| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lu Zhang, Yu Fang, Yajun Lian, Yuan Chen, Tianwen Wu, Yake Zheng, Huili Zong, Limin Sun, Ruifang Zhang, Zhenhua Wang, Yuming X. Brain-derived neurotrophic factor ameliorates learning deficits in a rat model of Alzheimer's disease induced by aβ1-42. PloS one. vol 10. issue 4. 2016-03-31. PMID:25849905. |
an emerging body of data suggests that the early onset of alzheimer's disease (ad) is associated with decreased brain-derived neurotrophic factor (bdnf). |
2016-03-31 |
2023-08-13 |
rat |
| Elyse Rosa, Margaret Fahnestoc. CREB expression mediates amyloid β-induced basal BDNF downregulation. Neurobiology of aging. vol 36. issue 8. 2016-03-17. PMID:26025137. |
in alzheimer's disease, accumulation of amyloid-β (aβ) is associated with loss of brain-derived neurotrophic factor (bdnf), synapses, and memory. |
2016-03-17 |
2023-08-13 |
human |
| Yu-Hui Liu, Shu-Sheng Jiao, Ye-Ran Wang, Xian-Le Bu, Xiu-Qing Yao, Yang Xiang, Qing-Hua Wang, Lin Wang, Juan Deng, Jing Li, Xin-Fu Zhou, Hua-Dong Zhou, Yan-Jiang Wan. Associations Between ApoEε4 Carrier Status and Serum BDNF Levels--New Insights into the Molecular Mechanism of ApoEε4 Actions in Alzheimer's Disease. Molecular neurobiology. vol 51. issue 3. 2016-03-10. PMID:24986007. |
associations between apoeε4 carrier status and serum bdnf levels--new insights into the molecular mechanism of apoeε4 actions in alzheimer's disease. |
2016-03-10 |
2023-08-13 |
human |
| Siresha Bathina, Undurti N Da. Brain-derived neurotrophic factor and its clinical implications. Archives of medical science : AMS. vol 11. issue 6. 2016-01-20. PMID:26788077. |
decreased levels of bdnf are associated with neurodegenerative diseases with neuronal loss, such as parkinson's disease, alzheimer's disease, multiple sclerosis and huntington's disease. |
2016-01-20 |
2023-08-13 |
Not clear |
| L Devi, M Ohn. TrkB reduction exacerbates Alzheimer's disease-like signaling aberrations and memory deficits without affecting β-amyloidosis in 5XFAD mice. Translational psychiatry. vol 5. 2016-01-07. PMID:25942043. |
accumulating evidence shows that brain-derived neurotrophic factor (bdnf) and its receptor tropomyosin-related kinase b (trkb) significantly decrease early in alzheimer's disease (ad). |
2016-01-07 |
2023-08-13 |
mouse |
| Xiang-Hua Liu, Zhao Geng, Jing Yan, Ting Li, Qun Chen, Qun-Ye Zhang, Zhe-Yu Che. Blocking GSK3β-mediated dynamin1 phosphorylation enhances BDNF-dependent TrkB endocytosis and the protective effects of BDNF in neuronal and mouse models of Alzheimer's disease. Neurobiology of disease. vol 74. 2016-01-06. PMID:25484286. |
blocking gsk3β-mediated dynamin1 phosphorylation enhances bdnf-dependent trkb endocytosis and the protective effects of bdnf in neuronal and mouse models of alzheimer's disease. |
2016-01-06 |
2023-08-13 |
mouse |
| Lucia Carboni, Francesca Lattanzio, Sanzio Candeletti, Elisa Porcellini, Elena Raschi, Federico Licastro, Patrizia Romuald. Peripheral leukocyte expression of the potential biomarker proteins Bdnf, Sirt1, and Psen1 is not regulated by promoter methylation in Alzheimer's disease patients. Neuroscience letters. vol 605. 2015-12-30. PMID:26275347. |
peripheral leukocyte expression of the potential biomarker proteins bdnf, sirt1, and psen1 is not regulated by promoter methylation in alzheimer's disease patients. |
2015-12-30 |
2023-08-13 |
human |
| Jasmine Nettiksimmons, Eleanor M Simonsick, Tamara Harris, Suzanne Satterfield, Caterina Rosano, Kristine Yaff. The associations between serum brain-derived neurotrophic factor, potential confounders, and cognitive decline: a longitudinal study. PloS one. vol 9. issue 3. 2015-12-14. PMID:24670553. |
although persons with alzheimer's disease have lower cortical levels of bdnf, evidence regarding the association between circulating bdnf and cognitive function is conflicting. |
2015-12-14 |
2023-08-12 |
Not clear |
| Roberta Falcone, Tiziana Marilena Florio, Erica Di Giacomo, Elisabetta Benedetti, Loredana Cristiano, Andrea Antonosante, Alessia Fidoamore, Mara Massimi, Marcello Alecci, Rodolfo Ippoliti, Antonio Giordano, Annamaria Cimin. PPARβ/δ and γ in a rat model of Parkinson's disease: possible involvement in PD symptoms. Journal of cellular biochemistry. vol 116. issue 5. 2015-12-08. PMID:25530507. |
on the other hand a detrimental role for pparβ/δ has been proposed in alzheimer, being closely related to the decrease of bdnf and trkfl. |
2015-12-08 |
2023-08-13 |
rat |
| Yasuhisa Ano, Makiko Ozawa, Toshiko Kutsukake, Shinya Sugiyama, Kazuyuki Uchida, Aruto Yoshida, Hiroyuki Nakayam. Preventive effects of a fermented dairy product against Alzheimer's disease and identification of a novel oleamide with enhanced microglial phagocytosis and anti-inflammatory activity. PloS one. vol 10. issue 3. 2015-12-08. PMID:25760987. |
here, in a mouse model of alzheimer's disease (5xfad), intake of a dairy product fermented with penicillium candidum had preventive effects on the disease by reducing the accumulation of amyloid β (aβ) and hippocampal inflammation (tnf-α and mip-1α production), and enhancing hippocampal neurotrophic factors (bdnf and gdnf). |
2015-12-08 |
2023-08-13 |
mouse |
| Renalice Neves Vieira, Joalce Dornelas Magalhães, Jemima Sant'Anna, Mateus Massao Moriguti, Débora Marques de Miranda, Luiz De Marco, Edgar Nunes de Moraes, Marco Aurélio Romano-Silva, Maria Aparecida Camargos Bicalho, Jonas Jardim de Paula, Marco Túlio Gualberto Cintr. The GAB2 and BDNF polymorphisms and the risk for late-onset Alzheimer's disease in an elderly Brazilian sample--ERRATUM. International psychogeriatrics. vol 27. issue 10. 2015-11-16. PMID:26126641. |
the gab2 and bdnf polymorphisms and the risk for late-onset alzheimer's disease in an elderly brazilian sample--erratum. |
2015-11-16 |
2023-08-13 |
Not clear |
| Bei-Yun Wang, Yuan Zhong, Zhe Zhao, Ya Mia. Epigenetic suppression of hippocampal BDNF mediates the memory deficiency induced by amyloid fibrils. Pharmacology, biochemistry, and behavior. vol 126. 2015-11-09. PMID:25242807. |
these results elucidate the epigenetic mechanism underlying the bdnf reduction induced by amyloid fibrils, and provided novel insights into the pathogenic mechanism of alzheimer's disease. |
2015-11-09 |
2023-08-13 |
rat |
| Min-Kyoo Shin, Hong-Gi Kim, Kil-Lyong Ki. A novel brain-derived neurotrophic factor-modulating peptide attenuates Aβ1-42-induced neurotoxicity in vitro. Neuroscience letters. vol 595. 2015-10-20. PMID:25849526. |
since bdnf expression is decreased in patients with alzheimer's disease, various strategies have attempted to increase bdnf levels. |
2015-10-20 |
2023-08-13 |
rat |
| Josiane Budni, Tatiani Bellettini-Santos, Francielle Mina, Michelle Lima Garcez, Alexandra Ioppi Zugn. The involvement of BDNF, NGF and GDNF in aging and Alzheimer's disease. Aging and disease. vol 6. issue 5. 2015-10-01. PMID:26425388. |
the involvement of bdnf, ngf and gdnf in aging and alzheimer's disease. |
2015-10-01 |
2023-08-13 |
Not clear |
| Elisabetta Benedetti, Barbara D'Angelo, Loredana Cristiano, Erica Di Giacomo, Francesca Fanelli, Sandra Moreno, Francesco Cecconi, Alessia Fidoamore, Andrea Antonosante, Roberta Falcone, Rodolfo Ippoliti, Antonio Giordano, Annamaria Cimin. Involvement of peroxisome proliferator-activated receptor β/δ (PPAR β/δ) in BDNF signaling during aging and in Alzheimer disease: possible role of 4-hydroxynonenal (4-HNE). Cell cycle (Georgetown, Tex.). vol 13. issue 8. 2015-08-14. PMID:24621497. |
involvement of peroxisome proliferator-activated receptor β/δ (ppar β/δ) in bdnf signaling during aging and in alzheimer disease: possible role of 4-hydroxynonenal (4-hne). |
2015-08-14 |
2023-08-12 |
Not clear |
| Lan Chang, Yunliang Wang, Huihui Ji, Dongjun Dai, Xuting Xu, Danjie Jiang, Qingxiao Hong, Huadan Ye, Xiaonan Zhang, Xiaohui Zhou, Yu Liu, Jinfeng Li, Zhongming Chen, Ying Li, Dongsheng Zhou, Renjie Zhuo, Yuzheng Zhang, Honglei Yin, Congcong Mao, Shiwei Duan, Qinwen Wan. Elevation of peripheral BDNF promoter methylation links to the risk of Alzheimer's disease. PloS one. vol 9. issue 11. 2015-08-10. PMID:25364831. |
elevation of peripheral bdnf promoter methylation links to the risk of alzheimer's disease. |
2015-08-10 |
2023-08-13 |
Not clear |
| Lan Chang, Yunliang Wang, Huihui Ji, Dongjun Dai, Xuting Xu, Danjie Jiang, Qingxiao Hong, Huadan Ye, Xiaonan Zhang, Xiaohui Zhou, Yu Liu, Jinfeng Li, Zhongming Chen, Ying Li, Dongsheng Zhou, Renjie Zhuo, Yuzheng Zhang, Honglei Yin, Congcong Mao, Shiwei Duan, Qinwen Wan. Elevation of peripheral BDNF promoter methylation links to the risk of Alzheimer's disease. PloS one. vol 9. issue 11. 2015-08-10. PMID:25364831. |
brain derived neurotrophic factor (bdnf) has been known to play an important role in various mental disorders or diseases such as alzheimer's disease (ad). |
2015-08-10 |
2023-08-13 |
Not clear |
| Antón Alvarez, Manuel Aleixandre, Carlos Linares, Eliezer Masliah, Herbert Moessle. Apathy and APOE4 are associated with reduced BDNF levels in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 42. issue 4. 2015-07-23. PMID:25024337. |
apathy and apoe4 are associated with reduced bdnf levels in alzheimer's disease. |
2015-07-23 |
2023-08-13 |
human |
| Antón Alvarez, Manuel Aleixandre, Carlos Linares, Eliezer Masliah, Herbert Moessle. Apathy and APOE4 are associated with reduced BDNF levels in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 42. issue 4. 2015-07-23. PMID:25024337. |
reduced brain-derived neurotrophic factor (bdnf) signaling is considered as a pathogenic event in early alzheimer's disease (ad), but the influence of apathy and apolipoprotein e ε4 allele (apoe4) on serum bdnf values was not previously investigated in ad. |
2015-07-23 |
2023-08-13 |
human |
| Yan Lin, Shuo Cheng, Zhutian Xie, Dongfeng Zhan. Association of rs6265 and rs2030324 polymorphisms in brain-derived neurotrophic factor gene with Alzheimer's disease: a meta-analysis. PloS one. vol 9. issue 4. 2015-05-28. PMID:24733169. |
the association between polymorphisms rs6265 and rs2030324 in brain-derived neurotrophic factor (bdnf) and alzheimer's disease (ad) has been widely reported, but the results remain controversial. |
2015-05-28 |
2023-08-13 |
Not clear |