| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Hirano, J Fujii, Y Nagai, M Sonobe, K Okamoto, H Araki, N Taniguchi, S Uen. A new variant Cu/Zn superoxide dismutase (Val7-->Glu) deduced from lymphocyte mRNA sequences from Japanese patients with familial amyotrophic lateral sclerosis. Biochemical and biophysical research communications. vol 204. issue 2. 1994-11-30. PMID:7980516. |
we have identified a new mutant cu/zn superoxide dismutase (sod1) deduced from the nucleotide sequences of peripheral blood lymphocyte mrna from japanese patients with familial amyotrophic lateral sclerosis (fals). |
1994-11-30 |
2023-08-12 |
Not clear |
| T Tsuda, S Munthasser, P E Fraser, M E Percy, I Rainero, G Vaula, L Pinessi, L Bergamini, G Vignocchi, D R McLachla. Analysis of the functional effects of a mutation in SOD1 associated with familial amyotrophic lateral sclerosis. Neuron. vol 13. issue 3. 1994-11-01. PMID:7917302. |
analysis of the functional effects of a mutation in sod1 associated with familial amyotrophic lateral sclerosis. |
1994-11-01 |
2023-08-12 |
human |
| T Tsuda, S Munthasser, P E Fraser, M E Percy, I Rainero, G Vaula, L Pinessi, L Bergamini, G Vignocchi, D R McLachla. Analysis of the functional effects of a mutation in SOD1 associated with familial amyotrophic lateral sclerosis. Neuron. vol 13. issue 3. 1994-11-01. PMID:7917302. |
mutations in the cu, zn superoxide dismutase (sod1) gene have been reported in some pedigrees with familial amyotrophic lateral sclerosis (fals). |
1994-11-01 |
2023-08-12 |
human |
| C T Jones, R J Swingler, D J Broc. Identification of a novel SOD1 mutation in an apparently sporadic amyotrophic lateral sclerosis patient and the detection of Ile113Thr in three others. Human molecular genetics. vol 3. issue 4. 1994-09-27. PMID:8069312. |
identification of a novel sod1 mutation in an apparently sporadic amyotrophic lateral sclerosis patient and the detection of ile113thr in three others. |
1994-09-27 |
2023-08-12 |
Not clear |
| D R Borchelt, M K Lee, H S Slunt, M Guarnieri, Z S Xu, P C Wong, R H Brown, D L Price, S S Sisodia, D W Clevelan. Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity. Proceedings of the National Academy of Sciences of the United States of America. vol 91. issue 17. 1994-09-14. PMID:8058797. |
familial amyotrophic lateral sclerosis (fals) has been linked to mutations in the homodimeric enzyme cu/zn superoxide dismutase 1 (sod1). |
1994-09-14 |
2023-08-12 |
Not clear |
| C M Troy, M L Shelansk. Down-regulation of copper/zinc superoxide dismutase causes apoptotic death in PC12 neuronal cells. Proceedings of the National Academy of Sciences of the United States of America. vol 91. issue 14. 1994-08-01. PMID:8022792. |
the discovery of missense mutations leading to reduced enzymatic activity in the copper/zinc superoxide dismutase (sod1) in human familial amyotrophic lateral sclerosis has heightened interest in the role of free radicals in neurodegenerations but left the mechanisms by which they may cause neuronal death unexplained. |
1994-08-01 |
2023-08-12 |
human |
| J D Rothstein, L A Bristol, B Hosler, R H Brown, R W Kunc. Chronic inhibition of superoxide dismutase produces apoptotic death of spinal neurons. Proceedings of the National Academy of Sciences of the United States of America. vol 91. issue 10. 1994-06-16. PMID:7910402. |
mutations in the gene for cu/zn superoxide dismutase (sod1) have been detected in some families with an autosomal dominant form of amyotrophic lateral sclerosis; these mutations appear to reduce the activity of this enzyme. |
1994-06-16 |
2023-08-12 |
Not clear |
| J D Rothstein, L A Bristol, B Hosler, R H Brown, R W Kunc. Chronic inhibition of superoxide dismutase produces apoptotic death of spinal neurons. Proceedings of the National Academy of Sciences of the United States of America. vol 91. issue 10. 1994-06-16. PMID:7910402. |
these data support the hypothesis that the loss of motor neurons in familial amyotrophic lateral sclerosis could be due to a reduction in sod1 activity, possibly potentiated by inefficient glutamate transport. |
1994-06-16 |
2023-08-12 |
Not clear |
| R Nakano, S Sato, T Inuzuka, K Sakimura, M Mishina, H Takahashi, F Ikuta, Y Honma, J Fujii, N Taniguch. A novel mutation in Cu/Zn superoxide dismutase gene in Japanese familial amyotrophic lateral sclerosis. Biochemical and biophysical research communications. vol 200. issue 2. 1994-06-03. PMID:8179602. |
recently, several missense mutations in the cu/zn superoxide dismutase gene (sod1) have been reported as a putative cause of chromosome-21q-linked familial amyotrophic lateral sclerosis (fals). |
1994-06-03 |
2023-08-12 |
Not clear |
| Mutations in the copper- and zinc-containing superoxide dismutase gene are associated with "Lou Gehrig's disease". Nutrition reviews. vol 51. issue 8. 1994-03-04. PMID:8302496. |
recent genetic analyses of patients with a familial, chromosome 21-linked form of amyotrophic lateral sclerosis (als), sometimes called lou gehrig's disease, suggest that mutations in the cytosolic copper/zinc superoxide dismutase (sod1) gene may be involved in development of the disease. |
1994-03-04 |
2023-08-12 |
Not clear |
| R A Lanius, C Krieger, R Wagey, C A Sha. Increased [35S]glutathione binding sites in spinal cords from patients with sporadic amyotrophic lateral sclerosis. Neuroscience letters. vol 163. issue 1. 1994-03-02. PMID:8295742. |
recent observations have suggested abnormalities in the gene for superoxide dismutase (sod1) in patients with the familial form of amyotrophic lateral sclerosis (als). |
1994-03-02 |
2023-08-12 |
human |
| C T Jones, D J Brock, A M Chancellor, C P Warlow, R J Swingle. Cu/Zn superoxide dismutase (SOD1) mutations and sporadic amyotrophic lateral sclerosis. Lancet (London, England). vol 342. issue 8878. 1993-11-18. PMID:8105280. |
cu/zn superoxide dismutase (sod1) mutations and sporadic amyotrophic lateral sclerosis. |
1993-11-18 |
2023-08-12 |
Not clear |
| H X Deng, A Hentati, J A Tainer, Z Iqbal, A Cayabyab, W Y Hung, E D Getzoff, P Hu, B Herzfeldt, R P Roo. Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase. Science (New York, N.Y.). vol 261. issue 5124. 1993-09-14. PMID:8351519. |
single-site mutants in the cu,zn superoxide dismutase (sod) gene (sod1) occur in patients with the fatal neurodegenerative disorder familial amyotrophic lateral sclerosis (fals). |
1993-09-14 |
2023-08-12 |
human |