| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jun Zhang, Zanchao Liu, Yuanyuan Pei, Wen Yang, Chicu Xie, Shiqi Lon. MicroRNA-322 Cluster Promotes Tau Phosphorylation via Targeting Brain-Derived Neurotrophic Factor. Neurochemical research. vol 43. issue 3. 2018-08-30. PMID:29464486. |
collectively, this study demonstrated a novel mirna-dependent manner of bdnf degradation in ad pathogenesis, it may drive a mirnas- or bdnf based therapeutic strategies against alzheimer's disease. |
2018-08-30 |
2023-08-13 |
mouse |
| Sahreh Shabani, Yaghoob Farbood, Seyyed Ali Mard, Alireza Sarkaki, Akram Ahangarpour, Layasadat Khorsand. The regulation of pituitary-thyroid abnormalities by peripheral administration of levothyroxine increased brain-derived neurotrophic factor and reelin protein expression in an animal model of Alzheimer's disease. Canadian journal of physiology and pharmacology. vol 96. issue 3. 2018-08-20. PMID:28846851. |
alzheimer's disease (ad) is associated with decreased serum levels of thyroid hormones (ths), increased levels of thyroid-stimulating hormone (tsh), and decreased protein expression of brain-derived neurotrophic factor (bdnf) and reelin in the hippocampus. |
2018-08-20 |
2023-08-13 |
Not clear |
| Chun Chen, Zhihao Wang, Zhentao Zhang, Xia Liu, Seong Su Kang, Ying Zhang, Keqiang Y. The prodrug of 7,8-dihydroxyflavone development and therapeutic efficacy for treating Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 115. issue 3. 2018-08-01. PMID:29295929. |
the bdnf mimetic compound 7,8-dihydroxyflavone (7,8-dhf), a potent small molecular trkb agonist, displays prominent therapeutic efficacy against alzheimer's disease (ad). |
2018-08-01 |
2023-08-13 |
mouse |
| M Florencia Iulita, M Beatriz Bistué Millón, Rowan Pentz, Lisi Flores Aguilar, Sonia Do Carmo, Simon Allard, Bernadeta Michalski, Edward N Wilson, Adriana Ducatenzeiler, Martin A Bruno, Margaret Fahnestock, A Claudio Cuell. Differential deregulation of NGF and BDNF neurotrophins in a transgenic rat model of Alzheimer's disease. Neurobiology of disease. vol 108. 2018-07-23. PMID:28865749. |
differential deregulation of ngf and bdnf neurotrophins in a transgenic rat model of alzheimer's disease. |
2018-07-23 |
2023-08-13 |
human |
| M Florencia Iulita, M Beatriz Bistué Millón, Rowan Pentz, Lisi Flores Aguilar, Sonia Do Carmo, Simon Allard, Bernadeta Michalski, Edward N Wilson, Adriana Ducatenzeiler, Martin A Bruno, Margaret Fahnestock, A Claudio Cuell. Differential deregulation of NGF and BDNF neurotrophins in a transgenic rat model of Alzheimer's disease. Neurobiology of disease. vol 108. 2018-07-23. PMID:28865749. |
evidence from human neuropathological studies indicates that the levels of the neurotrophins nerve growth factor (ngf) and brain-derived neurotrophic factor (bdnf) are compromised in alzheimer's disease. |
2018-07-23 |
2023-08-13 |
human |
| Martina Curto, Antonio Martocchia, Stefano Ferracuti, Fabrizia Comite, Sergio Scaccianoce, Paolo Girardi, Ferdinando Nicoletti, Paolo Falasch. Increased Total Urinary Cortisol (tUC) and Serum Brain-derived Neurotrophic Factor (BDNF) Ratio in Alzheimer Disease (AD)-affected Patients. Alzheimer disease and associated disorders. vol 31. issue 2. 2018-06-25. PMID:27196536. |
increased total urinary cortisol (tuc) and serum brain-derived neurotrophic factor (bdnf) ratio in alzheimer disease (ad)-affected patients. |
2018-06-25 |
2023-08-13 |
Not clear |
| Yen Ying Lim, Stephanie Rainey-Smith, Yoon Lim, Simon M Laws, Veer Gupta, Tenielle Porter, Pierrick Bourgeat, David Ames, Christopher Fowler, Olivier Salvado, Victor L Villemagne, Christopher C Rowe, Colin L Masters, Xin Fu Zhou, Ralph N Martins, Paul Maruf. BDNF Val66Met in preclinical Alzheimer's disease is associated with short-term changes in episodic memory and hippocampal volume but not serum mBDNF. International psychogeriatrics. vol 29. issue 11. 2018-06-12. PMID:28720165. |
bdnf val66met in preclinical alzheimer's disease is associated with short-term changes in episodic memory and hippocampal volume but not serum mbdnf. |
2018-06-12 |
2023-08-13 |
Not clear |
| Yen Ying Lim, Stephanie Rainey-Smith, Yoon Lim, Simon M Laws, Veer Gupta, Tenielle Porter, Pierrick Bourgeat, David Ames, Christopher Fowler, Olivier Salvado, Victor L Villemagne, Christopher C Rowe, Colin L Masters, Xin Fu Zhou, Ralph N Martins, Paul Maruf. BDNF Val66Met in preclinical Alzheimer's disease is associated with short-term changes in episodic memory and hippocampal volume but not serum mBDNF. International psychogeriatrics. vol 29. issue 11. 2018-06-12. PMID:28720165. |
the brain-derived neurotrophic factor (bdnf) val66met polymorphism met allele exacerbates amyloid (aβ) related decline in episodic memory (em) and hippocampal volume (hv) over 36-54 months in preclinical alzheimer's disease (ad). |
2018-06-12 |
2023-08-13 |
Not clear |
| Daniel Felsky, Jishu Xu, Lori B Chibnik, Julie A Schneider, Jo Knight, James L Kennedy, David A Bennett, Philip L De Jager, Aristotle N Voinesko. Genetic epistasis regulates amyloid deposition in resilient aging. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 13. issue 10. 2018-06-01. PMID:28322202. |
the brain-derived neurotrophic factor (bdnf) interacts with important genetic alzheimer's disease (ad) risk factors. |
2018-06-01 |
2023-08-13 |
Not clear |
| Mu-Han Li, Jing Zhang, Run-Qing Zhao, Xian-Zhe Dong, Yuan Hu, Ting Chen, Jie Li, Li Liu, Ping Li. [Effect of six class of Kaixin San formulas on pharmacological and preliminary mechanism of Alzheimer's disease mice]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 41. issue 7. 2018-05-15. PMID:28879742. |
kunming mice were selected and established a mouse model of alzheimer's by intraperitoneal injection of d-galactose and sodium nitrite, continued intragastric 4 weeks, using the ability of learning and memory in morris water maze test to evaluate the animals in each group; the content of bdnf in the hippocampus of mice with western blotting detected; elisa method for the detection of each group of mice hippocampal tau protein,p-tau protein, aβ,ach,ache and serum nt-probnp levels. |
2018-05-15 |
2023-08-13 |
mouse |
| Cheng-Chun Wu, Cheng-Chang Lien, Wen-Hsien Hou, Po-Min Chiang, Kuen-Jer Tsa. Gain of BDNF Function in Engrafted Neural Stem Cells Promotes the Therapeutic Potential for Alzheimer's Disease. Scientific reports. vol 6. 2018-04-24. PMID:27264956. |
gain of bdnf function in engrafted neural stem cells promotes the therapeutic potential for alzheimer's disease. |
2018-04-24 |
2023-08-13 |
Not clear |
| Yen Ying Lim, Jason Hassenstab, Carlos Cruchaga, Alison Goate, Anne M Fagan, Tammie L S Benzinger, Paul Maruff, Peter J Snyder, Colin L Masters, Ricardo Allegri, Jasmeer Chhatwal, Martin R Farlow, Neill R Graff-Radford, Christoph Laske, Johannes Levin, Eric McDade, John M Ringman, Martin Rossor, Stephen Salloway, Peter R Schofield, David M Holtzman, John C Morris, Randall J Batema. BDNF Val66Met moderates memory impairment, hippocampal function and tau in preclinical autosomal dominant Alzheimer's disease. Brain : a journal of neurology. vol 139. issue Pt 10. 2018-04-10. PMID:27521573. |
bdnf val66met moderates memory impairment, hippocampal function and tau in preclinical autosomal dominant alzheimer's disease. |
2018-04-10 |
2023-08-13 |
Not clear |
| Yen Ying Lim, Jason Hassenstab, Carlos Cruchaga, Alison Goate, Anne M Fagan, Tammie L S Benzinger, Paul Maruff, Peter J Snyder, Colin L Masters, Ricardo Allegri, Jasmeer Chhatwal, Martin R Farlow, Neill R Graff-Radford, Christoph Laske, Johannes Levin, Eric McDade, John M Ringman, Martin Rossor, Stephen Salloway, Peter R Schofield, David M Holtzman, John C Morris, Randall J Batema. BDNF Val66Met moderates memory impairment, hippocampal function and tau in preclinical autosomal dominant Alzheimer's disease. Brain : a journal of neurology. vol 139. issue Pt 10. 2018-04-10. PMID:27521573. |
see rogaeva and schmitt-ulms doi101093/aww201 for a scientific commentary on this article: the brain-derived neurotrophic factor (bdnf) val66met polymorphism is implicated in synaptic excitation and neuronal integrity, and has previously been shown to moderate amyloid-β-related memory decline and hippocampal atrophy in preclinical sporadic alzheimer's disease. |
2018-04-10 |
2023-08-13 |
Not clear |
| Yen Ying Lim, Jason Hassenstab, Carlos Cruchaga, Alison Goate, Anne M Fagan, Tammie L S Benzinger, Paul Maruff, Peter J Snyder, Colin L Masters, Ricardo Allegri, Jasmeer Chhatwal, Martin R Farlow, Neill R Graff-Radford, Christoph Laske, Johannes Levin, Eric McDade, John M Ringman, Martin Rossor, Stephen Salloway, Peter R Schofield, David M Holtzman, John C Morris, Randall J Batema. BDNF Val66Met moderates memory impairment, hippocampal function and tau in preclinical autosomal dominant Alzheimer's disease. Brain : a journal of neurology. vol 139. issue Pt 10. 2018-04-10. PMID:27521573. |
however, the effect of bdnf in autosomal dominant alzheimer's disease is unknown. |
2018-04-10 |
2023-08-13 |
Not clear |
| Yen Ying Lim, Jason Hassenstab, Carlos Cruchaga, Alison Goate, Anne M Fagan, Tammie L S Benzinger, Paul Maruff, Peter J Snyder, Colin L Masters, Ricardo Allegri, Jasmeer Chhatwal, Martin R Farlow, Neill R Graff-Radford, Christoph Laske, Johannes Levin, Eric McDade, John M Ringman, Martin Rossor, Stephen Salloway, Peter R Schofield, David M Holtzman, John C Morris, Randall J Batema. BDNF Val66Met moderates memory impairment, hippocampal function and tau in preclinical autosomal dominant Alzheimer's disease. Brain : a journal of neurology. vol 139. issue Pt 10. 2018-04-10. PMID:27521573. |
we aimed to determine the effect of bdnf val66met on cognitive function, hippocampal function, tau and amyloid-β in preclinical autosomal dominant alzheimer's disease. |
2018-04-10 |
2023-08-13 |
Not clear |
| Galit Weinstein, Sarah R Preis, Alexa S Beiser, Bernhard Kaess, Tai C Chen, Claudia Satizabal, Faisal Rahman, Emelia J Benjamin, Ramachandran S Vasan, Sudha Seshadr. Clinical and Environmental Correlates of Serum BDNF: A Descriptive Study with Plausible Implications for AD Research. Current Alzheimer research. vol 14. issue 7. 2018-04-10. PMID:28164772. |
brain derived neurotrophic factor (bdnf) may play a central role in the pathogenesis of alzheimer's disease (ad) through neurotrophic effects on basal cholinergic neurons. |
2018-04-10 |
2023-08-13 |
Not clear |
| N Janel, P Alexopoulos, A Badel, F Lamari, A C Camproux, J Lagarde, S Simon, C Feraudet-Tarisse, P Lamourette, M Arbones, J L Paul, B Dubois, M C Potier, M Sarazin, J M Delaba. Combined assessment of DYRK1A, BDNF and homocysteine levels as diagnostic marker for Alzheimer's disease. Translational psychiatry. vol 7. issue 6. 2018-03-26. PMID:28632203. |
combined assessment of dyrk1a, bdnf and homocysteine levels as diagnostic marker for alzheimer's disease. |
2018-03-26 |
2023-08-13 |
Not clear |
| Hailin Zhao, Azeem Alam, Chun-Yin San, Shiori Eguchi, Qian Chen, Qingquan Lian, Daqing M. Molecular mechanisms of brain-derived neurotrophic factor in neuro-protection: Recent developments. Brain research. vol 1665. 2018-03-22. PMID:28396009. |
this review summarizes the available information on the potential benefits of bdnf and the molecular mechanisms involved in several pathological conditions, including hypoxic brain injury, stroke, alzheimer's disease and parkinson's disease. |
2018-03-22 |
2023-08-13 |
Not clear |
| Shima Motamedi, Isaac Karimi, Fariba Jafar. The interrelationship of metabolic syndrome and neurodegenerative diseases with focus on brain-derived neurotrophic factor (BDNF): Kill two birds with one stone. Metabolic brain disease. vol 32. issue 3. 2018-03-02. PMID:28361262. |
the brain-derived neurotrophic factor (bdnf) is involved in metabolic syndrome (mets) and neurodegenerative diseases (ndd) like alzheimer's disease, huntington's disease, parkinson's disease and depression. |
2018-03-02 |
2023-08-13 |
Not clear |
| Marta Balietti, Cinzia Giuli, Patrizia Fattoretti, Paolo Fabbietti, Roberta Papa, Demetrio Postacchini, Fiorenzo Cont. Effect of a Comprehensive Intervention on Plasma BDNF in Patients with Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 57. issue 1. 2018-02-26. PMID:28222525. |
effect of a comprehensive intervention on plasma bdnf in patients with alzheimer's disease. |
2018-02-26 |
2023-08-13 |
Not clear |