01-06 |
2023-08-13 |
rat |
| Shu Zhu, Zhe Zhang, Lian-Qun Jia, Kai-Xuan Zhan, Li-Jun Wang, Nan Song, Yue Liu, Yan-Yan Cheng, Yong-Ju Yang, Le Guan, Dong-Yu Min, Guan-Lin Yan. Valproic acid attenuates global cerebral ischemia/reperfusion injury in gerbils via anti-pyroptosis pathways. Neurochemistry international. vol 124. 2019-12-24. PMID:30611759. |
the results showed that vpa attenuated the cognitive dysfunction, pyroptosis of the gerbils suffer from ischemic-reperfusion injury and decreased hippocampal neurons pyroptosis induced by oxygen-glucose deprivation in vitro. |
2019-12-24 |
2023-08-13 |
Not clear |
| Lucia Leone, Claudia Colussi, Katia Gironi, Valentina Longo, Salvatore Fusco, Domenica Donatella Li Puma, Marcello D'Ascenzo, Claudio Grass. Altered Nup153 Expression Impairs the Function of Cultured Hippocampal Neural Stem Cells Isolated from a Mouse Model of Alzheimer's Disease. Molecular neurobiology. vol 56. issue 8. 2019-12-17. PMID:30689197. |
impairment of adult hippocampal neurogenesis is an early event in alzheimer's disease (ad), playing a crucial role in cognitive dysfunction associated with this pathology. |
2019-12-17 |
2023-08-13 |
mouse |
| Chen Li, Chunting Hu, Ruili Wang, Hui Wang, Qiaoya Ma, Songsheng Chen, Ya H. Protective effect of sakuranetin in brain cells of dementia model rats. Cellular and molecular biology (Noisy-le-Grand, France). vol 65. issue 5. 2019-12-17. PMID:31304907. |
in this study, the effect of sak on spatial discrimination in a rat model of cognitive dysfunction exposed to d-galactose was investigated with respect to its effect on malondialdehyde (mda), superoxide dismutase (sod) and glutathione peroxidase (gpx) levels, and on the expressions of interleukin-6 (il-6), tumor necrosis factor-α (tnf-α) and nuclear factor-κb inhibitory factor-α (iκbα) in hippocampus of rats. |
2019-12-17 |
2023-08-13 |
rat |
| Mehtab Khan, Bart P F Rutten, Myeong Ok Ki. MST1 Regulates Neuronal Cell Death via JNK/Casp3 Signaling Pathway in HFD Mouse Brain and HT22 Cells. International journal of molecular sciences. vol 20. issue 10. 2019-12-03. PMID:31117242. |
in this study, we evaluated the mst1/c-jun n-terminal kinase (jnk) dependent oxidative damage mediated cognitive dysfunction in hfd-fed mice and stress-induced hippocampal ht22 (mice hippocampal) cells. |
2019-12-03 |
2023-08-13 |
mouse |