| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Juan Zhuang, Xin Wen, Yan-Qiu Zhang, Qun Shan, Zi-Feng Zhang, Gui-Hong Zheng, Shao-Hua Fan, Meng-Qiu Li, Dong-Mei Wu, Bin Hu, Jun Lu, Yuan-Lin Zhen. TDP-43 upregulation mediated by the NLRP3 inflammasome induces cognitive impairment in 2 2',4,4'-tetrabromodiphenyl ether (BDE-47)-treated mice. Brain, behavior, and immunity. vol 65. 2018-04-10. PMID:28532818. |
hippocampus-specific tdp-43 knockdown attenuated hippocampal apoptosis, restored synaptic protein levels and thus improved cognitive dysfunction in bde-47-treated mice. |
2018-04-10 |
2023-08-13 |
mouse |
| John A Wolf, Brian N Johnson, Victoria E Johnson, Mary E Putt, Kevin D Browne, Constance J Mietus, Daniel P Brown, Kathryn L Wofford, Douglas H Smith, M Sean Grady, Akiva S Cohen, D Kacy Culle. Concussion Induces Hippocampal Circuitry Disruption in Swine. Journal of neurotrauma. vol 34. issue 14. 2018-04-05. PMID:28298170. |
hippocampal-dependent deficits in learning and memory formation are a prominent feature of traumatic brain injury (tbi); however, the role of the hippocampus in cognitive dysfunction after concussion (mild tbi) is unknown. |
2018-04-05 |
2023-08-13 |
Not clear |
| Prabha Rajput, Ashok Jangra, Mohit Kwatra, Abhishek Mishra, Mangala Lahka. Alcohol aggravates stress-induced cognitive deficits and hippocampal neurotoxicity: Protective effect of melatonin. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 91. 2018-03-26. PMID:28477462. |
oxidative stress generated by chronic immobilization and alcohol consumption cause severe neurotoxicity in the hippocampus region that ultimately leads to cognitive dysfunction. |
2018-03-26 |
2023-08-13 |
mouse |
| Ning Yang, Lunxu Li, Zhengqian Li, Cheng Ni, Yiyun Cao, Taotao Liu, Miao Tian, Dehua Chui, Xiangyang Gu. Protective effect of dapsone on cognitive impairment induced by propofol involves hippocampal autophagy. Neuroscience letters. vol 649. 2018-03-08. PMID:28411068. |
we therefore aimed to investigate the effects of dds on propofol-induced cognitive dysfunction and associated hippocampal autophagy responses. |
2018-03-08 |
2023-08-13 |
rat |
| Ning Yang, Lunxu Li, Zhengqian Li, Cheng Ni, Yiyun Cao, Taotao Liu, Miao Tian, Dehua Chui, Xiangyang Gu. Protective effect of dapsone on cognitive impairment induced by propofol involves hippocampal autophagy. Neuroscience letters. vol 649. 2018-03-08. PMID:28411068. |
our exploration is the first to establish an in vivo link between central autophagy and cognitive dysfunction in aged hippocampus after propofol anesthesia and demonstrate that the prophylactic effect of dds on the cognitive impairment induced by propofol involves autophagy. |
2018-03-08 |
2023-08-13 |
rat |
| Mingjun Bi, Qin Li, Dadong Guo, Xiaoyu Ding, Weikang Bi, Yueheng Zhang, Yong Zo. Sulphoraphane Improves Neuronal Mitochondrial Function in Brain Tissue in Acute Carbon Monoxide Poisoning Rats. Basic & clinical pharmacology & toxicology. vol 120. issue 6. 2018-03-07. PMID:27983767. |
the aim of this study was to explore the pathogenesis of the ultrastructural and functional impairment of mitochondria and the protection of sulphoraphane (sfp) at different dosages on hippocampus neurons in rats after exposure to co. we found that co poisoning could induce advanced cognitive dysfunction, while the mitochondrial ultrastructure of neurons in rats of the co poisoning group was seriously damaged and mitochondrial membrane potential (ΔΨm) was accordingly reduced by transmission electron microscopy (tem) and jc-1 fluorescent probe assay. |
2018-03-07 |
2023-08-13 |
rat |
| Madhavan Nampoothiri, Nitesh Kumar, Grandhi Venkata Ramalingayya, Nampurath Gopalan Kutty, Nandakumar Krishnadas, Chamallamudi Mallikarjuna Ra. Effect of insulin on spatial memory in aluminum chloride-induced dementia in rats. Neuroreport. vol 28. issue 9. 2018-03-05. PMID:28498150. |
thus, the present study aimed to evaluate the prophylactic role of insulin and its combination with glucose and its possible mechanism(s) in an aluminum chloride (alcl3)-induced cognitive dysfunction model in rodents, with a special focus on memory centers namely, the hippocampus and the frontal cortex. |
2018-03-05 |
2023-08-13 |
rat |
| Madhavan Nampoothiri, Nitesh Kumar, Grandhi Venkata Ramalingayya, Nampurath Gopalan Kutty, Nandakumar Krishnadas, Chamallamudi Mallikarjuna Ra. Effect of insulin on spatial memory in aluminum chloride-induced dementia in rats. Neuroreport. vol 28. issue 9. 2018-03-05. PMID:28498150. |
the study suggests the inability of prophylactic insulin administration against cognitive dysfunction induced by environmental toxin (alcl3) in the hippocampus and the frontal cortex. |
2018-03-05 |
2023-08-13 |
rat |
| Xiaoxu Sun, Shanshan Li, Lixing Xu, Hao Wang, Zhanqiang Ma, Qiang Fu, Rong Qu, Shiping M. Paeoniflorin ameliorates cognitive dysfunction via regulating SOCS2/IRS-1 pathway in diabetic rats. Physiology & behavior. vol 174. 2018-02-26. PMID:28322909. |
current evidences support that inflammatory reaction, oxidative stress, as well as abnormal insulin signaling in the hippocampus are potential causes of tau hyperphosphorylation and finally induce cognitive dysfunction. |
2018-02-26 |
2023-08-13 |
rat |
| Wei-Gang Gong, Yan-Juan Wang, Hong Zhou, Xiao-Li Li, Feng Bai, Qing-Guo Ren, Zhi-Jun Zhan. Citalopram Ameliorates Synaptic Plasticity Deficits in Different Cognition-Associated Brain Regions Induced by Social Isolation in Middle-Aged Rats. Molecular neurobiology. vol 54. issue 3. 2018-02-07. PMID:26899575. |
we found that si could cause cognitive dysfunction and decrease synaptic protein (synaptophysin or psd93) expression in different brain regions associated with cognition, such as the prefrontal cortex, dorsal hippocampus, ventral hippocampus, amygdala, and caudal putamen, but not in the entorhinal cortex or posterior cingulate. |
2018-02-07 |
2023-08-13 |
rat |
| Molly J Goodfellow, Youn Ju Shin, Derick H Lindquis. Mitigation of postnatal ethanol-induced neuroinflammation ameliorates trace fear memory deficits in juvenile rats. Behavioural brain research. vol 338. 2018-02-07. PMID:28987617. |
results suggest neuroimmune activation in response to ethanol within the neonate hippocampus contributes to later-life cognitive dysfunction. |
2018-02-07 |
2023-08-13 |
human |
| Mar Puigdellívol, Ana Saavedra, Esther Pérez-Navarr. Cognitive dysfunction in Huntington's disease: mechanisms and therapeutic strategies beyond BDNF. Brain pathology (Zurich, Switzerland). vol 26. issue 6. 2018-01-17. PMID:27529673. |
in this review, we have focused on those findings related to corticostriatal and hippocampal cognitive dysfunction in hd, as well as on the underlying molecular mechanisms, which constitute potential therapeutic targets. |
2018-01-17 |
2023-08-13 |
Not clear |
| Fatemeh S Mojabi, Atoossa Fahimi, Shahrzad Moghadam, Sarah Moghadam, M Windy McNerneny, Ravikumar Ponnusamy, Alexander Kleschevnikov, William C Mobley, Ahmad Saleh. GABAergic hyperinnervation of dentate granule cells in the Ts65Dn mouse model of down syndrome: Exploring the role of App. Hippocampus. vol 26. issue 12. 2018-01-15. PMID:27701794. |
it has been suggested that increased gabaergic innervation in the hippocampus plays a significant role in cognitive dysfunction in down syndrome (ds). |
2018-01-15 |
2023-08-13 |
mouse |
| Sita Sharan Patel, Sahil Gupta, Malairaman Udayaban. Urtica dioica modulates hippocampal insulin signaling and recognition memory deficit in streptozotocin induced diabetic mice. Metabolic brain disease. vol 31. issue 3. 2018-01-12. PMID:26767366. |
stz induced diabetic mice showed significant decrease in hippocampal insulin signaling and translocation of glucose transporter type 4 (glut4) to neuronal membrane resulting in cognitive dysfunction and hypolocomotion. |
2018-01-12 |
2023-08-13 |
mouse |
| Ershun Liang, Min Ma, Lei Wang, Xue Liu, Jinfeng Xu, Mingxiang Zhang, Ruixue Yang, Yuxia Zha. The BET/BRD inhibitor JQ1 attenuates diabetes-induced cognitive impairment in rats by targeting Nox4-Nrf2 redox imbalance. Biochemical and biophysical research communications. vol 495. issue 1. 2018-01-05. PMID:29113796. |
our results provide evidence indicating that jq1 treatment could modulate nox4-nrf2 redox imbalance in the hippocampus and may be a promising agent for diabetes-associated cognitive dysfunction. |
2018-01-05 |
2023-08-13 |
rat |
| Angélica Roque, Alejandra Ochoa-Zarzosa, Luz Torne. Maternal separation activates microglial cells and induces an inflammatory response in the hippocampus of male rat pups, independently of hypothalamic and peripheral cytokine levels. Brain, behavior, and immunity. vol 55. 2017-12-29. PMID:26431692. |
adult animals subjected to chronic stress show an inflammatory response in the hippocampus which has been related to cognitive dysfunction and psychopathology. |
2017-12-29 |
2023-08-13 |
rat |
| Tami John, Naomi Lomeli, Daniela A Bot. Systemic cisplatin exposure during infancy and adolescence causes impaired cognitive function in adulthood. Behavioural brain research. vol 319. 2017-12-21. PMID:27851909. |
further, exposure to cisplatin during adolescence affected both hippocampus and amygdala dependent cognitive function, suggesting a more global cognitive dysfunction at this age. |
2017-12-21 |
2023-08-13 |
rat |
| Zhang Qi, Yuan Tianbao, Li Yanan, Xin Xi, He Jinhua, Wang Qiuju. Pre-treatment with nimodipine and 7.5% hypertonic saline protects aged rats against postoperative cognitive dysfunction via inhibiting hippocampal neuronal apoptosis. Behavioural brain research. vol 321. 2017-11-29. PMID:28017853. |
pre-treatment with nimodipine and 7.5% hypertonic saline protects aged rats against postoperative cognitive dysfunction via inhibiting hippocampal neuronal apoptosis. |
2017-11-29 |
2023-08-13 |
rat |
| Rui Hu, Pan Wei, Lu Jin, Teng Zheng, Wen-Yu Chen, Xiao-Ya Liu, Xiao-Dong Shi, Jing-Ru Hao, Nan Sun, Can Ga. Overexpression of EphB2 in hippocampus rescues impaired NMDA receptors trafficking and cognitive dysfunction in Alzheimer model. Cell death & disease. vol 8. issue 3. 2017-11-20. PMID:28358367. |
overexpression of ephb2 in hippocampus rescues impaired nmda receptors trafficking and cognitive dysfunction in alzheimer model. |
2017-11-20 |
2023-08-13 |
mouse |
| Morten Skøtt Thomsen, Jesper Tobias Andreasen, Maria Arvaniti, Kristi Anne Kohlmeie. Nicotinic Acetylcholine Receptors in the Pathophysiology of Al zheimer's Disease: The Role of Protein-Protein Interactions in Current and Future Treatment. Current pharmaceutical design. vol 22. issue 14. 2017-11-16. PMID:26818866. |
nicotinic acetylcholine receptors (nachrs) have been pursued for decades as potential molecular targets to treat cognitive dysfunction in alzheimer's disease (ad) due to their positioning within regions of the brain critical in learning and memory, such as the prefrontal cortex and hippocampus, and their demonstrated role in processes underlying cognition such as synaptic facilitation, and theta and gamma wave activity. |
2017-11-16 |
2023-08-13 |
Not clear |