| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bing Xie, Zanchao Liu, Wenxuan Liu, Lei Jiang, Rui Zhang, Dongsheng Cui, Qingfu Zhang, Shunjiang X. DNA Methylation and Tag SNPs of the BDNF Gene in Conversion of Amnestic Mild Cognitive Impairment into Alzheimer's Disease: A Cross-Sectional Cohort Study. Journal of Alzheimer's disease : JAD. vol 58. issue 1. 2018-02-26. PMID:28387675. |
dna methylation and tag snps of the bdnf gene in conversion of amnestic mild cognitive impairment into alzheimer's disease: a cross-sectional cohort study. |
2018-02-26 |
2023-08-13 |
Not clear |
| Bing Xie, Yao Xu, Zanchao Liu, Wenxuan Liu, Lei Jiang, Rui Zhang, Dongsheng Cui, Qingfu Zhang, Shunjiang X. Elevation of Peripheral BDNF Promoter Methylation Predicts Conversion from Amnestic Mild Cognitive Impairment to Alzheimer's Disease: A 5-Year Longitudinal Study. Journal of Alzheimer's disease : JAD. vol 56. issue 1. 2018-02-21. PMID:27935556. |
elevation of peripheral bdnf promoter methylation predicts conversion from amnestic mild cognitive impairment to alzheimer's disease: a 5-year longitudinal study. |
2018-02-21 |
2023-08-13 |
Not clear |
| Pin-Hsuan Lin, Shih-Jen Tsai, Chi-Wei Huang, Liu Mu-En, Shih-Wei Hsu, Chen-Chang Lee, Nai-Ching Chen, Ya-Ting Chang, Min-Yu Lan, Chiung-Chih Chan. Dose-dependent genotype effects of BDNF Val66Met polymorphism on default mode network in early stage Alzheimer's disease. Oncotarget. vol 7. issue 34. 2018-02-05. PMID:27494844. |
dose-dependent genotype effects of bdnf val66met polymorphism on default mode network in early stage alzheimer's disease. |
2018-02-05 |
2023-08-13 |
Not clear |
| Pin-Hsuan Lin, Shih-Jen Tsai, Chi-Wei Huang, Liu Mu-En, Shih-Wei Hsu, Chen-Chang Lee, Nai-Ching Chen, Ya-Ting Chang, Min-Yu Lan, Chiung-Chih Chan. Dose-dependent genotype effects of BDNF Val66Met polymorphism on default mode network in early stage Alzheimer's disease. Oncotarget. vol 7. issue 34. 2018-02-05. PMID:27494844. |
in humans, brain-derived neurotrophic factor (bdnf) has been shown to play a pivotal role in neurocognition, and its gene contains a functional polymorphism (val66met) that may explain individual differences in brain volume and memory-related activity.in this study, we enrolled 186 alzheimer's disease (ad) patients who underwent 3d t1 magnetic resonance imaging, and explored the gray matter (gm) structural covariance networks (scn). |
2018-02-05 |
2023-08-13 |
Not clear |
| Umed Boltaev, Yves Meyer, Farangis Tolibzoda, Teresa Jacques, Madalee Gassaway, Qihong Xu, Florence Wagner, Yan-Ling Zhang, Michelle Palmer, Edward Holson, Dalibor Same. Multiplex quantitative assays indicate a need for reevaluating reported small-molecule TrkB agonists. Science signaling. vol 10. issue 493. 2018-01-10. PMID:28831019. |
brain-derived neurotrophic factor (bdnf) and its receptor, tropomyosin-related kinase b (trkb), have emerged as key regulators of brain plasticity and represent disease-modifying targets for several brain disorders, including alzheimer's disease and major depressive disorder. |
2018-01-10 |
2023-08-13 |
Not clear |
| S-S Jiao, L-L Shen, C Zhu, X-L Bu, Y-H Liu, C-H Liu, X-Q Yao, L-L Zhang, H-D Zhou, D G Walker, J Tan, J Götz, X-F Zhou, Y-J Wan. Brain-derived neurotrophic factor protects against tau-related neurodegeneration of Alzheimer's disease. Translational psychiatry. vol 6. issue 10. 2017-12-04. PMID:27701410. |
reduced expression of brain-derived neurotrophic factor (bdnf) has a crucial role in the pathogenesis of alzheimer's disease (ad), which is characterized with the formation of neuritic plaques consisting of amyloid-beta (aβ) and neurofibrillary tangles composed of hyperphosphorylated tau protein. |
2017-12-04 |
2023-08-13 |
mouse |
| Guo-Dong Li, Rui Bi, Deng-Feng Zhang, Min Xu, Rongcan Luo, Dong Wang, Yiru Fang, Tao Li, Chen Zhang, Yong-Gang Ya. Female-specific effect of the BDNF gene on Alzheimer's disease. Neurobiology of aging. vol 53. 2017-11-16. PMID:28202203. |
female-specific effect of the bdnf gene on alzheimer's disease. |
2017-11-16 |
2023-08-13 |
Not clear |
| Yi-Chao Wei, Shao-Ran Wang, Xiao-Hong X. Sex differences in brain-derived neurotrophic factor signaling: Functions and implications. Journal of neuroscience research. vol 95. issue 1-2. 2017-11-13. PMID:27870405. |
finally, we discuss the implications of sex differences in bdnf signaling for gender-biased presentation of neurological and psychiatric diseases such as alzheimer's disease. |
2017-11-13 |
2023-08-13 |
rat |
| A Travaglia, D La Mendol. Zinc Interactions With Brain-Derived Neurotrophic Factor and Related Peptide Fragments. Vitamins and hormones. vol 104. 2017-11-02. PMID:28215299. |
dysregulation of bdnf signaling is involved in several neurodegenerative disorders, including alzheimer's disease. |
2017-11-02 |
2023-08-13 |
Not clear |
| C Sat. Releasing Mechanism of Neurotrophic Factors via Polysialic Acid. Vitamins and hormones. vol 104. 2017-11-02. PMID:28215308. |
the concentration of bdnf in body fluid is highly related to several neurodevelopmental and psychiatric diseases, including alzheimer's diseases, depression, schizophrenia, and bipolar disorder. |
2017-11-02 |
2023-08-13 |
Not clear |
| Elizabeth J Coulson, Perry F Bartlet. An exercise path to preventing Alzheimer's disease: An Editorial Highlight on 'Exercise and BDNF reduce Ab production by enhancing α-secretase processing of APP'. Journal of neurochemistry. vol 142. issue 2. 2017-10-26. PMID:28523793. |
an exercise path to preventing alzheimer's disease: an editorial highlight on 'exercise and bdnf reduce ab production by enhancing α-secretase processing of app'. |
2017-10-26 |
2023-08-13 |
Not clear |
| Elyse Rosa, Sujeivan Mahendram, Yazi D Ke, Lars M Ittner, Stephen D Ginsberg, Margaret Fahnestoc. Tau downregulates BDNF expression in animal and cellular models of Alzheimer's disease. Neurobiology of aging. vol 48. 2017-10-12. PMID:27676333. |
tau downregulates bdnf expression in animal and cellular models of alzheimer's disease. |
2017-10-12 |
2023-08-13 |
mouse |
| X-Y Qin, C Cao, N X Cawley, T-T Liu, J Yuan, Y P Loh, Y Chen. Decreased peripheral brain-derived neurotrophic factor levels in Alzheimer's disease: a meta-analysis study (N=7277). Molecular psychiatry. vol 22. issue 2. 2017-10-03. PMID:27113997. |
studies suggest that dysfunction of brain-derived neurotrophic factor (bdnf) is a possible contributor to the pathology and symptoms of alzheimer's disease (ad). |
2017-10-03 |
2023-08-13 |
human |
| Yosuke Takeda, Hiroshi Oue, Shinsuke Okada, Akira Kawano, Katsunori Koretake, Makoto Michikawa, Yasumasa Akagawa, Kazuhiro Tsug. Molar loss and powder diet leads to memory deficit and modifies the mRNA expression of brain-derived neurotrophic factor in the hippocampus of adult mice. BMC neuroscience. vol 17. issue 1. 2017-08-23. PMID:27919226. |
recent studies have shown that brain-derived neurotrophic factor (bdnf) is associated with tooth loss or soft diet in young animal model, and that bdnf expression is decreased in patients with alzheimer's disease. |
2017-08-23 |
2023-08-13 |
mouse |
| Saket M Nigam, Shaohua Xu, Joanna S Kritikou, Krisztina Marosi, Lennart Brodin, Mark P Mattso. Exercise and BDNF reduce Aβ production by enhancing α-secretase processing of APP. Journal of neurochemistry. vol 142. issue 2. 2017-08-10. PMID:28382744. |
using a transgenic mouse model of alzheimer's disease and cultured human neural cells, we demonstrate that exercise and bdnf reduce production of toxic aβ peptides through a mechanism involving enhanced α-secretase processing of app. |
2017-08-10 |
2023-08-13 |
mouse |
| Yinjie Li, Jikai Xu, Pu Xu, Shijie Song, Peng Liu, Tianyan Chi, Xuefei Ji, Ge Jin, Shimeng Qiu, Yapeng Hou, Chen Zheng, Lili Wang, Dali Meng, Libo Zo. Xanthoceras sorbifolia extracts ameliorate dendritic spine deficiency and cognitive decline via upregulation of BDNF expression in a rat model of Alzheimer's disease. Neuroscience letters. vol 629. 2017-07-26. PMID:27412235. |
xanthoceras sorbifolia extracts ameliorate dendritic spine deficiency and cognitive decline via upregulation of bdnf expression in a rat model of alzheimer's disease. |
2017-07-26 |
2023-08-13 |
rat |
| Mariela Mitre, Abigail Mariga, Moses V Cha. Neurotrophin signalling: novel insights into mechanisms and pathophysiology. Clinical science (London, England : 1979). vol 131. issue 1. 2017-07-07. PMID:27908981. |
in particular, lower levels of bdnf are associated with the aetiology of alzheimer's and huntington's diseases. |
2017-07-07 |
2023-08-13 |
Not clear |
| James W Daily, Sunmin Par. Interaction of BDNF rs6265 variants and energy and protein intake in the risk for glucose intolerance and type 2 diabetes in middle-aged adults. Nutrition (Burbank, Los Angeles County, Calif.). vol 33. 2017-06-26. PMID:27553771. |
brain-derived neurotrophic factor (bdnf) is associated with the risk for alzheimer's disease and type 2 diabetes. |
2017-06-26 |
2023-08-13 |
Not clear |
| Siresha Bathina, Nanduri Srinivas, Undurti N Da. Streptozotocin produces oxidative stress, inflammation and decreases BDNF concentrations to induce apoptosis of RIN5F cells and type 2 diabetes mellitus in Wistar rats. Biochemical and biophysical research communications. vol 486. issue 2. 2017-06-05. PMID:28315336. |
brain-derived neurotrophic factor (bdnf) is a neurotrophic factor and is known to possess anti-obesity, anti-diabetic actions and is believed to have a role in memory and alzheimer's disease. |
2017-06-05 |
2023-08-13 |
rat |
| Mohammed Ragab Abdel-Aziz Ali, Amira Morad Hussein Abo-Youssef, Basim Anwar Shehata Messiha, Mahmoud Mohamed Khatta. Tempol and perindopril protect against lipopolysaccharide-induced cognition impairment and amyloidogenesis by modulating brain-derived neurotropic factor, neuroinflammation and oxido-nitrosative stress. Naunyn-Schmiedeberg's archives of pharmacology. vol 389. issue 6. 2017-02-21. PMID:27026404. |
a behavioral study was conducted to evaluate spatial and nonspatial memory in mice, followed by a biochemical study involving assessment of brain levels of aβ and bdnf as alzheimer and neuroplasticity markers; tumor necrosis factor-alpha (tnf-α), nitric oxide end-products (nox), neuronal nitric oxide synthase (nnos), and inducible nitric oxide synthase (inos) as inflammatory markers; and superoxide dismutase (sod), malondialdehyde (mda), glutathione reduced (gsh), and nitrotyrosine (nt) as oxido-nitrosative stress markers. |
2017-02-21 |
2023-08-13 |
mouse |