| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sudheer K Tungtur, Heather M Wilkins, Robert S Rogers, Yomna Badawi, Jessica M Sage, Abdulbaki Agbas, Omar Jawdat, Richard J Barohn, Russell H Swerdlow, Hiroshi Nishimun. Oxaloacetate treatment preserves motor function in SOD1 Scientific reports. vol 11. issue 1. 2021-11-02. PMID:34040085. |
oxaloacetate treatment preserves motor function in sod1 amyotrophic lateral sclerosis (als) remains a devastating motor neuron disease with limited treatment options. |
2021-11-02 |
2023-08-13 |
Not clear |
| Nicholas G M Wells, Grant A Tillinghast, Alison L O'Neil, Colin A Smit. Free energy calculations of ALS-causing SOD1 mutants reveal common perturbations to stability and dynamics along the maturation pathway. Protein science : a publication of the Protein Society. vol 30. issue 9. 2021-11-01. PMID:34076319. |
with over 150 heritable mutations identified as disease-causative, superoxide dismutase 1 (sod1) has been a main target of amyotrophic lateral sclerosis (als) research and therapeutic efforts. |
2021-11-01 |
2023-08-13 |
Not clear |
| Carolyn A Brown, Cathy Lally, Varant Kupelian, W Dana Flander. Estimated Prevalence and Incidence of Amyotrophic Lateral Sclerosis and SOD1 and C9orf72 Genetic Variants. Neuroepidemiology. vol 55. issue 5. 2021-10-28. PMID:34247168. |
estimated prevalence and incidence of amyotrophic lateral sclerosis and sod1 and c9orf72 genetic variants. |
2021-10-28 |
2023-08-13 |
Not clear |
| Elena Obrador, Rosario Salvador, Patricia Marchio, Rafael López-Blanch, Ali Jihad-Jebbar, Pilar Rivera, Soraya L Vallés, Salvador Banacloche, Javier Alcácer, Nuria Colomer, Javier A Coronado, Sandra Alandes, Eraci Drehmer, María Benlloch, José M Estrel. Nicotinamide Riboside and Pterostilbene Cooperatively Delay Motor Neuron Failure in ALS SOD1 Molecular neurobiology. vol 58. issue 4. 2021-10-27. PMID:33174130. |
nicotinamide riboside and pterostilbene cooperatively delay motor neuron failure in als sod1 oxidative stress-induced damage is a major mechanism in the pathophysiology of amyotrophic lateral sclerosis (als). |
2021-10-27 |
2023-08-13 |
human |
| Achinta Sannigrahi, Sourav Chowdhury, Bidisha Das, Amrita Banerjee, Animesh Halder, Amaresh Kumar, Mohammed Saleem, Athi N Naganathan, Sanat Karmakar, Krishnananda Chattopadhya. The metal cofactor zinc and interacting membranes modulate SOD1 conformation-aggregation landscape in an in vitro ALS model. eLife. vol 10. 2021-10-26. PMID:33825682. |
aggregation of cu-zn superoxide dismutase (sod1) is implicated in the motor neuron disease, amyotrophic lateral sclerosis (als). |
2021-10-26 |
2023-08-13 |
Not clear |
| Rebecca San Gil, Benjamin E Clarke, Heath Ecroyd, Bernadett Kalmar, Linda Greensmit. Regional Differences in Heat Shock Protein 25 Expression in Brain and Spinal Cord Astrocytes of Wild-Type and SOD1 Cells. vol 10. issue 5. 2021-10-25. PMID:34069691. |
regional differences in heat shock protein 25 expression in brain and spinal cord astrocytes of wild-type and sod1 heterogeneity of glia in different cns regions may contribute to the selective vulnerability of neuronal populations in neurodegenerative conditions such as amyotrophic lateral sclerosis (als). |
2021-10-25 |
2023-08-13 |
Not clear |
| P J J Mandigers, F G Van Steenbeek, W Bergmann, M Vos-Loohuis, P A Leegwate. A knockout mutation associated with juvenile paroxysmal dyskinesia in Markiesje dogs indicates SOD1 pleiotropy. Human genetics. vol 140. issue 11. 2021-10-22. PMID:33677640. |
mutations in sod1 are known to cause recessive degenerative myelopathy in middle-aged dogs with low penetrance and dominant amyotrophic lateral sclerosis in humans with variable age of onset. |
2021-10-22 |
2023-08-13 |
human |
| P J J Mandigers, F G Van Steenbeek, W Bergmann, M Vos-Loohuis, P A Leegwate. A knockout mutation associated with juvenile paroxysmal dyskinesia in Markiesje dogs indicates SOD1 pleiotropy. Human genetics. vol 140. issue 11. 2021-10-22. PMID:33677640. |
our findings are similar to recent observations in human patients that a loss of function mutation in sod1 leads to a juvenile neurologic disease distinct from amyotrophic lateral sclerosis. |
2021-10-22 |
2023-08-13 |
human |
| Yinan Zhang, Radhia Benmohamed, Wei Zhang, Jinho Kim, Christina K Edgerly, Yaoqiu Zhu, Richard I Morimoto, Robert J Ferrante, Donald R Kirsch, Richard B Silverma. Chiral cyclohexane 1,3-diones as inhibitors of mutant SOD1-dependent protein aggregation for the treatment of ALS. ACS medicinal chemistry letters. vol 3. issue 7. 2021-10-21. PMID:22837812. |
cyclohexane 1,3-diones were identified as a class of molecules exhibiting a protective effect against mutant sod1 induced toxicity in pc-12 cells, but an optimized analogue had little or no effect on life extension in the g93a sod1 mouse model for amyotrophic lateral sclerosis (als). |
2021-10-21 |
2023-08-12 |
mouse |
| Esther S Choi, Nikolay V Dokholya. SOD1 oligomers in amyotrophic lateral sclerosis. Current opinion in structural biology. vol 66. 2021-10-15. PMID:33465527. |
sod1 oligomers in amyotrophic lateral sclerosis. |
2021-10-15 |
2023-08-13 |
Not clear |
| Anthony Agudelo, Victoria St Amand, Lindsey Grissom, Danielle Lafond, Toni Achilli, Asli Sahin, Robert Reenan, Geoff Stilwel. Age-dependent degeneration of an identified adult leg motor neuron in a Biology open. vol 9. issue 10. 2021-10-13. PMID:32994185. |
age-dependent degeneration of an identified adult leg motor neuron in a mutations in superoxide dismutase 1 (sod1) cause familial amyotrophic lateral sclerosis (als) in humans. |
2021-10-13 |
2023-08-13 |
Not clear |
| Julia M Harrison, Victor F Rafus. Muscle fiber-type specific terminal Schwann cell pathology leads to sprouting deficits following partial denervation in SOD1 Neurobiology of disease. vol 145. 2021-10-12. PMID:32827689. |
muscle fiber-type specific terminal schwann cell pathology leads to sprouting deficits following partial denervation in sod1 amyotrophic lateral sclerosis (als) is an adult-onset disease characterized by the progressive death of motoneurons and denervation of muscle fibers. |
2021-10-12 |
2023-08-13 |
Not clear |
| Lin Bai, Yafei Wang, Jia Huo, Shuai Li, Ya Wen, Qi Liu, Jing Yang, Yaling Liu, Rui L. Simvastatin accelerated motoneurons death in SOD1 Cell death & disease. vol 12. issue 4. 2021-10-12. PMID:33846297. |
simvastatin accelerated motoneurons death in sod1 amyotrophic lateral sclerosis (als) is a progressive neurodegenerative disease caused by motoneuron loss, for which there is currently no effective treatment. |
2021-10-12 |
2023-08-13 |
Not clear |
| Guillem Mòdol-Caballero, Mireia Herrando-Grabulosa, Sergi Verdés, Belén García-Lareu, Neus Hernández, Isaac Francos-Quijorna, Rubén López-Vales, Assumpció Bosch, Xavier Navarr. Gene Therapy Overexpressing Neuregulin 1 Type I in Combination With Neuregulin 1 Type III Promotes Functional Improvement in the SOD1 Frontiers in neurology. vol 12. 2021-10-12. PMID:34630277. |
gene therapy overexpressing neuregulin 1 type i in combination with neuregulin 1 type iii promotes functional improvement in the sod1 amyotrophic lateral sclerosis (als) is a fatal neurodegenerative disease affecting the neuromuscular system for which currently there is no effective therapy. |
2021-10-12 |
2023-08-13 |
mouse |
| Maia Farrugia Wismayer, Andrew Farrugia Wismayer, Adrian Pace, Neville Vassallo, Ruben J Cauch. SOD1 D91A variant in the southernmost tip of Europe: a heterozygous ALS patient resident on the island of Gozo. European journal of human genetics : EJHG. 2021-10-07. PMID:34616013. |
amyotrophic lateral sclerosis (als) is frequently caused by mutations in the sod1 gene. |
2021-10-07 |
2023-08-13 |
Not clear |
| Paulo Victor Sgobbi de Souza, Wladimir Bocca Vieira de Rezende Pinto, Igor Braga Farias, Bruno de Mattos Lombardi Badia, Icaro França Navarro Pinto, Gustavo Carvalho Costa, Carolina Maria Marin, Ana Carolina Dos Santos Jorge, Emília Correia Souto, Paulo de Lima Serrano, Roberta Ismael Lacerda Machado, Marco Antônio Troccoli Chieia, Enrico Bertini, Acary Souza Bulle Oliveir. Progressive spastic tetraplegia and axial hypotonia (STAHP) due to SOD1 deficiency: is it really a new entity? Orphanet journal of rare diseases. vol 16. issue 1. 2021-10-06. PMID:34380534. |
the main objective of this study is detail clinical, radiological, neurophysiological, and genetic findings of a brazilian cohort of patients with a recent described condition known as spastic tetraplegia and axial hypotonia (stahp) due to sod1 deficiency and compare with other cases described in the literature and discuss whether the clinical picture related to sod1 protein deficiency is a new entity or may be represent a very early-onset form of amyotrophic lateral sclerosis. |
2021-10-06 |
2023-08-13 |
Not clear |
| Cristina Ruiz-Ruiz, Nuria García-Magro, Pilar Negredo, Carlos Avendaño, Anindya Bhattacharya, Marc Ceusters, Antonio G Garcí. Chronic administration of P2X7 receptor antagonist JNJ-47965567 delays disease onset and progression, and improves motor performance in ALS SOD1 Disease models & mechanisms. vol 13. issue 10. 2021-10-01. PMID:33174532. |
chronic administration of p2x7 receptor antagonist jnj-47965567 delays disease onset and progression, and improves motor performance in als sod1 neuroinflammation is one of the main physiopathological mechanisms of amyotrophic lateral sclerosis (als), produced by the chronic activation of microglia in the cns. |
2021-10-01 |
2023-08-13 |
Not clear |
| Isabella Orienti, Monica Armida, Gabriella Dobrowolny, Rita Pepponi, Gabriella Sollazzini, Antonella Pezzola, Irene Casola, Antonio Musarò, Patrizia Popoli, Rosa Luisa Potenz. Fenretinide Beneficial Effects on Amyotrophic Lateral Sclerosis-associated SOD1 Neuroscience. vol 473. 2021-10-01. PMID:34363869. |
fenretinide beneficial effects on amyotrophic lateral sclerosis-associated sod1 amyotrophic lateral sclerosis (als) is the most frequent motor neuron disease for which effective treatment options are still lacking. |
2021-10-01 |
2023-08-13 |
Not clear |
| Ilaria Bicchi, Francesco Morena, Chiara Argentati, Laura Rota Nodari, Carla Emiliani, Maurizio Gelati, Angelo L Vescovi, Sabata Martin. Storage of Mutant Human SOD1 in Non-Neural Cells from the Type-1 Amyotrophic Lateral Sclerosis rat Biomedicines. vol 9. issue 9. 2021-10-01. PMID:34572266. |
storage of mutant human sod1 in non-neural cells from the type-1 amyotrophic lateral sclerosis rat herein, we explored the impact of the lysosome dysfunction during the progression of amyotrophic lateral sclerosis type-1 (als1). |
2021-10-01 |
2023-08-13 |
human |
| Ahmet Can Timucin, Suleyman Selim Cinaroglu, Osman Ugur Sezerman, Emel Timuci. Bridging the Bridging Imidazolate in the Bimetallic Center of the Cu/Zn SOD1 and ALS. Frontiers in chemistry. vol 9. 2021-09-21. PMID:34540798. |
metallation status of human cu/zn superoxide dismutase 1 (sod1) plays a pivotal role in the pathogenesis of amyotrophic lateral sclerosis (als). |
2021-09-21 |
2023-08-13 |
human |