| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chujie Qu, Changhua Qu, Linling Xu, Jun Shen, Dongwei Lv, Yaqing Li, Hao Song, Tian Li, Jiaxin Zheng, Junjian Zhan. Nuclear receptor TLX may be through regulating the SIRT1/NF-κB pathway to ameliorate cognitive impairment in chronic cerebral hypoperfusion. Brain research bulletin. vol 166. 2021-08-11. PMID:33197535. |
the aim of this study was to investigate the neuroprotective effects of tlx on cognitive dysfunction, hippocampal neurogenesis and neuroinflammation in a rat model of cch and to assess the possible mechanisms. |
2021-08-11 |
2023-08-13 |
rat |
| Liangyuan Suo, Mingyu Wan. Dexmedetomidine facilitates the expression of nNOS in the hippocampus to alleviate surgery-induced neuroinflammation and cognitive dysfunction in aged rats. Experimental and therapeutic medicine. vol 22. issue 3. 2021-08-11. PMID:34373724. |
dexmedetomidine facilitates the expression of nnos in the hippocampus to alleviate surgery-induced neuroinflammation and cognitive dysfunction in aged rats. |
2021-08-11 |
2023-08-13 |
rat |
| Vladimir F Lazarev, Magda Tsolaki, Elena R Mikhaylova, Konstantin A Benken, Maxim A Shevtsov, Alina D Nikotina, Mirna Lechpammer, Vladimir A Mitkevich, Alexander A Makarov, Alexey A Moskalev, Sergey A Kozin, Boris A Margulis, Irina V Guzhova, Evgeny Nudle. Extracellular GAPDH Promotes Alzheimer Disease Progression by Enhancing Amyloid-β Aggregation and Cytotoxicity. Aging and disease. vol 12. issue 5. 2021-08-04. PMID:34341704. |
lentivirus-driven gapdh overexpression in two ad animal models increased the level of apoptosis of hippocampal cells, neural degeneration, and cognitive dysfunction. |
2021-08-04 |
2023-08-13 |
Not clear |
| Guanghui Chen, Yizhong Wang, Yang Li, Lujun Zhang, Meixue Don. A novel hippocampus metabolite signature in diabetes mellitus rat model of diabetic encephalopathy. Metabolic brain disease. vol 35. issue 6. 2021-07-29. PMID:32367268. |
in this study, we have made an attempt to investigate the metabolic changes associated with the streptozocin (stz)-induced cognitive dysfunction in the hippocampus of the rat model, a classical rodent model for de, with the help of gas chromatography-mass spectrometry-based method. |
2021-07-29 |
2023-08-13 |
rat |
| Chuan-An Yi, Yu-Hong Jiang, Ye Wang, Yu-Xian Li, Shi-Chang Cai, Xiu-Yu Wu, Xiang-Shang Hu, Xing-Guang Wa. Black Bamboo Rhizome Extract Improves Cognitive Dysfunction by Upregulating the Expression of Hippocampal BDNF and CREB in Rats with Cerebral Ischaemia-Reperfusion Injury. Neuropsychiatric disease and treatment. vol 17. 2021-07-22. PMID:34285486. |
black bamboo rhizome extract improves cognitive dysfunction by upregulating the expression of hippocampal bdnf and creb in rats with cerebral ischaemia-reperfusion injury. |
2021-07-22 |
2023-08-13 |
rat |
| Wenjin Yang, Gaoyi Li, Ke Cao, Peng Ma, Yijun Guo, Wusong Tong, Jian Wa. Exogenous insulin-like growth factor 1 attenuates acute ischemic stroke-induced spatial memory impairment via modulating inflammatory response and tau phosphorylation. Neuropeptides. vol 83. 2021-07-16. PMID:32863068. |
intravenous igf-1 delivery increased the igf-1 levels in plasma, ischemic amygdala, hippocampus and cortex, improved the neurological dysfunction, cognitive deficits, cerebral infarction and brain edema. |
2021-07-16 |
2023-08-13 |
rat |
| Saeed Esmaeili-Mahani, Elham Haghparast, Akram Nezhadi, Mehdi Abbasnejad, Vahid Sheiban. Apelin-13 prevents hippocampal synaptic plasticity impairment in Parkinsonism rats. Journal of chemical neuroanatomy. vol 111. 2021-07-15. PMID:33161074. |
the hippocampus is involved in learning and memory for novel information and implicated within the cognitive dysfunction in parkinson's disease. |
2021-07-15 |
2023-08-13 |
rat |
| Yuanyu Zhao, Jin Liu, Jing Li, Feng Zhao, Shijuan Du, Yunzi Wang, Juan Li, Lijun Yang, Jiang Du, Yong Tan. Changes in hippocampal capillaries in transgenic type 2 diabetic mice: A stereological investigation. Anatomical record (Hoboken, N.J. : 2007). vol 304. issue 5. 2021-07-13. PMID:33015956. |
the cognitive dysfunction associated with type 2 diabetes mellitus (t2dm) has been widely studied, and many structures in the hippocampus, such as neurons and synapses, have been shown to play a crucial role in the cognitive decline. |
2021-07-13 |
2023-08-13 |
mouse |
| Mohammad Rumman, Shivani Pandey, Babita Singh, Mrinal Gupta, Saba Ubaid, Abbas Ali Mahd. Genistein Prevents Hypoxia-Induced Cognitive Dysfunctions by Ameliorating Oxidative Stress and Inflammation in the Hippocampus. Neurotoxicity research. vol 39. issue 4. 2021-07-13. PMID:33740236. |
genistein prevents hypoxia-induced cognitive dysfunctions by ameliorating oxidative stress and inflammation in the hippocampus. |
2021-07-13 |
2023-08-13 |
mouse |
| Mohammad Rumman, Shivani Pandey, Babita Singh, Mrinal Gupta, Saba Ubaid, Abbas Ali Mahd. Genistein Prevents Hypoxia-Induced Cognitive Dysfunctions by Ameliorating Oxidative Stress and Inflammation in the Hippocampus. Neurotoxicity research. vol 39. issue 4. 2021-07-13. PMID:33740236. |
altogether, our results showed that ge treatment prevents hypoxia-induced cognitive dysfunction in mice by reducing oxidative stress and suppressing neuroinflammation while increasing the expression of neuroprotective genes in the hippocampus. |
2021-07-13 |
2023-08-13 |
mouse |
| Wei Sun, Yang Yang, Zexiang Wu, Xiao Chen, Wen Li, Lei A. Chronic Cyanuric Acid Exposure Depresses Hippocampal LTP but Does Not Disrupt Spatial Learning or Memory in the Morris Water Maze. Neurotoxicity research. vol 39. issue 4. 2021-07-13. PMID:33751468. |
the hippocampus has been identified as a brain area which was especially vulnerable in developmental condition associated with cognitive dysfunction. |
2021-07-13 |
2023-08-13 |
rat |
| Weizhuo Lu, Jiyue We. Neuroprotective roles of total flavones of Camellia on early brain injury andcognitive dysfunction following subarachnoid hemorrhage in rats. Metabolic brain disease. vol 35. issue 5. 2021-07-09. PMID:32219683. |
not surprisingly, cognitive dysfunction and the upregulation of tau phosphorylation at ser262 (p-tau-ser262) in hippocampal tissues were markedly reduced by tfc treatment. |
2021-07-09 |
2023-08-13 |
rat |
| Yun Fan, Mei-Chuan Chou, Yen-Chin Liu, Ching-Kuan Liu, Chu-Huang Chen, Shiou-Lan Che. Intermittent Hypoxia Activates N-Methyl-D-Aspartate Receptors to Induce Anxiety Behaviors in a Mouse Model of Sleep-Associated Apnea. Molecular neurobiology. vol 58. issue 7. 2021-07-06. PMID:33660202. |
to evaluate how ih alters neuronal function to yield anxiety-like behavior and cognitive dysfunction, we examined synaptic plasticity and neuronal inflammation in related brain areas, including the medial prefrontal cortex (mpfc), striatum, and hippocampus. |
2021-07-06 |
2023-08-13 |
mouse |
| Shu Ye, Dao-Jun Xie, Peng Zhou, Hua-Wu Gao, Meng-Ting Zhang, Da-Bao Chen, Yun-Peng Qin, Xin Lei, Xin-Quan Li, Juan Liu, Ya-Xun Cheng, Yong-Chuan Yao, Biao Cai, Guo-Ming She. Huang-Pu-Tong-Qiao Formula Ameliorates the Hippocampus Apoptosis in Diabetic Cognitive Dysfunction Mice by Activating CREB/BDNF/TrkB Signaling Pathway. Evidence-based complementary and alternative medicine : eCAM. vol 2021. 2021-07-03. PMID:34211563. |
huang-pu-tong-qiao formula ameliorates the hippocampus apoptosis in diabetic cognitive dysfunction mice by activating creb/bdnf/trkb signaling pathway. |
2021-07-03 |
2023-08-13 |
mouse |
| Xiangming Liu, Yiming Ma, Ruoyun Ouyang, Zihang Zeng, Zijie Zhan, Huanhuan Lu, Yanan Cui, Zhongshang Dai, Lijuan Luo, Chenjie He, Herui Li, Dandan Zong, Yan Che. The relationship between inflammation and neurocognitive dysfunction in obstructive sleep apnea syndrome. Journal of neuroinflammation. vol 17. issue 1. 2021-07-02. PMID:32738920. |
previous studies have revealed that intermittent hypoxia (ih) conditions in osas patients elicited neuron injury (especially in the hippocampus and cortex), leading to cognitive dysfunction, a significant and extraordinary complication of osas patients. |
2021-07-02 |
2023-08-13 |
Not clear |
| b' Laura Vidal-Sancho, Sara Fern\\xc3\\xa1ndez-Garc\\xc3\\xada, Irene Sol\\xc3\\xa9s-Tarr\\xc3\\xa9s, Jordi Alberch, Xavier Xifr\\xc3\\xb. Decreased Myocyte Enhancer Factor 2 Levels in the Hippocampus of Huntington\'s Disease Mice Are Related to Cognitive Dysfunction. Molecular neurobiology. vol 57. issue 11. 2021-06-29. PMID:32757160.' |
decreased myocyte enhancer factor 2 levels in the hippocampus of huntington's disease mice are related to cognitive dysfunction. |
2021-06-29 |
2023-08-13 |
mouse |
| Jing Wu, Zhen Fan, Yuxing Zhao, Qiunan Chen, Qian Xia. Inhibition of soluble epoxide hydrolase (sEH) protects hippocampal neurons and reduces cognitive decline in type 2 diabetic mice. The European journal of neuroscience. vol 53. issue 8. 2021-06-29. PMID:33595911. |
moreover, the seh inhibitor trans-4-[4-(3-adamantan-1-y1-ureido)-cyclohexyloxy]-benzoic acid (t-aucb) prevents cognitive dysfunction and decreased ros accumulation and apoptosis in the diabetic hippocampus. |
2021-06-29 |
2023-08-13 |
mouse |
| Jingjing You, Linshan Sun, Jiangong Wang, Fengjiao Sun, Wentao Wang, Dan Wang, Xueli Fan, Dunjiang Liu, Zhicheng Xu, Changyun Qiu, Jinbo Chen, Haijing Yan, Bin Li. Role of Adiponectin-Notch pathway in cognitive dysfunction associated with depression and in the therapeutic effect of physical exercise. Aging cell. vol 20. issue 6. 2021-06-26. PMID:34053165. |
chronic stress inhibits the adiponectin-notch pathway and induces impaired hippocampal neurogenesis and cognitive dysfunction, which can be rescued by adiporon and running. |
2021-06-26 |
2023-08-13 |
mouse |
| Jingjing You, Linshan Sun, Jiangong Wang, Fengjiao Sun, Wentao Wang, Dan Wang, Xueli Fan, Dunjiang Liu, Zhicheng Xu, Changyun Qiu, Jinbo Chen, Haijing Yan, Bin Li. Role of Adiponectin-Notch pathway in cognitive dysfunction associated with depression and in the therapeutic effect of physical exercise. Aging cell. vol 20. issue 6. 2021-06-26. PMID:34053165. |
adiponectin knockout mice display depressive-like behaviors, associated with inhibited notch signaling, impaired hippocampal neurogenesis and cognitive dysfunction. |
2021-06-26 |
2023-08-13 |
mouse |
| Soo Jung Shin, Yunkwon Nam, Yong Ho Park, Min-Jeong Kim, Eunbeen Lee, Seong Gak Jeon, Bong-Seok Bae, Jiho Seo, Sung-Lye Shim, Jong-Seok Kim, Chang-Kyun Han, Sujin Kim, Yong Yook Lee, Minho Moo. Therapeutic effects of non-saponin fraction with rich polysaccharide from Korean red ginseng on aging and Alzheimer's disease. Free radical biology & medicine. vol 164. 2021-06-24. PMID:33422674. |
next, we investigated (1) the effects of nfp on ad pathologies, such as aβ deposition, neuroinflammation, neurodegeneration, mitochondrial dysfunction, and impaired adult hippocampal neurogenesis (ahn), in 5xfad transgenic mouse model of ad using immunostaining; (2) the effect of nfp on aβ-mediated mitochondrial respiration deficiency in ht22 mouse hippocampal neuronal cells (ht22) using seahorse xfp analysis; (3) the effect of nfp on cell proliferation using wst-1 analysis; and (4) the effect of nfp on aβ-induced cognitive dysfunction in 5xfad mouse model of ad using y-maze test. |
2021-06-24 |
2023-08-13 |
mouse |