| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jie Li, Songyun Zhang, Lihui Zhang, Ruiying Wang, Mian Wan. Effects of L-3-n-butylphthalide on cognitive dysfunction and NR2B expression in hippocampus of streptozotocin (STZ)-induced diabetic rats. Cell biochemistry and biophysics. vol 71. issue 1. 2016-04-25. PMID:25149651. |
effects of l-3-n-butylphthalide on cognitive dysfunction and nr2b expression in hippocampus of streptozotocin (stz)-induced diabetic rats. |
2016-04-25 |
2023-08-13 |
rat |
| Huanhuan Han, Qingqing Qian, Yan Yu, Daiwei Zhao, Guangchun Su. Lamotrigine attenuates cerebral ischemia-induced cognitive impairment and decreases β-amyloid and phosphorylated tau in the hippocampus in rats. Neuroreport. vol 26. issue 12. 2016-04-20. PMID:26164461. |
this study was carried out to examine the effects of ltg on cognitive dysfunction, β-amyloid1-42 accumulation, and tau protein hyperphosphorylation in the hippocampus of ischemic rats. |
2016-04-20 |
2023-08-13 |
rat |
| Johana A Gutiérrez-Vargas, Alejandro Múnera, Gloria P Cardona-Góme. CDK5 knockdown prevents hippocampal degeneration and cognitive dysfunction produced by cerebral ischemia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 35. issue 12. 2016-04-11. PMID:26104286. |
cdk5 knockdown prevents hippocampal degeneration and cognitive dysfunction produced by cerebral ischemia. |
2016-04-11 |
2023-08-13 |
rat |
| Tian Yue, Guo Shanbin, Ma Ling, Wang Yuan, Xu Ying, Zhao Pin. Sevoflurane aggregates cognitive dysfunction and hippocampal oxidative stress induced by β-amyloid in rats. Life sciences. vol 143. 2016-04-08. PMID:26551432. |
sevoflurane aggregates cognitive dysfunction and hippocampal oxidative stress induced by β-amyloid in rats. |
2016-04-08 |
2023-08-13 |
rat |
| Mayako Yamazaki, Mayuko Okabe, Noriyuki Yamamoto, Junko Yarimizu, Katsuya Harad. Novel 5-HT5A receptor antagonists ameliorate scopolamine-induced working memory deficit in mice and reference memory impairment in aged rats. Journal of pharmacological sciences. vol 127. issue 3. 2016-04-05. PMID:25837935. |
given that areas of the brain with high levels of 5-ht5a receptor expression, such as the hippocampus and cerebral cortex, have important functions in cognition and memory, we evaluated the chemically diverse, potent and brain-penetrating 5-ht5a receptor antagonists asp5736, as2030680, and as2674723 in rodent models of cognitive dysfunction associated with dementia. |
2016-04-05 |
2023-08-13 |
mouse |
| Yu He, Feng Wang, Shiqiang Chen, Mi Liu, Wei Pan, Xing L. The Protective Effect of Radix Polygoni Multiflori on Diabetic Encephalopathy via Regulating Myosin Light Chain Kinase Expression. Journal of diabetes research. vol 2015. 2016-03-29. PMID:26199947. |
the results showed that 8 weeks of radix polygoni multiflori treatment could improve the cognitive dysfunction of diabetic rats (p < 0.01), recover the ultrastructure of hippocampal neurons, and increase the number of synapses in a dose-dependent manner. |
2016-03-29 |
2023-08-13 |
rat |
| Somayeh Zargooshnia, Siamak Shahidi, Fatemeh Ghahremanitamadon, Ali Nikkhah, Mehdi Mehdizadeh, Sara Soleimani As. The protective effect of Borago Officinalis extract on amyloid β (25-35)-induced long term potentiation disruption in the dentate gyrus of male rats. Metabolic brain disease. vol 30. issue 1. 2016-03-17. PMID:25060965. |
this data suggest that aβ (25-35) can effectively inhibit ltp in the granular cells of the dg in hippocampus, and borage supplementation reverse the synaptic plasticity in dg following aβ treatment and that borage consumption may lead to an improvement of ad-induced cognitive dysfunction. |
2016-03-17 |
2023-08-13 |
rat |
| Shashi Kant Tiwari, Swati Agarwal, Lalit Kumar Singh Chauhan, Vijay Nath Mishra, Rajnish Kumar Chaturved. Bisphenol-A impairs myelination potential during development in the hippocampus of the rat brain. Molecular neurobiology. vol 51. issue 3. 2016-03-10. PMID:25084756. |
exposure to synthetic xenoestrogen bisphenol-a (bpa) causes cognitive dysfunction, impairs hippocampal neurogenesis, and causes onset of neurodevelopmental disorders. |
2016-03-10 |
2023-08-13 |
rat |
| Yang Li, Saiying Wang, Ke Ran, Zhonghua Hu, Zhaoqian Liu, Kaiming Dua. Differential hippocampal protein expression between normal aged rats and aged rats with postoperative cognitive dysfunction: A proteomic analysis. Molecular medicine reports. vol 12. issue 2. 2016-03-10. PMID:25936412. |
differential hippocampal protein expression between normal aged rats and aged rats with postoperative cognitive dysfunction: a proteomic analysis. |
2016-03-10 |
2023-08-13 |
rat |
| Yang Li, Saiying Wang, Ke Ran, Zhonghua Hu, Zhaoqian Liu, Kaiming Dua. Differential hippocampal protein expression between normal aged rats and aged rats with postoperative cognitive dysfunction: A proteomic analysis. Molecular medicine reports. vol 12. issue 2. 2016-03-10. PMID:25936412. |
the aim of the present study was to investigate the differences in the expression of hippocampal proteins between normal control aged rats and aged rats with postoperative cognitive dysfunction (pocd). |
2016-03-10 |
2023-08-13 |
rat |
| Albert Giralt, Ana Saavedra, Jordi Alberch, Esther Pérez-Navarr. Cognitive Dysfunction in Huntington's Disease: Humans, Mouse Models and Molecular Mechanisms. Journal of Huntington's disease. vol 1. issue 2. 2016-02-23. PMID:25063329. |
alterations in hippocampal synaptic plasticity and function found in hd mouse models highlight that changes in the functioning of the hippocampal formation contribute to cognitive dysfunction in humans. |
2016-02-23 |
2023-08-13 |
mouse |
| Flavie Darcet, Alain M Gardier, Raphael Gaillard, Denis J David, Jean-Philippe Guillou. Cognitive Dysfunction in Major Depressive Disorder. A Translational Review in Animal Models of the Disease. Pharmaceuticals (Basel, Switzerland). vol 9. issue 1. 2016-02-23. PMID:26901205. |
finally, the role of adult hippocampal neurogenesis in rodents in cognitive dysfunctions during mdd state was also discussed. |
2016-02-23 |
2023-08-13 |
Not clear |
| Prajapati Kasbe, Ashok Jangra, Mangala Lahka. Mangiferin ameliorates aluminium chloride-induced cognitive dysfunction via alleviation of hippocampal oxido-nitrosative stress, proinflammatory cytokines and acetylcholinesterase level. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). vol 31. 2016-02-22. PMID:26004900. |
mangiferin ameliorates aluminium chloride-induced cognitive dysfunction via alleviation of hippocampal oxido-nitrosative stress, proinflammatory cytokines and acetylcholinesterase level. |
2016-02-22 |
2023-08-13 |
mouse |
| Geert Jan Biessels, Lawrence P Reaga. Hippocampal insulin resistance and cognitive dysfunction. Nature reviews. Neuroscience. vol 16. issue 11. 2016-02-10. PMID:26462756. |
hippocampal insulin resistance and cognitive dysfunction. |
2016-02-10 |
2023-08-13 |
Not clear |
| Geert Jan Biessels, Lawrence P Reaga. Hippocampal insulin resistance and cognitive dysfunction. Nature reviews. Neuroscience. vol 16. issue 11. 2016-02-10. PMID:26462756. |
animal models of ir help to bridge these gaps and point to hippocampal ir as a potential mediator of cognitive dysfunction in t2dm, as well as in alzheimer disease (ad). |
2016-02-10 |
2023-08-13 |
Not clear |
| Xing-Wen Fan, Fu Chen, Yan Chen, Guan-Hao Chen, Huan-Huan Liu, Shi-Kuo Guan, Yun Deng, Yong Liu, Sheng-Jian Zhang, Wei-Jun Peng, Guo-Liang Jiang, Kai-Liang W. Electroacupuncture prevents cognitive impairments by regulating the early changes after brain irradiation in rats. PloS one. vol 10. issue 4. 2016-02-01. PMID:25830357. |
at the cellular/molecular level, the preventative effect of ea on cognitive dysfunction was not dependent on hippocampal neurogenesis; rather, it was related to synaptophysin expression. |
2016-02-01 |
2023-08-13 |
rat |
| Shun-Mei Lu, Bo Gui, Hong-Quan Dong, Xiang Zhang, Su-Su Zhang, Liu-Qing Hu, Hai-Ling Liu, Jie Sun, Yian-Ning Qia. Prophylactic lithium alleviates splenectomy-induced cognitive dysfunction possibly by inhibiting hippocampal TLR4 activation in aged rats. Brain research bulletin. vol 114. 2016-01-26. PMID:25839444. |
prophylactic lithium alleviates splenectomy-induced cognitive dysfunction possibly by inhibiting hippocampal tlr4 activation in aged rats. |
2016-01-26 |
2023-08-13 |
rat |
| Miranda C Staples, Airee Kim, Chitra D Mandya. Dendritic remodeling of hippocampal neurons is associated with altered NMDA receptor expression in alcohol dependent rats. Molecular and cellular neurosciences. vol 65. 2016-01-11. PMID:25769285. |
overall, these data provide the evidence that cie produces profound changes in hippocampal structural plasticity and in molecular tools that maintain hippocampal structural plasticity, and these alterations may underlie cognitive dysfunction associated with alcohol dependence. |
2016-01-11 |
2023-08-13 |
rat |
| Shiraz Tyebji, Ana Saavedra, Paula M Canas, Anna Pliassova, José M Delgado-García, Jordi Alberch, Rodrigo A Cunha, Agnès Gruart, Esther Pérez-Navarr. Hyperactivation of D1 and A2A receptors contributes to cognitive dysfunction in Huntington's disease. Neurobiology of disease. vol 74. 2016-01-06. PMID:25449908. |
in line with these findings, chronic (but not acute) combined treatment with d1r plus a2ar antagonists (sch23390 and sch58261, respectively) normalizes pka activity in the hippocampus, facilitates long-term potentiation in behaving r6/1 mice, and ameliorates cognitive dysfunction. |
2016-01-06 |
2023-08-13 |
mouse |
| Munjal M Acharya, Susanna Rosi, Timothy Jopson, Charles L Limol. Human neural stem cell transplantation provides long-term restoration of neuronal plasticity in the irradiated hippocampus. Cell transplantation. vol 24. issue 4. 2015-12-31. PMID:25289634. |
to explore the possible mechanisms underlying the capability of engrafted cells to ameliorate radiation-induced cognitive dysfunction we analyzed the expression patterns of the behaviorally induced activity-regulated cytoskeleton-associated protein (arc) in the hippocampus at 1 and 8 months postgrafting. |
2015-12-31 |
2023-08-13 |
human |