| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Nakano, T Inuzuka, K Kikugawa, H Takahashi, K Sakimura, J Fujii, N Taniguchi, S Tsuj. Instability of mutant Cu/Zn superoxide dismutase (Ala4Thr) associated with familial amyotrophic lateral sclerosis. Neuroscience letters. vol 211. issue 2. 1997-01-23. PMID:8830861. |
in about 20-25% of cases of familial amyotrophic lateral sclerosis (fals) patients have mutations in the cu/zn superoxide dismutase (sod1) gene. |
1997-01-23 |
2023-08-12 |
human |
| P F Kennel, F Finiels, F Revah, J Malle. Neuromuscular function impairment is not caused by motor neurone loss in FALS mice: an electromyographic study. Neuroreport. vol 7. issue 8. 1997-01-07. PMID:8856691. |
dominant mutations of human cu/zn superoxide dismutase (sod1) are found in about 20% of patients with familial amyotrophic lateral sclerosis (fals). |
1997-01-07 |
2023-08-12 |
mouse |
| R de la Rúa-Domènech, M Wiedmann, H O Mohammed, J F Cummings, T J Divers, C A Bat. Equine motor neuron disease is not linked to Cu/Zn superoxide dismutase mutations: sequence analysis of the equine Cu/Zn superoxide dismutase cDNA. Gene. vol 178. issue 1-2. 1996-12-31. PMID:8921896. |
we further sequenced the sod1 gene from 16 horses diagnosed with equine motor neuron disease (emnd) and eight unrelated, clinically normal horses to determine if this disease, similar to amyotrophic lateral sclerosis (als) in humans, is linked to sod1 mutations. |
1996-12-31 |
2023-08-12 |
human |
| E K Hoffman, H M Wilcox, R W Scott, R Sima. Proteasome inhibition enhances the stability of mouse Cu/Zn superoxide dismutase with mutations linked to familial amyotrophic lateral sclerosis. Journal of the neurological sciences. vol 139. issue 1. 1996-12-23. PMID:8836967. |
point mutations occurring within the cu/zn superoxide dismutase (sod1) gene have been implicated in the etiology of some cases of familial amyotrophic lateral sclerosis (fals). |
1996-12-23 |
2023-08-12 |
mouse |
| W Robberecht, T Aguirre, L Van den Bosch, P Tilkin, J J Cassiman, G Matthij. D90A heterozygosity in the SOD1 gene is associated with familial and apparently sporadic amyotrophic lateral sclerosis. Neurology. vol 47. issue 5. 1996-12-18. PMID:8909456. |
d90a heterozygosity in the sod1 gene is associated with familial and apparently sporadic amyotrophic lateral sclerosis. |
1996-12-18 |
2023-08-12 |
Not clear |
| M E Gurney, F B Cutting, P Zhai, A Doble, C P Taylor, P K Andrus, E D Hal. Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis. Annals of neurology. vol 39. issue 2. 1996-12-12. PMID:8967745. |
familial amyotrophic lateral sclerosis (fals) has been linked in some families to dominant mutations of the sod1 gene encoding cu,zn superoxide dismutase (cu,znsod). |
1996-12-12 |
2023-08-12 |
mouse |
| S M Chou, H S Wang, K Koma. Colocalization of NOS and SOD1 in neurofilament accumulation within motor neurons of amyotrophic lateral sclerosis: an immunohistochemical study. Journal of chemical neuroanatomy. vol 10. issue 3-4. 1996-11-27. PMID:8811414. |
colocalization of nos and sod1 in neurofilament accumulation within motor neurons of amyotrophic lateral sclerosis: an immunohistochemical study. |
1996-11-27 |
2023-08-12 |
Not clear |
| N Shibata, A Hirano, M Kobayashi, T Siddique, H X Deng, W Y Hung, T Kato, K Asayam. Intense superoxide dismutase-1 immunoreactivity in intracytoplasmic hyaline inclusions of familial amyotrophic lateral sclerosis with posterior column involvement. Journal of neuropathology and experimental neurology. vol 55. issue 4. 1996-09-20. PMID:8786408. |
this report concerns retrospective immunohistochemical and immunoelectron microscopic studies on superoxide dismutase-1 (sod1) in intracytoplasmic hyaline inclusions (ihis) of the anterior horn cells of three patients with familial amyotrophic lateral sclerosis (als) with posterior column involvement. |
1996-09-20 |
2023-08-12 |
human |
| M Kostrzewa, M S Damian, U Mülle. Superoxide dismutase 1: identification of a novel mutation in a case of familial amyotrophic lateral sclerosis. Human genetics. vol 98. issue 1. 1996-08-20. PMID:8682505. |
mutation analysis of the superoxide dismutase gene sod1 in a familial case of amyotrophic lateral sclerosis revealed a t --> c transition at codon 151 of exon 5. |
1996-08-20 |
2023-08-12 |
Not clear |
| A G Reaume, J L Elliott, E K Hoffman, N W Kowall, R J Ferrante, D F Siwek, H M Wilcox, D G Flood, M F Beal, R H Brown, R W Scott, W D Snide. Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury. Nature genetics. vol 13. issue 1. 1996-08-09. PMID:8673102. |
the discovery that some cases of familial amyotrophic lateral sclerosis (fals) are associated with mutations in the gene encoding cu/zn superoxide dismutase (sod1) has focused much attention on the function of sod1 as related to motor neuron survival. |
1996-08-09 |
2023-08-12 |
mouse |
| M Jackson, K E Morrison, A Al-Chalabi, M Bakker, P N Leig. Analysis of chromosome 5q13 genes in amyotrophic lateral sclerosis: homozygous NAIP deletion in a sporadic case. Annals of neurology. vol 39. issue 6. 1996-07-24. PMID:8651652. |
although defects in the gene encoding the enzyme cytosolic copper/zinc superoxide dismutase (sod1) have been reported in 20% of familial amyotrophic lateral sclerosis (als) patients, the etiology of the remaining familial cases and the more common sporadic form of the disease remains unknown. |
1996-07-24 |
2023-08-12 |
Not clear |
| Z Mourelatos, N K Gonatas, A Stieber, M E Gurney, M C Dal Cant. The Golgi apparatus of spinal cord motor neurons in transgenic mice expressing mutant Cu,Zn superoxide dismutase becomes fragmented in early, preclinical stages of the disease. Proceedings of the National Academy of Sciences of the United States of America. vol 93. issue 11. 1996-07-17. PMID:8643599. |
dominant mutations of the sod1 gene encoding cu,zn superoxide dismutase have been found in members of certain families with familial amyotrophic lateral sclerosis (als). |
1996-07-17 |
2023-08-12 |
mouse |
| K Rooke, D A Figlewicz, F Y Han, G A Roulea. Analysis of the KSP repeat of the neurofilament heavy subunit in familiar amyotrophic lateral sclerosis. Neurology. vol 46. issue 3. 1996-06-13. PMID:8618684. |
we screened the ksp repeat region of the nefh gene in 117 unrelated individuals who inherited familial amyotrophic lateral sclerosis as an autosomal trait but who do not have the mutation in the sod1 locus, and we found no variants in any individual. |
1996-06-13 |
2023-08-12 |
Not clear |
| P H Tu, P Raju, K A Robinson, M E Gurney, J Q Trojanowski, V M Le. Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions. Proceedings of the National Academy of Sciences of the United States of America. vol 93. issue 7. 1996-05-24. PMID:8610185. |
mutations in the human cu,zn superoxide dismutase gene (sod1) are found in 20% of kindreds with familial amyotrophic lateral sclerosis. |
1996-05-24 |
2023-08-12 |
mouse |
| P H Tu, P Raju, K A Robinson, M E Gurney, J Q Trojanowski, V M Le. Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions. Proceedings of the National Academy of Sciences of the United States of America. vol 93. issue 7. 1996-05-24. PMID:8610185. |
transgenic mice (line g1h) expressing a human sod1 containing a mutation of gly-93 --> ala (g93a) develop a motor neuron disease similar to familial amyotrophic lateral sclerosis, but transgenic mice (line n1029) expressing a wild-type human sod1 transgene do not. |
1996-05-24 |
2023-08-12 |
mouse |
| P H Tu, P Raju, K A Robinson, M E Gurney, J Q Trojanowski, V M Le. Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions. Proceedings of the National Academy of Sciences of the United States of America. vol 93. issue 7. 1996-05-24. PMID:8610185. |
these findings link a specific sod1 mutation with alterations in the neuronal cytoskeleton of patients with amyotrophic lateral sclerosis. |
1996-05-24 |
2023-08-12 |
mouse |
| G A Rouleau, A W Clark, K Rooke, A Pramatarova, A Krizus, O Suchowersky, J P Julien, D Figlewic. SOD1 mutation is associated with accumulation of neurofilaments in amyotrophic lateral sclerosis. Annals of neurology. vol 39. issue 1. 1996-03-05. PMID:8572658. |
sod1 mutation is associated with accumulation of neurofilaments in amyotrophic lateral sclerosis. |
1996-03-05 |
2023-08-12 |
mouse |
| G A Rouleau, A W Clark, K Rooke, A Pramatarova, A Krizus, O Suchowersky, J P Julien, D Figlewic. SOD1 mutation is associated with accumulation of neurofilaments in amyotrophic lateral sclerosis. Annals of neurology. vol 39. issue 1. 1996-03-05. PMID:8572658. |
mutations in the cu/zn superoxide dismutase (sod1) gene are found in 15 to 20% of patients with familial amyotrophic lateral sclerosis (fals). |
1996-03-05 |
2023-08-12 |
mouse |
| K Nishiyama, S Kwak, S Murayama, M Watanabe, J Goto, K Asayama, I Kanazaw. Increased Cu/Zn superoxide dismutase-like immunoreactivity in the swollen axons of rats intoxicated chronically with beta,beta'-iminodipropionitrile. Neuroscience letters. vol 194. issue 3. 1995-12-07. PMID:7478239. |
demonstration of a genetic linkage between the cu/zn superoxide dismutase (sod1) gene and familial amyotrophic lateral sclerosis (als) has aroused interest in the role of sod1 in spinal motoneuronal death. |
1995-12-07 |
2023-08-12 |
rat |
| O Garofalo, D A Figlewicz, S M Thomas, R Butler, L Lebuis, G Rouleau, V Meininger, P N Leig. Superoxide dismutase activity in lymphoblastoid cells from motor neurone disease/amyotrophic lateral sclerosis (MND/ALS) patients. Journal of the neurological sciences. vol 129 Suppl. 1995-11-24. PMID:7595631. |
point mutations in the gene encoding cu,zn superoxide dismutase (sod1) are associated with autosomal dominant familial amyotrophic lateral sclerosis (fals). |
1995-11-24 |
2023-08-12 |
Not clear |