| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nidhi K Bhatia, Priya Modi, Shilpa Sharma, Shashank Dee. Quercetin and Baicalein Act as Potent Antiamyloidogenic and Fibril Destabilizing Agents for SOD1 Fibrils. ACS chemical neuroscience. vol 11. issue 8. 2021-04-14. PMID:32208672. |
amyotrophic lateral sclerosis (als) is a fatal neurodegenerative disease that has been associated with the deposition of aggregates of superoxide dismutase 1 (sod1). |
2021-04-14 |
2023-08-13 |
Not clear |
| Audrey Dangoumau, Sylviane Marouillat, Roxane Coelho, François Wurmser, Céline Brulard, Shanez Haouari, Frédéric Laumonnier, Philippe Corcia, Christian R Andres, Hélène Blasco, Patrick Vourc'. Dysregulations of Expression of Genes of the Ubiquitin/SUMO Pathways in an In Vitro Model of Amyotrophic Lateral Sclerosis Combining Oxidative Stress and SOD1 Gene Mutation. International journal of molecular sciences. vol 22. issue 4. 2021-04-14. PMID:33670299. |
dysregulations of expression of genes of the ubiquitin/sumo pathways in an in vitro model of amyotrophic lateral sclerosis combining oxidative stress and sod1 gene mutation. |
2021-04-14 |
2023-08-13 |
Not clear |
| Colin K W Lim, Michael Gapinske, Alexandra K Brooks, Wendy S Woods, Jackson E Powell, M Alejandra Zeballos C, Jackson Winter, Pablo Perez-Pinera, Thomas Ga. Treatment of a Mouse Model of ALS by In Vivo Base Editing. Molecular therapy : the journal of the American Society of Gene Therapy. vol 28. issue 4. 2021-04-06. PMID:31991108. |
amyotrophic lateral sclerosis (als) is a debilitating and fatal disorder that can be caused by mutations in the superoxide dismutase 1 (sod1) gene. |
2021-04-06 |
2023-08-13 |
mouse |
| Xinxin Zuo, Jie Zhou, Yinming Li, Kai Wu, Zonggui Chen, Zhiwei Luo, Xiaorong Zhang, Yi Liang, Miguel A Esteban, Yu Zhou, Xiang-Dong F. TDP-43 aggregation induced by oxidative stress causes global mitochondrial imbalance in ALS. Nature structural & molecular biology. vol 28. issue 2. 2021-03-31. PMID:33398173. |
amyotrophic lateral sclerosis (als) was initially thought to be associated with oxidative stress when it was first linked to mutant superoxide dismutase 1 (sod1). |
2021-03-31 |
2023-08-13 |
mouse |
| Veronica Granatiero, Nicole M Sayles, Angela M Savino, Csaba Konrad, Michael G Kharas, Hibiki Kawamata, Giovanni Manfred. Modulation of the IGF1R-MTOR pathway attenuates motor neuron toxicity of human ALS SOD1 Autophagy. 2021-03-27. PMID:33749521. |
modulation of the igf1r-mtor pathway attenuates motor neuron toxicity of human als sod1 als (amyotrophic lateral sclerosis), the most common motor neuron disease, causes muscle denervation and rapidly fatal paralysis. |
2021-03-27 |
2023-08-13 |
human |
| Michela Dell'Orco, Valentina Sardone, Amy S Gardiner, Orietta Pansarasa, Matteo Bordoni, Nora I Perrone-Bizzozero, Cristina Cered. HuD regulates SOD1 expression during oxidative stress in differentiated neuroblastoma cells and sporadic ALS motor cortex. Neurobiology of disease. vol 148. 2021-03-23. PMID:33271327. |
using differentiated sh-sy5y cells along with brain tissues from sporadic amyotrophic lateral sclerosis (sals) patients, we assessed hud-dependent regulation of sod1 mrna. |
2021-03-23 |
2023-08-13 |
human |
| Samantha K Barton, Chew L Lau, Mathew D F Chiam, Doris Tomas, Hakan Muyderman, Philip M Beart, Bradley J Turne. Mutant TDP-43 Expression Triggers TDP-43 Pathology and Cell Autonomous Effects on Primary Astrocytes: Implications for Non-cell Autonomous Pathology in ALS. Neurochemical research. vol 45. issue 6. 2021-03-22. PMID:32410044. |
motor neuron degeneration in amyotrophic lateral sclerosis (als) caused by mutations in superoxide dismutase 1 (sod1) is partly non-cell autonomous, involving cellular dysfunction of astrocytes. |
2021-03-22 |
2023-08-13 |
Not clear |
| Ben Niu, Brian C Mackness, Jill A Zitzewitz, C Robert Matthews, Michael L Gros. Trifluoroethanol Partially Unfolds G93A SOD1 Leading to Protein Aggregation: A Study by Native Mass Spectrometry and FPOP Protein Footprinting. Biochemistry. vol 59. issue 39. 2021-03-17. PMID:32924445. |
misfolding of cu, zn superoxide dismutase (sod1) variants may lead to protein aggregation and ultimately amyotrophic lateral sclerosis (als). |
2021-03-17 |
2023-08-13 |
Not clear |
| Claire Guissart, Kevin Mouzat, Jovana Kantar, Baptiste Louveau, Paul Vilquin, Anne Polge, Cédric Raoul, Serge Lumbros. Premature termination codons in SOD1 causing Amyotrophic Lateral Sclerosis are predicted to escape the nonsense-mediated mRNA decay. Scientific reports. vol 10. issue 1. 2021-03-15. PMID:33244158. |
premature termination codons in sod1 causing amyotrophic lateral sclerosis are predicted to escape the nonsense-mediated mrna decay. |
2021-03-15 |
2023-08-13 |
Not clear |
| Anna Martínez-Muriana, Diego Pastor, Renzo Mancuso, Amaya Rando, Rosario Osta, Salvador Martínez, Rubèn López-Vales, Xavier Navarr. Combined intramuscular and intraspinal transplant of bone marrow cells improves neuromuscular function in the SOD1 Stem cell research & therapy. vol 11. issue 1. 2021-03-11. PMID:32033585. |
combined intramuscular and intraspinal transplant of bone marrow cells improves neuromuscular function in the sod1 the simultaneous contribution of several etiopathogenic disturbances makes amyotrophic lateral sclerosis (als) a fatal and challenging disease. |
2021-03-11 |
2023-08-13 |
Not clear |
| Elena Abati, Nereo Bresolin, Giacomo Comi, Stefania Cort. Silence superoxide dismutase 1 (SOD1): a promising therapeutic target for amyotrophic lateral sclerosis (ALS). Expert opinion on therapeutic targets. vol 24. issue 4. 2021-03-10. PMID:32125907. |
silence superoxide dismutase 1 (sod1): a promising therapeutic target for amyotrophic lateral sclerosis (als). |
2021-03-10 |
2023-08-13 |
Not clear |
| Jelena Cveticanin, Tridib Mondal, Elizabeth M Meiering, Michal Sharon, Amnon Horovit. Insight into the Autosomal-Dominant Inheritance Pattern of SOD1-Associated ALS from Native Mass Spectrometry. Journal of molecular biology. vol 432. issue 23. 2021-03-05. PMID:33058881. |
about 20% of all familial amyotrophic lateral sclerosis (als) cases are associated with mutations in superoxide dismutase (sod1), a homodimeric protein. |
2021-03-05 |
2023-08-13 |
Not clear |
| Efrat Shavit-Stein, Ihab Abu Rahal, Doron Bushi, Orna Gera, Roni Sharon, Shany G Gofrit, Lea Pollak, Kate Mindel, Nicola Maggio, Yoel Kloog, Joab Chapman, Amir Dor. Brain Protease Activated Receptor 1 Pathway: A Therapeutic Target in the Superoxide Dismutase 1 (SOD1) Mouse Model of Amyotrophic Lateral Sclerosis. International journal of molecular sciences. vol 21. issue 10. 2021-02-22. PMID:32408605. |
brain protease activated receptor 1 pathway: a therapeutic target in the superoxide dismutase 1 (sod1) mouse model of amyotrophic lateral sclerosis. |
2021-02-22 |
2023-08-13 |
mouse |
| Jade Pham, Matt Keon, Samuel Brennan, Nitin Saksen. Connecting RNA-Modifying Similarities of TDP-43, FUS, and SOD1 with MicroRNA Dysregulation Amidst A Renewed Network Perspective of Amyotrophic Lateral Sclerosis Proteinopathy. International journal of molecular sciences. vol 21. issue 10. 2021-02-11. PMID:32422969. |
connecting rna-modifying similarities of tdp-43, fus, and sod1 with microrna dysregulation amidst a renewed network perspective of amyotrophic lateral sclerosis proteinopathy. |
2021-02-11 |
2023-08-13 |
Not clear |
| Paulo R Mouro, Ana P R Povinelli, Vitor B P Leite, Jorge Chahin. Exploring Folding Aspects of Monomeric Superoxide Dismutase. The journal of physical chemistry. B. vol 124. issue 4. 2021-02-08. PMID:31898906. |
recent studies have associated the absence of bound metals (apo protein) and mutations in cu-zn human superoxide dismutase (sod1) with amyotrophic lateral sclerosis (als) disease, suggesting mechanisms of sod1 aggregation. |
2021-02-08 |
2023-08-13 |
human |
| Weisong Duan, Moran Guo, Le Yi, Yakun Liu, Zhongyao Li, Yanqin Ma, Guisen Zhang, Yaling Liu, Hui Bu, Xueqin Song, Chunyan L. The deletion of mutant SOD1 via CRISPR/Cas9/sgRNA prolongs survival in an amyotrophic lateral sclerosis mouse model. Gene therapy. vol 27. issue 3-4. 2021-02-02. PMID:31819203. |
the deletion of mutant sod1 via crispr/cas9/sgrna prolongs survival in an amyotrophic lateral sclerosis mouse model. |
2021-02-02 |
2023-08-13 |
mouse |
| Weisong Duan, Moran Guo, Le Yi, Yakun Liu, Zhongyao Li, Yanqin Ma, Guisen Zhang, Yaling Liu, Hui Bu, Xueqin Song, Chunyan L. The deletion of mutant SOD1 via CRISPR/Cas9/sgRNA prolongs survival in an amyotrophic lateral sclerosis mouse model. Gene therapy. vol 27. issue 3-4. 2021-02-02. PMID:31819203. |
the superoxide dismutase 1 (sod1) mutation is one of the most notable causes of amyotrophic lateral sclerosis (als), and modifying the mutant sod1 gene is the best approach for the treatment of patients with als linked to the mutations in this gene. |
2021-02-02 |
2023-08-13 |
mouse |
| Diane Ly, Anjila Dongol, Peter Cuthbertson, Thomas V Guy, Nicholas J Geraghty, Reece A Sophocleous, Lucia Sin, Bradley J Turner, Debbie Watson, Justin J Yerbury, Ronald Sluyte. The P2X7 receptor antagonist JNJ-47965567 administered thrice weekly from disease onset does not alter progression of amyotrophic lateral sclerosis in SOD1 Purinergic signalling. vol 16. issue 1. 2021-02-01. PMID:32170537. |
the p2x7 receptor antagonist jnj-47965567 administered thrice weekly from disease onset does not alter progression of amyotrophic lateral sclerosis in sod1 the atp-gated p2x7 ion channel has emerging roles in amyotrophic lateral sclerosis (als) progression. |
2021-02-01 |
2023-08-13 |
Not clear |
| Mohammad Saee. Fractal genomics of SOD1 evolution. Immunogenetics. vol 72. issue 9-10. 2021-02-01. PMID:33237378. |
point mutations causing amyotrophic lateral sclerosis do not impact the fractal organization of human sod1. |
2021-02-01 |
2023-08-13 |
human |
| Makoto Hideshima, Goichi Beck, Misaki Yamadera, Yuichi Motoyama, Kensuke Ikenaka, Keita Kakuda, Hiroshi Tsuda, Seiichi Nagano, Harutoshi Fujimura, Eiichi Morii, Shigeo Murayama, Hideki Mochizuk. A clinicopathological study of ALS with L126S mutation in the SOD1 gene presenting with isolated inferior olivary hypertrophy. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 40. issue 2. 2021-01-19. PMID:31863610. |
we report an autopsy case of amyotrophic lateral sclerosis with l126s mutation in the superoxide dismutase 1 (sod1) gene (sod1). |
2021-01-19 |
2023-08-13 |
Not clear |