| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fatemeh Ghahremanitamadon, Siamak Shahidi, Somayeh Zargooshnia, Ali Nikkhah, Akram Ranjbar, Sara Soleimani As. Protective effects of Borago officinalis extract on amyloid β-peptide(25-35)-induced memory impairment in male rats: a behavioral study. BioMed research international. vol 2014. 2015-03-30. PMID:25013802. |
this data suggests that borage could improve the learning impairment and oxidative damage in the hippocampal tissue following a β treatment and that borage consumption may lead to an improvement of ad-induced cognitive dysfunction. |
2015-03-30 |
2023-08-13 |
rat |
| Hiroaki Sacai, Sachie Sasaki-Hamada, Azusa Sugiyama, Akiyoshi Saitoh, Kazuhiro Mori, Mitsuhiko Yamada, Jun-Ichiro Ok. The impairment in spatial learning and hippocampal LTD induced through the PKA pathway in juvenile-onset diabetes rats are rescued by modulating NMDA receptor function. Neuroscience research. vol 81-82. 2015-02-21. PMID:24552988. |
although an earlier onset age of diabetes has been identified as one of the strongest risk factors associated with cognitive dysfunction, little is known about the effects of cognitive performance associated with hippocampal function. |
2015-02-21 |
2023-08-12 |
rat |
| R C Bates, B J Stith, K E Stevens, C E Adam. Reduced CHRNA7 expression in C3H mice is associated with increases in hippocampal parvalbumin and glutamate decarboxylase-67 (GAD67) as well as altered levels of GABA(A) receptor subunits. Neuroscience. vol 273. 2015-02-09. PMID:24836856. |
decreased expression of chrna7, the gene encoding the α7(∗) subtype of nicotinic receptor, may contribute to the cognitive dysfunction observed in schizophrenia by disrupting the inhibitory/excitatory balance in the hippocampus. |
2015-02-09 |
2023-08-13 |
mouse |
| Tarick Megahed, Bharathi Hattiangady, Bing Shuai, Ashok K Shett. Parvalbumin and neuropeptide Y expressing hippocampal GABA-ergic inhibitory interneuron numbers decline in a model of Gulf War illness. Frontiers in cellular neuroscience. vol 8. 2015-01-26. PMID:25620912. |
because pv+ and npy+ interneurons play roles in maintaining normal cognitive function and neurogenesis, and controlling the activity of excitatory neurons in the hippocampus, reduced numbers of these interneurons may be one of the major causes of cognitive dysfunction and reduced neurogenesis observed in gwi. |
2015-01-26 |
2023-08-13 |
rat |
| Tarick Megahed, Bharathi Hattiangady, Bing Shuai, Ashok K Shett. Parvalbumin and neuropeptide Y expressing hippocampal GABA-ergic inhibitory interneuron numbers decline in a model of Gulf War illness. Frontiers in cellular neuroscience. vol 8. 2015-01-26. PMID:25620912. |
hence, strategies that improve inhibitory neurotransmission in the hippocampus may prove beneficial for reversing cognitive dysfunction in gwi. |
2015-01-26 |
2023-08-13 |
rat |
| Ming-Jang Chiu, Ya-Fang Chen, Ta-Fu Chen, Shieh-Yueh Yang, Fan-Pei Gloria Yang, Tien-Wen Tseng, Jen-Jie Chieh, Jia-Chun Rare Chen, Kai-Yuan Tzen, Mau-Sun Hua, Herng-Er Horn. Plasma tau as a window to the brain-negative associations with brain volume and memory function in mild cognitive impairment and early Alzheimer's disease. Human brain mapping. vol 35. issue 7. 2015-01-22. PMID:24129926. |
neurofibrillary tangles are associated with cognitive dysfunction, and hippocampal atrophy with increased csf tau markers. |
2015-01-22 |
2023-08-12 |
Not clear |
| Shanli Yang, Cai Jiang, Haicheng Ye, Jing Tao, Jia Huang, Yanling Gao, Zhicheng Lin, Lidian Che. Effect of integrated cognitive therapy on hippocampal functional connectivity patterns in stroke patients with cognitive dysfunction: a resting-state FMRI study. Evidence-based complementary and alternative medicine : eCAM. vol 2014. 2014-12-30. PMID:25548595. |
effect of integrated cognitive therapy on hippocampal functional connectivity patterns in stroke patients with cognitive dysfunction: a resting-state fmri study. |
2014-12-30 |
2023-08-13 |
human |
| Kristopher D Langdon, Shirley Granter-Button, Carolyn W Harley, Frances Moody-Corbett, James Peeling, Dale Corbet. A cognitive rehabilitation paradigm effective in male rats lacks efficacy in female rats. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 34. issue 10. 2014-11-24. PMID:25052554. |
in experiment 1, we confirmed hypoperfusion-induced cognitive dysfunction using a 2 × 2 (surgery × diet) experimental design, without alterations in hippocampal architecture. |
2014-11-24 |
2023-08-13 |
rat |
| Fengying Yang, Xiaolei Chu, Miaomiao Yin, Xiaolei Liu, Hairui Yuan, Yanmei Niu, Li F. mTOR and autophagy in normal brain aging and caloric restriction ameliorating age-related cognition deficits. Behavioural brain research. vol 264. 2014-11-05. PMID:24525424. |
here we showed a decline of autophagic degradation in mice hippocampus in correlation with age-dependent cognitive dysfunction, whereas the activity of mtor and its upstream brain-derived neurotrophic factor (bdnf)/phosphatidylinositide 3-kinase (pi3k)/protein kinase b (akt) signaling was decreased with aging. |
2014-11-05 |
2023-08-12 |
mouse |
| Zhiyan Lu, Jinwei Wu, Guangyuan Cheng, Jianying Tian, Zeqing Lu, Yongyi B. Methylmercury chloride damage to the adult rat hippocampus cannot be detected by proton magnetic resonance spectroscopy. Neural regeneration research. vol 9. issue 17. 2014-11-04. PMID:25368649. |
previous studies have found that methylmercury can damage hippocampal neurons and accordingly cause cognitive dysfunction. |
2014-11-04 |
2023-08-13 |
rat |
| Sadia Saleem, Saiqa Tabassum, Sana Ahmed, Tahira Perveen, Saida Haide. Senescence related alteration in hippocampal biogenic amines produces neuropsychological deficits in rats. Pakistan journal of pharmaceutical sciences. vol 27. issue 4. 2014-09-18. PMID:25015449. |
the major goal of the present study was to investigate the age associated cognitive dysfunction and other behavioral changes and their association with age related alterations in levels of neurotransmitters, such as dopamine (da) and serotonin (5-ht) in the hippocampal region. |
2014-09-18 |
2023-08-13 |
rat |
| Yuki Kuwabara, Masato Ishizeki, Naoto Watamura, Junya Toba, Aya Yoshii, Takafumi Inoue, Toshio Ohshim. Impairments of long-term depression induction and motor coordination precede Aβ accumulation in the cerebellum of APPswe/PS1dE9 double transgenic mice. Journal of neurochemistry. vol 130. issue 3. 2014-09-16. PMID:24684630. |
amyloid beta (aβ) peptides in extracellular aβ plaques, produced from the amyloid precursor protein (app) via sequential processing by β- and γ-secretases, impair hippocampal synaptic plasticity, and cause cognitive dysfunction in ad patients. |
2014-09-16 |
2023-08-12 |
mouse |
| Changsheng Li, Sufang Liu, Ying Xing, Feng Ta. The role of hippocampal tau protein phosphorylation in isoflurane-induced cognitive dysfunction in transgenic APP695 mice. Anesthesia and analgesia. vol 119. issue 2. 2014-09-11. PMID:24977637. |
the role of hippocampal tau protein phosphorylation in isoflurane-induced cognitive dysfunction in transgenic app695 mice. |
2014-09-11 |
2023-08-13 |
mouse |
| Changsheng Li, Sufang Liu, Ying Xing, Feng Ta. The role of hippocampal tau protein phosphorylation in isoflurane-induced cognitive dysfunction in transgenic APP695 mice. Anesthesia and analgesia. vol 119. issue 2. 2014-09-11. PMID:24977637. |
in the present study, we tested our hypothesis that enhanced tau protein phosphorylation in hippocampus contributes to isoflurane-induced cognitive dysfunction in a mouse model of alzheimer disease. |
2014-09-11 |
2023-08-13 |
mouse |
| Rong Hu, Dong Huang, Jianbin Tong, Qin Liao, Zhonghua Hu, Wen Ouyan. Aspartic acid in the hippocampus: a biomarker for postoperative cognitive dysfunction. Neural regeneration research. vol 9. issue 2. 2014-09-10. PMID:25206795. |
aspartic acid in the hippocampus: a biomarker for postoperative cognitive dysfunction. |
2014-09-10 |
2023-08-13 |
rat |
| Rong Hu, Dong Huang, Jianbin Tong, Qin Liao, Zhonghua Hu, Wen Ouyan. Aspartic acid in the hippocampus: a biomarker for postoperative cognitive dysfunction. Neural regeneration research. vol 9. issue 2. 2014-09-10. PMID:25206795. |
it is evident that hippocampal metabolite changes are involved in the formation of cognitive dysfunction after isoflurane anesthesia. |
2014-09-10 |
2023-08-13 |
rat |
| Rong Hu, Dong Huang, Jianbin Tong, Qin Liao, Zhonghua Hu, Wen Ouyan. Aspartic acid in the hippocampus: a biomarker for postoperative cognitive dysfunction. Neural regeneration research. vol 9. issue 2. 2014-09-10. PMID:25206795. |
results suggested that aspartic acid concentration in the hippocampus may be a biomarker for predicting the occurrence and disease progress of cognitive dysfunction. |
2014-09-10 |
2023-08-13 |
rat |
| Shuhai Lin, Basem Kanawati, Liangfeng Liu, Michael Witting, Min Li, Jiandong Huang, Philippe Schmitt-Kopplin, Zongwei Ca. Ultrahigh resolution mass spectrometry-based metabolic characterization reveals cerebellum as a disturbed region in two animal models. Talanta. vol 118. 2014-08-28. PMID:24274269. |
in the previous reports about cognitive dysfunction, cerebellum was thought to be a less affected tissue by genetic or environmental alterations in comparison to other tissues in the brain including hippocampus under the same conditions. |
2014-08-28 |
2023-08-12 |
mouse |
| Li Tian, Huang Nie, Yang Zhang, Yu Chen, Zhengwu Peng, Min Cai, Haidong Wei, Pei Qin, Hailong Dong, Lize Xion. Recombinant human thioredoxin-1 promotes neurogenesis and facilitates cognitive recovery following cerebral ischemia in mice. Neuropharmacology. vol 77. 2014-08-26. PMID:24212059. |
cerebral ischemia (ci) can induce loss of hippocampal neurons, causing cognitive dysfunction such as learning and memory deficits. |
2014-08-26 |
2023-08-12 |
mouse |
| Li Tian, Huang Nie, Yang Zhang, Yu Chen, Zhengwu Peng, Min Cai, Haidong Wei, Pei Qin, Hailong Dong, Lize Xion. Recombinant human thioredoxin-1 promotes neurogenesis and facilitates cognitive recovery following cerebral ischemia in mice. Neuropharmacology. vol 77. 2014-08-26. PMID:24212059. |
in adult mammals, the hippocampal dentate gyrus contains neural stem cells (nscs) that continuously generate newborn neurons and integrate into the pre-existing networks throughout life, which may ameliorate cognitive dysfunction following ci. |
2014-08-26 |
2023-08-12 |
mouse |