| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Atrayee Sarkar, Andrei G Gasic, Margaret S Cheung, Greg Morriso. Effects of Protein Crowders and Charge on the Folding of Superoxide Dismutase 1 Variants: A Computational Study. The journal of physical chemistry. B. 2022-06-10. PMID:35686856. |
the neurodegenerative disease amyotrophic lateral sclerosis (als) is associated with the misfolding and aggregation of the metalloenzyme protein superoxide dismutase 1 (sod1) via mutations that destabilize the monomer-dimer interface. |
2022-06-10 |
2023-08-14 |
Not clear |
| Xinyu Bian, Xiaoyu Zhuang, Zhong Zheng, Shu Liu, Zhiqiang Liu, Fengrui Son. Unfolding and aggregation of oxidized metal-deficient superoxide dismutase and isoflavone inhibition based on ion mobility mass spectrometry and ThT fluorescence assay. Archives of biochemistry and biophysics. 2022-06-06. PMID:35667444. |
structurally abnormal cu, zn-superoxide dismutase (sod1) is considered one of the causes of amyotrophic lateral sclerosis. |
2022-06-06 |
2023-08-14 |
Not clear |
| Rachel Franklin, Michael Hare, Joseph S Beckma. Determining Copper and Zinc Content in Superoxide Dismutase Using Electron Capture Dissociation Under Native Spray Conditions. Methods in molecular biology (Clifton, N.J.). vol 2500. 2022-06-03. PMID:35657595. |
the loss of zinc from cu, zn sod1 has been shown to induce motor neuron death and could have a causal role in the fatal neurodegenerative disease, amyotrophic lateral sclerosis (als). |
2022-06-03 |
2023-08-14 |
Not clear |
| Liang Zhao, Xiang Wu, Xiaofeng Wang, Chunying Duan, Hongyan Wang, Amol Punjabi, Yang Zhao, Yuanwei Zhang, Zuoshang Xu, Haifeng Gao, Gang Ha. Development of Excipient-Free Freeze-Dryable Unimolecular Hyperstar Polymers for Efficient siRNA Silencing. ACS macro letters. vol 6. issue 7. 2022-06-02. PMID:35650873. |
the sirna/hyperstar complexes showed sirna transfection efficiency that was superior to that of lipofectamine2000 in regard to the gene for human cu, zn superoxide dismutase 1 (sod1), whose mutation causes familial amyotrophic lateral sclerosis. |
2022-06-02 |
2023-08-13 |
human |
| Elisa Perciballi, Federica Bovio, Jessica Rosati, Federica Arrigoni, Angela D'Anzi, Serena Lattante, Maurizio Gelati, Fabiola De Marchi, Ivan Lombardi, Giorgia Ruotolo, Matilde Forcella, Letizia Mazzini, Sandra D'Alfonso, Lucia Corrado, Mario Sabatelli, Amelia Conte, Luca De Gioia, Sabata Martino, Angelo Luigi Vescovi, Paola Fusi, Daniela Ferrar. Characterization of the p.L145F and p.S135N Mutations in SOD1: Impact on the Metabolism of Fibroblasts Derived from Amyotrophic Lateral Sclerosis Patients. Antioxidants (Basel, Switzerland). vol 11. issue 5. 2022-05-28. PMID:35624679. |
characterization of the p.l145f and p.s135n mutations in sod1: impact on the metabolism of fibroblasts derived from amyotrophic lateral sclerosis patients. |
2022-05-28 |
2023-08-13 |
Not clear |
| Julia Smirnova, Julia Gavrilova, Andra Noormägi, Karin Valmsen, Hegne Pupart, Jinghui Luo, Vello Tõugu, Peep Paluma. Evaluation of Zn Molecules (Basel, Switzerland). vol 27. issue 10. 2022-05-28. PMID:35630637. |
evaluation of zn the tight binding of cu and zn ions to superoxide dismutase 1 (sod1) maintains the protein stability, associated with amyotrophic lateral sclerosis (als). |
2022-05-28 |
2023-08-13 |
Not clear |
| Elizaveta Ustyantseva, Sophia V Pavlova, Anastasia A Malakhova, Kirill Ustyantsev, Suren M Zakian, Sergey P Medvede. Oxidative stress monitoring in iPSC-derived motor neurons using genetically encoded biosensors of H Scientific reports. vol 12. issue 1. 2022-05-27. PMID:35624228. |
here, we establish an approach for monitoring the redox state of live motor neurons with sod1 mutations associated with amyotrophic lateral sclerosis. |
2022-05-27 |
2023-08-13 |
human |
| Xiaoping Shen, Chunyan Tang, Qin Kang, Yu Zhu, Shengyuan Xu, Jianxiang Jiang, Renshi X. Distribution Changes of Neural Precursor Cells in the Brain Stem of Tg(SOD1*G93A)1Gur Mice. Neuro-degenerative diseases. 2022-05-18. PMID:35584655. |
the alteration of vimentin-containing cells (vccs) proliferation, differentiation and migration in the brain stem of amyotrophic lateral sclerosis (als)-like transgenic mice (tg(sod1*g93a)1gur mice) (tg mice) and wild-type mice (wt mice) at the different disease stages of tg mice were studied in this study. |
2022-05-18 |
2023-08-13 |
mouse |
| Klaus Højgaard Jensen, Anna Katharina Stalder, Rasmus Wernersson, Tim-Christoph Roloff-Handschin, Daniel Hvidberg Hansen, Peter M A Groene. A molecular view of amyotrophic lateral sclerosis through the lens of interaction network modules. PloS one. vol 17. issue 5. 2022-05-16. PMID:35576218. |
despite the discovery of familial cases with mutations in cu/zn-superoxide dismutase (sod1), guanine nucleotide exchange c9orf72, tar dna-binding protein 43 (tardbp) and rna-binding protein fus as well as a number of other genes linked to amyotrophic lateral sclerosis (als), the etiology and molecular pathogenesis of this devastating disease is still not understood. |
2022-05-16 |
2023-08-13 |
Not clear |
| Tina Link, Heli Sheth, Avary Andrews, Dhriti Raguram, Anne Roundhill, Varun Vija. Role of Superoxide Dismutase in Amyotrophic Lateral Sclerosis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35555820. |
amyotrophic lateral sclerosis (als), or lou gehrig's disease, is an adult-onset neurodegenerative disorder that has been linked to over 200 mutations from the sod1 gene. |
2022-05-13 |
2023-08-13 |
Not clear |
| Tina Link, Heli Sheth, Avary Andrews, Dhriti Raguram, Anne Roundhill, Varun Vija. Role of Superoxide Dismutase in Amyotrophic Lateral Sclerosis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35555820. |
further research is needed to determine specifically how mutations of sod1 lead to motor neuron death, and the resulting symptoms of amyotrophic lateral sclerosis. |
2022-05-13 |
2023-08-13 |
Not clear |
| Ishrat Jahan, Shahid M Nayee. Conformational dynamics of superoxide dismutase (SOD1) in osmolytes: a molecular dynamics simulation study. RSC advances. vol 10. issue 46. 2022-05-06. PMID:35516947. |
amyotrophic lateral sclerosis (als) is a progressive neurodegenerative disease caused by the misfolding of cu, zn superoxide dismutase (sod1). |
2022-05-06 |
2023-08-13 |
Not clear |
| Benjamin G Trist, Sian Genoud, Stéphane Roudeau, Alexander Rookyard, Amr Abdeen, Veronica Cottam, Dominic J Hare, Melanie White, Jens Altvater, Jennifer A Fifita, Alison Hogan, Natalie Grima, Ian P Blair, Kai Kysenius, Peter J Crouch, Asuncion Carmona, Yann Rufin, Stéphane Claverol, Stijn Van Malderen, Gerald Falkenberg, David J Paterson, Bradley Smith, Claire Troakes, Caroline Vance, Christopher E Shaw, Safa Al-Sarraj, Stuart Cordwell, Glenda Halliday, Richard Ortega, Kay L Doubl. Altered SOD1 maturation and post-translational modification in amyotrophic lateral sclerosis spinal cord. Brain : a journal of neurology. 2022-05-05. PMID:35512359. |
altered sod1 maturation and post-translational modification in amyotrophic lateral sclerosis spinal cord. |
2022-05-05 |
2023-08-13 |
Not clear |
| Benjamin G Trist, Sian Genoud, Stéphane Roudeau, Alexander Rookyard, Amr Abdeen, Veronica Cottam, Dominic J Hare, Melanie White, Jens Altvater, Jennifer A Fifita, Alison Hogan, Natalie Grima, Ian P Blair, Kai Kysenius, Peter J Crouch, Asuncion Carmona, Yann Rufin, Stéphane Claverol, Stijn Van Malderen, Gerald Falkenberg, David J Paterson, Bradley Smith, Claire Troakes, Caroline Vance, Christopher E Shaw, Safa Al-Sarraj, Stuart Cordwell, Glenda Halliday, Richard Ortega, Kay L Doubl. Altered SOD1 maturation and post-translational modification in amyotrophic lateral sclerosis spinal cord. Brain : a journal of neurology. 2022-05-05. PMID:35512359. |
aberrant self-assembly and toxicity of wild-type and mutant superoxide dismutase 1 (sod1) has been widely examined in silico, in vitro, and in transgenic animal models of amyotrophic lateral sclerosis (als). |
2022-05-05 |
2023-08-13 |
Not clear |
| Debasish Kumar Ghosh, Abhishek Kumar, Akash Ranja. T54R mutation destabilizes the dimer of superoxide dismutase 1 RSC advances. vol 10. issue 18. 2022-05-02. PMID:35492906. |
different mutations in the superoxide dismutase 1 (sod1) protein cause its misfolding, loss of dimerization and aggravate its aggregation in the amyotrophic lateral sclerosis disease. |
2022-05-02 |
2023-08-13 |
Not clear |
| Rachael Bartlett, Diane Ly, Neil R Cashman, Ronald Sluyter, Justin J Yerbur. P2X7 receptor activation mediates superoxide dismutase 1 (SOD1) release from murine NSC-34 motor neurons. Purinergic signalling. 2022-04-28. PMID:35478453. |
mutant superoxide dismutase 1 (sod1) can be constitutively released from motor neurons and transmitted to naïve motor neurons to promote the progression of amyotrophic lateral sclerosis (als). |
2022-04-28 |
2023-08-13 |
Not clear |
| Teresa Cunha-Oliveira, Daniela Franco Silva, Luis Segura, Inês Baldeiras, Ricardo Marques, Tatiana Rosenstock, Paulo J Oliveira, Filomena S G Silv. Redox profiles of Amyotrophic Lateral Sclerosis lymphoblasts with or without known SOD1 mutations. European journal of clinical investigation. 2022-04-25. PMID:35467758. |
redox profiles of amyotrophic lateral sclerosis lymphoblasts with or without known sod1 mutations. |
2022-04-25 |
2023-08-13 |
Not clear |
| Masaaki Yoshikawa, Shin Aizawa, Ronald W Oppenheim, Carol Milliga. Neurovascular unit pathology is observed very early in disease progression in the mutant SOD1 Experimental neurology. 2022-04-19. PMID:35439439. |
neurovascular unit pathology is observed very early in disease progression in the mutant sod1 amyotrophic lateral sclerosis (als) is a debilitating neurodegenerative disease characterized by motor neuron degeneration that causes neuromuscular denervation, resulting in muscle weakness and atrophy. |
2022-04-19 |
2023-08-13 |
mouse |
| René Günther, Arun Pal, Chloe Williams, Vitaly L Zimyanin, Maria Liehr, Cläre von Neubeck, Mechthild Krause, Mrudula G Parab, Susanne Petri, Norman Kalmbach, Stefan L Marklund, Jared Sterneckert, Peter Munch Andersen, Florian Wegner, Jonathan D Gilthorpe, Andreas Herman. Alteration of Mitochondrial Integrity as Upstream Event in the Pathophysiology of SOD1-ALS. Cells. vol 11. issue 7. 2022-04-12. PMID:35406813. |
little is known about the early pathogenic events by which mutant superoxide dismutase 1 (sod1) causes amyotrophic lateral sclerosis (als). |
2022-04-12 |
2023-08-13 |
human |
| Shawn C C Hsueh, Mark Nijland, Xubiao Peng, Benjamin Hilton, Steven S Plotki. First Principles Calculation of Protein-Protein Dimer Affinities of ALS-Associated SOD1 Mutants. Frontiers in molecular biosciences. vol 9. 2022-04-11. PMID:35402516. |
monomerization increases the likelihood of sod1 misfolding into conformations associated with aggregation, cellular toxicity, and neuronal death in familial amyotrophic lateral sclerosis (fals). |
2022-04-11 |
2023-08-13 |
Not clear |