| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wei Li, Xu Li, Xin Xin, Peng-Cheng Kan, Yan Ya. MicroRNA-613 regulates the expression of brain-derived neurotrophic factor in Alzheimer's disease. Bioscience trends. vol 10. issue 5. 2017-01-30. PMID:27545218. |
in the present study, the mrna and protein expression level of bdnf was detected in serum, and cerebrospinal fluid (csf) of patients with mild cognitive impairment (mci), dementia of alzheimer's type (dat), and hippocampus in app/ps1 mice. |
2017-01-30 |
2023-08-13 |
mouse |
| Florence Guillot, Susanna Kemppainen, Gregoire Lavasseur, Pasi O Miettinen, Serge Laroche, Heikki Tanila, Sabrina Davi. Brain-Specific Basal and Novelty-Induced Alternations in PI3K-Akt and MAPK/ERK Signaling in a Middle-Aged AβPP/PS1 Mouse Model of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 51. issue 4. 2016-12-29. PMID:26923018. |
although it is well established that insulin/igf and bdnf signaling are dysfunctionally regulated in alzheimer's disease, there are very few studies documenting changes in major target proteins in different murine models of the disease. |
2016-12-29 |
2023-08-13 |
mouse |
| Jiajia Lin, Ling Huang, Jie Yu, Siying Xiang, Jialing Wang, Jinrong Zhang, Xiaojun Yan, Wei Cui, Shan He, Qinwen Wan. Fucoxanthin, a Marine Carotenoid, Reverses Scopolamine-Induced Cognitive Impairments in Mice and Inhibits Acetylcholinesterase in Vitro. Marine drugs. vol 14. issue 4. 2016-12-19. PMID:27023569. |
based on our current findings, we anticipate that fucoxanthin might exhibit great therapeutic efficacy for the treatment of alzheimer's disease by acting on multiple targets, including inhibiting ache and increasing bdnf expression. |
2016-12-19 |
2023-08-13 |
mouse |
| Bianca Seifert, Robert Eckenstaler, Raik Rönicke, Julia Leschik, Beat Lutz, Klaus Reymann, Volkmar Lessmann, Tanja Brigadsk. Amyloid-Beta Induced Changes in Vesicular Transport of BDNF in Hippocampal Neurons. Neural plasticity. vol 2016. 2016-12-13. PMID:26881108. |
investigation of disease-related changes in bdnf transport might provide insights into the cellular mechanism underlying, for example, alzheimer's disease (ad). |
2016-12-13 |
2023-08-13 |
human |
| Jesus J Gomar, Concepcion Conejero-Goldberg, Edward D Huey, Peter Davies, Terry E Goldber. Lack of neural compensatory mechanisms of BDNF val66met met carriers and APOE E4 carriers in healthy aging, mild cognitive impairment, and Alzheimer's disease. Neurobiology of aging. vol 39. 2016-12-13. PMID:26923413. |
lack of neural compensatory mechanisms of bdnf val66met met carriers and apoe e4 carriers in healthy aging, mild cognitive impairment, and alzheimer's disease. |
2016-12-13 |
2023-08-13 |
human |
| Bernadeta Michalski, Maria M Corrada, Claudia H Kawas, Margaret Fahnestoc. Brain-derived neurotrophic factor and TrkB expression in the "oldest-old," the 90+ Study: correlation with cognitive status and levels of soluble amyloid-beta. Neurobiology of aging. vol 36. issue 12. 2016-08-15. PMID:26410307. |
decreased brain-derived neurotrophic factor (bdnf) contributes to memory loss in alzheimer's disease (ad), and soluble assemblies of amyloid-beta (aβ) and tau contribute to neurodegeneration. |
2016-08-15 |
2023-08-13 |
human |
| Jing-Hui Song, Jin-Tai Yu, Lan Ta. Brain-Derived Neurotrophic Factor in Alzheimer's Disease: Risk, Mechanisms, and Therapy. Molecular neurobiology. vol 52. issue 3. 2016-08-10. PMID:25354497. |
however, changes of bdnf level and expression have been reported in the cns as well as blood of alzheimer's disease (ad) patients in the last decade, which indicates a potential role of bdnf in the pathogenesis of ad. |
2016-08-10 |
2023-08-13 |
Not clear |
| Y Y Lim, V L Villemagne, S M Laws, R H Pietrzak, P J Snyder, D Ames, K A Ellis, K Harrington, A Rembach, R N Martins, C C Rowe, C L Masters, P Maruf. APOE and BDNF polymorphisms moderate amyloid β-related cognitive decline in preclinical Alzheimer's disease. Molecular psychiatry. vol 20. issue 11. 2016-08-02. PMID:25288138. |
apoe and bdnf polymorphisms moderate amyloid β-related cognitive decline in preclinical alzheimer's disease. |
2016-08-02 |
2023-08-13 |
human |
| Ganesh Ambigapathy, Zhaoqing Zheng, Joyce Keife. Regulation of BDNF chromatin status and promoter accessibility in a neural correlate of associative learning. Epigenetics. vol 10. issue 10. 2016-08-01. PMID:26336984. |
brain-derived neurotrophic factor (bdnf) gene expression critically controls learning and its aberrant regulation is implicated in alzheimer's disease and a host of neurodevelopmental disorders. |
2016-08-01 |
2023-08-13 |
Not clear |
| Joyce Keifer, Zhaoqing Zheng, Ganesh Ambigapath. A MicroRNA-BDNF Negative Feedback Signaling Loop in Brain: Implications for Alzheimer's Disease. MicroRNA (Shariqah, United Arab Emirates). vol 4. issue 2. 2016-07-27. PMID:26456533. |
however, in alzheimer's disease (ad), a progressive neurodegenerative disorder resulting in memory loss and eventually dementia that is characterized by reduced levels of bdnf in brain, the balance between bdnf and mirna is shifted toward inhibitory control by mirnas. |
2016-07-27 |
2023-08-13 |
Not clear |
| Michal Schnaider Beeri, Joshua Sonne. Brain BDNF expression as a biomarker for cognitive reserve against Alzheimer disease progression. Neurology. vol 86. issue 8. 2016-07-04. PMID:26819454. |
brain bdnf expression as a biomarker for cognitive reserve against alzheimer disease progression. |
2016-07-04 |
2023-08-13 |
Not clear |
| Peter Deng, Audrey Torrest, Kari Pollock, Heather Dahlenburg, Geralyn Annett, Jan A Nolta, Kyle D Fin. Clinical trial perspective for adult and juvenile Huntington's disease using genetically-engineered mesenchymal stem cells. Neural regeneration research. vol 11. issue 5. 2016-06-23. PMID:27335539. |
our biological delivery system for bdnf sets the precedent for adult stem cell therapy in the brain and could potentially be modified for other neurodegenerative disorders such as amyotrophic lateral sclerosis (als), spinocerebellar ataxia (sca), alzheimer's disease, and some forms of parkinson's disease. |
2016-06-23 |
2023-08-13 |
Not clear |
| David Lau, C Peter Bengtson, Bettina Buchthal, Hilmar Badin. BDNF Reduces Toxic Extrasynaptic NMDA Receptor Signaling via Synaptic NMDA Receptors and Nuclear-Calcium-Induced Transcription of inhba/Activin A. Cell reports. vol 12. issue 8. 2016-06-17. PMID:26279570. |
this process, which confers protection against ischemic brain damage in a mouse stroke model, may be compromised in huntington's disease, alzheimer's disease, or aging-related neurodegenerative conditions that are associated with reduced bdnf levels and/or enhanced extrasynaptic nmda receptor signaling. |
2016-06-17 |
2023-08-13 |
mouse |
| Renalice Neves Vieira, Joalce Dornelas Magalhães, Jemima Sant'Anna, Mateus Massao Moriguti, Jonas Jardim de Paula, Marco Túlio Gualberto Cintra, Débora Marques de Miranda, Luiz De Marco, Edgar Nunes de Moraes, Marco Aurélio Romano-Silva, Maria Aparecida Camargos Bicalh. The GAB2 and BDNF polymorphisms and the risk for late-onset Alzheimer's disease in an elderly Brazilian sample. International psychogeriatrics. vol 27. issue 10. 2016-06-03. PMID:25853819. |
the gab2 and bdnf polymorphisms and the risk for late-onset alzheimer's disease in an elderly brazilian sample. |
2016-06-03 |
2023-08-13 |
Not clear |
| Renalice Neves Vieira, Joalce Dornelas Magalhães, Jemima Sant'Anna, Mateus Massao Moriguti, Jonas Jardim de Paula, Marco Túlio Gualberto Cintra, Débora Marques de Miranda, Luiz De Marco, Edgar Nunes de Moraes, Marco Aurélio Romano-Silva, Maria Aparecida Camargos Bicalh. The GAB2 and BDNF polymorphisms and the risk for late-onset Alzheimer's disease in an elderly Brazilian sample. International psychogeriatrics. vol 27. issue 10. 2016-06-03. PMID:25853819. |
evidences suggest that gab2 and bdnf genes may be associated with alzheimer's disease (ad). |
2016-06-03 |
2023-08-13 |
Not clear |
| André Jerónimo-Santos, Sandra Henriques Vaz, Sara Parreira, Sofia Rapaz-Lérias, António P Caetano, Valérie Buée-Scherrer, Eero Castrén, Claudia A Valente, David Blum, Ana Maria Sebastião, Maria José Diógene. Dysregulation of TrkB Receptors and BDNF Function by Amyloid-β Peptide is Mediated by Calpain. Cerebral cortex (New York, N.Y. : 1991). vol 25. issue 9. 2016-05-10. PMID:24860020. |
trkb and bdnf signaling are impaired in alzheimer's disease (ad), a neurodegenerative disease involving accumulation of amyloid-β (aβ) peptide. |
2016-05-10 |
2023-08-13 |
human |
| Ana Kim, Anne M Fagan, Alison M Goate, Tammie L S Benzinger, John C Morris, Denise Hea. Lack of an association of BDNF Val66Met polymorphism and plasma BDNF with hippocampal volume and memory. Cognitive, affective & behavioral neuroscience. vol 15. issue 3. 2016-05-09. PMID:25784293. |
measures of the bdnf genotype, plasma bdnf, mri-based hippocampal volume, and memory performance were obtained from the knight alzheimer disease research center (adrc) and the alzheimer's disease neuroimaging initiative (adni). |
2016-05-09 |
2023-08-13 |
Not clear |
| Jin Bae Weon, Youn Sik Jung, Choong Je M. Cognitive-Enhancing Effect of Dianthus superbus var. Longicalycinus on Scopolamine-Induced Memory Impairment in Mice. Biomolecules & therapeutics. vol 24. issue 3. 2016-05-02. PMID:27133261. |
these results indicated that d. superbus improved memory functioning accompanied by inhibition of ache and upregulation of bdnf, suggesting that d. superbus may be a useful therapeutic agent for the prevention or treatment of alzheimer's disease. |
2016-05-02 |
2023-08-13 |
mouse |
| Jung Yeon Lim, Charles P Reighard, Damian C Crowthe. The pro-domains of neurotrophins, including BDNF, are linked to Alzheimer's disease through a toxic synergy with Aβ. Human molecular genetics. vol 24. issue 14. 2016-04-28. PMID:25954034. |
the pro-domains of neurotrophins, including bdnf, are linked to alzheimer's disease through a toxic synergy with aβ. |
2016-04-28 |
2023-08-13 |
drosophila_melanogaster |
| Jung Yeon Lim, Charles P Reighard, Damian C Crowthe. The pro-domains of neurotrophins, including BDNF, are linked to Alzheimer's disease through a toxic synergy with Aβ. Human molecular genetics. vol 24. issue 14. 2016-04-28. PMID:25954034. |
bdnf levels are lower in the brains of individuals with alzheimer's disease (ad), suggesting a pathogenic involvement. |
2016-04-28 |
2023-08-13 |
drosophila_melanogaster |