| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pishan Chang, Daniel Bush, Stephanie Schorge, Mark Good, Tara Canonica, Nathanael Shing, Suzanna Noy, Frances K Wiseman, Neil Burgess, Victor L J Tybulewicz, Matthew C Walker, Elizabeth M C Fishe. Altered Hippocampal-Prefrontal Neural Dynamics in Mouse Models of Down Syndrome. Cell reports. vol 30. issue 4. 2020-10-19. PMID:31995755. |
dp1tyb mice show slower decision-making (unrelated to the gene dose of dyrk1a, which has been implicated in ds cognitive dysfunction) and altered theta dynamics (reduced frequency, increased hippocampal-mpfc coherence, and increased modulation of hippocampal high gamma); dp10yey mice show impaired alternation performance and reduced theta modulation of hippocampal low gamma; and dp17yey mice are not significantly different from the wild type. |
2020-10-19 |
2023-08-13 |
mouse |
| Yiying Bian, Li Meng, Jianghua Peng, Junfeng Li, Rui Wei, Lei Huo, Huan Yang, Ying Wang, Jun Fu, Liangfang Shen, Jidong Hon. Effect of radiochemotherapy on the cognitive function and diffusion tensor and perfusion weighted imaging for high-grade gliomas: A prospective study. Scientific reports. vol 9. issue 1. 2020-10-16. PMID:30979930. |
the radiation-induced fa decrease in the bilateral hippocampus preceded cognitive dysfunction, and dti of the hippocampus may provide a useful biomarker for predicting radiation-induced neurocognitive impairment in patients with hggs. |
2020-10-16 |
2023-08-13 |
Not clear |
| Dongliang Li, Lingling Liu, Liang Li, Xingang Li, Bin Huang, Changqing Zhou, Zhaohang Zhang, Chunling Wang, Ping Dong, Xiyan Zhang, Bo Yang, Li Zhan. Sevoflurane Induces Exaggerated and Persistent Cognitive Decline in a Type II Diabetic Rat Model by Aggregating Hippocampal Inflammation. Frontiers in pharmacology. vol 8. 2020-10-01. PMID:29238302. |
the results suggest that diabetic gk rats exhibit cognitive dysfunction probably due to increased hippocampal inflammation, and that sevoflurane induces exaggerated and persistent cognitive decline in gk rat by aggregating hippocampal inflammation. |
2020-10-01 |
2023-08-13 |
rat |
| Marco Cascella, Sabrina Bimont. The role of general anesthetics and the mechanisms of hippocampal and extra-hippocampal dysfunctions in the genesis of postoperative cognitive dysfunction. Neural regeneration research. vol 12. issue 11. 2020-10-01. PMID:29239315. |
the role of general anesthetics and the mechanisms of hippocampal and extra-hippocampal dysfunctions in the genesis of postoperative cognitive dysfunction. |
2020-10-01 |
2023-08-13 |
Not clear |
| Shengjun Ji, Xin Ding, Jiang Ji, Haohao Wu, Rui Sun, Xiaoyang Li, Liyuan Zhang, Ye Tia. Cranial irradiation inhibits hippocampal neurogenesis via DNMT1 and DNMT3A. Oncology letters. vol 15. issue 3. 2020-10-01. PMID:29435016. |
impairment of neurogenesis in the hippocampus following whole-brain irradiation is the most important mechanism of radiation-induced cognitive dysfunction. |
2020-10-01 |
2023-08-13 |
rat |
| Marion T Turnbull, Zoran Boskovic, Elizabeth J Coulso. Acute Down-regulation of BDNF Signaling Does Not Replicate Exacerbated Amyloid-β Levels and Cognitive Impairment Induced by Cholinergic Basal Forebrain Lesion. Frontiers in molecular neuroscience. vol 11. 2020-10-01. PMID:29520217. |
degeneration of basal forebrain cholinergic neurons (bfcns) precedes hippocampal degeneration and pathological amyloid-beta (aβ) accumulation, and underpins the development of cognitive dysfunction in sporadic alzheimer's disease (ad). |
2020-10-01 |
2023-08-13 |
mouse |
| Bombi Lee, Insop Shim, Hyejung Le. Gypenosides Attenuate Lipopolysaccharide-Induced Neuroinflammation and Memory Impairment in Rats. Evidence-based complementary and alternative medicine : eCAM. vol 2018. 2020-10-01. PMID:30018656. |
in the present study, whether gps could improve cognitive dysfunction and chronic inflammation caused by injecting lipopolysaccharide (lps) in the hippocampus was investigated. |
2020-10-01 |
2023-08-13 |
rat |
| Eliedonna Cacao, Sidath Kapukotuwa, Francis A Cucinott. Modeling Reveals the Dependence of Hippocampal Neurogenesis Radiosensitivity on Age and Strain of Rats. Frontiers in neuroscience. vol 12. 2020-10-01. PMID:30618596. |
cognitive dysfunction following radiation treatment for brain cancers in both children and adults have been correlated to impairment of neurogenesis in the hippocampal dentate gyrus. |
2020-10-01 |
2023-08-13 |
mouse |
| Terry L Davidson, Sabrina Jones, Megan Roy, Richard J Stevenso. The Cognitive Control of Eating and Body Weight: It's More Than What You "Think". Frontiers in psychology. vol 10. 2020-10-01. PMID:30814963. |
the implications of this research for mechanism are discussed within the context of a "vicious-cycle model," which describes how eating a wd could impair hippocampal function, producing cognitive deficits that promote increased wd intake and body weight gain, which could contribute to further hippocampal dysfunction, cognitive decline, and excess eating and weight gain. |
2020-10-01 |
2023-08-13 |
human |
| Hae June Lee, Yeonghoon Son, Minyoung Lee, Changjong Moon, Sung Ho Kim, In Sik Shin, Miyoung Yang, Sangwoo Bae, Joong Sun Ki. Sodium butyrate prevents radiation-induced cognitive impairment by restoring pCREB/BDNF expression. Neural regeneration research. vol 14. issue 9. 2020-10-01. PMID:31089051. |
these findings suggest that sodium butyrate can improve radiation-induced cognitive dysfunction through inhibiting the decrease in hippocampal phosphorylated camp response element binding protein/brain-derived neurotrophic factor expression. |
2020-10-01 |
2023-08-13 |
mouse |
| Lin Wu, Dandan Guo, Qi Liu, Fei Gao, Xiaochen Wang, Xueying Song, Fuwu Wang, Ren-Zhi Zha. Abnormal Development of Dendrites in Adult-Born Rat Hippocampal Granule Cells Induced by Cyclophosphamide. Frontiers in cellular neuroscience. vol 11. 2020-09-30. PMID:28680394. |
as abnormalities in adult hippocampal neurogenesis may serve as substrate for cognitive dysfunction, the present study examines the effect of cyclophosphamide (cpp), a widely prescribed chemotherapeutic agent, on dendritic development of adult-born hippocampal granule cells in the rat. |
2020-09-30 |
2023-08-13 |
rat |
| Pei-Pei Feng, Pu Deng, Li-Hua Liu, Qi Ai, Jie Yin, Zhe Liu, Gai-Mei Wan. Electroacupuncture Alleviates Postoperative Cognitive Dysfunction in Aged Rats by Inhibiting Hippocampal Neuroinflammation Activated via Microglia/TLRs Pathway. Evidence-based complementary and alternative medicine : eCAM. vol 2017. 2020-09-30. PMID:28684969. |
electroacupuncture alleviates postoperative cognitive dysfunction in aged rats by inhibiting hippocampal neuroinflammation activated via microglia/tlrs pathway. |
2020-09-30 |
2023-08-13 |
rat |
| Pei-Pei Feng, Pu Deng, Li-Hua Liu, Qi Ai, Jie Yin, Zhe Liu, Gai-Mei Wan. Electroacupuncture Alleviates Postoperative Cognitive Dysfunction in Aged Rats by Inhibiting Hippocampal Neuroinflammation Activated via Microglia/TLRs Pathway. Evidence-based complementary and alternative medicine : eCAM. vol 2017. 2020-09-30. PMID:28684969. |
the aim of this study was to examine whether ea improves cognitive dysfunction caused by surgery and to investigate the pathological mechanism of tlr2 and tlr4 in the hippocampus of aged rats. |
2020-09-30 |
2023-08-13 |
rat |
| Chunfang Yi, Zhiyun Fu, Xiaofeng Lu. Dexmedetomidine on autophagy of hippocampal neurons in aged rats under sevoflurane anesthesia. Experimental and therapeutic medicine. vol 16. issue 2. 2020-09-30. PMID:30112038. |
effects of dexmedetomidine on autophagy of hippocampal neurons and cognitive dysfunction in aged rats under sevoflurane anesthesia were investigated. |
2020-09-30 |
2023-08-13 |
rat |
| Bao-Liang Zhang, Yue-Shan Fan, Ji-Wei Wang, Zi-Wei Zhou, Yin-Gang Wu, Meng-Chen Yang, Dong-Dong Sun, Jian-Ning Zhan. Cognitive impairment after traumatic brain injury is associated with reduced long-term depression of excitatory postsynaptic potential in the rat hippocampal dentate gyrus. Neural regeneration research. vol 13. issue 10. 2020-09-30. PMID:30136690. |
hippocampal excitability is strongly correlated with cognitive dysfunction and remote symptomatic epilepsy. |
2020-09-30 |
2023-08-13 |
rat |
| Li-Li Li, Mei-Fang Jin, Hong N. Zinc/CaMK II Associated-Mitophagy Signaling Contributed to Hippocampal Mossy Fiber Sprouting and Cognitive Deficits Following Neonatal Seizures and Its Regulation by Chronic Leptin Treatment. Frontiers in neurology. vol 9. 2020-09-30. PMID:30319532. |
flurothyl-induced seizures (rs group) significantly down-regulated mitophagy markers pink, drp1, phb, and memory marker camk ii alpha while up-regulating zinc transporters znt3, znt4, zip7, and autophagy execution molecular cathepsin-e, which were paralleled with hippocampal aberrant mossy fiber sprouting and cognitive dysfunction. |
2020-09-30 |
2023-08-13 |
rat |
| Tsuyoshi Hashizume, Bo-Kyung Son, Sakiko Taniguchi, Koichi Ito, Yoshihiro Noda, Tamao Endo, Michiko Nanao-Hamai, Sumito Ogawa, Masahiro Akishit. Establishment of Novel Murine Model showing Vascular Inflammation-derived Cognitive Dysfunction. Scientific reports. vol 9. issue 1. 2020-09-30. PMID:30858535. |
iba1/mhcii-double-positive microglia activation was also seen in the hippocampus, suggesting that vascular inflammation drives neuroinflammation and subsequent cognitive dysfunction. |
2020-09-30 |
2023-08-13 |
mouse |
| Man-Man Zong, Zhi-Qiang Zhou, Mu-Huo Ji, Min Jia, Hui Tang, Jian-Jun Yan. Activation of β2-Adrenoceptor Attenuates Sepsis-Induced Hippocampus-Dependent Cognitive Impairments by Reversing Neuroinflammation and Synaptic Abnormalities. Frontiers in cellular neuroscience. vol 13. 2020-09-30. PMID:31354429. |
sepsis-associated encephalopathy induces cognitive dysfunction via mechanisms that commonly involve neuroinflammation and synaptic plasticity impairment of the hippocampus. |
2020-09-30 |
2023-08-13 |
mouse |
| Qingxia Kong, Xia Min, Ran Sun, Jianying Gao, Ruqing Liang, Lei Li, Xu Ch. Effects of pharmacological treatments on hippocampal NCAM1 and ERK2 expression in epileptic rats with cognitive dysfunction. Oncology letters. vol 12. issue 3. 2020-09-29. PMID:27588125. |
effects of pharmacological treatments on hippocampal ncam1 and erk2 expression in epileptic rats with cognitive dysfunction. |
2020-09-29 |
2023-08-13 |
rat |
| Qingxia Kong, Xia Min, Ran Sun, Jianying Gao, Ruqing Liang, Lei Li, Xu Ch. Effects of pharmacological treatments on hippocampal NCAM1 and ERK2 expression in epileptic rats with cognitive dysfunction. Oncology letters. vol 12. issue 3. 2020-09-29. PMID:27588125. |
the present study aimed to investigate the effects of various pharmacological agents on the hippocampal expression of neural cell adhesion molecule 1 (ncam1) and extracellular signal-regulated kinase 2 (erk2) in epileptic rats with cognitive dysfunction. |
2020-09-29 |
2023-08-13 |
rat |