| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zeinab Momeni, Maricris Bautista, Joseph Neapetung, Rylan Urban, Yasuhiko Yamamoto, Anand Krishnan, Verónica A Campanucc. RAGE signaling is required for AMPA receptor dysfunction in the hippocampus of hyperglycemic mice. Physiology & behavior. vol 229. 2021-06-21. PMID:33221393. |
in rodent animal models, cognitive dysfunction can manifest as impaired hippocampal synaptic plasticity. |
2021-06-21 |
2023-08-13 |
mouse |
| Lan Xiao, Vinay Kumar Sharma, Leila Toulabi, Xuyu Yang, Cheol Lee, Daniel Abebe, Areg Peltekian, Irina Arnaoutova, Hong Lou, Y Peng Lo. Neurotrophic factor-α1, a novel tropin is critical for the prevention of stress-induced hippocampal CA3 cell death and cognitive dysfunction in mice: comparison to BDNF. Translational psychiatry. vol 11. issue 1. 2021-06-18. PMID:33414376. |
stress leads to brain pathology including hippocampal degeneration, cognitive dysfunction, and potential mood disorders. |
2021-06-18 |
2023-08-13 |
mouse |
| Zuo Zhang, Hongli Zhou, Jiyin Zho. Neuritin inhibits astrogliosis to ameliorate diabetic cognitive dysfunction. Journal of molecular endocrinology. vol 66. issue 4. 2021-06-16. PMID:33729996. |
further, the impact of the overexpression of neuritin in the cortex and the hippocampus on diabetic cognitive dysfunction and astrogliosis in type 2 diabetic (db/db) mice was assessed. |
2021-06-16 |
2023-08-13 |
mouse |
| Zuo Zhang, Hongli Zhou, Jiyin Zho. Neuritin inhibits astrogliosis to ameliorate diabetic cognitive dysfunction. Journal of molecular endocrinology. vol 66. issue 4. 2021-06-16. PMID:33729996. |
neuritin overexpression in the hippocampus of db/db mice significantly ameliorated cognitive dysfunction, hippocampal neuronal impairment, and synaptic plasticity deterioration, and inhibited astrogliosis and the jak2/stat3 signaling pathway in the hippocampus. |
2021-06-16 |
2023-08-13 |
mouse |
| Na Li, Su-Yun Hong, Jun Li, Gai-Mei Wang, Zhe Liu, Yi Lian. [Effect of electroacupuncture pretreatment on hippocampal oxidative stress in aged mice with postoperative cognitive dysfunction]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. vol 41. issue 6. 2021-06-07. PMID:34085482. |
[effect of electroacupuncture pretreatment on hippocampal oxidative stress in aged mice with postoperative cognitive dysfunction]. |
2021-06-07 |
2023-08-13 |
mouse |
| Na Li, Su-Yun Hong, Jun Li, Gai-Mei Wang, Zhe Liu, Yi Lian. [Effect of electroacupuncture pretreatment on hippocampal oxidative stress in aged mice with postoperative cognitive dysfunction]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. vol 41. issue 6. 2021-06-07. PMID:34085482. |
to observe the effect of electroacupuncture (ea) pretreatment on hippocampal oxidative stress in aged mice with postoperative cognitive dysfunction (pocd) and explore the relevant mechanism of ea pretreatment on the improvement of learning and memory in pocd aged mice. |
2021-06-07 |
2023-08-13 |
mouse |
| Haiyang Zhang, Wenjing Jiao, Hailin Cui, Qinghong Sun, Honggang Fa. Combined exposure of alumina nanoparticles and chronic stress exacerbates hippocampal neuronal ferroptosis via activating IFN-γ/ASK1/JNK signaling pathway in rats. Journal of hazardous materials. vol 411. 2021-06-03. PMID:33858114. |
ask1 inhibitor gs-4997 also improved hippocampal neuronal ferroptosis and cognitive dysfunction by inhibiting ask1/jnk signaling pathway. |
2021-06-03 |
2023-08-13 |
rat |
| Victoria Macht, Fulton T Crews, Ryan P Vetren. Neuroimmune and epigenetic mechanisms underlying persistent loss of hippocampal neurogenesis following adolescent intermittent ethanol exposure. Current opinion in pharmacology. vol 50. 2021-05-31. PMID:31778865. |
the mechanisms underlying the persistent aie-induced loss of adult hippocampal neurogenesis could contribute to broader neurodegeneration, loss of hippocampal neuroplasticity, and cognitive dysfunction. |
2021-05-31 |
2023-08-13 |
Not clear |
| Zihan Xu, Wei Lu, Yongzhen Miao, Hui Li, Xiaodan Xie, Fang Zhan. mRNA profiling reveals the potential mechanism of TIPE2 in attenuating cognitive deficits in APP/PS1 mice. International immunopharmacology. vol 87. 2021-05-27. PMID:32707494. |
taken together, increased adeno-associated virus (aav)-mediated tipe2 overexpression in the hippocampus of app/ps1 mice reversed cognitive dysfunction. |
2021-05-27 |
2023-08-13 |
mouse |
| Xinyan Dong, Xiaoxu Hao, Peng Xu, Miao Fan, Xuehui Wang, Xin Huang, Peifang Jiang, Linghui Zeng, Yicheng Xi. RNA sequencing analysis of cortex and hippocampus in a kainic acid rat model of temporal lobe epilepsy to identify mechanisms and therapeutic targets related to inflammation, immunity and cognition. International immunopharmacology. vol 87. 2021-05-27. PMID:32736192. |
collectively, this study demonstrated the changes of gene transcriptome in the cortex and hippocampus in the signature phases after the ka administration, illustrating the association between epileptogenesis, inflammation genes and cognitive dysfunction, and may benefit identifying novel therapeutic targets for treating tle and its comorbidities. |
2021-05-27 |
2023-08-13 |
rat |
| Xinxin Xu, Xi Xiao, Yuxing Yan, Tao Zhan. Activation of liver X receptors prevents emotional and cognitive dysfunction by suppressing microglial M1-polarization and restoring synaptic plasticity in the hippocampus of mice. Brain, behavior, and immunity. vol 94. 2021-05-27. PMID:33662504. |
activation of liver x receptors prevents emotional and cognitive dysfunction by suppressing microglial m1-polarization and restoring synaptic plasticity in the hippocampus of mice. |
2021-05-27 |
2023-08-13 |
mouse |
| Giusy Tassone, Arian Kola, Daniela Valensin, Cecilia Pozz. Dynamic Interplay between Copper Toxicity and Mitochondrial Dysfunction in Alzheimer's Disease. Life (Basel, Switzerland). vol 11. issue 5. 2021-05-27. PMID:33923275. |
ad is characterized by severe cognitive dysfunctions associated with neuronal loss and connection disruption, mainly occurring in specific brain areas such as the hippocampus, cerebral cortex, and amygdala, compromising memory, language, reasoning, and social behavior. |
2021-05-27 |
2023-08-13 |
Not clear |
| Qiong-Yan Tang, Min Li, Lei Chen, Jia-Mei Jiang, Sheng-Lan Gao, Fan Xiao, Wei Zou, Ping Zhang, Yong-Jun Che. Adiponectin Mediates the Protection of H Frontiers in behavioral neuroscience. vol 15. 2021-05-26. PMID:34025367. |
adiponectin mediates the protection of h emerging evidence shows that chronic restraint stress (crs) can induce cognitive dysfunction, which involves in hippocampal damage. |
2021-05-26 |
2023-08-13 |
Not clear |
| Paula Moyano, Javier Sanjuan, José Manuel García, María José Anadon, Maria Victoria Naval, Emma Sola, Jimena García, María Teresa Frejo, Javier Del Pin. Dysregulation of prostaglandine E2 and BDNF signaling mediated by estrogenic dysfunction induces primary hippocampal neuronal cell death after single and repeated paraquat treatment. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 144. 2021-05-21. PMID:32738378. |
paraquat (pq) produces hippocampal neuronal cell death and cognitive dysfunctions after unique and continued exposure, but the mechanisms are not understood. |
2021-05-21 |
2023-08-13 |
Not clear |
| Paula Moyano, Javier Sanjuan, José Manuel García, María José Anadon, Maria Victoria Naval, Emma Sola, Jimena García, María Teresa Frejo, Javier Del Pin. Dysregulation of prostaglandine E2 and BDNF signaling mediated by estrogenic dysfunction induces primary hippocampal neuronal cell death after single and repeated paraquat treatment. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 144. 2021-05-21. PMID:32738378. |
primary hippocampal wildtype or βapp-tau silenced cells were co-treated with pq with or without e2, n-acetylcysteine (nac), ns-398 (cyclooxygenase-2 inhibitor), mf63 (pges-1 inhibitor) and/or recombinant brain-derived neurotrophic factor (bdnf) during one- and fourteen-days to studied pq effect on prostaglandin e2 (pge2) and bdnf signaling and their involvement in hyperphosphorylated tau (ptau) and amyloid-beta (aβ) protein formation, and oxidative stress generation, that lead to neuronal cell loss through estrogenic disruption, as a possible mechanism of cognitive dysfunctions produced by pq. |
2021-05-21 |
2023-08-13 |
Not clear |
| Manman Zhao, Junling Gao, Changmeng Cui, Yanan Zhang, Xiaohua Jiang, Jianzhong Cu. Inhibition of PTEN Ameliorates Secondary Hippocampal Injury and Cognitive Deficits after Intracerebral Hemorrhage: Involvement of AKT/FoxO3a/ATG-Mediated Autophagy. Oxidative medicine and cellular longevity. vol 2021. 2021-05-20. PMID:33777313. |
however, systemic administration of pten inhibitor bpv or hippocampal injection of pten sirna could prevent hippocampal neuronal injury and cognitive dysfunctions after ich. |
2021-05-20 |
2023-08-13 |
rat |
| Junjun Zhang, Yujuan Zhang, Meiling Xu, Zhigang Miao, Ye Tia. Inhibition of the CDK5/caspase-3 Pathway by p5-TAT Protects Hippocampal Neurogenesis and Alleviates Radiation-induced Cognitive Dysfunction. Neuroscience. vol 463. 2021-05-19. PMID:33838288. |
inhibition of the cdk5/caspase-3 pathway by p5-tat protects hippocampal neurogenesis and alleviates radiation-induced cognitive dysfunction. |
2021-05-19 |
2023-08-13 |
Not clear |
| Junjun Zhang, Yujuan Zhang, Meiling Xu, Zhigang Miao, Ye Tia. Inhibition of the CDK5/caspase-3 Pathway by p5-TAT Protects Hippocampal Neurogenesis and Alleviates Radiation-induced Cognitive Dysfunction. Neuroscience. vol 463. 2021-05-19. PMID:33838288. |
whether inhibition of cdk5 and the relevant caspase-3 could improve hippocampal neurogenesis and ameliorate radiation-induced cognitive dysfunction needs further exploration. |
2021-05-19 |
2023-08-13 |
Not clear |
| Junjun Zhang, Yujuan Zhang, Meiling Xu, Zhigang Miao, Ye Tia. Inhibition of the CDK5/caspase-3 Pathway by p5-TAT Protects Hippocampal Neurogenesis and Alleviates Radiation-induced Cognitive Dysfunction. Neuroscience. vol 463. 2021-05-19. PMID:33838288. |
we hypothesized that inhibition of the cdk5/caspase-3 pathway by p5-tat could protect hippocampal neurogenesis and alleviate radiation-induced cognitive dysfunction. |
2021-05-19 |
2023-08-13 |
Not clear |
| Junjun Zhang, Yujuan Zhang, Meiling Xu, Zhigang Miao, Ye Tia. Inhibition of the CDK5/caspase-3 Pathway by p5-TAT Protects Hippocampal Neurogenesis and Alleviates Radiation-induced Cognitive Dysfunction. Neuroscience. vol 463. 2021-05-19. PMID:33838288. |
inhibition of hippocampal neurogenesis and proliferation as well as cognitive dysfunction was also observed. |
2021-05-19 |
2023-08-13 |
Not clear |