| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' Gabriella Dobrowolny, Elisa Lepore, Martina Martini, Laura Barberi, Abigail Nunn, Bianca Maria Scicchitano, Antonio Musar\\xc3\\xb. Metabolic Changes Associated With Muscle Expression of SOD1 Frontiers in physiology. vol 9. 2020-10-01. PMID:30042688.' |
metabolic changes associated with muscle expression of sod1 amyotrophic lateral sclerosis (als) is a severe neurodegenerative disorder, classified into sporadic or familial forms and characterized by motor neurons death, muscle atrophy, weakness, and paralysis. |
2020-10-01 |
2023-08-13 |
mouse |
| Daisy Sproviero, Sabrina La Salvia, Marta Giannini, Valeria Crippa, Stella Gagliardi, Stefano Bernuzzi, Luca Diamanti, Mauro Ceroni, Orietta Pansarasa, Angelo Poletti, Cristina Cered. Pathological Proteins Are Transported by Extracellular Vesicles of Sporadic Amyotrophic Lateral Sclerosis Patients. Frontiers in neuroscience. vol 12. 2020-10-01. PMID:30072868. |
amyotrophic lateral sclerosis (als) is a progressive adult-onset neurodegenerative disease, that affects cortical, bulbar and spinal motor neurons, and it is considered a proteinopathy, in which pathological proteins (sod1, tdp-43, and fus) may accumulate and interfere with neuronal functions eventually leading to cell death. |
2020-10-01 |
2023-08-13 |
Not clear |
| Matteo Bordoni, Orietta Pansarasa, Michela Dell'Orco, Valeria Crippa, Stella Gagliardi, Daisy Sproviero, Stefano Bernuzzi, Luca Diamanti, Mauro Ceroni, Gabriella Tedeschi, Angelo Poletti, Cristina Cered. Nuclear Phospho-SOD1 Protects DNA from Oxidative Stress Damage in Amyotrophic Lateral Sclerosis. Journal of clinical medicine. vol 8. issue 5. 2020-10-01. PMID:31121901. |
we already demonstrated that in peripheral blood mononuclear cells (pbmcs) of sporadic amyotrophic lateral sclerosis (sals) patients, superoxide dismutase 1 (sod1) was present in an aggregated form in the cytoplasmic compartment. |
2020-10-01 |
2023-08-13 |
Not clear |
| Anna Shteinfer-Kuzmine, Shirel Argueti, Rajeev Gupta, Neta Shvil, Salah Abu-Hamad, Yael Gropper, Jan Hoeber, Andrea Magrì, Angela Messina, Elena N Kozlova, Varda Shoshan-Barmatz, Adrian Israelso. A VDAC1-Derived N-Terminal Peptide Inhibits Mutant SOD1-VDAC1 Interactions and Toxicity in the SOD1 Model of ALS. Frontiers in cellular neuroscience. vol 13. 2020-10-01. PMID:31474832. |
mutations in superoxide dismutase (sod1) are the second most common cause of familial amyotrophic lateral sclerosis (als), a fatal neurodegenerative disease caused by the death of motor neurons in the brain and spinal cord. |
2020-10-01 |
2023-08-13 |
Not clear |
| Cecilia Garcia, Jose Manuel Vidal-Taboada, Enrique Syriani, Maria Salvado, Miguel Morales, Josep Game. Haplotype Analysis of the First A4V- Frontiers in genetics. vol 10. 2020-10-01. PMID:31781168. |
haplotype analysis of the first a4v- despite the genetic heterogeneity reported in familial amyotrophic lateral sclerosis (als) (fals), cu/zn superoxide-dismutase (sod1) gene mutations are the second most common cause of the disease, accounting for around 20% of all families (als1) and isolated sporadic cases (sals). |
2020-10-01 |
2023-08-13 |
human |
| Gabriel N Valbuena, Lavinia Cantoni, Massimo Tortarolo, Caterina Bendotti, Hector C Keu. Spinal Cord Metabolic Signatures in Models of Fast- and Slow-Progressing SOD1 Frontiers in neuroscience. vol 13. 2020-10-01. PMID:31920474. |
spinal cord metabolic signatures in models of fast- and slow-progressing sod1 the rate of disease progression in amyotrophic lateral sclerosis (als) is highly variable, even between patients with the same genetic mutations. |
2020-10-01 |
2023-08-13 |
Not clear |
| Anika M Helferich, Pamela J McLean, Jochen H Weishaupt, Karin M Danze. Commentary: alpha-synuclein interacts with SOD1 and promotes its oligomerization. Journal of neurology & neuromedicine. vol 1. issue 7. 2020-09-30. PMID:27853754. |
alpha-synuclein and cu, zn superoxide dismutase (sod1) are both aggregation-prone proteins that are associated with parkinson's disease (pd) and amyotrophic lateral sclerosis (als), respectively. |
2020-09-30 |
2023-08-13 |
human |
| Luke McAlary, J Andrew Aquilina, Justin J Yerbur. Susceptibility of Mutant SOD1 to Form a Destabilized Monomer Predicts Cellular Aggregation and Toxicity but Not Frontiers in neuroscience. vol 10. 2020-09-30. PMID:27867347. |
susceptibility of mutant sod1 to form a destabilized monomer predicts cellular aggregation and toxicity but not amyotrophic lateral sclerosis (als) is a fatal neurodegenerative disease characterized by the rapid and progressive degeneration of upper and lower motor neurons in the spinal cord, brain stem and motor cortex. |
2020-09-30 |
2023-08-13 |
Not clear |
| René Günther, Alexander Balck, Jan C Koch, Tobias Nientiedt, Michael Sereda, Mathias Bähr, Paul Lingor, Lars Tönge. Rho Kinase Inhibition with Fasudil in the SOD1 Frontiers in pharmacology. vol 8. 2020-09-30. PMID:28197100. |
rho kinase inhibition with fasudil in the sod1 despite an improved understanding of the genetic background and the pathomechanisms of amyotrophic lateral sclerosis (als) no novel disease-modifying therapies have been successfully implemented in clinical routine. |
2020-09-30 |
2023-08-13 |
mouse |
| Rachael Bartlett, Vanessa Sluyter, Debbie Watson, Ronald Sluyter, Justin J Yerbur. P2X7 antagonism using Brilliant Blue G reduces body weight loss and prolongs survival in female SOD1 PeerJ. vol 5. 2020-09-30. PMID:28265522. |
p2x7 antagonism using brilliant blue g reduces body weight loss and prolongs survival in female sod1 amyotrophic lateral sclerosis (als) is a rapidly progressive neurodegenerative disease characterised by the accumulation of aggregated proteins, microglia activation and motor neuron loss. |
2020-09-30 |
2023-08-13 |
Not clear |
| Alexandre Henriques, Vincent Croixmarie, Alexandra Bouscary, Althéa Mosbach, Céline Keime, Claire Boursier-Neyret, Bernard Walter, Michael Spedding, Jean-Philippe Loeffle. Sphingolipid Metabolism Is Dysregulated at Transcriptomic and Metabolic Levels in the Spinal Cord of an Animal Model of Amyotrophic Lateral Sclerosis. Frontiers in molecular neuroscience. vol 10. 2020-09-30. PMID:29354030. |
to gain insight into the molecular mechanisms underlying disease progression in amyotrophic lateral sclerosis, we have performed rna-sequencing and lipidomic profiling in spinal cord of symptomatic sod1 |
2020-09-30 |
2023-08-13 |
Not clear |
| Simona Damiano, Anna Sasso, Roberta Accetta, Marcellino Monda, Bruno De Luca, Luigi Michele Pavone, Anna Belfiore, Mariarosaria Santillo, Paolo Mondol. Effect of Mutated Cu, Zn Superoxide Dismutase (SOD1 Frontiers in physiology. vol 9. 2020-09-30. PMID:29881358. |
it is also known that about 20% of familial amyotrophic lateral sclerosis (fals) is due to mutations in the gene coding for sod1. |
2020-09-30 |
2023-08-13 |
Not clear |
| Fernando G Vieira, Theo Hatzipetros, Kenneth Thompson, Andy J Moreno, Joshua D Kidd, Valerie R Tassinari, Beth Levine, Steven Perrin, Alan Gil. CuATSM efficacy is independently replicated in a SOD1 mouse model of ALS while unmetallated ATSM therapy fails to reveal benefits. IBRO reports. vol 2. 2020-09-30. PMID:30135932. |
a copper chelator known as diacetylbis(n(4)-methylthiosemicarbazonato) copper ii (cuatsm), has been reported to be efficacious in multiple transgenic sod1 models of amyotrophic lateral sclerosis (als), a fatal neurodegenerative disorder affecting motor neurons. |
2020-09-30 |
2023-08-13 |
mouse |
| Ilaria Ferrari, Chiara Verpelli, Arianna Crespi, Carlo Sala, Diego Fornasari, Grazia Pietrin. SOD1 stimulates lamellipodial protrusions in Neuro 2A cell lines. Communicative & integrative biology. vol 11. issue 3. 2020-09-30. PMID:30214670. |
we here investigated the effects of overexpressed superoxide dismutase (sod)1 and amyotrophic lateral sclerosis (als)-linked sod1 mutants g93a and g147s in neuro 2a (n2a) cell lines, and found a three-fold increase in lamellipodia either in cells cultured under differentiated or undifferentiated growth conditions. |
2020-09-30 |
2023-08-13 |
Not clear |
| Jeremy Jeffrey, Hannah D'Cunha, Masatoshi Suzuk. Blood Level of Glial Fibrillary Acidic Protein (GFAP) Does not Correlate With Disease Progression in a Rat Model of Familial ALS (SOD1 Frontiers in neurology. vol 9. 2020-09-30. PMID:30487774. |
blood level of glial fibrillary acidic protein (gfap) does not correlate with disease progression in a rat model of familial als (sod1 amyotrophic lateral sclerosis (als) is a neurodegenerative disease characterized by specific loss of motor neurons in the spinal cord and brain stem. |
2020-09-30 |
2023-08-13 |
rat |
| Luke McAlary, Steven S Plotkin, Justin J Yerbury, Neil R Cashma. Prion-Like Propagation of Protein Misfolding and Aggregation in Amyotrophic Lateral Sclerosis. Frontiers in molecular neuroscience. vol 12. 2020-09-29. PMID:31736708. |
the neuromuscular disorder amyotrophic lateral sclerosis (als) is characterized by protein inclusions formed by either tar dna-binding protein of 43 kda (tdp-43), cu/zn superoxide dismutase (sod1), or fused in sarcoma (fus), in both upper and lower motor neurons. |
2020-09-29 |
2023-08-13 |
Not clear |
| Antonio Canosa, Maurizio Grassano, Marco Barberis, Maura Brunetti, Umberto Manera, Rosario Vasta, Stefania Cammarosano, Giovanni De Marco, Andrea Calvo, Adriano Chiò, Cristina Mogli. A familial amyotrophic lateral sclerosis pedigree discordant for a novel p.Glu46Asp heterozygous OPTN variant and the p.Ala5Val heterozygous SOD1 missense mutation. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 75. 2020-09-29. PMID:32223976. |
a familial amyotrophic lateral sclerosis pedigree discordant for a novel p.glu46asp heterozygous optn variant and the p.ala5val heterozygous sod1 missense mutation. |
2020-09-29 |
2023-08-13 |
human |
| Antonio Canosa, Maurizio Grassano, Marco Barberis, Maura Brunetti, Umberto Manera, Rosario Vasta, Stefania Cammarosano, Giovanni De Marco, Andrea Calvo, Adriano Chiò, Cristina Mogli. A familial amyotrophic lateral sclerosis pedigree discordant for a novel p.Glu46Asp heterozygous OPTN variant and the p.Ala5Val heterozygous SOD1 missense mutation. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 75. 2020-09-29. PMID:32223976. |
about 10% of amyotrophic lateral sclerosis (als) cases are familial (fals), mainly related to mutations in c9orf72, sod1, tardbp, and fus genes. |
2020-09-29 |
2023-08-13 |
human |
| Xiaojie Zhang, Sheng Chen, Kaili Lu, Feng Wang, Jiangshan Deng, Zhouwei Xu, Xiuzhe Wang, Qinming Zhou, Weidong Le, Yuwu Zha. Verapamil Ameliorates Motor Neuron Degeneration and Improves Lifespan in the SOD1 Aging and disease. vol 10. issue 6. 2020-09-28. PMID:31788329. |
verapamil ameliorates motor neuron degeneration and improves lifespan in the sod1 amyotrophic lateral sclerosis (als) is a progressive, paralytic disorder caused by selective degeneration of motor neurons in the brain and spinal cord. |
2020-09-28 |
2023-08-13 |
Not clear |
| Hiroaki Kaku, Alexander V Ludlow, Michael F Gutknecht, Thomas L Rothstei. FAIM Opposes Aggregation of Mutant SOD1 That Typifies Some Forms of Familial Amyotrophic Lateral Sclerosis. Frontiers in neuroscience. vol 14. 2020-09-28. PMID:32153351. |
faim opposes aggregation of mutant sod1 that typifies some forms of familial amyotrophic lateral sclerosis. |
2020-09-28 |
2023-08-13 |
Not clear |