Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Ji Zhang, Kaili Chen, Yizhe Chen, Lingchen Hua, Siping Chen, Xin Chen, Liangyu Zou, Shupeng Li, Xifei Yang, Yuanyuan She. Pathology reduction and motor behavior improvement associated with ultrasound-mediated delivery of arctiin to the motor cortex in a mutant SOD1 mouse model of amyotrophic lateral sclerosis. Ultrasonics. vol 144. 2024-09-01. PMID:39217855. |
pathology reduction and motor behavior improvement associated with ultrasound-mediated delivery of arctiin to the motor cortex in a mutant sod1 mouse model of amyotrophic lateral sclerosis. |
2024-09-01 |
2024-09-04 |
mouse |
Léa Bedja-Iacona, Elodie Richard, Sylviane Marouillat, Céline Brulard, Tarek Alouane, Stéphane Beltran, Christian R Andres, Hélène Blasco, Philippe Corcia, Charlotte Veyrat-Durebex, Patrick Vourc'. Post-Translational Variants of Major Proteins in Amyotrophic Lateral Sclerosis Provide New Insights into the Pathophysiology of the Disease. International journal of molecular sciences. vol 25. issue 16. 2024-08-29. PMID:39201350. |
here, we present the ptms and ptvs of four major amyotrophic lateral sclerosis (als) proteins, sod1, tdp-43, fus, and tbk1. |
2024-08-29 |
2024-09-01 |
Not clear |
Esther Sue Choi, Brianna Hnath, Congzhou Mike Sha, Nikolay V Dokholya. Unveiling the double-edged sword: SOD1 trimers possess tissue-selective toxicity and bind septin-7 in motor neuron-like cells. Structure (London, England : 1993). 2024-08-29. PMID:39208794. |
misfolded species of superoxide dismutase 1 (sod1) are associated with increased death in amyotrophic lateral sclerosis (als) models compared to insoluble protein aggregates. |
2024-08-29 |
2024-09-04 |
Not clear |
Lee J Martin, Shannon J Koh, Antionette Price, Dongseok Park, Byung Woo Ki. Nuclear Localization of Human SOD1 in Motor Neurons in Mouse Model and Patient Amyotrophic Lateral Sclerosis: Possible Links to Cholinergic Phenotype, NADPH Oxidase, Oxidative Stress, and DNA Damage. International journal of molecular sciences. vol 25. issue 16. 2024-08-29. PMID:39201793. |
nuclear localization of human sod1 in motor neurons in mouse model and patient amyotrophic lateral sclerosis: possible links to cholinergic phenotype, nadph oxidase, oxidative stress, and dna damage. |
2024-08-29 |
2024-09-04 |
mouse |
Zihao Liu, Huan Zhang, Kaili Lu, Li Chen, Yueqi Zhang, Zhouwei Xu, Hongsheng Zhou, Junfeng Sun, Mengyang Xu, Qi Ouyang, Garth J Thompson, Yi Yang, Ni Su, Xiaojun Cai, Li Cao, Yuwu Zhao, Lixian Jiang, Yuanyi Zheng, Xiaojie Zhan. Low-intensity pulsed ultrasound modulates disease progression in the SOD1 Cell reports. vol 43. issue 9. 2024-08-24. PMID:39180748. |
low-intensity pulsed ultrasound modulates disease progression in the sod1 amyotrophic lateral sclerosis (als) is a devastating neurodegenerative disease characterized by the progressive loss of motor neurons in the brain and spinal cord, and there are no effective drug treatments. |
2024-08-24 |
2024-08-27 |
Not clear |
Jinrui Zhou, Fuxiang Li, Bin Jia, Zicong Wu, Zhonghai Huang, Meiting He, Huandi Weng, Kwok-Fai So, Wenrui Qu, Qing-Ling Fu, Libing Zho. Intranasal delivery of small extracellular vesicles reduces the progress of amyotrophic lateral sclerosis and the overactivation of complement-coagulation cascade and NF-ĸB signaling in SOD1 Journal of nanobiotechnology. vol 22. issue 1. 2024-08-23. PMID:39174972. |
intranasal delivery of small extracellular vesicles reduces the progress of amyotrophic lateral sclerosis and the overactivation of complement-coagulation cascade and nf-ĸb signaling in sod1 amyotrophic lateral sclerosis (als) is a fatal disease characterized by progressive motoneuron degeneration, and effective clinical treatments are lacking. |
2024-08-23 |
2024-08-25 |
Not clear |
Sonia Cabeza-Fernández, Rubí Hernández-Rojas, Angeles Casillas-Bajo, Nikiben Patel, Alerie G de la Fuente, Hugo Cabedo, Jose A Gomez-Sanche. Schwann cell JUN expression worsens motor performance in an amyotrophic lateral sclerosis mouse model. Glia. 2024-08-16. PMID:39149866. |
to study the potential role of repair schwann cells on motoneuron survival in amyotrophic lateral sclerosis, we generated a mouse line that over-expresses jun in the schwann cells of the sod1 |
2024-08-16 |
2024-08-18 |
mouse |
Maximilian Wiesenfarth, Yalda Forouhideh-Wiesenfarth, Zeynep Elmas, Özlem Parlak, Ulrike Weiland, Christine Herrmann, Joachim Schuster, Axel Freischmidt, Kathrin Müller, Reiner Siebert, Kornelia Günther, Elke Fröhlich, Antje Knehr, Tatiana Simak, Franziska Bachhuber, Martin Regensburger, Susanne Petri, Thomas Klopstock, Peter Reilich, Florian Schöberl, Peggy Schumann, Peter Körtvélyessy, Thomas Meyer, Wolfgang P Ruf, Simon Witzel, Hayrettin Tumani, David Brenner, Johannes Dorst, Albert C Ludolp. Clinical characterization of common pathogenic variants of SOD1-ALS in Germany. Journal of neurology. 2024-08-14. PMID:39141064. |
pathogenic variants in the cu/zn superoxide dismutase (sod1) gene can be detected in approximately 2% of sporadic and 11% of familial amyotrophic lateral sclerosis (als) patients in europe. |
2024-08-14 |
2024-08-16 |
Not clear |
Riko Tabuchi, Yurika Momozawa, Yuki Hayashi, Hisashi Noma, Hidenori Ichijo, Takao Fujisaw. SoDCoD: a comprehensive database of Cu/Zn superoxide dismutase conformational diversity caused by ALS-linked gene mutations and other perturbations. Database : the journal of biological databases and curation. vol 2024. 2024-08-10. PMID:39126203. |
a structural alteration in copper/zinc superoxide dismutase (sod1) is one of the common features caused by amyotrophic lateral sclerosis (als)-linked mutations. |
2024-08-10 |
2024-08-13 |
Not clear |
Matthew J Fogarty, Joy R Drieberg-Thompson, Mark C Bellingham, Peter G Noake. Timeline of hypoglossal motor neuron death and intrinsic tongue muscle denervation in high-copy number SOD1 Frontiers in neurology. vol 15. 2024-08-09. PMID:39119557. |
timeline of hypoglossal motor neuron death and intrinsic tongue muscle denervation in high-copy number sod1 in amyotrophic lateral sclerosis (als) |
2024-08-09 |
2024-08-12 |
Not clear |
Liam M Koehn, Roshan Jalaldeen, Joseph Pelle, Joseph A Nicolazz. Plasma, brain and spinal cord concentrations of caffeine are reduced in the SOD1 European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2024-08-04. PMID:39098618. |
plasma, brain and spinal cord concentrations of caffeine are reduced in the sod1 modifications to the small intestine and liver are known to occur during the symptomatic disease period of amyotrophic lateral sclerosis (als), a member of the motor neuron disease (mnd) family of neurodegenerative disorders. |
2024-08-04 |
2024-08-07 |
Not clear |
Junyang Liu, Weijia Zhao, Jie Guo, Kaiwen Kang, Hua Li, Xiaohang Yang, Jie Li, Qiang Wang, Haifa Qia. Electroacupuncture Alleviates Motor Dysfunction by Regulating Neuromuscular Junction Disruption and Neuronal Degeneration in SOD1 Brain research bulletin. 2024-07-31. PMID:39084570. |
electroacupuncture alleviates motor dysfunction by regulating neuromuscular junction disruption and neuronal degeneration in sod1 amyotrophic lateral sclerosis (als) is a fatal neurological disease characterized by the progressive destruction of the neuromuscular junction (nmj) and the degeneration of motor neurons, eventually leading to atrophy and paralysis of voluntary muscles responsible for motion and breathing. |
2024-07-31 |
2024-08-03 |
Not clear |
Rayne S S Magalhães, José R Monteiro Neto, Gabriela D Ribeiro, Luan H Paranhos, Elis C A Eleutheri. Trehalose Protects against Superoxide Dismutase 1 Proteinopathy in an Amyotrophic Lateral Sclerosis Model. Antioxidants (Basel, Switzerland). vol 13. issue 7. 2024-07-27. PMID:39061876. |
this work aimed to study the effect of trehalose in protecting cells against sod1 proteinopathy associated with amyotrophic lateral sclerosis (als). |
2024-07-27 |
2024-07-29 |
human |
Jochen H Weishaupt, Péter Körtvélyessy, Peggy Schumann, Ivan Valkadinov, Ute Weyen, Jasper Hesebeck-Brinckmann, Kanchi Weishaupt, Matthias Endres, Peter M Andersen, Martin Regensburger, Marie Dreger, Jan C Koch, Julian Conrad, Thomas Meye. Tofersen decreases neurofilament levels supporting the pathogenesis of the SOD1 p.D91A variant in amyotrophic lateral sclerosis patients. Communications medicine. vol 4. issue 1. 2024-07-25. PMID:39054363. |
tofersen decreases neurofilament levels supporting the pathogenesis of the sod1 p.d91a variant in amyotrophic lateral sclerosis patients. |
2024-07-25 |
2024-07-28 |
Not clear |
Jochen H Weishaupt, Péter Körtvélyessy, Peggy Schumann, Ivan Valkadinov, Ute Weyen, Jasper Hesebeck-Brinckmann, Kanchi Weishaupt, Matthias Endres, Peter M Andersen, Martin Regensburger, Marie Dreger, Jan C Koch, Julian Conrad, Thomas Meye. Tofersen decreases neurofilament levels supporting the pathogenesis of the SOD1 p.D91A variant in amyotrophic lateral sclerosis patients. Communications medicine. vol 4. issue 1. 2024-07-25. PMID:39054363. |
since the antisense oligonucleotide tofersen has recently become available for the treatment of amyotrophic lateral sclerosis (als) caused by mutations in sod1, determining the causality of the over 230 sod1 variants has become even more important. |
2024-07-25 |
2024-07-28 |
Not clear |
Thomas Meyer, Peggy Schumann, Patrick Weydt, Susanne Petri, Jochen H Weishaupt, Ute Weyen, Jan C Koch, René Günther, Martin Regensburger, Matthias Boentert, Maximilian Wiesenfarth, Yasemin Koc, Felix Kolzarek, Dagmar Kettemann, Jenny Norden, Sarah Bernsen, Zeynep Elmas, Julian Conrad, Ivan Valkadinov, Maximilian Vidovic, Johannes Dorst, Albert C Ludolph, Jasper Hesebeck-Brinckmann, Susanne Spittel, Christoph Münch, André Maier, Péter Körtvélyess. Clinical and patient-reported outcomes and neurofilament response during tofersen treatment in SOD1-related ALS-A multicenter observational study over 18 months. Muscle & nerve. 2024-07-20. PMID:39031772. |
in amyotrophic lateral sclerosis (als) caused by sod1 mutations (sod1-als), tofersen received accelerated approval in the united states and is available via expanded access programs (eap) outside the united states. |
2024-07-20 |
2024-07-24 |
Not clear |
Marco Vinceti, Teresa Urbano, Tommaso Filippini, Roberta Bedin, Cecilia Simonini, Gianni Sorarù, Francesca Trojsi, Bernhard Michalke, Jessica Mandriol. Changes in Cerebrospinal Fluid Concentrations of Selenium Species Induced by Tofersen Administration in Subjects with Amyotrophic Lateral Sclerosis Carrying SOD1 Gene Mutations. Biological trace element research. 2024-07-17. PMID:39017978. |
changes in cerebrospinal fluid concentrations of selenium species induced by tofersen administration in subjects with amyotrophic lateral sclerosis carrying sod1 gene mutations. |
2024-07-17 |
2024-07-19 |
human |
Krishna Neupane, Abhishek Narayan, Supratik Sen Mojumdar, Gaurav Adhikari, Craig R Garen, Michael T Woodsid. Direct observation of prion-like propagation of protein misfolding templated by pathogenic mutants. Nature chemical biology. 2024-07-15. PMID:39009686. |
we observed prion-like conversion in single molecules of superoxide dismutase-1 (sod1), whose misfolding is linked to amyotrophic lateral sclerosis. |
2024-07-15 |
2024-07-18 |
Not clear |
Alexandra Weiss, James W Gilbert, Iris Valeria Rivera Flores, Jillian Belgrad, Chantal Ferguson, Elif O Dogan, Nicholas Wightman, Kit Mocarski, Dimas Echeverria, Ashley Summers, Brianna Bramato, Nicholas McHugh, Raymond Furgal, Nozomi Yamada, David Cooper, Kathryn Monopoli, Bruno M D C Godinho, Matthew R Hassler, Ken Yamada, Paul L Greer, Nils Henninger, Robert H Brown, Anastasia Khvorov. RNAi-mediated silencing of SOD1 profoundly extends survival and functional outcomes in ALS mice. bioRxiv : the preprint server for biology. 2024-07-09. PMID:38979291. |
amyotrophic lateral sclerosis (als) is a fatal neurodegenerative condition, with 20% of familial and 2-3% of sporadic cases linked to mutations in the cytosolic superoxide dismutase (sod1) gene. |
2024-07-09 |
2024-07-12 |
mouse |
Pedro Lucas Grangeiro de Sá Barreto Lima, Eugenia Machado Couto, Paulo Ribeiro Nóbreg. Response letter to: a homozygous p.Val120Leu (c.358G > C) SOD1 mutation led to slowly progressive amyotrophic lateral sclerosis in a Brazilian family. Amyotrophic lateral sclerosis & frontotemporal degeneration. 2024-07-04. PMID:38963716. |
response letter to: a homozygous p.val120leu (c.358g > c) sod1 mutation led to slowly progressive amyotrophic lateral sclerosis in a brazilian family. |
2024-07-04 |
2024-07-11 |
Not clear |