| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sonia Sanchez-Bezanilla, Rebecca J Hood, Lyndsey E Collins-Praino, Renée J Turner, Frederick R Walker, Michael Nilsson, Lin Kooi On. More than motor impairment: A spatiotemporal analysis of cognitive impairment and associated neuropathological changes following cortical photothrombotic stroke. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 41. issue 9. 2021-11-17. PMID:33779358. |
conversely, we observed persistent neuronal loss together with concomitant increased neuroinflammation and amyloid-β accumulation in the hippocampus, which likely accounts for the persistent cognitive dysfunction. |
2021-11-17 |
2023-08-13 |
mouse |
| Chiung-Hui Liu, Wen-Chieh Liao, Hsin-Hua Li, Li-Ho Tseng, Wei-Han Wang, Hsin Tung, Pin-Jiun Lin, Hsin-Tung Jao, Wen-Yuan Liu, Ching-Sui Hung, Chih-Li Lin, Ying-Jui H. Treatment with the combination of clavulanic acid and valproic acid led to recovery of neuronal and behavioral deficits in an epilepsy rat model. Fundamental & clinical pharmacology. vol 35. issue 6. 2021-11-16. PMID:34545633. |
rats with ptz-induced kindling exhibited seizures, motor dysfunction, cognitive impairment, and cell loss and reduction of neurogenesis in the hippocampus. |
2021-11-16 |
2023-08-13 |
rat |
| Caitlin A Finney, Margaret J Morris, R Frederick Westbrook, Nicole M Jone. Hippocampal silent infarct leads to subtle cognitive decline that is associated with inflammation and gliosis at twenty-four hours after injury in a rat model. Behavioural brain research. vol 401. 2021-11-15. PMID:33358919. |
our data demonstrate that hippocampal si can lead to cognitive dysfunction 24 -hs after injury. |
2021-11-15 |
2023-08-13 |
rat |
| Paula Moyano, Javier Sanjuna, José Manuel Garcia, Jimena Garcia, María Teresa Frejo, María Victoria Naval, Javier Del Pin. Paraquat Treatment Compromises the Clearance of β-Amyloid and Tau Proteins and Induces Primary Hippocampal Neuronal Cell Death through HSP70, P20S, and TFEB Disruption. Chemical research in toxicology. vol 34. issue 5. 2021-11-12. PMID:33156613. |
the herbicide paraquat (pq) induces hippocampal neuronal cell loss and cognitive dysfunction after one and repeated treatment. |
2021-11-12 |
2023-08-13 |
Not clear |
| Xiaoyan Zhu, Jian Huang, Yongji Wu, Shanting Zhao, Xuejun Cha. Effect of Heat Stress on Hippocampal Neurogenesis: Insights into the Cellular and Molecular Basis of Neuroinflammation-Induced Deficits. Cellular and molecular neurobiology. 2021-11-12. PMID:34767143. |
furthermore, we provide valuable insights into the molecular and cellular mechanisms underlying neuroinflammation-induced deficits in hippocampal neurogenesis, particularly relating to cognitive dysfunction following heat stress. |
2021-11-12 |
2023-08-13 |
Not clear |
| Xiaoyan Zhu, Jian Huang, Yongji Wu, Shanting Zhao, Xuejun Cha. Effect of Heat Stress on Hippocampal Neurogenesis: Insights into the Cellular and Molecular Basis of Neuroinflammation-Induced Deficits. Cellular and molecular neurobiology. 2021-11-12. PMID:34767143. |
lastly, we aim to identify potential mechanisms through which neuroinflammation induces cognitive dysfunction, and elucidate how neuroinflammation contributes to defective hippocampal neurogenesis. |
2021-11-12 |
2023-08-13 |
Not clear |
| Ana Belen Lopez-Rodriguez, Edel Hennessy, Carol L Murray, Arshed Nazmi, Hugh J Delaney, Dáire Healy, Steven G Fagan, Michael Rooney, Erika Stewart, Anouchka Lewis, Niamh de Barra, Philip Scarry, Louise Riggs-Miller, Delphine Boche, Mark O Cunningham, Colm Cunningha. Acute systemic inflammation exacerbates neuroinflammation in Alzheimer's disease: IL-1β drives amplified responses in primed astrocytes and neuronal network dysfunction. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17. issue 10. 2021-11-09. PMID:34080771. |
systemic lps triggered microglial il-1β, astrocytic chemokines, il-6, and acute cognitive dysfunction, whereas il-1β disrupted hippocampal gamma rhythm, all selectively in app/ps1 mice. |
2021-11-09 |
2023-08-13 |
mouse |
| Naoki Takada, Yoki Nakamura, Keisuke Ikeda, Naoki Takaoka, Kazue Hisaoka-Nakashima, Seigo Sanoh, Yaichiro Kotake, Yoshihiro Nakata, Norimitsu Moriok. Treatment with Histone Deacetylase Inhibitor Attenuates Peripheral Inflammation-Induced Cognitive Dysfunction and Microglial Activation: The Effect of SAHA as a Peripheral HDAC Inhibitor. Neurochemical research. vol 46. issue 9. 2021-11-03. PMID:34081246. |
taken together, these findings demonstrate that inhibition of peripheral hdac plays a critical role in preventing cognitive dysfunction induced by peripheral inflammation via the regulation of anti-inflammatory cytokine production and the inhibition of microglial functions in the hippocampus. |
2021-11-03 |
2023-08-13 |
Not clear |
| Baiqing He, Jian Wan. METTL3 regulates hippocampal gene transcription via N6-methyladenosine methylation in sevoflurane-induced postoperative cognitive dysfunction mouse. Aging. vol 13. issue 19. 2021-11-03. PMID:34611079. |
mettl3 regulates hippocampal gene transcription via n6-methyladenosine methylation in sevoflurane-induced postoperative cognitive dysfunction mouse. |
2021-11-03 |
2023-08-13 |
mouse |
| Yongyan Xie, Bo Yan, Min Hou, Maofu Zhou, Chao Liu, Mengsheng Sun, Kun He, Cong Fang, Yaohui Chen, Liping Huan. Erzhi pills ameliorate cognitive dysfunction and alter proteomic hippocampus profiles induced by d-galactose and Aβ Pharmaceutical biology. vol 59. issue 1. 2021-10-28. PMID:34672897. |
erzhi pills ameliorate cognitive dysfunction and alter proteomic hippocampus profiles induced by d-galactose and aβ erzhi pills are a classic chinese medicine prescription, but their effects on alzheimer's disease (ad) are not clear. |
2021-10-28 |
2023-08-13 |
Not clear |
| Xianshengjie Lang, Na Zhao, Qiang He, Xun Li, Xuejiao Li, Chuanning Sun, Xianliang Zhan. Treadmill exercise mitigates neuroinflammation and increases BDNF via activation of SIRT1 signaling in a mouse model of T2DM. Brain research bulletin. vol 165. 2021-10-26. PMID:32987101. |
we found that treadmill exercise for 8 weeks can significantly improve the cognitive dysfunction, alleviate activation of proinflammatory microglia m1 (iba1 labeling) in the hippocampus of t2dm mice, and reduce the levels of proinflammatory factors il-1β, il-6, tnf-α, increase the expression levels of anti-inflammatory factors il-10, tgf-β1, and promote the release of bdnf. |
2021-10-26 |
2023-08-13 |
mouse |
| Hui Zhang, Li Ma, Wen-Zhi Guo, Lin-Bo Jiao, Hong-Yu Zhao, Ya-Qun Ma, Xue-Mei Ha. TSPO ligand etifoxine attenuates LPS-induced cognitive dysfunction in mice. Brain research bulletin. vol 165. 2021-10-26. PMID:33075418. |
etifoxine pretreatment alleviated hippocampal inflammation, increased brain levels of progesterone, allopregnanolone and attenuated cognitive dysfunction in lps-injected mice. |
2021-10-26 |
2023-08-13 |
mouse |
| Rafael Alcalá-Vida, Marta Garcia-Forn, Carla Castany-Pladevall, Jordi Creus-Muncunill, Yoko Ito, Enrique Blanco, Arantxa Golbano, Kilian Crespí-Vázquez, Aled Parry, Guy Slater, Shamith Samarajiwa, Sandra Peiró, Luciano Di Croce, Masashi Narita, Esther Pérez-Navarr. Neuron type-specific increase in lamin B1 contributes to nuclear dysfunction in Huntington's disease. EMBO molecular medicine. vol 13. issue 2. 2021-10-22. PMID:33369245. |
supporting lamin b1 alterations as a causal role in mutant huntingtin-mediated neurodegeneration, pharmacological normalization of lamin b1 levels in the hippocampus of the r6/1 mouse model of hd by betulinic acid administration restored nuclear homeostasis and prevented motor and cognitive dysfunction. |
2021-10-22 |
2023-08-13 |
mouse |
| Bin Zhu, Zhi-Gang Wang, Jie Ding, Ning Liu, DA-Ming Wang, Liang-Cai Ding, Chun Yan. Chronic lipopolysaccharide exposure induces cognitive dysfunction without affecting BDNF expression in the rat hippocampus. Experimental and therapeutic medicine. vol 7. issue 3. 2021-10-21. PMID:24520281. |
chronic lipopolysaccharide exposure induces cognitive dysfunction without affecting bdnf expression in the rat hippocampus. |
2021-10-21 |
2023-08-12 |
rat |
| Bin Zhu, Zhi-Gang Wang, Jie Ding, Ning Liu, DA-Ming Wang, Liang-Cai Ding, Chun Yan. Chronic lipopolysaccharide exposure induces cognitive dysfunction without affecting BDNF expression in the rat hippocampus. Experimental and therapeutic medicine. vol 7. issue 3. 2021-10-21. PMID:24520281. |
the results indicate that lps induces cognitive dysfunction, which is associated with increased expression levels of pro-inflammatory cytokines and aβ, but does not affect the expression of bdnf in the hippocampus. |
2021-10-21 |
2023-08-12 |
rat |
| Bharathi Hattiangady, Ramkumar Kuruba, Ashok K Shett. Acute Seizures in Old Age Leads to a Greater Loss of CA1 Pyramidal Neurons, an Increased Propensity for Developing Chronic TLE and a Severe Cognitive Dysfunction. Aging and disease. vol 2. issue 1. 2021-10-20. PMID:21339903. |
however, it is unclear whether as activity in old age would result in a greater magnitude of hippocampal neurodegeneration and inflammation, and an increased predilection for developing chronic temporal lobe epilepsy (tle) and cognitive dysfunction. |
2021-10-20 |
2023-08-12 |
rat |
| Seong Su Kang, Eun Hee Ahn, Xia Liu, Matthew Bryson, Gary W Miller, David Weinshenker, Keqiang Y. ApoE4 inhibition of VMAT2 in the locus coeruleus exacerbates Tau pathology in Alzheimer's disease. Acta neuropathologica. vol 142. issue 1. 2021-10-19. PMID:33895869. |
our data reveal that apoe4 boosts tau neurotoxicity via vmat2 inhibition, reduces hippocampal volume, and induces cognitive dysfunction in an aep- and tau n368-dependent manner, while conversely apoe3 binds tau and protects it from cleavage. |
2021-10-19 |
2023-08-13 |
human |
| Chen Qiu, Min Wang, Wen Yu, Zheng Rong, He-Sheng Zheng, Ting Sun, Shui-Bing Liu, Ming-Gao Zhao, Yu-Mei W. Activation of the Hippocampal LXRβ Improves Sleep-Deprived Cognitive Impairment by Inhibiting Neuroinflammation. Molecular neurobiology. vol 58. issue 10. 2021-10-08. PMID:34278533. |
this study correlates a deficit of lxrβ in cognitive dysfunction in sd associated with hmgb1 inflammatory pathway in hippocampus, and lxrs may serve as a potential therapeutic target for cognitive impairment with anti-inflammation. |
2021-10-08 |
2023-08-13 |
mouse |
| Xiaoyan Zhu, Yongji Wu, Jiarong Pan, Cixia Li, Jian Huang, Enhui Cui, Ziluo Chen, Wentai Zhou, Xuejun Chai, Shanting Zha. Neuroinflammation Induction and Alteration of Hippocampal Neurogenesis in Mice Following Developmental Exposure to Gossypol. The international journal of neuropsychopharmacology. vol 24. issue 5. 2021-10-06. PMID:33283869. |
exposure to certain physical or chemical factors during the perinatal period can lead to many neuropathological defects that cause high cognitive dysfunction and are accompanied by abnormal hippocampal neurogenesis and plasticity. |
2021-10-06 |
2023-08-13 |
mouse |
| Jianhua Qin, Qingjun Ma, Dongmei M. Low-dose Sevoflurane Attenuates Cardiopulmonary Bypass (CPB)- induced Postoperative Cognitive Dysfunction (POCD) by Regulating Hippocampus Apoptosis via PI3K/AKT Pathway. Current neurovascular research. vol 17. issue 3. 2021-09-29. PMID:32400333. |
low-dose sevoflurane attenuates cardiopulmonary bypass (cpb)- induced postoperative cognitive dysfunction (pocd) by regulating hippocampus apoptosis via pi3k/akt pathway. |
2021-09-29 |
2023-08-13 |
Not clear |