| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M C Dal Canto, M E Gurne. A low expressor line of transgenic mice carrying a mutant human Cu,Zn superoxide dismutase (SOD1) gene develops pathological changes that most closely resemble those in human amyotrophic lateral sclerosis. Acta neuropathologica. vol 93. issue 6. 1997-08-05. PMID:9194892. |
a low expressor line of transgenic mice carrying a mutant human cu,zn superoxide dismutase (sod1) gene develops pathological changes that most closely resemble those in human amyotrophic lateral sclerosis. |
1997-08-05 |
2023-08-12 |
mouse |
| M C Dal Canto, M E Gurne. A low expressor line of transgenic mice carrying a mutant human Cu,Zn superoxide dismutase (SOD1) gene develops pathological changes that most closely resemble those in human amyotrophic lateral sclerosis. Acta neuropathologica. vol 93. issue 6. 1997-08-05. PMID:9194892. |
about 15-20% of patients with familial amyotrophic lateral sclerosis (als) carry one of several missense mutations in the gene for cu,zn superoxide dismutase (sod1). |
1997-08-05 |
2023-08-12 |
mouse |
| L I Bruijn, M F Beal, M W Becher, J B Schulz, P C Wong, D L Price, D W Clevelan. Elevated free nitrotyrosine levels, but not protein-bound nitrotyrosine or hydroxyl radicals, throughout amyotrophic lateral sclerosis (ALS)-like disease implicate tyrosine nitration as an aberrant in vivo property of one familial ALS-linked superoxide dismutase 1 mutant. Proceedings of the National Academy of Sciences of the United States of America. vol 94. issue 14. 1997-08-05. PMID:9207139. |
mutations in superoxide dismutase 1 (sod1; ec 1.15.1.1) are responsible for a proportion of familial amyotrophic lateral sclerosis (als) through acquisition of an as-yet-unidentified toxic property or properties. |
1997-08-05 |
2023-08-12 |
mouse |
| B Bereznai, A Winkler, G D Borasio, T Gasse. A novel SOD1 mutation in an Austrian family with amyotrophic lateral sclerosis. Neuromuscular disorders : NMD. vol 7. issue 2. 1997-07-18. PMID:9131652. |
a novel sod1 mutation in an austrian family with amyotrophic lateral sclerosis. |
1997-07-18 |
2023-08-12 |
Not clear |
| Y Watanabe, N Kuno, Y Kono, E Nanba, E Ohama, K Nakashima, K Takahash. Absence of the mutant SOD1 in familial amyotrophic lateral sclerosis (FALS) with two base pair deletion in the SOD1 gene. Acta neurologica Scandinavica. vol 95. issue 3. 1997-06-18. PMID:9088386. |
absence of the mutant sod1 in familial amyotrophic lateral sclerosis (fals) with two base pair deletion in the sod1 gene. |
1997-06-18 |
2023-08-12 |
human |
| Y Watanabe, N Kuno, Y Kono, E Nanba, E Ohama, K Nakashima, K Takahash. Absence of the mutant SOD1 in familial amyotrophic lateral sclerosis (FALS) with two base pair deletion in the SOD1 gene. Acta neurologica Scandinavica. vol 95. issue 3. 1997-06-18. PMID:9088386. |
we determined the activity, content and mrna of cu/zn superoxide dismutase (sod1), and copper ion concentration in a japanese pedigree of familial amyotrophic lateral sclerosis (fals) having two basepair deletion in the 126th codon of the sod1 gene. |
1997-06-18 |
2023-08-12 |
human |
| K Nishiyama, S Murayama, S Kwak, I Kanazaw. Expression of the copper-zinc superoxide dismutase gene in amyotrophic lateral sclerosis. Annals of neurology. vol 41. issue 4. 1997-04-24. PMID:9124814. |
the demonstration of a genetic linkage between the copper-zinc superoxide dismutase (sod1) gene and familial amyotrophic lateral sclerosis has aroused interest in the role of sod1 in motoneuronal death. |
1997-04-24 |
2023-08-12 |
human |
| K Nishiyama, S Murayama, S Kwak, I Kanazaw. Expression of the copper-zinc superoxide dismutase gene in amyotrophic lateral sclerosis. Annals of neurology. vol 41. issue 4. 1997-04-24. PMID:9124814. |
we investigated the expression of the human sod1 gene at a cellular level in the motoneurons of patients with sporadic amyotrophic lateral sclerosis, patients with familial amyotrophic lateral sclerosis, and normal control subjects, using a quantitative in situ hybridization technique. |
1997-04-24 |
2023-08-12 |
human |
| K Nishiyama, S Murayama, S Kwak, I Kanazaw. Expression of the copper-zinc superoxide dismutase gene in amyotrophic lateral sclerosis. Annals of neurology. vol 41. issue 4. 1997-04-24. PMID:9124814. |
our study indicated that vulnerable neurons in amyotrophic lateral sclerosis exhibit high levels of sod1 messenger rna, suggesting a close relationship between the sod1 gene and the pathogenesis of amyotrophic lateral sclerosis. |
1997-04-24 |
2023-08-12 |
human |
| L I Bruijn, M W Becher, M K Lee, K L Anderson, N A Jenkins, N G Copeland, S S Sisodia, J D Rothstein, D R Borchelt, D L Price, D W Clevelan. ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions. Neuron. vol 18. issue 2. 1997-03-28. PMID:9052802. |
high levels of familial amyotrophic lateral sclerosis (als)-linked sod1 mutants g93a and g37r were previously shown to mediate disease in mice through an acquired toxic property. |
1997-03-28 |
2023-08-12 |
mouse |
| D Jaarsma, J C Holstege, D Troost, M Davis, J Kennis, E D Haasdijk, V J de Jon. Induction of c-Jun immunoreactivity in spinal cord and brainstem neurons in a transgenic mouse model for amyotrophic lateral sclerosis. Neuroscience letters. vol 219. issue 3. 1997-03-20. PMID:8971809. |
transgenic mice carrying amyotrophic lateral sclerosis (als)-linked superoxide dismutase 1 (sod1) mutations develop a motoneuron disease resembling human als. |
1997-03-20 |
2023-08-12 |
mouse |
| S Kato, A Kawata, M Oda, N Arai, T Komori, H Tanab. Absence of SOD1 gene abnormalities in familial amyotrophic lateral sclerosis with posterior column involvement without Lewy-body-like hyaline inclusions. Acta neuropathologica. vol 92. issue 5. 1997-03-12. PMID:8922067. |
absence of sod1 gene abnormalities in familial amyotrophic lateral sclerosis with posterior column involvement without lewy-body-like hyaline inclusions. |
1997-03-12 |
2023-08-12 |
Not clear |
| M E Cudkowicz, D McKenna-Yasek, P E Sapp, W Chin, B Geller, D L Hayden, D A Schoenfeld, B A Hosler, H R Horvitz, R H Brow. Epidemiology of mutations in superoxide dismutase in amyotrophic lateral sclerosis. Annals of neurology. vol 41. issue 2. 1997-03-12. PMID:9029070. |
the clinical characteristics of patients with familial amyotrophic lateral sclerosis arising from sod1 mutations are similar to those lacking sod1 defects. |
1997-03-12 |
2023-08-12 |
Not clear |
| M Morita, M Aoki, K Abe, T Hasegawa, R Sakuma, Y Onodera, N Ichikawa, M Nishizawa, Y Itoyam. A novel two-base mutation in the Cu/Zn superoxide dismutase gene associated with familial amyotrophic lateral sclerosis in Japan. Neuroscience letters. vol 205. issue 2. 1997-03-07. PMID:8907321. |
we have identified a novel two-base mutation in exon 1 of the cu/zn superoxide dismutase (sod1) gene (tgc to ttt), which resulted in cys6 to phe substitution in a japanese family with amyotrophic lateral sclerosis (als). |
1997-03-07 |
2023-08-12 |
Not clear |
| T Juneja, M A Pericak-Vance, N G Laing, S Dave, T Siddiqu. Prognosis in familial amyotrophic lateral sclerosis: progression and survival in patients with glu100gly and ala4val mutations in Cu,Zn superoxide dismutase. Neurology. vol 48. issue 1. 1997-02-26. PMID:9008494. |
familial amyotrophic lateral sclerosis (fals) is an autosomal dominant neurodegenerative disorder affecting motor neurons and is associated with mutations in the cu,zn superoxide dismutase gene (sod1) in a subset (approximately 15%) of fals families. |
1997-02-26 |
2023-08-12 |
Not clear |
| W Robberecht, T Aguirre, L Van den Bosch, P Theys, H Nees, J J Cassiman, G Matthij. Familial juvenile focal amyotrophy of the upper extremity (Hirayama disease). Superoxide dismutase 1 genotype and activity. Archives of neurology. vol 54. issue 1. 1997-02-25. PMID:9006413. |
we recently described a family with amyotrophic lateral sclerosis associated with a mutation in the superoxide dismutase 1 (sod1) gene substituting an aspartate for an alanine (d9oa). |
1997-02-25 |
2023-08-12 |
Not clear |
| Y Watanabe, Y Kono, E Nanba, E Ohama, K Nakashim. Instability of expressed Cu/Zn superoxide dismutase with 2 bp deletion found in familial amyotrophic lateral sclerosis. FEBS letters. vol 400. issue 1. 1997-02-11. PMID:9000523. |
the mutant cu/zn superoxide dismutase (sod1) associated with familial amyotrophic lateral sclerosis (fals) with a 2 bp deletion was produced in two protein expression systems. |
1997-02-11 |
2023-08-12 |
Not clear |
| P G Ince, P J Shaw, J Y Slade, C Jones, P Hudgso. Familial amyotrophic lateral sclerosis with a mutation in exon 4 of the Cu/Zn superoxide dismutase gene: pathological and immunocytochemical changes. Acta neuropathologica. vol 92. issue 4. 1997-02-05. PMID:8891072. |
detailed molecular pathology studies and clinicopathological phenotyping of familial amyotrophic lateral sclerosis (fals) with characterised mutations in the gene encoding cu/zn superoxide dismutase (sod1) will yield important insights into the pathogenesis of motor neuron degeneration. |
1997-02-05 |
2023-08-12 |
Not clear |
| C B Kunst, E Mezey, M J Brownstein, D Patterso. Mutations in SOD1 associated with amyotrophic lateral sclerosis cause novel protein interactions. Nature genetics. vol 15. issue 1. 1997-01-28. PMID:8988176. |
mutations in sod1 associated with amyotrophic lateral sclerosis cause novel protein interactions. |
1997-01-28 |
2023-08-12 |
mouse |
| C B Kunst, E Mezey, M J Brownstein, D Patterso. Mutations in SOD1 associated with amyotrophic lateral sclerosis cause novel protein interactions. Nature genetics. vol 15. issue 1. 1997-01-28. PMID:8988176. |
a subset of familial and sporadic amyotrophic lateral sclerosis (als-a fatal disorder characterised by progressive motor neuron degeneration) cases are due to mutations in the gene encoding cu,zn superoxide dismutase (sod1). |
1997-01-28 |
2023-08-12 |
mouse |