| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Guillem Mòdol-Caballero, Mireia Herrando-Grabulosa, Belén García-Lareu, Neus Solanes, Sergi Verdés, Rosario Osta, Isaac Francos-Quijorna, Rubèn López-Vales, Ana Cristina Calvo, Assumpció Bosch, Xavier Navarr. Gene therapy for overexpressing Neuregulin 1 type I in skeletal muscles promotes functional improvement in the SOD1 Neurobiology of disease. vol 137. 2021-01-15. PMID:32032731. |
gene therapy for overexpressing neuregulin 1 type i in skeletal muscles promotes functional improvement in the sod1 amyotrophic lateral sclerosis (als) is a neurodegenerative disorder affecting motoneurons (mns), with no effective treatment currently available. |
2021-01-15 |
2023-08-13 |
Not clear |
| Sonam Parakh, Sina Shadfar, Emma R Perri, Audrey M G Ragagnin, Claudia V Piattoni, Mariela B Fogolín, Kristy C Yuan, Hamideh Shahheydari, Emily K Don, Collen J Thomas, Yuning Hong, Marcelo A Comini, Angela S Laird, Damian M Spencer, Julie D Atki. The Redox Activity of Protein Disulfide Isomerase Inhibits ALS Phenotypes in Cellular and Zebrafish Models. iScience. vol 23. issue 5. 2021-01-10. PMID:32446203. |
pathological forms of tar dna-binding protein 43 (tdp-43) are present in almost all cases of amyotrophic lateral sclerosis (als), and 20% of familial als cases are due to mutations in superoxide dismutase 1 (sod1). |
2021-01-10 |
2023-08-13 |
zebrafish |
| Sevda Diker, Pınar Gelener, Kerem Teralı, Mahmut Cerkez Ergoren, Ceren Tunca, A Nazlı Başak, Ersin Ta. A combined clinical and computational approach to understand the SOD1 Acta neurologica Belgica. 2021-01-09. PMID:33420941. |
a combined clinical and computational approach to understand the sod1 here, we aim to provide a comprehensive clinical and biomolecular description of familial amyotrophic lateral sclerosis (fals) in a 25-year-old female patient with respect to the sod1 |
2021-01-09 |
2023-08-13 |
Not clear |
| Xiaoyu Zhuang, Xiuxiu Li, Bing Zhao, Zhiqiang Liu, Fengrui Song, Jianzhong L. Native Mass Spectrometry Based Method for Studying the Interactions between Superoxide Dismutase 1 and Stilbenoids. ACS chemical neuroscience. vol 11. issue 2. 2020-12-21. PMID:31820923. |
to inhibit the abnormal aggregation of cu, zn-superoxide dismutase (sod1) is regarded as a potential therapeutic strategy of sod1-linked amyotrophic lateral sclerosis (als). |
2020-12-21 |
2023-08-13 |
Not clear |
| Sara L Dominguez, Timothy Earr, Michelle Dourado, Hai Ngu, William J Meilandt, Jesse E Hanso. Inducible EphA4 knockout causes motor deficits in young mice and is not protective in the SOD1 Scientific reports. vol 10. issue 1. 2020-12-18. PMID:32973290. |
inducible epha4 knockout causes motor deficits in young mice and is not protective in the sod1 amyotrophic lateral sclerosis (als) is a neurodegenerative disease characterized by motor neuron loss that ultimately leads to fatal paralysis. |
2020-12-18 |
2023-08-13 |
mouse |
| Cindy Gill, James P Phelan, Theo Hatzipetros, Joshua D Kidd, Valerie R Tassinari, Beth Levine, Monica Z Wang, Andrew Moreno, Kenneth Thompson, Marcel Maier, Jan Grimm, Alan Gill, Fernando G Vieir. SOD1-positive aggregate accumulation in the CNS predicts slower disease progression and increased longevity in a mutant SOD1 mouse model of ALS. Scientific reports. vol 9. issue 1. 2020-12-04. PMID:31040321. |
non-natively folded variants of superoxide dismutase 1 (sod1) are thought to contribute to the pathogenesis of familial amyotrophic lateral sclerosis (als), however the relative toxicities of these variants are controversial. |
2020-12-04 |
2023-08-13 |
mouse |
| E I Ustyantseva, S P Medvedev, A S Vetchinova, S N Illarioshkin, S V Leonov, S M Zakia. Generation of an induced pluripotent stem cell line, ICGi014-A, by reprogramming peripheral blood mononuclear cells from a patient with homozygous D90A mutation in SOD1 causing Amyotrophic lateral sclerosis. Stem cell research. vol 42. 2020-12-04. PMID:31830646. |
generation of an induced pluripotent stem cell line, icgi014-a, by reprogramming peripheral blood mononuclear cells from a patient with homozygous d90a mutation in sod1 causing amyotrophic lateral sclerosis. |
2020-12-04 |
2023-08-13 |
Not clear |
| Rachelle Balez, Tracey Berg, Monique Bax, Sonia Sanz Muñoz, Mauricio C Cabral-da-Silva, Martin Engel, Dzung Do-Ha, Claire H Stevens, Dominic Rowe, Shu Yang, Ian P Blair, Lezanne Oo. The mRNA-based reprogramming of fibroblasts from a SOD1 Stem cell research. vol 42. 2020-12-04. PMID:32006803. |
the mrna-based reprogramming of fibroblasts from a sod1 dermal fibroblasts were donated by a 43 year old male patient with clinically diagnosed familial amyotrophic lateral sclerosis (als), carrying the sod1 |
2020-12-04 |
2023-08-13 |
Not clear |
| Stefanie D Boyd, Morgan S Ullrich, Jenifer S Calvo, Fatemeh Behnia, Gabriele Meloni, Duane D Winkle. Mutations in Superoxide Dismutase 1 (Sod1) Linked to Familial Amyotrophic Lateral Sclerosis Can Disrupt High-Affinity Zinc-Binding Promoted by the Copper Chaperone for Sod1 (Ccs). Molecules (Basel, Switzerland). vol 25. issue 5. 2020-12-04. PMID:32121118. |
mutations in superoxide dismutase 1 (sod1) linked to familial amyotrophic lateral sclerosis can disrupt high-affinity zinc-binding promoted by the copper chaperone for sod1 (ccs). |
2020-12-04 |
2023-08-13 |
Not clear |
| Stefanie D Boyd, Morgan S Ullrich, Jenifer S Calvo, Fatemeh Behnia, Gabriele Meloni, Duane D Winkle. Mutations in Superoxide Dismutase 1 (Sod1) Linked to Familial Amyotrophic Lateral Sclerosis Can Disrupt High-Affinity Zinc-Binding Promoted by the Copper Chaperone for Sod1 (Ccs). Molecules (Basel, Switzerland). vol 25. issue 5. 2020-12-04. PMID:32121118. |
while there are a multitude of sod1 mutations linked to the familial form of amyotrophic lateral sclerosis (fals), characterizations by multiple research groups have been unable to realize strong commonalities among mutants. |
2020-12-04 |
2023-08-13 |
Not clear |
| Emily Feneberg, Martin R Turner, Olaf Ansorge, Kevin Talbo. Amyotrophic lateral sclerosis with a heterozygous D91A SOD1 variant and classical ALS-TDP neuropathology. Neurology. vol 95. issue 13. 2020-12-04. PMID:32769137. |
amyotrophic lateral sclerosis with a heterozygous d91a sod1 variant and classical als-tdp neuropathology. |
2020-12-04 |
2023-08-13 |
Not clear |
| Kallol Dutta, Sai Sampath Thammisetty, Hejer Boutej, Christine Bareil, Jean-Pierre Julie. Mitigation of ALS Pathology by Neuron-Specific Inhibition of Nuclear Factor Kappa B Signaling. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 26. 2020-11-20. PMID:32457070. |
to investigate the role of neuronal nf-κb activity in pathogenesis of amyotrophic lateral sclerosis (als), we generated transgenic mice with neuron-specific expression of a super-repressor form of the nf-κb inhibitor (iκbα-sr), which were then crossed with mice of both sexes, expressing als-linked gene mutants for tar dna-binding protein (tdp-43) and superoxide dismutase 1 (sod1). |
2020-11-20 |
2023-08-13 |
mouse |
| Dharma Rao Tompa, Saraboji Kadhirve. Changes in hydrophobicity mainly promotes the aggregation tendency of ALS associated SOD1 mutants. International journal of biological macromolecules. vol 145. 2020-11-19. PMID:31669277. |
the mutations in cu/zn superoxide dismutase (sod1) causing its misfolding and aggregation are found linked to the motor neuron disorder, amyotrophic lateral sclerosis. |
2020-11-19 |
2023-08-13 |
Not clear |
| Myung Geun Kook, SeungEun Lee, Nari Shin, Dasom Kong, Da-Hyun Kim, Min-Soo Kim, Hyun Kyoung Kang, Soon Won Choi, Kyung-Sun Kan. Repeated intramuscular transplantations of hUCB-MSCs improves motor function and survival in the SOD1 G Scientific reports. vol 10. issue 1. 2020-11-17. PMID:32005848. |
repeated intramuscular transplantations of hucb-mscs improves motor function and survival in the sod1 g amyotrophic lateral sclerosis (als) is a fatal neurodegenerative disease that is characterized by loss of motor neurons and degeneration of neuromuscular junctions. |
2020-11-17 |
2023-08-13 |
human |
| Mengqi Zhang, Sahar Gelfman, Janice McCarthy, Matthew B Harms, Cristiane A M Moreno, David B Goldstein, Andrew S Alle. Incorporating external information to improve sparse signal detection in rare-variant gene-set-based analyses. Genetic epidemiology. vol 44. issue 4. 2020-11-10. PMID:32043633. |
we illustrate our approach with a gene-set analysis of amyotrophic lateral sclerosis (als) and implicate a number of gene-sets containing sod1 and nek1 as well as showing enrichment of small p values for gene-sets containing known als genes. |
2020-11-10 |
2023-08-13 |
Not clear |
| Eric J Granucci, Ana Griciuc, Kaly A Mueller, Alexandra N Mills, Hoang Le, Amanda M Dios, Danielle McGinty, Joao Pereira, David Elmaleh, James D Berry, Sabrina Paganoni, Merit E Cudkowicz, Rudolph E Tanzi, Ghazaleh Sadri-Vakil. Cromolyn sodium delays disease onset and is neuroprotective in the SOD1 Scientific reports. vol 9. issue 1. 2020-11-03. PMID:31776380. |
cromolyn sodium delays disease onset and is neuroprotective in the sod1 accumulating evidence suggests that neuroinflammatory processes are implicated in the initiation and progression of amyotrophic lateral sclerosis (als). |
2020-11-03 |
2023-08-13 |
Not clear |
| Qi Zhou, Lei Zhu, Weiwen Qiu, Yue Liu, Fang Yang, Wenzhi Chen, Renshi X. Nicotinamide Riboside Enhances Mitochondrial Proteostasis and Adult Neurogenesis through Activation of Mitochondrial Unfolded Protein Response Signaling in the Brain of ALS SOD1 International journal of biological sciences. vol 16. issue 2. 2020-11-02. PMID:31929756. |
nicotinamide riboside enhances mitochondrial proteostasis and adult neurogenesis through activation of mitochondrial unfolded protein response signaling in the brain of als sod1 amyotrophic lateral sclerosis (als) is caused by the progressive degeneration of motor neurons in the spinal cord, the brain stem, and the motor cortex. |
2020-11-02 |
2023-08-13 |
human |
| Fabian Kreilaus, Stefan Guerra, Rebecca Masanetz, Victoria Menne, Justin Yerbury, Tim Kar. Novel behavioural characteristics of the superoxide dismutase 1 G93A (SOD1 Genes, brain, and behavior. vol 19. issue 2. 2020-10-07. PMID:31412164. |
novel behavioural characteristics of the superoxide dismutase 1 g93a (sod1 amyotrophic lateral sclerosis (als) involves the rapid degeneration of upper and lower motor neurons leading to weakening and paralysis of voluntary movements. |
2020-10-07 |
2023-08-13 |
Not clear |
| Aron Workma. Nucleation and kinetics of SOD1 aggregation in human cells for ALS1. Molecular and cellular biochemistry. vol 466. issue 1-2. 2020-10-07. PMID:32056106. |
aberrant structural formations of cu/zn superoxide dismutase enzyme (sod1) are the probable mechanism by which circumscribed mutations in the sod1 gene cause familial amyotrophic lateral sclerosis (als1). |
2020-10-07 |
2023-08-13 |
human |
| Ivana Sirangelo, Filomena M Vella, Gaetano Irace, Giuseppe Manco, Clara Iannuzz. Glycation in Demetalated Superoxide Dismutase 1 Prevents Amyloid Aggregation and Produces Cytotoxic Ages Adducts. Frontiers in molecular biosciences. vol 3. 2020-10-01. PMID:27695694. |
superoxide dismutase 1 (sod1) has been implicated with familial amyotrophic lateral sclerosis (fals) through accumulation of protein amyloid aggregates in motor neurons of patients. |
2020-10-01 |
2023-08-13 |
Not clear |