| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kaviya Selvaraj, Nivethitha Manickam, Elamathi Kumaran, Kayalvizhi Thangadurai, Gokul Elumalai, Aravinthan Sekar, Risna Kanjirassery Radhakrishnan, Mahesh Kandasam. Deterioration of neuroregenerative plasticity in association with testicular atrophy and dysregulation of the hypothalamic-pituitary-gonadal (HPG) axis in Huntington's disease: A putative role of the huntingtin gene in steroidogenesis. The Journal of steroid biochemistry and molecular biology. vol 197. 2020-07-06. PMID:31715317. |
huntington's disease (hd) is an autosomal dominant progressive neurodegenerative disorder mainly affecting the structure and functions of the striatum, cerebral cortex and hippocampus leading to movement disorders, cognitive dysfunctions and emotional disturbances. |
2020-07-06 |
2023-08-13 |
human |
| Yatao Liu, Wei Liu, Xiaoqing Wang, Zhanhai Wan, Fengxian Gu, Li Ma, Yufang Len. Hippocampal astrocyte dysfunction contributes to etomidate-induced long-lasting synaptic inhibition. Biochemical and biophysical research communications. vol 519. issue 4. 2020-06-22. PMID:31558319. |
furthermore, continual activation of hippocampal astrocytes following administration of a sedative dose (8 mg/kg) of etomidate induced synaptic inhibition and cognitive dysfunction. |
2020-06-22 |
2023-08-13 |
mouse |
| Louise Flood, Sergiy V Korol, Lisa Ekselius, Bryndis Birnir, Zhe Ji. Interferon-γ potentiates GABA Journal of neuroimmunology. vol 337. 2020-06-17. PMID:31505410. |
in conclusion, the potentiation of gabaergic currents in hippocampal neurons by ifn-γ may contribute to the disturbed neuronal excitability and cognitive dysfunction during neuroinflammation. |
2020-06-17 |
2023-08-13 |
rat |
| Svenja Kiljan, Marloes Prins, Bart M Baselmans, John G J M Bol, Geert J Schenk, Anne-Marie van Da. Enhanced GABAergic Immunoreactivity in Hippocampal Neurons and Astroglia of Multiple Sclerosis Patients. Journal of neuropathology and experimental neurology. vol 78. issue 6. 2020-06-16. PMID:31100147. |
research suggests that hippocampal lesions and gabaergic neurotransmitter changes contribute to cognitive dysfunction. |
2020-06-16 |
2023-08-13 |
human |
| Hao Chen, Yi Peng, Li Wang, Xin Wan. Sevoflurane attenuates cognitive dysfunction and NLRP3-dependent caspase-1/11-GSDMD pathway-mediated pyroptosis in the hippocampus Archives of physiology and biochemistry. 2020-06-15. PMID:32538180. |
sevoflurane attenuates cognitive dysfunction and nlrp3-dependent caspase-1/11-gsdmd pathway-mediated pyroptosis in the hippocampus septic encephalopathy (se) is a devastating consequence of sepsis, a hyper-triggered host response against infectious challenge, which ultimately leads to brain damage. |
2020-06-15 |
2023-08-13 |
mouse |
| Sara Amiri, Kayhan Azadmanesh, Marzieh Dehghan Shasaltaneh, Vafa Mayahi, Nasser Naghd. The Implication of Androgens in the Presence of Protein Kinase C to Repair Alzheimer’s Disease-Induced Cognitive Dysfunction Iranian biomedical journal. vol 24. issue 2. 2020-06-05. PMID:31677609. |
the implication of androgens in the presence of protein kinase c to repair alzheimer’s disease-induced cognitive dysfunction aging, as a major risk factor of memory deficiency, affects neural signaling pathways in hippocampus. |
2020-06-05 |
2023-08-13 |
Not clear |
| Qiongyu Lin, Fengcai Shen, Qiuping Zhou, Peixian Huang, Lanfen Lin, Mengmeng Chen, Xuan Chen, Shuqi Jiang, Shaoru He, Hongke Zeng, Yiyu Den. Interleukin-1β Disturbs the Proliferation and Differentiation of Neural Precursor Cells in the Hippocampus via Activation of Notch Signaling in Postnatal Rats Exposed to Lipopolysaccharide. ACS chemical neuroscience. vol 10. issue 5. 2020-05-29. PMID:30817119. |
here we investigated whether changes in interleukin-1β (il-1β) are associated with cognitive dysfunction in later life of septic neonatal rats through suppression of neurogenesis in the hippocampus. |
2020-05-29 |
2023-08-13 |
rat |
| Hongchang Gao, Qiaoying Jiang, Hui Ji, Jie Ning, Chen Li, Hong Zhen. Type 1 diabetes induces cognitive dysfunction in rats associated with alterations of the gut microbiome and metabolomes in serum and hippocampus. Biochimica et biophysica acta. Molecular basis of disease. vol 1865. issue 12. 2020-05-29. PMID:31472216. |
type 1 diabetes induces cognitive dysfunction in rats associated with alterations of the gut microbiome and metabolomes in serum and hippocampus. |
2020-05-29 |
2023-08-13 |
rat |
| Hongchang Gao, Qiaoying Jiang, Hui Ji, Jie Ning, Chen Li, Hong Zhen. Type 1 diabetes induces cognitive dysfunction in rats associated with alterations of the gut microbiome and metabolomes in serum and hippocampus. Biochimica et biophysica acta. Molecular basis of disease. vol 1865. issue 12. 2020-05-29. PMID:31472216. |
in this study, therefore, we investigated changes in the gut microbiome and metabolome in serum and hippocampus between advanced-stage t1d (ast1d) rats with cognitive decline and age-matched controls (amc), and explored the possible mechanism of the gut-microbiota-metabolite axis in t1d-induced cognitive dysfunction. |
2020-05-29 |
2023-08-13 |
rat |
| Xiao-Yu Sun, Teng Zheng, Xiu Yang, Le Liu, Shen-Shen Gao, Han-Bing Xu, Yu-Tong Song, Kun Tong, Li Yang, Ya Gao, Tong Wu, Jing-Ru Hao, Chen Lu, Tao Ma, Can Ga. HDAC2 hyperexpression alters hippocampal neuronal transcription and microglial activity in neuroinflammation-induced cognitive dysfunction. Journal of neuroinflammation. vol 16. issue 1. 2020-05-14. PMID:31796106. |
hdac2 hyperexpression alters hippocampal neuronal transcription and microglial activity in neuroinflammation-induced cognitive dysfunction. |
2020-05-14 |
2023-08-13 |
Not clear |
| Lan-Xue Zhao, Yan-Hui Ge, Jia-Bing Li, Cai-Hong Xiong, Ping-Yee Law, Jian-Rong Xu, Yu Qiu, Hong-Zhuan Che. M1 muscarinic receptors regulate the phosphorylation of AMPA receptor subunit GluA1 FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 33. issue 5. 2020-05-12. PMID:30794430. |
m1 muscarinic receptors regulate the phosphorylation of ampa receptor subunit glua1 m1 muscarinic acetylcholine receptors are highly expressed in key areas that control cognition, such as the cortex and hippocampus, representing one potential therapeutic target for cognitive dysfunctions of alzheimer's disease and schizophrenia. |
2020-05-12 |
2023-08-13 |
Not clear |
| Yuyuan Gao, Hongmei Tang, Kun Nie, Ruiming Zhu, Liang Gao, Shujun Feng, Limin Wang, Jiehao Zhao, Zhiheng Huang, Yuhu Zhang, Lijuan Wan. Hippocampal damage and white matter lesions contribute to cognitive impairment in MPTP-lesioned mice with chronic cerebral hypoperfusion. Behavioural brain research. vol 368. 2020-04-23. PMID:30959125. |
the aim of this study was to investigate the effect of chronic cerebral hypoperfusion (cch) on cognitive dysfunction, structural abnormalities of the hippocampus and white matter (wm), and levels of inflammatory cytokines in control and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-lesioned mouse models. |
2020-04-23 |
2023-08-13 |
mouse |
| Fanqing Meng, Ning Li, Dongliang Li, Bingfeng Song, Liang L. The presence of elevated circulating trimethylamine N-oxide exaggerates postoperative cognitive dysfunction in aged rats. Behavioural brain research. vol 368. 2020-04-23. PMID:30980850. |
one week after surgery, rats underwent laparotomy exhibited hippocampal-dependent cognitive dysfunction as evidenced by reduced contextual freezing time, which was associated with elevated plasma proinflammatory cytokine levels, increased microglia-mediated neuroinflammation and reactive oxygen species (ros) production in the hippocampus. |
2020-04-23 |
2023-08-13 |
rat |
| Fanqing Meng, Ning Li, Dongliang Li, Bingfeng Song, Liang L. The presence of elevated circulating trimethylamine N-oxide exaggerates postoperative cognitive dysfunction in aged rats. Behavioural brain research. vol 368. 2020-04-23. PMID:30980850. |
treatment with tmao, which elevated plasma tmao before and 1 week after surgery, further increased microglia-mediated neuroinflammation and ros production in the hippocampus, resulting in exaggerated cognitive dysfunction in laparotomy group but not in sham-operation group. |
2020-04-23 |
2023-08-13 |
rat |
| Liang Zhao, Chuanyang Zhang, Guilin Cao, Xueyi Dong, Dongliang Li, Lei Jian. Higher Circulating Trimethylamine N-oxide Sensitizes Sevoflurane-Induced Cognitive Dysfunction in Aged Rats Probably by Downregulating Hippocampal Methionine Sulfoxide Reductase A. Neurochemical research. vol 44. issue 11. 2020-04-06. PMID:31486012. |
higher circulating trimethylamine n-oxide sensitizes sevoflurane-induced cognitive dysfunction in aged rats probably by downregulating hippocampal methionine sulfoxide reductase a. |
2020-04-06 |
2023-08-13 |
rat |
| Sara Chavoshinezhad, Homa Mohseni Kouchesfahani, Abolhassan Ahmadiani, Leila Dargah. Interferon beta ameliorates cognitive dysfunction in a rat model of Alzheimer's disease: Modulation of hippocampal neurogenesis and apoptosis as underlying mechanism. Progress in neuro-psychopharmacology & biological psychiatry. vol 94. 2020-03-30. PMID:31152860. |
interferon beta ameliorates cognitive dysfunction in a rat model of alzheimer's disease: modulation of hippocampal neurogenesis and apoptosis as underlying mechanism. |
2020-03-30 |
2023-08-13 |
rat |
| Corinne G Jolivalt, Alexandra Marquez, David Quach, Michelle C Navarro Diaz, Carlos Anaya, Betelhem Kifle, Nabeel Muttalib, Gabriela Sanchez, Lucy Guernsey, Mike Hefferan, Darrel R Smith, Paul Fernyhough, Karl Johe, Nigel A Calcut. Amelioration of Both Central and Peripheral Neuropathy in Mouse Models of Type 1 and Type 2 Diabetes by the Neurogenic Molecule NSI-189. Diabetes. vol 68. issue 11. 2020-03-17. PMID:31492662. |
nsi-189 is a new chemical entity that when orally administered promotes neurogenesis in the adult hippocampus, increases hippocampal volume, enhances synaptic plasticity, and reduces cognitive dysfunction. |
2020-03-17 |
2023-08-13 |
mouse |
| Tao Sun, Zhi Liu, Mengying Liu, Ying Guo, Huan Sun, Jikai Zhao, Zhen Lan, Biyao Lian, Jiqiang Zhan. Hippocampus-specific Rictor knockdown inhibited 17β-estradiol induced neuronal plasticity and spatial memory improvement in ovariectomized mice. Behavioural brain research. vol 364. 2020-03-09. PMID:30753873. |
taken together, the current studies provided the first direct evidence for the important role of rictor in estrogenic action on the hippocampus, indicating that it may be a therapeutic target for the treatment of e2-related, hippocampus-dependent cognitive dysfunction. |
2020-03-09 |
2023-08-13 |
mouse |
| Jin-Hee Seo, Hye-Sang Park, Sang-Seo Park, Chang-Ju Kim, Dong-Hyun Kim, Tae-Woon Ki. Physical exercise ameliorates psychiatric disorders and cognitive dysfunctions by hippocampal mitochondrial function and neuroplasticity in post-traumatic stress disorder. Experimental neurology. vol 322. 2020-02-24. PMID:31446079. |
physical exercise ameliorates psychiatric disorders and cognitive dysfunctions by hippocampal mitochondrial function and neuroplasticity in post-traumatic stress disorder. |
2020-02-24 |
2023-08-13 |
Not clear |
| Hang Thi Nguyet Pham, Sinh Viet Phan, Hong Nguyen Tran, Xuyen Thi Phi, Xoan Thi Le, Khoi Minh Nguyen, Hironori Fujiwara, Masanori Yoneyama, Kiyokazu Ogita, Taro Yamaguchi, Kinzo Matsumot. Bacopa monnieri (L.) Ameliorates Cognitive Deficits Caused in a Trimethyltin-Induced Neurotoxicity Model Mice. Biological & pharmaceutical bulletin. vol 42. issue 8. 2020-01-14. PMID:31366873. |
extract (bme) ameliorated cognitive dysfunction in animal models of dementia by enhancing synaptic plasticity-related signaling in the hippocampus and protecting cholinergic neurons in the medial septum. |
2020-01-14 |
2023-08-13 |
mouse |