| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Keiko Ishida, Masaki Yamamoto, Kensuke Misawa, Hitomi Nishimura, Koichi Misawa, Noriyasu Ota, Akira Shimotoyodom. Coffee polyphenols prevent cognitive dysfunction and suppress amyloid β plaques in APP/PS2 transgenic mouse. Neuroscience research. vol 154. 2021-02-01. PMID:31121203. |
immunohistochemical analysis revealed that chronic treatment with coffee polyphenols prevented cognitive dysfunction and significantly reduced the amount of amyloid β (aβ) plaques in the hippocampus. |
2021-02-01 |
2023-08-13 |
mouse |
| Tae-Woon Kim, Sang-Seo Park, Joon-Young Park, Hye-Sang Par. Infusion of Plasma from Exercised Mice Ameliorates Cognitive Dysfunction by Increasing Hippocampal Neuroplasticity and Mitochondrial Functions in 3xTg-AD Mice. International journal of molecular sciences. vol 21. issue 9. 2021-02-01. PMID:32384696. |
infusion of plasma from exercised mice ameliorates cognitive dysfunction by increasing hippocampal neuroplasticity and mitochondrial functions in 3xtg-ad mice. |
2021-02-01 |
2023-08-13 |
mouse |
| Elif Cinar, Gul Yalcin-Cakmakli, Esen Saka, Ayse Ulusoy, Sinan Yuruker, Bulent Elibol, Banu C Te. Modelling cognitive deficits in Parkinson's disease: Is CA2 a gateway for hippocampal synucleinopathy? Experimental neurology. vol 330. 2021-02-01. PMID:32437708. |
to investigate the hippocampal involvement in cognitive dysfunction of pd, we generated an experimental model by inducing midbrain and hippocampal α-synuclein pathology simultaneously. |
2021-02-01 |
2023-08-13 |
Not clear |
| Estibaliz Etxeberria-Rekalde, Saioa Alzola-Aldamizetxebarria, Stefanie Flunkert, Isabella Hable, Magdalena Daurer, Joerg Neddens, Birgit Hutter-Paie. Quantification of Huntington's Disease Related Markers in the R6/2 Mouse Model. Frontiers in molecular neuroscience. vol 13. 2021-01-30. PMID:33505246. |
neurodegeneration in hd begins in the striatum and spreads to other brain regions such as cortex and hippocampus, causing motor and cognitive dysfunctions. |
2021-01-30 |
2023-08-13 |
mouse |
| Manimaran Ramani, Kiara Miller, Namasivayam Ambalavanan, Lori L McMaho. Increased Excitability and Heightened Magnitude of Long-Term Potentiation at Hippocampal CA3-CA1 Synapses in a Mouse Model of Neonatal Hyperoxia Exposure. Frontiers in synaptic neuroscience. vol 12. 2021-01-26. PMID:33488380. |
preterm infants exposed to supraphysiological oxygen (hyperoxia) during the neonatal period have hippocampal atrophy and cognitive dysfunction later in childhood and as adolescents. |
2021-01-26 |
2023-08-13 |
mouse |
| Qian-Juan Fang, Bing-Huan Chi, Qi-Cheng Lin, Chen-Miao Huang, Shao-Wu Jin, Jia-Jing Cai, Ke Nan, Yuan Han, Yuan-Xiang Tao, Hong Cao, Jun L. Surgery-induced downregulation of hippocampal sirtuin-1 contributes to cognitive dysfunction by inhibiting autophagy and activating apoptosis in aged mice. American journal of translational research. vol 12. issue 12. 2021-01-14. PMID:33437385. |
surgery-induced downregulation of hippocampal sirtuin-1 contributes to cognitive dysfunction by inhibiting autophagy and activating apoptosis in aged mice. |
2021-01-14 |
2023-08-13 |
mouse |
| Suvi R K Hokkanen, Mia Kero, Karri Kaivola, Sally Hunter, Hannah A D Keage, Anna Kiviharju, Anna Raunio, Pentti J Tienari, Anders Paetau, Fiona E Matthews, Jane Fleming, Caroline Graff, Tuomo M Polvikoski, Liisa Myllykangas, Carol Brayn. Putative risk alleles for LATE-NC with hippocampal sclerosis in population-representative autopsy cohorts. Brain pathology (Zurich, Switzerland). vol 30. issue 2. 2021-01-13. PMID:31376286. |
limbic-predominant age-related tar-dna-binding protein-43 (tdp-43) encephalopathy with hippocampal sclerosis pathology (late-nc + hs) is a neurodegenerative disorder characterized by severe hippocampal ca1 neuron loss and tdp-43-pathology, leading to cognitive dysfunction and dementia. |
2021-01-13 |
2023-08-13 |
Not clear |
| Si-Min Chen, Min Li, Juan Xie, Sha Li, Shi-Shi Xiang, Hai-Yao Liu, Zhuo Chen, Ping Zhang, Xin Kuang, Xiao-Qing Tan. Hydrogen sulfide attenuates postoperative cognitive dysfunction through promoting the pathway of Warburg effect-synaptic plasticity in hippocampus. Toxicology and applied pharmacology. vol 409. 2021-01-11. PMID:33068621. |
hydrogen sulfide attenuates postoperative cognitive dysfunction through promoting the pathway of warburg effect-synaptic plasticity in hippocampus. |
2021-01-11 |
2023-08-13 |
Not clear |
| Tao Liang, Huihui Ju, Yile Zhou, Yajie Yang, Yi Shi, Hao Fan. Inhibition of glycogen synthase kinase 3β improves cognitive function in aged mice by upregulating claudin presences in cerebral endothelial cells. Acta biochimica et biophysica Sinica. vol 52. issue 4. 2021-01-06. PMID:32141492. |
compared with young mice, aged mice had increased leftover signals of dextran in the hippocampus and a lower score in the maze test, suggesting that aged mice have abnormal leakage of bbb and cognitive dysfunction. |
2021-01-06 |
2023-08-13 |
mouse |
| Xin Wang, Zhao-Xiang Meng, Ying-Zhu Chen, Yu-Ping Li, Hong-Yu Zhou, Man Yang, Ting-Ting Zhao, Yu-Lai Gong, Yi Wu, Tao Li. Enriched environment enhances histone acetylation of NMDA receptor in the hippocampus and improves cognitive dysfunction in aged mice. Neural regeneration research. vol 15. issue 12. 2020-12-22. PMID:32594057. |
enriched environment enhances histone acetylation of nmda receptor in the hippocampus and improves cognitive dysfunction in aged mice. |
2020-12-22 |
2023-08-13 |
mouse |
| Xin Wang, Zhao-Xiang Meng, Ying-Zhu Chen, Yu-Ping Li, Hong-Yu Zhou, Man Yang, Ting-Ting Zhao, Yu-Lai Gong, Yi Wu, Tao Li. Enriched environment enhances histone acetylation of NMDA receptor in the hippocampus and improves cognitive dysfunction in aged mice. Neural regeneration research. vol 15. issue 12. 2020-12-22. PMID:32594057. |
these data confirm that an enriched environment can improve cognitive dysfunction in age-associated memory impairment mice, and suggest that the mechanisms may be related to the increased expression of creb binding protein and the increased degree of total histone acetylation in the hippocampus of age-associated memory impairment mice, which may cause the increase of histone acetylation of glun2b gene promoter and the enhancement of glun2b mrna transcription and protein expression in hippocampus. |
2020-12-22 |
2023-08-13 |
mouse |
| Zhao-Hui Yao, Jing Wang, Bing-Zhen Shen, Yu-Tong Li, Xiao-Li Yao, Shao-Feng Zhang, Yong Zhang, Ji-Chang Hu, Yan-Chun Xi. Identification of a hippocampal lncRNA-regulating network in cognitive dysfunction caused by chronic cerebral hypoperfusion. Aging. vol 12. issue 19. 2020-12-19. PMID:33040050. |
identification of a hippocampal lncrna-regulating network in cognitive dysfunction caused by chronic cerebral hypoperfusion. |
2020-12-19 |
2023-08-13 |
Not clear |
| Xuan Kang, Cheng Li, Yan Xie, Ling-Li He, Fan Xiao, Ke-Bin Zhan, Yi-Yun Tang, Xiang Li, Xiao-Qing Tan. Hippocampal ornithine decarboxylase/spermidine pathway mediates H Journal of advanced research. vol 27. 2020-12-16. PMID:33318864. |
hippocampal ornithine decarboxylase/spermidine pathway mediates h we have previously demonstrated the antagonistic role of hydrogen sulfide (h2s) in the cognitive dysfunction of streptozotocin (stz)-induced diabetic rats. |
2020-12-16 |
2023-08-13 |
rat |
| Lili Chen, Dan Song, Beibei Chen, Xuemei Yang, Oumei Chen. Activation of liver X receptor promotes hippocampal neurogenesis and improves long-term cognitive function recovery in acute cerebral ischemia-reperfusion mice. Journal of neurochemistry. vol 154. issue 2. 2020-12-10. PMID:31602646. |
cerebral ischemia (ci) leads to cognitive dysfunction due to the loss of hippocampal neurons. |
2020-12-10 |
2023-08-13 |
mouse |
| Huimin Kong, Huaili Wang, Zhihong Zhuo, Zhenbiao Li, Peichao Tian, Jing Wu, Jian Liu, Zheng Chen, Jiyao Zhang, Qiang Lu. Inhibition of miR-181a-5p reduces astrocyte and microglia activation and oxidative stress by activating SIRT1 in immature rats with epilepsy. Laboratory investigation; a journal of technical methods and pathology. vol 100. issue 9. 2020-11-23. PMID:32461588. |
inhibition of mir-181a-5p protected the hippocampus against epilepsy, including hippocampal insults, neuronal apoptosis, astrocyte and microglia activation, neuroinflammation, oxidative stress, mitochondrial function, and cognitive dysfunction. |
2020-11-23 |
2023-08-13 |
rat |
| Mark R Etherton, Panagiotis Fotiadis, Anne-Katrin Giese, Juan E Iglesias, Ona Wu, Natalia S Ros. White Matter Hyperintensity Burden Is Associated With Hippocampal Subfield Volume in Stroke. Frontiers in neurology. vol 11. 2020-11-18. PMID:33193055. |
for these reasons, an investigation into the relationship between wmh and hippocampal subfield volume may further delineate how wmh predispose to post-stroke cognitive dysfunction. |
2020-11-18 |
2023-08-13 |
Not clear |
| Dong-Sheng Sun, Gang Zhong, Hong-Xia Cao, Yu Hu, Xiao-Yue Hong, Ting Li, Xiao Li, Qian Liu, Qun Wang, Dan Ke, Gong-Ping Liu, Rong-Hong Ma, Dan-Ju Lu. Repeated Restraint Stress Led to Cognitive Dysfunction by NMDA Receptor-Mediated Hippocampal CA3 Dendritic Spine Impairments in Juvenile Sprague-Dawley Rats. Frontiers in molecular neuroscience. vol 13. 2020-11-17. PMID:33192290. |
although numerous studies have indicated that chronic stress causes cognitive dysfunction with the impairment of synaptic structures and functions, the relationship between cognitive deficits induced by repeated restraint stress and the level of nmda receptors in the subregion of the hippocampus has been relatively unknown until now. |
2020-11-17 |
2023-08-13 |
rat |
| Marek Sąsiadek, Marcin Hartel, Małgorzata Siger, Katarzyna Katulska, Agata Majos, Ewa Kluczewska, Halina Bartosik-Psujek, Alina Kułakowska, Agnieszka Słowik, Barbara Steinborn, Monika Adamczyk-Sowa, Alicja Kalinowska, Ewa Krzystanek, Robert Bonek, Zbigniew Serafin, Jarosław Sławek, Przemysław Nowacki, Adam Stępień, Sergiusz Jóżwiak, Konrad Rejdak, Krzysztof Selmaj, Jerzy Waleck. Recommendations of the Polish Medical Society of Radiology and the Polish Society of Neurology for a protocol concerning routinely used magnetic resonance imaging in patients with multiple sclerosis. Neurologia i neurochirurgia polska. vol 54. issue 5. 2020-11-04. PMID:33085075. |
it is also the best tool to assess brain atrophy in patients with ms in terms of grey matter volume (gmv) and white matter volume (wmv) as well as local atrophy (by measuring the volume of thalamus, corpus callosum, subcortical nuclei, and hippocampus) as parameters that correlate with disability progression and cognitive dysfunctions. |
2020-11-04 |
2023-08-13 |
human |
| Bin Liu, Jing Liu, Jian-Gong Wang, Cui-Lan Liu, Hai-Jing Ya. AdipoRon improves cognitive dysfunction of Alzheimer's disease and rescues impaired neural stem cell proliferation through AdipoR1/AMPK pathway. Experimental neurology. vol 327. 2020-10-27. PMID:32070713. |
the in vivo study showed that adiporon improved either cognitive dysfunction or impaired nscs proliferation in hippocampus dg region in app/ps1 transgenic (tg) mice. |
2020-10-27 |
2023-08-13 |
mouse |
| Bin Liu, Jing Liu, Jian-Gong Wang, Cui-Lan Liu, Hai-Jing Ya. AdipoRon improves cognitive dysfunction of Alzheimer's disease and rescues impaired neural stem cell proliferation through AdipoR1/AMPK pathway. Experimental neurology. vol 327. 2020-10-27. PMID:32070713. |
taken together, these results suggested that adiporon alleviated the cognitive dysfunction of ad mice, inhibited the aβ deposition by inhibiting bace1 expression and promoted the impaired hippocampal nscs proliferation on the early stage in vivo. |
2020-10-27 |
2023-08-13 |
mouse |