| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Katherine E A Lewis, William Bennett, Christopher L Blizzard, Adrian K West, Roger S Chung, Meng Inn Chua. The influence of metallothionein treatment and treadmill running exercise on disease onset and survival in SOD1 The European journal of neuroscience. vol 52. issue 4. 2021-06-21. PMID:31954073. |
the influence of metallothionein treatment and treadmill running exercise on disease onset and survival in sod1 amyotrophic lateral sclerosis (als) is a fatal neurodegenerative disease, characterised by the degeneration of motor neurons innervating skeletal muscle. |
2021-06-21 |
2023-08-13 |
Not clear |
| Jun Zhu, Ningjing Ou, Yuxuan Song, Rui Hu, Wei Zhang, Zhen Liang, Yongjiao Yang, Xiaoqiang Li. Identification and verification of key genes in varicocele rats through high-throughput sequencing and bioinformatics analysis. Andrologia. vol 52. issue 9. 2021-06-21. PMID:32459877. |
gene ontology (go) functional enrichment analysis and kyoto encyclopedia of genes and genomes (kegg) pathway enrichment analysis demonstrated that sod1, casp9, atg7, casp3 and sirt1 are enriched in regulation of oxidative stress-induced cell death (go:1,903,201) and amyotrophic lateral sclerosis (kegg:05,014). |
2021-06-21 |
2023-08-13 |
rat |
| Dharma Rao Tompa, Sureshan Muthusamy, Srimari Srikanth, Saraboji Kadhirve. Molecular dynamics of far positioned surface mutations of Cu/Zn SOD1 promotes altered structural stability and metal-binding site: Structural clues to the pathogenesis of amyotrophic lateral sclerosis. Journal of molecular graphics & modelling. vol 100. 2021-06-21. PMID:32768728. |
molecular dynamics of far positioned surface mutations of cu/zn sod1 promotes altered structural stability and metal-binding site: structural clues to the pathogenesis of amyotrophic lateral sclerosis. |
2021-06-21 |
2023-08-13 |
Not clear |
| Dharma Rao Tompa, Sureshan Muthusamy, Srimari Srikanth, Saraboji Kadhirve. Molecular dynamics of far positioned surface mutations of Cu/Zn SOD1 promotes altered structural stability and metal-binding site: Structural clues to the pathogenesis of amyotrophic lateral sclerosis. Journal of molecular graphics & modelling. vol 100. 2021-06-21. PMID:32768728. |
cu/zn superoxide dismutase (sod1) mutations are associated to the motor neuron disorder, amyotrophic lateral sclerosis (als), which is characterized by aggregates of the misfolded proteins. |
2021-06-21 |
2023-08-13 |
Not clear |
| Itsuki Anzai, Eiichi Tokuda, Sumika Handa, Hidemi Misawa, Shuji Akiyama, Yoshiaki Furukaw. Oxidative misfolding of Cu/Zn-superoxide dismutase triggered by non-canonical intramolecular disulfide formation. Free radical biology & medicine. vol 147. 2021-06-18. PMID:31863908. |
misfolded cu/zn-superoxide dismutase (sod1) is a pathological species in a subset of amyotrophic lateral sclerosis (als). |
2021-06-18 |
2023-08-13 |
Not clear |
| Lucas S Dantas, Lucas G Viviani, Alex Inague, Erika Piccirillo, Leandro de Rezende, Graziella E Ronsein, Ohara Augusto, Marisa H G Medeiros, Antonia T do Amaral, Sayuri Miyamot. Lipid aldehyde hydrophobicity affects apo-SOD1 modification and aggregation. Free radical biology & medicine. vol 156. 2021-06-18. PMID:32598986. |
the accumulation of cu,zn-superoxide dismutase (sod1) aggregates has been associated with familial cases of amyotrophic lateral sclerosis (als). |
2021-06-18 |
2023-08-13 |
human |
| SOD1 Targeted as Treatment for Amyotrophic Lateral Sclerosis. American journal of medical genetics. Part A. vol 182. issue 11. 2021-06-15. PMID:33200912. |
sod1 targeted as treatment for amyotrophic lateral sclerosis. |
2021-06-15 |
2023-08-13 |
Not clear |
| Emma R Perri, Sonam Parakh, Marta Vidal, Prachi Mehta, Yi Ma, Adam K Walker, Julie D Atki. The Cysteine (Cys) Residues Cys-6 and Cys-111 in Mutant Superoxide Dismutase 1 (SOD1) A4V Are Required for Induction of Endoplasmic Reticulum Stress in Amyotrophic Lateral Sclerosis. Journal of molecular neuroscience : MN. vol 70. issue 9. 2021-06-10. PMID:32445072. |
the cysteine (cys) residues cys-6 and cys-111 in mutant superoxide dismutase 1 (sod1) a4v are required for induction of endoplasmic reticulum stress in amyotrophic lateral sclerosis. |
2021-06-10 |
2023-08-13 |
Not clear |
| Chetan Singh Rajpurohit, Vivek Kumar, Arquimedes Cheffer, Danyllo Oliveira, Henning Ulrich, Oswaldo Keith Okamoto, Mayana Zatz, Uzair Ahmad Ansari, Vinay Kumar Khanna, Aditya Bhushan Pan. Mechanistic Insights of Astrocyte-Mediated Hyperactive Autophagy and Loss of Motor Neuron Function in SOD1 Molecular neurobiology. vol 57. issue 10. 2021-06-09. PMID:32676988. |
mechanistic insights of astrocyte-mediated hyperactive autophagy and loss of motor neuron function in sod1 amyotrophic lateral sclerosis (als) is a fatal neurodegenerative disorder with no cure. |
2021-06-09 |
2023-08-13 |
Not clear |
| Jacob I Ayers, Guilian Xu, Kristy Dillon, Qing Lu, Zhijuan Chen, John Beckman, Alma K Moreno-Romero, Diana L Zamora, Ahmad Galaleldeen, David R Borchel. Variation in the vulnerability of mice expressing human superoxide dismutase 1 to prion-like seeding: a study of the influence of primary amino acid sequence. Acta neuropathologica communications. vol 9. issue 1. 2021-06-07. PMID:34016165. |
misfolded forms of superoxide dismutase 1 (sod1) with mutations associated with familial amyotrophic lateral sclerosis (fals) exhibit prion characteristics, including the ability to act as seeds to accelerate motor neuron disease in mouse models. |
2021-06-07 |
2023-08-13 |
mouse |
| Gareth S A Wrigh. Molecular and pharmacological chaperones for SOD1. Biochemical Society transactions. vol 48. issue 4. 2021-06-01. PMID:32794552. |
mutations can prevent sod1 post-translational processing leading to misfolding and cytoplasmic aggregation in familial amyotrophic lateral sclerosis (als). |
2021-06-01 |
2023-08-13 |
Not clear |
| Kashfia Shafiq, Nitesh Sanghai, Ying Guo, Jiming Kon. Implication of post-translationally modified SOD1 in pathological aging. GeroScience. vol 43. issue 2. 2021-05-31. PMID:33608813. |
in this review, we focus on some of the dominant paradigms of pathological aging, such as amyotrophic lateral sclerosis (als), alzheimer's disease (ad), and parkinson's disease (pd), and predict that the antioxidant superoxide dismutase 1 (sod1), when post-translationally modified by aging-associated oxidative stress, acts as a mechanism to accelerated aging in these age-related neurodegenerative diseases. |
2021-05-31 |
2023-08-13 |
Not clear |
| Carmen Hummel, Omid Leylamian, Anna Pösch, Joachim Weis, Eleonora Aronica, Cordian Beyer, Sonja Johan. Expression and Cell Type-specific Localization of Inflammasome Sensors in the Spinal Cord of SOD1 Neuroscience. vol 463. 2021-05-19. PMID:33781799. |
expression and cell type-specific localization of inflammasome sensors in the spinal cord of sod1 inflammasomes are key components of the innate immune system and activation of these multiprotein platforms is a crucial event in the etiopathology of amyotrophic lateral sclerosis (als). |
2021-05-19 |
2023-08-13 |
Not clear |
| Takumi Ohyama, Kunisato Kuroi, Taiyu Wakabayashi, Nobuhiro Fujimaki, Takakazu Nakabayash. Enhancement of Oxidative Reaction by the Intramolecular Electron Transfer between the Coordinated Redox-Active Metal Ions in SOD1. The journal of physical chemistry. B. vol 124. issue 11. 2021-05-14. PMID:32101437. |
the denatured cu, zn superoxide dismutase (sod1) has the pro-oxidant activity that is suggested to be related with the pathogenesis of amyotrophic lateral sclerosis (als). |
2021-05-14 |
2023-08-13 |
Not clear |
| Lev Starikov, Andreas H Kottman. Diminished Ventral Oligodendrocyte Precursor Generation Results in the Subsequent Over-production of Dorsal Oligodendrocyte Precursors of Aberrant Morphology and Function. Neuroscience. vol 450. 2021-05-14. PMID:32450295. |
these opcs take on an altered morphology, do not participate in the removal of excitatory vglut1 synapses from injured motor neurons, and exhibit morphological features similar to those found in the vicinity of motor neurons in the sod1 mouse model of amyotrophic lateral sclerosis (als). |
2021-05-14 |
2023-08-13 |
mouse |
| Naoto Iwakawa, Daichi Morimoto, Erik Walinda, Sarah Leeb, Masahiro Shirakawa, Jens Danielsson, Kenji Sugas. Transient Diffusive Interactions with a Protein Crowder Affect Aggregation Processes of Superoxide Dismutase 1 β-Barrel. The journal of physical chemistry. B. vol 125. issue 10. 2021-05-14. PMID:33657322. |
aggregate formation of superoxide dismutase 1 (sod1) inside motor neurons is known as a major factor in onset of amyotrophic lateral sclerosis. |
2021-05-14 |
2023-08-13 |
Not clear |
| Chika Takashima, Yasuhiro Kosuge, Masahisa Inoue, Shin-Ichi Ono, Eiichi Tokud. A Metal-Free, Disulfide Oxidized Form of Superoxide Dismutase 1 as a Primary Misfolded Species with Prion-Like Properties in the Extracellular Environments Surrounding Motor Neuron-Like Cells. International journal of molecular sciences. vol 22. issue 8. 2021-05-12. PMID:33923808. |
superoxide dismutase 1 (sod1) is a metalloenzyme with high structural stability, but a lack of cu and zn ions decreases its stability and enhances the likelihood of misfolding, which is a pathological hallmark of amyotrophic lateral sclerosis (als). |
2021-05-12 |
2023-08-13 |
Not clear |
| Annarita Miccio, Panagiotis Antoniou, Sorana Ciura, Edor Kabash. Novel genome-editing-based approaches to treat motor neuron diseases: Promises and challenges. Molecular therapy : the journal of the American Society of Gene Therapy. 2021-04-29. PMID:33823304. |
amyotrophic lateral sclerosis (als) is caused by a number of mutations, with c9orf72 repeat expansions the most common genetic cause and sod1 gain-of-function mutations the first genetic cause identified for this disease. |
2021-04-29 |
2023-08-13 |
Not clear |
| Edmund Charles Jenkins, Gabriella Casalena, Maria Gomez, Dazhi Zhao, Timothy C Kenny, Nagma Shah, Giovanni Manfredi, Doris Germai. Raloxifene is a Female-specific Proteostasis Therapeutic in the Spinal Cord. Endocrinology. vol 162. issue 2. 2021-04-28. PMID:33269387. |
in the sod1-g93a mouse model of amyotrophic lateral sclerosis, we found that even a low dose of raloxifene causes a significant decrease in mutant sod1 aggregates in the spinal cord, accompanied by a delay in the decline of muscle strength in females, but not in males. |
2021-04-28 |
2023-08-13 |
mouse |
| Hanhui Fu, Kang Zhang, Xunzhe Yang, Libo Li, Liying Cu. Slow progression of amyotrophic lateral sclerosis in a Chinese patient carrying SOD1 p.S135T mutation. Amyotrophic lateral sclerosis & frontotemporal degeneration. 2021-04-16. PMID:33860706. |
slow progression of amyotrophic lateral sclerosis in a chinese patient carrying sod1 p.s135t mutation. |
2021-04-16 |
2023-08-13 |
Not clear |