| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Iago Méndez-López, Francisco J Sancho-Bielsa, Tobias Engel, Antonio G García, Juan Fernando Padí. Progressive Mitochondrial SOD1 International journal of molecular sciences. vol 22. issue 15. 2021-09-08. PMID:34360957. |
progressive mitochondrial sod1 in recent years, the "non-autonomous motor neuron death" hypothesis has become more consolidated behind amyotrophic lateral sclerosis (als). |
2021-09-08 |
2023-08-13 |
mouse |
| Gabriel Rodrigues Coutinho Pereira, Bárbara de Azevedo Abrahim Vieira, Joelma Freire De Mesquit. Comprehensive in silico analysis and molecular dynamics of the superoxide dismutase 1 (SOD1) variants related to amyotrophic lateral sclerosis. PloS one. vol 16. issue 2. 2021-08-31. PMID:33630959. |
comprehensive in silico analysis and molecular dynamics of the superoxide dismutase 1 (sod1) variants related to amyotrophic lateral sclerosis. |
2021-08-31 |
2023-08-13 |
Not clear |
| Stéphane Roudeau, Benjamin G Trist, Asuncion Carmona, Katherine M Davies, Glenda M Halliday, Yann Rufin, Stéphane Claverol, Stijn J M Van Malderen, Gerald Falkenberg, Kay L Double, Richard Orteg. Native Separation and Metallation Analysis of SOD1 Protein from the Human Central Nervous System: a Methodological Workflow. Analytical chemistry. vol 93. issue 32. 2021-08-31. PMID:34348022. |
abnormal metallation and aggregation of sod1 are suspected to play a role in amyotrophic lateral sclerosis and parkinson's disease, but data describing sod1 metal occupancy in human tissues have not previously been reported. |
2021-08-31 |
2023-08-13 |
human |
| Andrea Magrì, Pierpaolo Risiglione, Antonella Caccamo, Beatrice Formicola, Marianna Flora Tomasello, Cristina Arrigoni, Stefania Zimbone, Francesca Guarino, Francesca Re, Angela Messin. Small Hexokinase 1 Peptide against Toxic SOD1 G93A Mitochondrial Accumulation in ALS Rescues the ATP-Related Respiration. Biomedicines. vol 9. issue 8. 2021-08-30. PMID:34440152. |
mutations in cu/zn superoxide dismutase (sod1) gene represent one of the most common causes of amyotrophic lateral sclerosis (als), a fatal neurodegenerative disorder that specifically affects motor neurons (mns). |
2021-08-30 |
2023-08-13 |
Not clear |
| Marcia LeVatte, Matthias Lipfert, Dipankar Roy, Andriy Kovalenko, David Scott Wishar. Cloning and high-level expression of monomeric human superoxide dismutase 1 (SOD1) and its interaction with pyrimidine analogs. PloS one. vol 16. issue 2. 2021-08-27. PMID:33635895. |
superoxide dismutase 1 (sod1) is known to be involved in the pathogenesis of amyotrophic lateral sclerosis (als) and is therefore considered to be an important als drug target. |
2021-08-27 |
2023-08-13 |
human |
| Asako Otomo, Suzuka Ono, Kai Sato, Shun Mitsui, Kento Shimakura, Hiroshi Kimura, Shinji Hadan. High-throughput quantitative analysis of axonal transport in cultured neurons from SOD1 Neuroscience research. 2021-08-16. PMID:34352295. |
high-throughput quantitative analysis of axonal transport in cultured neurons from sod1 amyotrophic lateral sclerosis (als) is a neurodegenerative disease characterized by selective loss of motor neurons. |
2021-08-16 |
2023-08-13 |
mouse |
| Mio Une, Miho Yamakawa, Yasuhiro Watanabe, Kazuyuki Uchino, Naoto Honda, Mayuka Adachi, Mami Nakanishi, Akihiro Umezawa, Yasushi Kawata, Kenji Nakashima, Ritsuko Hanajim. SOD1-interacting proteins: Roles of aggregation cores and protein degradation systems. Neuroscience research. vol 170. 2021-08-04. PMID:32726594. |
cu/zn superoxide dismutase (sod1) mutations are associated with amyotrophic lateral sclerosis (als). |
2021-08-04 |
2023-08-13 |
mouse |
| M-D-M Amador, F Muratet, E Teyssou, S Boillée, S Millecamp. New advances in Amyotrophic Lateral Sclerosis genetics: Towards gene therapy opportunities for familial and young cases. Revue neurologique. vol 177. issue 5. 2021-07-29. PMID:33810837. |
screening of four main genes (c9orf72, sod1, tardbp and fus) identified the causes in 15% of amyotrophic lateral sclerosis (als) patients (two third of the familial cases and 8% of the sporadic ones) but their respective contribution to als phenotype varies according the age of disease onset. |
2021-07-29 |
2023-08-13 |
Not clear |
| Xiao Li, Chongyang Chen, Xu Zhan, Binyao Li, Zaijun Zhang, Shupeng Li, Yongmei Xie, Xiangrong Song, Yuanyuan Shen, Jianjun Liu, Ping Liu, Gong-Ping Liu, Xifei Yan. R13 preserves motor performance in SOD1 Theranostics. vol 11. issue 15. 2021-07-29. PMID:34158851. |
r13 preserves motor performance in sod1 amyotrophic lateral sclerosis (als) is a progressive neurodegenerative disease characterized by death of motor neurons in the brain and spinal cord. |
2021-07-29 |
2023-08-13 |
Not clear |
| Julia Post, Anja Schaffrath, Ian Gering, Sonja Hartwig, Stefan Lehr, N Jon Shah, Karl-Josef Langen, Dieter Willbold, Janine Kutzsche, Antje Willuwei. Oral Treatment with RD2RD2 Impedes Development of Motoric Phenotype and Delays Symptom Onset in SOD1 International journal of molecular sciences. vol 22. issue 13. 2021-07-21. PMID:34209129. |
oral treatment with rd2rd2 impedes development of motoric phenotype and delays symptom onset in sod1 neuroinflammation is a pathological hallmark of several neurodegenerative disorders and plays a key role in the pathogenesis of amyotrophic lateral sclerosis (als). |
2021-07-21 |
2023-08-13 |
Not clear |
| Tanya S McDonald, Vinod Kumar, Jenny N Fung, Trent M Woodruff, John D Le. Glucose clearance and uptake is increased in the SOD1 FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 35. issue 7. 2021-07-16. PMID:34118098. |
glucose clearance and uptake is increased in the sod1 metabolic disturbances are associated with the progression of the neurodegenerative disorder, amyotrophic lateral sclerosis (als). |
2021-07-16 |
2023-08-13 |
Not clear |
| Wenting Liu, Sharmila Venugopal, Sana Majid, In Sook Ahn, Graciel Diamante, Jason Hong, Xia Yang, Scott H Chandle. Single-cell RNA-seq analysis of the brainstem of mutant SOD1 mice reveals perturbed cell types and pathways of amyotrophic lateral sclerosis. Neurobiology of disease. vol 141. 2021-07-14. PMID:32360664. |
single-cell rna-seq analysis of the brainstem of mutant sod1 mice reveals perturbed cell types and pathways of amyotrophic lateral sclerosis. |
2021-07-14 |
2023-08-13 |
mouse |
| Isil Keskin, Elaheh Ekhtiari Bidhendi, Matthew Marklund, Peter M Andersen, Thomas Brännström, Stefan L Marklund, Ulrika Nordströ. Peripheral administration of SOD1 aggregates does not transmit pathogenic aggregation to the CNS of SOD1 transgenic mice. Acta neuropathologica communications. vol 9. issue 1. 2021-07-12. PMID:34158126. |
in transgenic (tg) mouse models of superoxide dismutase-1 (sod1)-linked amyotrophic lateral sclerosis (als), inoculation of minute amounts of human sod1 (hsod1) aggregates into the spinal cord or peripheral nerves induces premature als-like disease and template-directed hsod1 aggregation that spreads along the neuroaxis. |
2021-07-12 |
2023-08-13 |
mouse |
| Michael MacLean, Judyta Juranek, Swetha Cuddapah, Raquel López-Díez, Henry H Ruiz, Jiyuan Hu, Laura Frye, Huilin Li, Paul F Gugger, Ann Marie Schmid. Microglia RAGE exacerbates the progression of neurodegeneration within the SOD1 Journal of neuroinflammation. vol 18. issue 1. 2021-07-07. PMID:34130712. |
microglia rage exacerbates the progression of neurodegeneration within the sod1 burgeoning evidence highlights seminal roles for microglia in the pathogenesis of neurodegenerative diseases including amyotrophic lateral sclerosis (als). |
2021-07-07 |
2023-08-13 |
Not clear |
| Kate L Osman, Sabrina Kohlberg, Alexis Mok, Ryan Brooks, Lori A Lind, Katelyn McCormack, Andries Ferreira, Matan Kadosh, Mary K Fagan, Elizabeth Bearce, Nicole L Nichols, Joan R Coates, Teresa E Leve. Optimizing the Translational Value of Mouse Models of ALS for Dysphagia Therapeutic Discovery. Dysphagia. vol 35. issue 2. 2021-06-30. PMID:31300881. |
the goal of this study was to compare dysphagia phenotypes in low and high copy number (lcn and hcn) transgenic superoxide dismutase 1 (sod1) mouse models of als to accelerate the discovery of novel and effective treatments for dysphagia and early amyotrophic lateral sclerosis (als) diagnosis. |
2021-06-30 |
2023-08-13 |
mouse |
| Justin J Yerbury, Neil R Cashma. Selenium-based compounds: Emerging players in the ever-unfolding story of SOD1 in amyotrophic lateral sclerosis. EBioMedicine. vol 59. 2021-06-29. PMID:32891934. |
selenium-based compounds: emerging players in the ever-unfolding story of sod1 in amyotrophic lateral sclerosis. |
2021-06-29 |
2023-08-13 |
Not clear |
| Hai-Yan Shang, Jing-Jing Zhang, Zhen-Fa Fu, Yu-Fei Liu, Song Li, Sheng Chen, Wei-Dong L. Therapeutic effects of hirsutella sinensis on the disease onset and progression of amyotrophic lateral sclerosis in SOD1 CNS neuroscience & therapeutics. vol 26. issue 1. 2021-06-25. PMID:31318169. |
therapeutic effects of hirsutella sinensis on the disease onset and progression of amyotrophic lateral sclerosis in sod1 although the pathophysiology of amyotrophic lateral sclerosis (als) is still not completely understood, the deregulated microglia polarization and neuroinflammation have been shown to contribute to the pathogenesis and progression of this disease. |
2021-06-25 |
2023-08-13 |
Not clear |
| N Rei, D M Rombo, M F Ferreira, Y Baqi, C E Müller, J A Ribeiro, A M Sebastião, S H Va. Hippocampal synaptic dysfunction in the SOD1 Neuropharmacology. vol 171. 2021-06-25. PMID:32311420. |
hippocampal synaptic dysfunction in the sod1 amyotrophic lateral sclerosis (als) mostly affects motor neurons, but non-motor neural and cognitive alterations have been reported in als mouse models and patients. |
2021-06-25 |
2023-08-13 |
mouse |
| Koh Tadokoro, Toru Yamashita, Jingwei Shang, Yasuyuki Ohta, Emi Nomura, Ryuta Morihara, Yoshio Omote, Mami Takemoto, Koji Ab. Switching the Proteolytic System from the Ubiquitin-Proteasome System to Autophagy in the Spinal Cord of an Amyotrophic Lateral Sclerosis Mouse Model. Neuroscience. vol 466. 2021-06-22. PMID:33974963. |
however, since it is unclear how these two proteolytic pathways contribute to the pathogenesis of amyotrophic lateral sclerosis (als), we investigated the switching mechanism from ups to autophagy by pharmacologically modifying these pathways by treating the spinal cords of female als mouse model bearing g93a human sod1 (g93a mice) with mg132 or 3-methyladenine (3ma). |
2021-06-22 |
2023-08-13 |
mouse |
| Katherine E A Lewis, William Bennett, Christopher L Blizzard, Adrian K West, Roger S Chung, Meng Inn Chua. The influence of metallothionein treatment and treadmill running exercise on disease onset and survival in SOD1 The European journal of neuroscience. vol 52. issue 4. 2021-06-21. PMID:31954073. |
the influence of metallothionein treatment and treadmill running exercise on disease onset and survival in sod1 amyotrophic lateral sclerosis (als) is a fatal neurodegenerative disease, characterised by the degeneration of motor neurons innervating skeletal muscle. |
2021-06-21 |
2023-08-13 |
Not clear |