| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Biying Yang, Jingrui Pan, Xiao-Ni Zhang, Hongxuan Wang, Lei He, Xiaoming Rong, Xiangpen Li, Ying Pen. NRF2 activation suppresses motor neuron ferroptosis induced by the SOD1 Neurobiology of disease. 2023-06-23. PMID:37352984. |
nrf2 activation suppresses motor neuron ferroptosis induced by the sod1 the progressive neurodegenerative disease amyotrophic lateral sclerosis (als) is caused by a decline in motor neuron function, resulting in worsened motor impairments, malnutrition, respiratory failure and mortality, and there is a lack of effective clinical treatments. |
2023-06-23 |
2023-08-14 |
Not clear |
| Chengyou Zheng, Weifen Li, Tahir Ali, Ziting Peng, Jieli Liu, Zhengying Pan, Jinxing Feng, Shupeng L. Ibrutinib Delays ALS Installation and Increases Survival of SOD1 Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2023-06-16. PMID:37326908. |
ibrutinib delays als installation and increases survival of sod1 amyotrophic lateral sclerosis (als) is a fatal multisystem degenerative disorder with minimal available therapeutic. |
2023-06-16 |
2023-08-14 |
Not clear |
| Shilpa Sharma, Vijay Raj Tomar, Shashank Dee. Myricetin: A Potent Anti-Amyloidogenic Polyphenol against Superoxide Dismutase 1 Aggregation. ACS chemical neuroscience. 2023-06-14. PMID:37314311. |
amyotrophic lateral sclerosis (als) is believed to be caused by the aggregation of misfolded or mutated superoxide dismutase 1 (sod1). |
2023-06-14 |
2023-08-14 |
Not clear |
| Stefania Santarelli, Chiara Londero, Alessia Soldano, Carlotta Candelaresi, Leonardo Todeschini, Luisa Vernizzi, Paola Bellost. Frontiers in neuroscience. vol 17. 2023-06-05. PMID:37274187. |
indeed, despite the physiological and morphological differences between the fly and the human brain, most of the biochemical and molecular aspects regulating protein homeostasis, including autophagy, are conserved between the two species.in this review, we will provide an overview of the most common neurodegenerative proteinopathies, which include polyq diseases (huntington's disease, spinocerebellar ataxia 1, 2, and 3), amyotrophic lateral sclerosis (c9orf72, sod1, tdp-43, fus), alzheimer's disease (app, tau) parkinson's disease (a-syn, parkin and pink1, lrrk2) and prion diseases, highlighting the studies using drosophila that have contributed to understanding the conserved mechanisms and elucidating the role of autophagy in these diseases. |
2023-06-05 |
2023-08-14 |
human |
| Snehal Aouti, Sivaraman Padavattan, Balasundaram Padmanabha. Structure-based discovery of an antipsychotic drug, paliperidone, as a modulator of human superoxide dismutase 1: a potential therapeutic target in amyotrophic lateral sclerosis. Acta crystallographica. Section D, Structural biology. 2023-05-19. PMID:37204819. |
aggregates of the antioxidant superoxide dismutase 1 (sod1) are one of the major contributors to the pathogenesis of amyotrophic lateral sclerosis (als). |
2023-05-19 |
2023-08-14 |
human |
| Akira Hosomi, Chinatsu Okachi, Yudai Fujiwar. Human SOD1 is secreted via a conventional secretion pathway in Saccharomyces cerevisiae. Biochemical and biophysical research communications. vol 666. 2023-05-14. PMID:37182284. |
sod1 is a causative gene of amyotrophic lateral sclerosis (als). |
2023-05-14 |
2023-08-14 |
human |
| Cindy V Ly, Margaret D Ireland, Wade K Self, James Bollinger, Jennifer Jockel-Balsarotti, Hillary Herzog, Peggy Allred, Leah Miller, Michael Doyle, Isabel Anez-Bruzual, Bhavesh Trikamji, Ted Hyman, Tyler Kung, Katherine Nicholson, Robert C Bucelli, Bruce W Patterson, Randall J Bateman, Timothy M Mille. Protein kinetics of superoxide dismutase-1 in familial and sporadic amyotrophic lateral sclerosis. Annals of clinical and translational neurology. 2023-04-29. PMID:37119480. |
accumulation of misfolded superoxide dismutase-1 (sod1) is a pathological hallmark of sod1-related amyotrophic lateral sclerosis (als) and is observed in sporadic als where its role in pathogenesis is controversial. |
2023-04-29 |
2023-08-14 |
Not clear |
| Yoshihiro Kitaoka, Soju Seki, Sou Kawata, Akira Nishiura, Kohei Kawamura, Shin-Ichiro Hiraoka, Mikihiko Kogo, Susumu Tanak. Analysis of Feeding Behavior Characteristics in the Cu/Zn Superoxide Dismutase 1 (SOD1) SOD1G93A Mice Model for Amyotrophic Lateral Sclerosis (ALS). Nutrients. vol 15. issue 7. 2023-04-13. PMID:37049492. |
analysis of feeding behavior characteristics in the cu/zn superoxide dismutase 1 (sod1) sod1g93a mice model for amyotrophic lateral sclerosis (als). |
2023-04-13 |
2023-08-14 |
mouse |
| Takayuki Kondo, Ikuyo Inoue, Kazuhiro Umeyama, Masahito Watanabe, Hitomi Matsunari, Ayuko Uchikura, Kazuaki Nakano, Kayoko Tsukita, Keiko Imamura, Hiroshi Nagashima, Haruhisa Inou. A Transgenic Pig Model With Human Mutant SOD1 Exhibits the Early Pathology of Amyotrophic Lateral Sclerosis. Laboratory investigation; a journal of technical methods and pathology. vol 103. issue 2. 2023-04-11. PMID:37039150. |
a transgenic pig model with human mutant sod1 exhibits the early pathology of amyotrophic lateral sclerosis. |
2023-04-11 |
2023-08-14 |
human |
| Ao Yun Zhang, Chad M Dashnaw, Mayte Gonzalez, Jordan C Koone, Nick A Wells, Colin A Smith, Matthew J Guberman-Pfeffer, Bryan F Sha. Oxidation of Dueling Cysteine Promotes Subunit Exchange in SOD1. ACS chemical neuroscience. 2023-04-06. PMID:37023050. |
the heterodimerization of wild-type (wt) cu, zn superoxide dismutase-1 (sod1) and mutant sod1 might be a critical step in the pathogenesis of sod1-linked amyotrophic lateral sclerosis (als). |
2023-04-06 |
2023-08-14 |
Not clear |
| Katherine L Marshall, Labchan Rajbhandari, Arun Venkatesan, Nicholas J Maragakis, Mohamed H Fara. Enhanced axonal regeneration of ALS patient iPSC-derived motor neurons harboring SOD1 Scientific reports. vol 13. issue 1. 2023-04-05. PMID:37020097. |
enhanced axonal regeneration of als patient ipsc-derived motor neurons harboring sod1 amyotrophic lateral sclerosis (als) is a devastating neurodegenerative disease, characterized by degeneration of upper and lower motor neurons that leads to muscle weakness, paralysis, and death, but the effects of disease-causing mutations on axonal outgrowth of neurons derived from human induced pluripotent stem cells (ipsc)-derived motor neurons (hipsc-mn) are poorly understood. |
2023-04-05 |
2023-08-14 |
human |
| Xiaojiao Xu, Qiu Yang, Zheyi Liu, Rong Zhang, Hang Yu, Manli Wang, Sheng Chen, Guowang Xu, Yaping Shao, Weidong L. Integrative analysis of metabolomics and proteomics unravels purine metabolism disorder in the SOD1 Neurobiology of disease. 2023-03-31. PMID:37001614. |
integrative analysis of metabolomics and proteomics unravels purine metabolism disorder in the sod1 amyotrophic lateral sclerosis (als) is a fatal neurodegenerative disease with progressive paralysis of limbs and bulb in patients, the cause of which remains unclear. |
2023-03-31 |
2023-08-14 |
Not clear |
| Thomas Meyer, Peggy Schumann, Patrick Weydt, Susanne Petri, Yasemin Koc, Susanne Spittel, Sarah Bernsen, René Günther, Jochen H Weishaupt, Marie Dreger, Felix Kolzarek, Dagmar Kettemann, Jenny Norden, Matthias Boentert, Maximilian Vidovic, Christian Meisel, Christoph Münch, André Maier, Péter Körtvélyess. Neurofilament light chain response during therapy with antisense oligonucleotide Tofersen in SOD1-related ALS - treatment experience in clinical practice. Muscle & nerve. 2023-03-17. PMID:36928619. |
in amyotrophic lateral sclerosis (als) caused by superoxide dismutase 1 (sod1) gene mutations (sod1-als), the antisense oligonucleotide tofersen had been investigated in a phase 3 study (valor) and subsequently introduced in an expanded access program. |
2023-03-17 |
2023-08-14 |
Not clear |
| Yujun Zhou, Jingshu Tang, Jiaqi Lan, Yong Zhang, Hongyue Wang, Qiuyu Chen, Yuying Kang, Yang Sun, Xinhong Feng, Lei Wu, Hongtao Jin, Shizhong Chen, Ying Pen. Honokiol alleviated neurodegeneration by reducing oxidative stress and improving mitochondrial function in mutant SOD1 cellular and mouse models of amyotrophic lateral sclerosis. Acta pharmaceutica Sinica. B. vol 13. issue 2. 2023-03-06. PMID:36873166. |
honokiol alleviated neurodegeneration by reducing oxidative stress and improving mitochondrial function in mutant sod1 cellular and mouse models of amyotrophic lateral sclerosis. |
2023-03-06 |
2023-08-14 |
mouse |
| Hamza Dakhil Zaji, Bagher Seyedalipour, Haider Munzer Hanun, Payam Baziyar, Saman Hosseinkhani, Mona Akhlagh. Computational insight into in silico analysis and molecular dynamics simulation of the dimer interface residues of ALS-linked hSOD1 forms in apo/holo states: a combined experimental and bioinformatic perspective. 3 Biotech. vol 13. issue 3. 2023-02-27. PMID:36845075. |
the aggregation of misfolded sod1 proteins in neurodegenerative illnesses is a key pathological hallmark in amyotrophic lateral sclerosis (als). |
2023-02-27 |
2023-08-14 |
Not clear |
| Parth Sarathi Naya. Nanozyme mediated SOD1 strategy linked to nanochaperone facilitate aggregation inhibition in amyotrophic lateral sclerosis. Biophysical journal. vol 122. issue 3S1. 2023-02-14. PMID:36784339. |
nanozyme mediated sod1 strategy linked to nanochaperone facilitate aggregation inhibition in amyotrophic lateral sclerosis. |
2023-02-14 |
2023-08-14 |
Not clear |
| Shilpa Sharma, Vijay Raj Tomar, Abhilash Jayaraj, Shashank Dee. A computational strategy for therapeutic development against superoxide dismutase (SOD1) amyloid formation: effect of polyphenols on the various events in the aggregation pathway. Physical chemistry chemical physics : PCCP. 2023-02-09. PMID:36756854. |
pathology of superoxide dismutase 1 (sod1) aggregation is linked to a neurodegenerative disease known as amyotrophic lateral sclerosis (als). |
2023-02-09 |
2023-08-14 |
Not clear |
| Albert J B Lee, Tyler E Kittel, Renaid B Kim, Thao-Nguyen Bach, Tian Zhang, Cassie S Mitchel. Comparing therapeutic modulators of the SOD1 G93A Amyotrophic Lateral Sclerosis mouse pathophysiology. Frontiers in neuroscience. vol 16. 2023-02-06. PMID:36741054. |
comparing therapeutic modulators of the sod1 g93a amyotrophic lateral sclerosis mouse pathophysiology. |
2023-02-06 |
2023-08-14 |
mouse |
| Paulo R Mouro, Murilo N Sanches, Vitor B P Leite, Jorge Chahin. Exploring the Folding Mechanism of Dimeric Superoxide Dismutase. The journal of physical chemistry. B. 2023-01-31. PMID:36716437. |
the cu/zn human superoxide dismutase (sod1) is a dimeric metalloenzyme whose genetic mutations are directly related to amyotrophic lateral sclerosis (als), so understanding its folding mechanism is of fundamental importance. |
2023-01-31 |
2023-08-14 |
human |
| Sharad Kumar Suthar, Sang-Yoon Le. The Role of Superoxide Dismutase 1 in Amyotrophic Lateral Sclerosis: Identification of Signaling Pathways, Regulators, Molecular Interaction Networks, and Biological Functions through Bioinformatics. Brain sciences. vol 13. issue 1. 2023-01-21. PMID:36672132. |
mutations in superoxide dismutase 1 (sod1) result in misfolding and aggregation of the protein, causing neurodegenerative amyotrophic lateral sclerosis (als). |
2023-01-21 |
2023-08-14 |
Not clear |