| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Li-Li Qiu, Mu-Huo Ji, Hui Zhang, Jiao-Jiao Yang, Xiao-Ru Sun, Hui Tang, Jing Wang, Wen-Xue Liu, Jian-Jun Yan. NADPH oxidase 2-derived reactive oxygen species in the hippocampus might contribute to microglial activation in postoperative cognitive dysfunction in aged mice. Brain, behavior, and immunity. vol 51. 2017-01-10. PMID:26254234. |
nadph oxidase 2-derived reactive oxygen species in the hippocampus might contribute to microglial activation in postoperative cognitive dysfunction in aged mice. |
2017-01-10 |
2023-08-13 |
mouse |
| Masaki Ueno, Yoichi Chiba, Koichi Matsumoto, Ryuta Murakami, Ryuji Fujihara, Machi Kawauchi, Hiroshi Miyanaka, Toshitaka Nakagaw. Blood-brain barrier damage in vascular dementia. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 36. issue 2. 2017-01-09. PMID:26607405. |
the bbb in the hippocampus and the olfactory bulb was mildly deteriorated in aged senescence accelerated prone mice (samp8) showing cognitive dysfunction. |
2017-01-09 |
2023-08-13 |
mouse |
| Su-Chung Youn, Li-You Chen, Ruei-Jen Chiou, Te-Jen Lai, Wen-Chieh Liao, Fu-Der Mai, Hung-Ming Chan. Comprehensive Application of Time-of-flight Secondary Ion Mass Spectrometry (TOF-SIMS) for Ionic Imaging and Bio-energetic Analysis of Club Drug-induced Cognitive Deficiency. Scientific reports. vol 5. 2016-12-13. PMID:26674573. |
excessive exposure to club drug (ghb) would cause cognitive dysfunction in which impaired hippocampal ca(2+)-mediated neuroplasticity may correlate with this deficiency. |
2016-12-13 |
2023-08-13 |
rat |
| Su-Chung Youn, Li-You Chen, Ruei-Jen Chiou, Te-Jen Lai, Wen-Chieh Liao, Fu-Der Mai, Hung-Ming Chan. Comprehensive Application of Time-of-flight Secondary Ion Mass Spectrometry (TOF-SIMS) for Ionic Imaging and Bio-energetic Analysis of Club Drug-induced Cognitive Deficiency. Scientific reports. vol 5. 2016-12-13. PMID:26674573. |
as impaired ca(2+)-mediated signaling and oxidative stress significantly contribute to ghb-induced cognitive dysfunction, delivering agent(s) that improves hippocampal bio-energetics may thus serve as a promising strategy to counteract the club drug-induced cognitive dysfunction emerging in our society nowadays. |
2016-12-13 |
2023-08-13 |
rat |
| Sumangali Kailainathan, Thomas M Piers, Jee Hyun Yi, Seongmin Choi, Mark S Fahey, Eva Borger, Frank J Gunn-Moore, Laurie O'Neill, Michael Lever, Daniel J Whitcomb, Kwangwook Cho, Shelley J Alle. Activation of a synapse weakening pathway by human Val66 but not Met66 pro-brain-derived neurotrophic factor (proBDNF). Pharmacological research. vol 104. 2016-12-13. PMID:26687096. |
healthy young carriers of the met66 form (present in ∼30% caucasians) have reduced hippocampal volume and impaired hippocampal-dependent memory function, yet the same polymorphic population shows enhanced cognitive recovery after traumatic brain injury, delayed cognitive dysfunction during aging, and lower risk of late-onset alzheimer's disease (ad) compared to those with the more common val66 polymorphism. |
2016-12-13 |
2023-08-13 |
human |
| Aditya Arya, Anamika Gangwar, Sushil Kumar Singh, Manas Roy, Mainak Das, Niroj Kumar Sethy, Kalpana Bhargav. Cerium oxide nanoparticles promote neurogenesis and abrogate hypoxia-induced memory impairment through AMPK-PKC-CBP signaling cascade. International journal of nanomedicine. vol 11. 2016-10-25. PMID:27069362. |
hypoxia-induced generation of reactive nitrogen and oxygen species reportedly affects the cortex and hippocampus regions of the brain, promoting memory impairment and cognitive dysfunction. |
2016-10-25 |
2023-08-13 |
Not clear |
| Yi He, Zhi Li, Yun-Xia Zu. Nerve Blockage Attenuates Postoperative Inflammation in Hippocampus of Young Rat Model with Surgical Trauma. Mediators of inflammation. vol 2015. 2016-09-21. PMID:26664150. |
our results indicated that nerve blockage could downregulate proinflammatory cytokines in hippocampus after humeral fixation surgery, which may ameliorate the postoperative cognitive dysfunction in young rats. |
2016-09-21 |
2023-08-13 |
rat |
| Qiong Xiang, Jie Zhang, Chun-Yan Li, Yan Wang, Mao-Jun Zeng, Zhi-Xin Cai, Rong-Bo Tian, Wei Jia, Xian-Hui L. Insulin resistance-induced hyperglycemia decreased the activation of Akt/CREB in hippocampus neurons: Molecular evidence for mechanism of diabetes-induced cognitive dysfunction. Neuropeptides. vol 54. 2016-09-13. PMID:26344332. |
insulin resistance-induced hyperglycemia decreased the activation of akt/creb in hippocampus neurons: molecular evidence for mechanism of diabetes-induced cognitive dysfunction. |
2016-09-13 |
2023-08-13 |
rat |
| Jennifer N Pearson, Shane Rowley, Li-Ping Liang, Andrew M White, Brian J Day, Manisha Pate. Reactive oxygen species mediate cognitive deficits in experimental temporal lobe epilepsy. Neurobiology of disease. vol 82. 2016-08-24. PMID:26184893. |
using a synthetic catalytic antioxidant, we show that pharmacological removal of reactive oxygen species (ros) prevents 1) oxidative stress, 2) deficits in mitochondrial oxygen consumption rates, 3) hippocampal neuronal loss and 4) cognitive dysfunction without altering the intensity of the initial status epilepticus (se) or epilepsy development in a rat model of se-induced tle. |
2016-08-24 |
2023-08-13 |
rat |
| M Dolores Muñoz, Mónica Antolín-Vallespín, Silvia Tapia-González, Amelia Sánchez-Capel. Smad3 deficiency inhibits dentate gyrus LTP by enhancing GABAA neurotransmission. Journal of neurochemistry. vol 137. issue 2. 2016-08-22. PMID:26826552. |
alteration of gaba neurotransmission is thought to produce hippocampal cognitive dysfunction in down's syndrome or alzheimer's disease, and here we provide new insights into the hippocampal changes in an animal model of parkinson's disease. |
2016-08-22 |
2023-08-13 |
mouse |
| Aaron Kandola, Joshua Hendrikse, Paul J Lucassen, Murat Yüce. Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment. Frontiers in human neuroscience. vol 10. 2016-08-15. PMID:27524962. |
notably, many psychiatric and neurological disorders have been associated with hippocampal dysfunction, which may underlie the expression of certain symptoms common to these disorders, including (aspects of) cognitive dysfunction. |
2016-08-15 |
2023-08-13 |
human |
| Paula L Vieira-Brock, Lisa M McFadden, Shannon M Nielsen, Misty D Smith, Glen R Hanson, Annette E Fleckenstei. Nicotine Administration Attenuates Methamphetamine-Induced Novel Object Recognition Deficits. The international journal of neuropsychopharmacology. vol 18. issue 12. 2016-08-10. PMID:26164716. |
furthermore, extensive evidence indicates that nicotine prevents and/or improves memory deficits in different models of cognitive dysfunction and these nicotinic effects might be mediated by hippocampal or cortical nicotinic acetylcholine receptors. |
2016-08-10 |
2023-08-13 |
rat |
| Sakiko Taniguchi, Hisato Mizuno, Masayoshi Kuwahara, Koichi It. Early attenuation of long-term potentiation in senescence-accelerated mouse prone 8. Experimental brain research. vol 233. issue 11. 2016-08-04. PMID:26195169. |
our study is the first report on quantitative analysis of synaptic function at samp8 hippocampus and corroborates the behavioral studies showing cognitive dysfunction with age; therefore, it will be helpful for future studies on aging. |
2016-08-04 |
2023-08-13 |
mouse |
| L Fei, H Yong-Jun, M Zhang-Min, X Bing, W Shuang, S Qian-qian, L Ju. Rosiglitazone Attenuates Memory Impairment in Aged Rat with Diabetes by Inhibiting NF-kappa B Signal Pathway Activation. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. vol 123. issue 9. 2016-08-01. PMID:26285068. |
compared with the diabetic group, level of serum crp, inflammatory cytokines and over-activation of nf-κb signalling pathway in the hippocampus were restored partially concomitant with attenuation of cognitive dysfunction indicated as markedly decreased escape latency and distance during mwm test in the rosiglitazone treatment group. |
2016-08-01 |
2023-08-13 |
rat |
| Natalie Matosin, Francesca Fernandez-Enright, Jeremy S Lum, Martin Engel, Jessica L Andrews, Nils C Gassen, Klaus V Wagner, Mathias V Schmidt, Kelly A Newel. Molecular evidence of synaptic pathology in the CA1 region in schizophrenia. NPJ schizophrenia. vol 2. 2016-07-19. PMID:27430010. |
these findings support the presence of extensive molecular abnormalities to psd95 and several of its associated proteins in the ca1 region in schizophrenia, offering a small but significant step toward understanding how proteins in the psd are altered in the schizophrenia brain, and their relevance to overall hippocampal and cognitive dysfunction in the illness. |
2016-07-19 |
2023-08-13 |
human |
| Keita Sasaki, Olaposi Idowu Omotuyi, Mutsumi Ueda, Kazuyuki Shinohara, Hiroshi Ued. NMDA receptor agonists reverse impaired psychomotor and cognitive functions associated with hippocampal Hbegf-deficiency in mice. Molecular brain. vol 8. issue 1. 2016-07-06. PMID:26637193. |
structural and functional changes of the hippocampus are correlated with psychiatric disorders and cognitive dysfunctions. |
2016-07-06 |
2023-08-13 |
mouse |
| Keita Sasaki, Olaposi Idowu Omotuyi, Mutsumi Ueda, Kazuyuki Shinohara, Hiroshi Ued. NMDA receptor agonists reverse impaired psychomotor and cognitive functions associated with hippocampal Hbegf-deficiency in mice. Molecular brain. vol 8. issue 1. 2016-07-06. PMID:26637193. |
genetic deletion of heparin-binding epidermal growth factor-like growth factor (hb-egf), which is predominantly expressed in cortex and hippocampus, also causes similar psychiatric and cognitive dysfunctions, accompanying down-regulated nmda receptor signaling. |
2016-07-06 |
2023-08-13 |
mouse |
| Kaliris Y Salas-Ramirez, Ciara Bagnall, Leslie Frias, Syed A Abdali, Tim A Ahles, Karen Hubbar. Doxorubicin and cyclophosphamide induce cognitive dysfunction and activate the ERK and AKT signaling pathways. Behavioural brain research. vol 292. 2016-06-14. PMID:26099816. |
therefore, as a first step to identity the potential signaling pathways involved in this cognitive dysfunction, the protein levels of extracellular signal-regulated kinase 1/2 (erk1/2), akt (neuroprotectant) bdnf and (structural protein) psd95 in hippocampal lysates were measured. |
2016-06-14 |
2023-08-13 |
human |
| Eun-Jeong Yang, Sangzin Ahn, Junghwa Ryu, Moon-Seok Choi, Shinkyu Choi, Young Hae Chong, Jin-Won Hyun, Moon-Jeong Chang, Hye-Sun Ki. Phloroglucinol Attenuates the Cognitive Deficits of the 5XFAD Mouse Model of Alzheimer's Disease. PloS one. vol 10. issue 8. 2016-05-13. PMID:26284625. |
we also found that the administration of phloroglucinol to the hippocampal region attenuated the impairments in cognitive dysfunction observed in 22-week-old 5xfad (tg6799) mice, which are used as an ad animal model. |
2016-05-13 |
2023-08-13 |
mouse |
| Bombi Lee, Bongjun Sur, Seong-Guk Cho, Mijung Yeom, Insop Shim, Hyejung Lee, Dae-Hyun Hah. Wogonin Attenuates Hippocampal Neuronal Loss and Cognitive Dysfunction in Trimethyltin-Intoxicated Rats. Biomolecules & therapeutics. vol 24. issue 3. 2016-05-02. PMID:27133262. |
wogonin attenuates hippocampal neuronal loss and cognitive dysfunction in trimethyltin-intoxicated rats. |
2016-05-02 |
2023-08-13 |
rat |