| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yeongjin Baek, Tae-Gyun Woo, Jinsook Ahn, Dukwon Lee, Yonghoon Kwon, Bum-Joon Park, Nam-Chul H. Structural analysis of the overoxidized Cu/Zn-superoxide dismutase in ROS-induced ALS filament formation. Communications biology. vol 5. issue 1. 2022-10-12. PMID:36224351. |
eukaryotic cu, zn-superoxide dismutase (sod1) is primarily responsible for cytotoxic filament formation in amyotrophic lateral sclerosis (als) neurons. |
2022-10-12 |
2023-08-14 |
Not clear |
| Yoshiaki Furukaw. A pathological link between dysregulated copper binding in Cu/Zn-superoxide dismutase and amyotrophic lateral sclerosis. Journal of clinical biochemistry and nutrition. vol 71. issue 2. 2022-10-10. PMID:36213785. |
mutations in the gene coding cu/zn-superoxide dismutase (sod1) are linked to a familial form of amyotrophic lateral sclerosis (als), and its pathological hallmark includes abnormal accumulation of mutant sod1 proteins in spinal motorneurons. |
2022-10-10 |
2023-08-14 |
Not clear |
| P Corcia, P Lejeune, P Vourc'h, S Beltran, A S Piegay, H Blasco, V Meininge. Comparison between PFN1 and SOD1 mutations in Amyotrophic Lateral Sclerosis. European journal of neurology. 2022-09-30. PMID:36176198. |
comparison between pfn1 and sod1 mutations in amyotrophic lateral sclerosis. |
2022-09-30 |
2023-08-14 |
mouse |
| Elif Kubat Oktem, Busra Aydin, Metin Yazar, Kazim Yalcin Arg. Integrative Analysis of Motor Neuron and Microglial Transcriptomes from SOD1 Journal of molecular neuroscience : MN. 2022-09-30. PMID:36178612. |
integrative analysis of motor neuron and microglial transcriptomes from sod1 amyotrophic lateral sclerosis (als) is a fatal disease of motor neurons that mainly affects the motor cortex, brainstem, and spinal cord. |
2022-09-30 |
2023-08-14 |
Not clear |
| Timothy M Miller, Merit E Cudkowicz, Angela Genge, Pamela J Shaw, Gen Sobue, Robert C Bucelli, Adriano Chiò, Philip Van Damme, Albert C Ludolph, Jonathan D Glass, Jinsy A Andrews, Suma Babu, Michael Benatar, Christopher J McDermott, Thos Cochrane, Sowmya Chary, Sheena Chew, Han Zhu, Fan Wu, Ivan Nestorov, Danielle Graham, Peng Sun, Manjit McNeill, Laura Fanning, Toby A Ferguson, Stephanie Fradett. Trial of Antisense Oligonucleotide Tofersen for The New England journal of medicine. vol 387. issue 12. 2022-09-21. PMID:36129998. |
trial of antisense oligonucleotide tofersen for the intrathecally administered antisense oligonucleotide tofersen reduces synthesis of the superoxide dismutase 1 (sod1) protein and is being studied in patients with amyotrophic lateral sclerosis (als) associated with mutations in |
2022-09-21 |
2023-08-14 |
Not clear |
| Jinmeng Liu, Fenghua Zhou, Yanchun Chen, Yingjun Guan, Fandi Meng, Zhenhan Zhao, Xuemei Wang, Xueshuai Gao, Xin Jiang, Haoyun Zhang, Qing Wang, Shuanhu Zhou, Xin Wan. Wnt5a protects motor neurons in amyotrophic lateral sclerosis by regulating the Wnt/Ca American journal of translational research. vol 14. issue 8. 2022-09-15. PMID:36105066. |
wnt5a protects motor neurons in amyotrophic lateral sclerosis by regulating the wnt/ca we aimed to detect the expression profile of downstream signaling molecules of non-canonical wnt pathway in sod1 |
2022-09-15 |
2023-08-14 |
Not clear |
| Nirnay Samanta, Yasser B Ruiz-Blanco, Zamira Fetahaj, David Gnutt, Carter Lantz, Joseph A Loo, Elsa Sanchez-Garcia, Simon Ebbinghau. Superoxide dismutase 1 folding stability as a target for molecular tweezers in SOD1-related amyotrophic lateral sclerosis. Chembiochem : a European journal of chemical biology. 2022-09-09. PMID:36083789. |
here, we investigate the modulation mechanism of unfolding and aggregation pathways of sod1, which are involved in amyotrophic lateral sclerosis (als), by clr01. |
2022-09-09 |
2023-08-14 |
Not clear |
| Issa O Yusuf, Tao Qiao, Sepideh Parsi, Ronak Tilvawala, Paul R Thompson, Zuoshang X. Protein citrullination marks myelin protein aggregation and disease progression in mouse ALS models. Acta neuropathologica communications. vol 10. issue 1. 2022-09-08. PMID:36076282. |
to determine whether pc contribute to amyotrophic lateral sclerosis (als), a deadly neurodegenerative disease characterized by loss of motor neurons, paralysis, and eventual death, we investigated alterations of pc and pad2 in two different transgenic mouse models of als expressing human mutant sod1 |
2022-09-08 |
2023-08-14 |
mouse |
| Jacques Durand, Anton Filipchu. Electrical and Morphological Properties of Developing Motoneurons in Postnatal Mice and Early Abnormalities in SOD1 Transgenic Mice. Advances in neurobiology. vol 28. 2022-09-06. PMID:36066832. |
in this chapter, we review electrical and morphological properties of lumbar motoneurons during postnatal development in wild-type (wt) and transgenic superoxide dismutase 1 (sod1) mice, models of amyotrophic lateral sclerosis. |
2022-09-06 |
2023-08-14 |
mouse |
| Federica De Lazzari, Francesco Agostini, Davide Doni, Sandro Malacrida, Mauro A Zordan, Paola Costantini, Luigi Bubacco, Federica Sandrelli, Marco Bisagli. DJ-1 and SOD1 Act Independently in the Protection against Anoxia in Antioxidants (Basel, Switzerland). vol 11. issue 8. 2022-08-26. PMID:36009245. |
among the different enzymes involved in the antioxidant response, sod1 and dj-1 have both been associated with the pathogenesis of amyotrophic lateral sclerosis and parkinson's disease, suggesting a possible interplay in their mechanism of action. |
2022-08-26 |
2023-08-14 |
Not clear |
| Benjamin G Trist, Jennifer A Fifita, Alison Hogan, Natalie Grima, Bradley Smith, Claire Troakes, Caroline Vance, Christopher Shaw, Safa Al-Sarraj, Ian P Blair, Kay L Doubl. Co-deposition of SOD1, TDP-43 and p62 proteinopathies in ALS: evidence for multifaceted pathways underlying neurodegeneration. Acta neuropathologica communications. vol 10. issue 1. 2022-08-25. PMID:36008843. |
pairwise interactions between superoxide dismutase 1 (sod1), tar dna-binding protein 43 (tdp-43) and ubiquitin-binding protein 62/sequestosome 1 (p62) proteinopathies have been reported in multiple transgenic cellular and animal models of amyotrophic lateral sclerosis (als), however corresponding examination of these relationships in patient tissues is lacking. |
2022-08-25 |
2023-08-14 |
Not clear |
| Eleonora Dalla Bella, Enrica Bersano, Maria Grazia Bruzzone, Cinzia Gellera, Viviana Pensato, Giuseppe Lauria, Monica Consonn. Behavioral and Cognitive Phenotypes of Patients With Amyotrophic Lateral Sclerosis Carrying SOD1 Variants. Neurology. 2022-08-19. PMID:35985819. |
behavioral and cognitive phenotypes of patients with amyotrophic lateral sclerosis carrying sod1 variants. |
2022-08-19 |
2023-08-14 |
Not clear |
| Masanori Sawamura, Keiko Imamura, Rie Hikawa, Takako Enami, Ayako Nagahashi, Hodaka Yamakado, Hidenori Ichijo, Takao Fujisawa, Hirofumi Yamashita, Sumio Minamiyama, Misako Kaido, Hiromi Wada, Makoto Urushitani, Haruhisa Inoue, Naohiro Egawa, Ryosuke Takahash. Cellular analysis of SOD1 protein-aggregation propensity and toxicity: a case of ALS with slow progression harboring homozygous SOD1-D92G mutation. Scientific reports. vol 12. issue 1. 2022-07-25. PMID:35879519. |
mutations within superoxide dismutase 1 (sod1) cause amyotrophic lateral sclerosis (als), accounting for approximately 20% of familial cases. |
2022-07-25 |
2023-08-14 |
human |
| Kosuke Yamazaki, Shinya Tahara, Takumi Ohyama, Kunisato Kuroi, Takakazu Nakabayash. SOD1 gains pro-oxidant activity upon aberrant oligomerization: change in enzymatic activity by intramolecular disulfide bond cleavage. Scientific reports. vol 12. issue 1. 2022-07-11. PMID:35817830. |
copper-zinc superoxide dismutase (sod1) has been proposed as one of the causative proteins of amyotrophic lateral sclerosis (als). |
2022-07-11 |
2023-08-14 |
Not clear |
| Jie Zhang, An Wen, Wen Chai, Huiting Liang, Chunyan Tang, Weiming Gan, Renshi X. Potential proteomic alteration in the brain of Tg(SOD1*G93A)1Gur mice: A new pathogenesis insight of amyotrophic lateral sclerosis. Cell biology international. 2022-07-08. PMID:35801511. |
potential proteomic alteration in the brain of tg(sod1*g93a)1gur mice: a new pathogenesis insight of amyotrophic lateral sclerosis. |
2022-07-08 |
2023-08-14 |
mouse |
| Elena R Rhymes, Andrew P Tosolini, Alexander D Fellows, William Mahy, Neil Q McDonald, Giampietro Schiav. Bimodal regulation of axonal transport by the GDNF-RET signalling axis in healthy and diseased motor neurons. Cell death & disease. vol 13. issue 7. 2022-07-07. PMID:35798698. |
deficits in axonal transport are one of the earliest pathological outcomes in several models of amyotrophic lateral sclerosis (als), including sod1 |
2022-07-07 |
2023-08-14 |
Not clear |
| Xueling Liu, Jun Zhang, Jie Li, Chengjie Song, Yuguang Sh. Pharmacological Inhibition of ALCAT1 Mitigates Amyotrophic Lateral Sclerosis by Attenuating SOD1 Protein Aggregation. Molecular metabolism. 2022-06-30. PMID:35772643. |
pharmacological inhibition of alcat1 mitigates amyotrophic lateral sclerosis by attenuating sod1 protein aggregation. |
2022-06-30 |
2023-08-14 |
Not clear |
| Xueling Liu, Jun Zhang, Jie Li, Chengjie Song, Yuguang Sh. Pharmacological Inhibition of ALCAT1 Mitigates Amyotrophic Lateral Sclerosis by Attenuating SOD1 Protein Aggregation. Molecular metabolism. 2022-06-30. PMID:35772643. |
mutations in the copper-zinc superoxide dismutase (sod1) gene cause familial amyotrophic lateral sclerosis (als), a progressive fatal neuromuscular disease characterized by motor neurons death and severe skeletal muscle degeneration. |
2022-06-30 |
2023-08-14 |
Not clear |
| Gabriela Bortolança Chiarotto, Luciana Politti Cartarozzi, Matheus Perez, Ana Laura Midori Rossi Tomiyama, Mateus Vidigal de Castro, Adriana S S Duarte, Ângela Cristina Malheiros Luzo, Alexandre Leite Rodrigues de Oliveir. Delayed onset, immunomodulation, and lifespan improvement of SOD1 Brain research bulletin. 2022-06-19. PMID:35718222. |
delayed onset, immunomodulation, and lifespan improvement of sod1 amyotrophic lateral sclerosis (als) is a neurodegenerative disease characterized by the selective and progressive loss of motor neurons from the spinal cord, brain stem, and motor cortex. |
2022-06-19 |
2023-08-14 |
human |
| E Srinivasan, G Chandrasekhar, R Rajasekara. Probing the polyphenolic flavonoid, morin as a highly efficacious inhibitor against amyloid(A4V) mutant SOD1 in fatal amyotrophic lateral sclerosis. Archives of biochemistry and biophysics. 2022-06-11. PMID:35690129. |
probing the polyphenolic flavonoid, morin as a highly efficacious inhibitor against amyloid(a4v) mutant sod1 in fatal amyotrophic lateral sclerosis. |
2022-06-11 |
2023-08-14 |
human |