| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yu Shi, Xiangyu Guo, Jie Zhang, Hanchi Zhou, Bei Sun, Jing Fen. DNA binding protein HMGB1 secreted by activated microglia promotes the apoptosis of hippocampal neurons in diabetes complicated with OSA. Brain, behavior, and immunity. vol 73. 2019-08-06. PMID:29920330. |
compared with c57 control mice, kk-ay control mice exhibited increased cognitive dysfunction, microglial activation and hippocampal neuronal apoptosis. |
2019-08-06 |
2023-08-13 |
mouse |
| Zhuangzhuang Chen, Di Zhong, Guozhong L. The role of microglia in viral encephalitis: a review. Journal of neuroinflammation. vol 16. issue 1. 2019-08-05. PMID:30967139. |
on the other hand, microglia mediate presynaptic membrane damage in the hippocampus through complement, resulting in long-term memory impairment and cognitive dysfunction in patients with encephalitis. |
2019-08-05 |
2023-08-13 |
Not clear |
| Jie Zheng, Su Min, Bin Hu, Qin Liu, Yunqiang Wa. Nrdp1 is involved in hippocampus apoptosis in cardiopulmonary bypass-induced cognitive dysfunction via the regulation of ErbB3 protein levels. International journal of molecular medicine. vol 43. issue 4. 2019-07-30. PMID:30720051. |
nrdp1 is involved in hippocampus apoptosis in cardiopulmonary bypass-induced cognitive dysfunction via the regulation of erbb3 protein levels. |
2019-07-30 |
2023-08-13 |
rat |
| Tianhai Wang, Hongge Zhu, Yanshen Hou, Weixin Gu, Haichuan Wu, Yiwen Luan, Cheng Xiao, Chunyi Zho. Galantamine reversed early postoperative cognitive deficit via alleviating inflammation and enhancing synaptic transmission in mouse hippocampus. European journal of pharmacology. vol 846. 2019-07-29. PMID:30586550. |
interestingly, daily intraperitoneal administration of galantamine, an inhibitor of acetylcholinesterase, reversed cognitive dysfunction in surgery mice and attenuated accumulation of microglia and protein levels of il-1β, il-6 and tnf-α in the hippocampus. |
2019-07-29 |
2023-08-13 |
mouse |
| Irene Sánchez-Rodríguez, Agnès Gruart, José María Delgado-García, Lydia Jiménez-Díaz, Juan D Navarro-Lópe. Role of GirK Channels in Long-Term Potentiation of Synaptic Inhibition in an In Vivo Mouse Model of Early Amyloid- International journal of molecular sciences. vol 20. issue 5. 2019-07-01. PMID:30866445. |
role of girk channels in long-term potentiation of synaptic inhibition in an in vivo mouse model of early amyloid- imbalances of excitatory/inhibitory synaptic transmission occur early in the pathogenesis of alzheimer's disease (ad), leading to hippocampal hyperexcitability and causing synaptic, network, and cognitive dysfunctions. |
2019-07-01 |
2023-08-13 |
mouse |
| Muaz Belviranlı, Nilsel Okuda. Exercise Training Protects Against Aging-Induced Cognitive Dysfunction via Activation of the Hippocampal PGC-1α/FNDC5/BDNF Pathway. Neuromolecular medicine. vol 20. issue 3. 2019-05-14. PMID:29971668. |
exercise training protects against aging-induced cognitive dysfunction via activation of the hippocampal pgc-1α/fndc5/bdnf pathway. |
2019-05-14 |
2023-08-13 |
rat |
| Muaz Belviranlı, Nilsel Okuda. Exercise Training Protects Against Aging-Induced Cognitive Dysfunction via Activation of the Hippocampal PGC-1α/FNDC5/BDNF Pathway. Neuromolecular medicine. vol 20. issue 3. 2019-05-14. PMID:29971668. |
these findings show that aging-induced cognitive dysfunction is associated with a decrease in hippocampal expression of pgc-1α, fndc5, and bdnf, and that exercise training might improve cognitive functioning via activation of these genes and proteins. |
2019-05-14 |
2023-08-13 |
rat |
| Ane Murueta-Goyena, Naiara Ortuzar, Pascual Ángel Gargiulo, José Vicente Lafuente, Harkaitz Bengoetxe. Short-Term Exposure to Enriched Environment in Adult Rats Restores MK-801-Induced Cognitive Deficits and GABAergic Interneuron Immunoreactivity Loss. Molecular neurobiology. vol 55. issue 1. 2019-05-08. PMID:28822057. |
in this work, we aimed to investigate if a short exposure to enriched environment (ee) in early adulthood (p55-p73) was an effective strategy to improve cognitive dysfunction and to restore interneuron expression in medial prefrontal cortex (mpfc) and hippocampus (hpc). |
2019-05-08 |
2023-08-13 |
rat |
| Yasuhiro Kosuge, Nobuhiro Osada, Akiko Shimomura, Hiroko Miyagishi, Taira Wada, Kumiko Ishige, Shigeki Shimba, Yoshihisa It. Relevance of the hippocampal endoplasmic reticulum stress response in a mouse model of chronic kidney disease. Neuroscience letters. vol 677. 2019-04-09. PMID:29680250. |
a previous study has demonstrated that hippocampal oxidative stress contributes to cognitive dysfunction in ckd model mice. |
2019-04-09 |
2023-08-13 |
mouse |
| Amina Chaalal, Roseline Poirier, David Blum, Serge Laroche, Valérie Enderli. Thyroid Hormone Supplementation Restores Spatial Memory, Hippocampal Markers of Neuroinflammation, Plasticity-Related Signaling Molecules, and β-Amyloid Peptide Load in Hypothyroid Rats. Molecular neurobiology. vol 56. issue 1. 2019-04-01. PMID:29796989. |
together, these findings suggest that normalization of hippocampal t3 signaling is sufficient to reverse molecular and cognitive dysfunctions associated with hypothyroidism. |
2019-04-01 |
2023-08-13 |
rat |
| Christina M Grimm, Sonat Aksamaz, Stefanie Schulz, Jasper Teutsch, Piotr Sicinski, Birgit Liss, Dennis Kätze. Schizophrenia-related cognitive dysfunction in the Cyclin-D2 knockout mouse model of ventral hippocampal hyperactivity. Translational psychiatry. vol 8. issue 1. 2019-04-01. PMID:30301879. |
schizophrenia-related cognitive dysfunction in the cyclin-d2 knockout mouse model of ventral hippocampal hyperactivity. |
2019-04-01 |
2023-08-13 |
mouse |
| Kang Ma, Rongwei Li, Hengli Zhao, Jie Qu, Ning Mu, Xin Liu, Shi Wang, Chuanyan Yang, Hua Feng, Liang Tan, Fei L. Cattle Encephalon Glycoside and Ignotin Reduce Early Brain Injury and Cognitive Dysfunction after Subarachnoid Hemorrhage in Rats. Neuroscience. vol 388. 2019-03-29. PMID:30036663. |
this study explores a potential treatment for cognitive dysfunction following sah with the demonstration that multi-target drug cattle encephalon glycoside and ignotin (cegi) can relieve cognitive dysfunction by decreasing hippocampal neuron apoptosis following sah in rats. |
2019-03-29 |
2023-08-13 |
rat |
| Kang Ma, Rongwei Li, Hengli Zhao, Jie Qu, Ning Mu, Xin Liu, Shi Wang, Chuanyan Yang, Hua Feng, Liang Tan, Fei L. Cattle Encephalon Glycoside and Ignotin Reduce Early Brain Injury and Cognitive Dysfunction after Subarachnoid Hemorrhage in Rats. Neuroscience. vol 388. 2019-03-29. PMID:30036663. |
these results indicate that high doses of cegi can decrease hippocampal neuron apoptosis and relieve cognitive dysfunction in rats, suggesting that multitarget-drug cegi exhibits a neuroprotective effect in sah via the mitochondrial apoptosis pathway. |
2019-03-29 |
2023-08-13 |
rat |
| Jie Gao, Bingrui Xiong, Bo Zhang, Shan Li, Niannian Huang, Gaofeng Zhan, Riyue Jiang, Ling Yang, Yeshun Wu, Liying Miao, Bin Zhu, Chun Yang, Ailin Lu. Sulforaphane Alleviates Lipopolysaccharide-induced Spatial Learning and Memory Dysfunction in Mice: The Role of BDNF-mTOR Signaling Pathway. Neuroscience. vol 388. 2019-03-29. PMID:30086367. |
in addition, hippocampal levels of inflammatory cytokines, synaptic proteins, bdnf-tropomyosin receptor kinase b (trkb) and mtor signaling pathways were altered in the processes of lps-induced cognitive dysfunction and sfn's therapeutic effects. |
2019-03-29 |
2023-08-13 |
mouse |
| Jie Gao, Bingrui Xiong, Bo Zhang, Shan Li, Niannian Huang, Gaofeng Zhan, Riyue Jiang, Ling Yang, Yeshun Wu, Liying Miao, Bin Zhu, Chun Yang, Ailin Lu. Sulforaphane Alleviates Lipopolysaccharide-induced Spatial Learning and Memory Dysfunction in Mice: The Role of BDNF-mTOR Signaling Pathway. Neuroscience. vol 388. 2019-03-29. PMID:30086367. |
furthermore, we found that ana-12 (a trkb inhibitor) or rapamycin (a mtor inhibitor) could block the beneficial effects of sfn on lps-induced cognitive dysfunction, and that hippocampal levels of synaptic proteins, bdnf-trkb and mtor signaling pathways were also notably changed. |
2019-03-29 |
2023-08-13 |
mouse |
| Lan Luo, Jinyu Ma, Yue Li, Zongkang Hu, Chengfeng Jiang, Hao Cai, Cheng Su. Cystatin C Induces Insulin Resistance in Hippocampal Neurons and Promotes Cognitive Dysfunction in Rodents. Neuroscience bulletin. vol 34. issue 3. 2019-03-20. PMID:29667002. |
cystatin c induces insulin resistance in hippocampal neurons and promotes cognitive dysfunction in rodents. |
2019-03-20 |
2023-08-13 |
Not clear |
| Qi Zhang, Yanan Li, Yongjuan Bao, Chunping Yin, Xi Xin, Yangyang Guo, Fang Gao, Shuping Huo, Xiuli Wang, Qiujun Wan. Pretreatment with nimodipine reduces incidence of POCD by decreasing calcineurin mediated hippocampal neuroapoptosis in aged rats. BMC anesthesiology. vol 18. issue 1. 2019-03-08. PMID:29661144. |
pretreatment with nimodipine can lower the apoptosis rate of hippocampal neuron to reduce the incidence of postoperative cognitive dysfunction (pocd). |
2019-03-08 |
2023-08-13 |
rat |
| Weiwei Wu, Yan Wu, Gao Cheng, Chi Zhang, Hongxian Wang, Yuanhai L. A Mouse Model of Hepatic Ischemia-Reperfusion Injury Demonstrates Potentially Reversible Effects on Hippocampal Neurons and Postoperative Cognitive Function. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2019-03-04. PMID:30808858. |
conclusions a mouse model of hepatic ischemia-reperfusion injury showed transient and reversible cognitive dysfunction, changes in hippocampal neurons, and expression of inflammatory cytokines. |
2019-03-04 |
2023-08-13 |
mouse |
| Yuanyuan Liu, Mengying Wei, Kexin Yue, Mingxin Hu, Shizhe Li, Lihui Men, Zifeng Pi, Zhiqiang Liu, Zhongying Li. Study on Urine Metabolic Profile of Aβ25-35-Induced Alzheimer's Disease Using UHPLC-Q-TOF-MS. Neuroscience. vol 394. 2019-03-01. PMID:30316910. |
the results showed that compared with healthy control rats, ad rats suffered from cognitive dysfunction, hippocampus damage, aβ formation and tau phosphorylation at 8 weeks after surgery, suggesting that the aβ25-35-induced ad model was successfully established. |
2019-03-01 |
2023-08-13 |
rat |
| Yang Xing, Dan Zo. Ethanol-induced cognitive dysfunction is associated with alterations in the mammalian target of rapamycin signalling pathway in the hippocampus of male mice. Neuroreport. vol 29. issue 14. 2019-02-27. PMID:30063559. |
ethanol-induced cognitive dysfunction is associated with alterations in the mammalian target of rapamycin signalling pathway in the hippocampus of male mice. |
2019-02-27 |
2023-08-13 |
mouse |